Development Level

Tbio 1,544 | 10,625
Tdark 863 | 7,003
Tchem 475 | 1,890
Tclin 300 | 602

Collection

Eligible non-olfactory GPCR Proteins 113 | 143
Eligible Ion Channel Proteins 61 | 117
Eligible Kinase Proteins 17 | 134

IMPC Term

preweaning lethality, complete... 71 | 633
preweaning lethality, incomple... 52 | 260
abnormal behavior 51 | 226
decreased lean body mass 45 | 195
decreased total body fat amoun... 36 | 186
decreased bone mineral content 34 | 157
decreased bone mineral density 34 | 126
increased or absent threshold ... 31 | 128
decreased grip strength 30 | 123
decreased body weight 28 | 174
hyperactivity 25 | 108
abnormal bone structure 24 | 131
embryonic lethality prior to t... 24 | 187
enlarged heart 22 | 111
increased circulating alkaline... 22 | 119
abnormal retina morphology 20 | 100
decreased circulating choleste... 20 | 85
decreased circulating HDL chol... 18 | 77
increased mean corpuscular vol... 18 | 91
decreased circulating triglyce... 17 | 83
decreased circulating glucose ... 16 | 121
hypoactivity 16 | 89
increased grip strength 16 | 83
increased lean body mass 16 | 107
decreased prepulse inhibition 15 | 52
increased bone mineral content 15 | 92
increased circulating HDL chol... 15 | 63
increased mean corpuscular hem... 15 | 93
abnormal retinal pigmentation 14 | 61
increased circulating choleste... 14 | 53
short tibia 14 | 82
decreased body length 13 | 108
decreased circulating alanine ... 13 | 53
decreased circulating insulin ... 13 | 75
decreased fasted circulating g... 13 | 49
decreased rib number 13 | 59
increased body weight 13 | 42
increased circulating sodium l... 13 | 71
increased total body fat amoun... 13 | 57
abnormal gait 12 | 51
abnormal sleep behavior 12 | 63
impaired glucose tolerance 12 | 52
increased blood urea nitrogen ... 12 | 44
increased bone mineral density 12 | 52
abnormal bone mineralization 11 | 55
abnormal embryo size 11 | 112
cardiovascular system phenotyp... 11 | 35
decreased startle reflex 11 | 48
abnormal seminal vesicle morph... 10 | 47
decreased heart weight 10 | 44
decreased lumbar vertebrae num... 10 | 62
embryonic lethality prior to o... 10 | 148
improved glucose tolerance 10 | 56
increased exploration in new e... 10 | 56
increased heart weight 10 | 37
increased hematocrit 10 | 36
increased hemoglobin content 10 | 45
limb grasping 10 | 35
tremors 10 | 34
abnormal lens morphology 9 | 73
decreased leukocyte cell numbe... 9 | 54
decreased mean corpuscular vol... 9 | 50
increased circulating calcium ... 9 | 32
increased leukocyte cell numbe... 9 | 37
increased sacral vertebrae num... 9 | 62
male infertility 9 | 62
prenatal lethality prior to he... 9 | 64
thrombocytopenia 9 | 46
decreased hemoglobin content 8 | 53
decreased mean corpuscular hem... 8 | 34
increased circulating total pr... 8 | 20
increased fasted circulating g... 8 | 68
small testis 8 | 37
abnormal heart morphology 7 | 51
absent vibrissae 7 | 14
decreased caudal vertebrae num... 7 | 49
decreased eosinophil cell numb... 7 | 41
decreased neutrophil cell numb... 7 | 37
female infertility 7 | 34
increased circulating chloride... 7 | 43
increased circulating creatini... 7 | 29
increased circulating phosphat... 7 | 24
increased circulating potassiu... 7 | 31
increased circulating triglyce... 7 | 24
persistence of hyaloid vascula... 7 | 22
abnormal behavioral response t... 6 | 52
abnormal coat appearance 6 | 25
abnormal coat/hair pigmentatio... 6 | 54
abnormal epididymis morphology 6 | 31
abnormal neural tube closure 6 | 37
abnormal spleen morphology 6 | 36
abnormal vibrissa morphology 6 | 17
absent startle reflex 6 | 15
decreased NK T cell number 6 | 28
decreased T cell number 6 | 31
decreased circulating LDL chol... 6 | 37
decreased circulating serum al... 6 | 79
decreased circulating total pr... 6 | 41
decreased vertical activity 6 | 22
enlarged spleen 6 | 26

Disease

osteosarcoma 1,199 | 7,933
ovarian cancer 1,169 | 8,484
psoriasis 1,111 | 6,685
medulloblastoma, large-cell 1,064 | 6,234
glioblastoma 973 | 5,572
atypical teratoid / rhabdoid tumor 741 | 4,369
lung cancer 690 | 4,466
lung carcinoma 687 | 2,844
pilocytic astrocytoma 678 | 3,086
invasive ductal carcinoma 554 | 2,950
interstitial cystitis 553 | 2,299
oligodendroglioma 544 | 2,849
non-small cell lung cancer 537 | 2,798
Carcinoma 535 | 2,147
lung adenocarcinoma 533 | 2,713
intraductal papillary-mucinous neoplasm (IPMN) 532 | 3,289
primitive neuroectodermal tumor 520 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 517 | 2,956
pediatric high grade glioma 512 | 2,712
Breast cancer 509 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 497 | 2,988
malignant mesothelioma 496 | 3,162
Cancer 465 | 2,346
subependymal giant cell astrocytoma 455 | 2,287
ulcerative colitis 441 | 2,087
ependymoma 434 | 2,514
pancreatic cancer 417 | 2,300
adult high grade glioma 405 | 2,148
pituitary cancer 389 | 1,972
astrocytic glioma 381 | 2,241
ductal carcinoma in situ 355 | 1,745
diabetes mellitus 333 | 1,663
group 4 medulloblastoma 328 | 1,875
cystic fibrosis 321 | 1,665
tuberculosis 312 | 1,557
posterior fossa group A ependymoma 296 | 1,511
Pick disease 295 | 1,893
breast carcinoma 295 | 1,614
medulloblastoma 280 | 1,524
astrocytoma 279 | 1,493
colon cancer 272 | 1,475
group 3 medulloblastoma 271 | 2,254
cutaneous lupus erythematosus 250 | 1,056
primary pancreatic ductal adenocarcinoma 240 | 1,271
adrenocortical carcinoma 239 | 1,427
posterior fossa group B ependymoma 239 | 1,530
sonic hedgehog group medulloblastoma 238 | 1,482
pancreatic ductal adenocarcinoma liver metastasis 223 | 1,795
atypical teratoid/rhabdoid tumor 214 | 1,095
Rheumatoid Arthritis 203 | 1,160
active Crohn's disease 185 | 918
juvenile dermatomyositis 175 | 1,189
spina bifida 173 | 1,064
primary Sjogren syndrome 169 | 789
nasopharyngeal carcinoma 167 | 1,056
gastric carcinoma 165 | 832
Schizophrenia 161 | 501
acute quadriplegic myopathy 157 | 1,157
esophageal adenocarcinoma 151 | 737
Obesity 149 | 616
Atopic dermatitis 148 | 944
Alzheimer's disease 145 | 644
Down syndrome 137 | 548
Multiple Sclerosis 135 | 498
dermatomyositis 135 | 933
Duchenne muscular dystrophy 134 | 602
Epilepsy 131 | 346
Multiple myeloma 126 | 1,327
mucosa-associated lymphoid tissue lymphoma 124 | 480
aldosterone-producing adenoma 119 | 664
fibroadenoma 117 | 557
non primary Sjogren syndrome sicca 112 | 840
Autistic Disorder 105 | 320
active ulcerative colitis 105 | 477
non-small cell lung carcinoma 102 | 413
Parkinson's disease 101 | 364
autosomal dominant Emery-Dreifuss muscular dystrophy 101 | 499
acute myeloid leukemia 97 | 780
Intellectual disability 96 | 573
Kidney disease 94 | 396
Waldenstrons macroglobulinemia 93 | 765
pancreatic carcinoma 93 | 567
Hypertension 92 | 287
Asthma 91 | 349
Endometriosis 90 | 535
Prostatic Neoplasms 90 | 471
progressive supranuclear palsy 89 | 674
Mammary Neoplasms 88 | 410
Bipolar Disorder 80 | 266
nephrosclerosis 78 | 329
Amyotrophic Lateral Sclerosis 74 | 431
sarcoidosis 74 | 358
Heart disease 73 | 279
Atherosclerosis 72 | 275
IGA Glomerulonephritis 72 | 454
tuberculosis and treatment for 6 months 72 | 686
urothelial carcinoma 72 | 318
Neurodegenerative disease 71 | 383
Cerebrovascular disease 70 | 231
chronic lymphosyte leukemia 68 | 232

Tissue

Female tissues 2,962 | 18,647
Urinary Tract 2,919 | 18,444
Nervous System 2,879 | 18,561
Endocrine System 2,875 | 18,512
Digestive Tract 2,851 | 18,473
Skin and soft tissues 2,779 | 18,115
Liver and Pancreas 2,726 | 18,136
Blood and immune system 2,697 | 17,995
Cardiovascular System 2,676 | 17,958
Male tissues 2,651 | 17,969
Respiratory system 2,594 | 17,484

Target Family

Non-IDG 1,510 | 11,971
oGPCR 420 | 421
GPCR 364 | 406
Enzyme 349 | 4,146
Ion Channel 206 | 341
Transporter 178 | 473
Kinase 145 | 634
Transcription Factor 5 | 1,400
Epigenetic 4 | 242
Nuclear Receptor 1 | 48

UniProt Keyword

Cell membrane 3,182 | 3,182
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
HLA class II histocompatibility antigen, DRB1-14 beta chain HLA-DRB1 Tbio Non-IDG 0.00000 337
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Taste receptor type 1 member 3 TAS1R3 Tbio GPCR -2.19758 165.4 232
Taste receptor type 1 member 1 TAS1R1 Tbio GPCR -1.71516 50.8 165
Monocarboxylate transporter 14 SLC16A14 Tdark Transporter -0.69265 4.88 34
Monocarboxylate transporter 13 SLC16A13 Tdark Transporter -0.40437 1.87 71
Transmembrane protease serine 6 TMPRSS6 Tchem Enzyme -1.99222 118.1 102