Development Level

Tbio 502 | 10,625
Tdark 108 | 7,003
Tchem 74 | 1,890
Tclin 34 | 602

Collection

Eligible Ion Channel Proteins 8 | 117
Eligible Kinase Proteins 7 | 134
Eligible non-olfactory GPCR Proteins 5 | 143

IMPC Term

preweaning lethality, complete... 31 | 633
preweaning lethality, incomple... 16 | 260
abnormal behavior 15 | 226
decreased total body fat amoun... 12 | 186
decreased body weight 11 | 174
embryonic lethality prior to t... 10 | 187
decreased circulating choleste... 9 | 85
increased mean corpuscular vol... 9 | 91
abnormal bone structure 8 | 131
abnormal embryo size 8 | 112
decreased bone mineral density 8 | 126
decreased circulating HDL chol... 8 | 77
decreased lean body mass 8 | 195
hyperactivity 8 | 108
increased bone mineral content 8 | 92
increased lean body mass 8 | 107
increased mean corpuscular hem... 8 | 93
abnormal retina morphology 7 | 100
decreased bone mineral content 7 | 157
increased body weight 7 | 42
increased or absent threshold ... 7 | 128
decreased circulating glucose ... 6 | 121
decreased circulating insulin ... 6 | 75
decreased grip strength 6 | 123
increased circulating alkaline... 6 | 119
increased circulating sodium l... 6 | 71
increased fasted circulating g... 6 | 68
prenatal lethality prior to he... 6 | 64
decreased mean corpuscular vol... 5 | 50
decreased prepulse inhibition 5 | 52
hypoactivity 5 | 89
improved glucose tolerance 5 | 56
increased bone mineral density 5 | 52
increased circulating chloride... 5 | 43
increased total body fat amoun... 5 | 57
abnormal QRS complex 4 | 25
abnormal neural tube closure 4 | 37
cardiovascular system phenotyp... 4 | 35
decreased T cell number 4 | 31
decreased circulating alanine ... 4 | 53
decreased circulating aspartat... 4 | 27
decreased circulating total pr... 4 | 41
decreased circulating triglyce... 4 | 83
decreased startle reflex 4 | 48
enlarged heart 4 | 111
increased blood urea nitrogen ... 4 | 44
increased circulating choleste... 4 | 53
increased grip strength 4 | 83
increased heart weight 4 | 37
male infertility 4 | 62
persistence of hyaloid vascula... 4 | 22
abnormal behavioral response t... 3 | 52
abnormal bone mineralization 3 | 55
abnormal embryo turning 3 | 15
abnormal hindbrain development 3 | 24
abnormal midbrain development 3 | 22
abnormal pericardium morpholog... 3 | 11
abnormal retinal pigmentation 3 | 61
abnormal sleep behavior 3 | 63
abnormal spleen morphology 3 | 36
decreased circulating LDL chol... 3 | 37
decreased circulating alkaline... 3 | 41
decreased circulating fructosa... 3 | 31
decreased circulating iron lev... 3 | 25
decreased circulating potassiu... 3 | 17
decreased circulating serum al... 3 | 79
decreased effector memory CD8-... 3 | 24
decreased exploration in new e... 3 | 9
decreased hemoglobin content 3 | 53
decreased lumbar vertebrae num... 3 | 62
decreased rib number 3 | 59
embryonic lethality prior to o... 3 | 148
impaired glucose tolerance 3 | 52
increased circulating HDL chol... 3 | 63
increased circulating free fat... 3 | 17
increased circulating iron lev... 3 | 25
increased circulating phosphat... 3 | 24
increased exploration in new e... 3 | 56
increased startle reflex 3 | 38
abnormal coat/hair pigmentatio... 2 | 54
abnormal cornea morphology 2 | 24
abnormal gait 2 | 51
abnormal lens morphology 2 | 73
abnormal vertebrae morphology 2 | 14
abnormal vibrissa morphology 2 | 17
absent startle reflex 2 | 15
decreased body length 2 | 108
decreased caudal vertebrae num... 2 | 49
decreased fasted circulating g... 2 | 49
decreased heart rate variabili... 2 | 11
decreased total retina thickne... 2 | 20
decreased vertical activity 2 | 22
increased circulating aspartat... 2 | 17
increased circulating calcium ... 2 | 32
increased circulating total pr... 2 | 20
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased prepulse inhibition 2 | 21
short tibia 2 | 82
small testis 2 | 37

Disease

osteosarcoma 347 | 7,933
ovarian cancer 346 | 8,484
medulloblastoma, large-cell 314 | 6,234
glioblastoma 287 | 5,572
psoriasis 260 | 6,685
atypical teratoid / rhabdoid tumor 212 | 4,369
lung cancer 186 | 4,466
pilocytic astrocytoma 172 | 3,086
Carcinoma 165 | 2,147
lung carcinoma 162 | 2,844
posterior fossa group B ependymoma 162 | 1,530
oligodendroglioma 153 | 2,849
pediatric high grade glioma 149 | 2,712
primitive neuroectodermal tumor 149 | 3,031
Breast cancer 148 | 3,094
invasive ductal carcinoma 147 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 142 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 130 | 2,988
malignant mesothelioma 130 | 3,162
astrocytic glioma 125 | 2,241
ependymoma 124 | 2,514
lung adenocarcinoma 122 | 2,713
intraductal papillary-mucinous neoplasm (IPMN) 116 | 3,289
non-small cell lung cancer 114 | 2,798
interstitial cystitis 109 | 2,299
adult high grade glioma 105 | 2,148
pancreatic cancer 103 | 2,300
Pick disease 102 | 1,893
group 3 medulloblastoma 99 | 2,254
subependymal giant cell astrocytoma 97 | 2,287
pituitary cancer 93 | 1,972
group 4 medulloblastoma 92 | 1,875
ulcerative colitis 91 | 2,087
Cancer 84 | 2,346
ductal carcinoma in situ 81 | 1,745
medulloblastoma 80 | 1,524
chronic rhinosinusitis 78 | 512
nasopharyngeal carcinoma 77 | 1,056
colon cancer 76 | 1,475
cystic fibrosis 76 | 1,665
astrocytoma 69 | 1,493
sonic hedgehog group medulloblastoma 69 | 1,482
breast carcinoma 66 | 1,614
primary pancreatic ductal adenocarcinoma 65 | 1,271
atypical teratoid/rhabdoid tumor 63 | 1,095
posterior fossa group A ependymoma 63 | 1,511
tuberculosis 63 | 1,557
Intellectual disability 58 | 573
adrenocortical carcinoma 53 | 1,427
spina bifida 53 | 1,064
juvenile dermatomyositis 51 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,795
acute quadriplegic myopathy 50 | 1,157
Polydactyly 46 | 93
cutaneous lupus erythematosus 45 | 1,056
diabetes mellitus 45 | 1,663
gastric carcinoma 45 | 832
Alzheimer's disease 42 | 644
Ciliopathy 41 | 57
Joubert syndrome 41 | 61
Retinitis pigmentosa 41 | 153
Nephronophthisis 40 | 74
Obesity 39 | 616
progressive supranuclear palsy 38 | 674
dermatomyositis 37 | 933
Rheumatoid Arthritis 35 | 1,160
aldosterone-producing adenoma 35 | 664
Atopic dermatitis 34 | 944
Primary ciliary dyskinesia 34 | 73
Waldenstrons macroglobulinemia 34 | 765
active Crohn's disease 34 | 918
Multiple myeloma 33 | 1,327
Neurodegenerative disease 33 | 383
esophageal adenocarcinoma 33 | 737
Duchenne muscular dystrophy 30 | 602
Schizophrenia 30 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 30 | 499
non primary Sjogren syndrome sicca 30 | 840
Meckel syndrome 29 | 48
Bardet-Biedl Syndrome 28 | 40
Situs Inversus 27 | 48
tuberculosis and treatment for 6 months 27 | 686
Amyotrophic Lateral Sclerosis 26 | 431
Down syndrome 26 | 548
Endometriosis 25 | 535
primary Sjogren syndrome 25 | 789
fibroadenoma 24 | 557
mucosa-associated lymphoid tissue lymphoma 24 | 480
Autistic Disorder 23 | 320
Nonsyndromic deafness 23 | 121
Epilepsy 22 | 346
Fundus dystrophy 22 | 77
Kidney disease 22 | 396
cystic fibrosis and chronic rhinosinusitis 22 | 213
Asphyxiating thoracic dystrophy 21 | 32
Multiple Sclerosis 21 | 498
Parkinson's disease 21 | 364
acute myeloid leukemia 21 | 780
glioblastoma multiforme 20 | 347
non-small cell lung carcinoma 20 | 413

Tissue

Nervous System 717 | 18,561
Digestive Tract 716 | 18,473
Female tissues 716 | 18,647
Endocrine System 714 | 18,512
Urinary Tract 713 | 18,444
Liver and Pancreas 712 | 18,136
Cardiovascular System 711 | 17,958
Male tissues 711 | 17,969
Blood and immune system 709 | 17,995
Skin and soft tissues 708 | 18,115
Respiratory system 704 | 17,484

Target Family

Non-IDG 505 | 11,971
Enzyme 98 | 4,146
Kinase 45 | 634
Ion Channel 34 | 341
GPCR 15 | 406
Transporter 10 | 473
Epigenetic 6 | 242
Transcription Factor 4 | 1,400
Nuclear Receptor 1 | 48

UniProt Keyword

Cell projection 718 | 718
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Stereocilin STRC Tbio Non-IDG 35.9 7
Cilia- and flagella-associated protein 77 CFAP77 Tdark Non-IDG 0.00000 11
Tyrosine-protein phosphatase non-receptor type 13 PTPN13 Tchem Enzyme -2.20613 177.9 120
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.80380 77.2 248
Receptor-type tyrosine-protein phosphatase eta PTPRJ Tbio Enzyme -1.94494 110.6 235
Sodium/calcium exchanger 2 SLC8A2 Tbio Transporter -1.56223 31.9 51
Cytoplasmic polyadenylation element-binding protein 1 CPEB1 Tbio Non-IDG -2.20580 171.1 185
Cation channel sperm-associated protein 4 CATSPER4 Tchem Ion Channel 0.06 0.89 32
Protein C21orf2 C21orf2 Tbio Non-IDG -1.66840 37.4 95