Development Level

Tbio 1,702 | 11,445
Tdark 930 | 6,588
Tchem 448 | 1,598
Tclin 310 | 613

Collection

RFA-RM-18-021 159 | 328
GPCR: IDG Consortium (Targets) 98 | 126
Ion Channel: IDG Consortium (T... 51 | 99
GPCR: IDG Consortium (Complete... 24 | 25
Kinase: IDG Consortium (Target... 16 | 125
Kinase: IDG Consortium (Comple... 6 | 37

IMPC Phenotype

preweaning lethality, complete... 104 | 979
preweaning lethality, incomple... 92 | 499
abnormal behavior 68 | 298
decreased vertical activity 53 | 208
decreased total body fat amoun... 42 | 207
enlarged heart 38 | 210
embryonic lethality prior to t... 36 | 278
abnormal bone structure 35 | 187
hyperactivity 33 | 148
decreased bone mineral content 32 | 151
increased lean body mass 32 | 172
abnormal embryo size 31 | 220
increased total body fat amoun... 30 | 134
decreased body weight 28 | 161
abnormal heart morphology 27 | 162
abnormal seminal vesicle morph... 27 | 114
decreased lean body mass 26 | 135
increased or absent threshold ... 25 | 101
decreased bone mineral density 24 | 126
decreased grip strength 23 | 116
embryonic lethality prior to o... 23 | 239
abnormal retina morphology 21 | 71
decreased startle reflex 21 | 75
increased circulating alkaline... 21 | 122
decreased circulating glucose ... 20 | 126
hypoactivity 20 | 132
impaired glucose tolerance 19 | 75
increased startle reflex 19 | 112
abnormal sleep behavior 18 | 70
decreased fasted circulating g... 18 | 65
decreased lymphocyte cell numb... 18 | 83
increased bone mineral content 18 | 108
increased mean corpuscular vol... 18 | 92
short tibia 18 | 97
decreased circulating choleste... 17 | 93
abnormal eye morphology 16 | 68
abnormal gait 16 | 69
decreased prepulse inhibition 16 | 82
embryonic growth retardation 16 | 106
increased mean corpuscular hem... 16 | 96
small superior vagus ganglion 16 | 74
improved glucose tolerance 15 | 79
increased heart weight 15 | 62
cataract 14 | 92
decreased body length 14 | 101
decreased circulating HDL chol... 14 | 68
decreased circulating triglyce... 14 | 79
edema 14 | 59
increased leukocyte cell numbe... 14 | 47
decreased leukocyte cell numbe... 13 | 73
increased circulating HDL chol... 13 | 80
increased circulating choleste... 13 | 66
increased circulating sodium l... 13 | 71
increased circulating triglyce... 13 | 42
increased monocyte cell number 13 | 63
decreased circulating insulin ... 12 | 76
increased fasted circulating g... 12 | 76
limb grasping 12 | 41
tremors 12 | 39
abnormal behavioral response t... 11 | 66
decreased mean corpuscular vol... 11 | 79
increased circulating chloride... 11 | 41
increased hematocrit 11 | 46
increased neutrophil cell numb... 11 | 46
male infertility 11 | 123
small testis 11 | 58
abnormal lens morphology 10 | 81
abnormal neural tube closure 10 | 46
decreased hemoglobin content 10 | 68
decreased mean corpuscular hem... 10 | 50
hydrometra 10 | 53
increased blood urea nitrogen ... 10 | 48
increased bone mineral density 10 | 72
increased hemoglobin content 10 | 45
increased vertical activity 10 | 24
prenatal lethality prior to he... 10 | 87
abnormal kidney morphology 9 | 65
abnormal skin morphology 9 | 50
abnormal testis morphology 9 | 43
cardiovascular system phenotyp... 9 | 36
decreased circulating creatini... 9 | 39
decreased erythrocyte cell num... 9 | 62
decreased heart weight 9 | 27
increased circulating creatini... 9 | 38
increased lymphocyte cell numb... 9 | 32
persistence of hyaloid vascula... 9 | 33
abnormal coat appearance 8 | 31
abnormal coat-hair pigmentatio... 8 | 64
abnormal cornea morphology 8 | 31
abnormal epididymis morphology 8 | 42
abnormal locomotor behavior 8 | 24
abnormal pericardium morpholog... 8 | 26
decreased circulating total pr... 8 | 49
enlarged spleen 8 | 41
impaired pupillary reflex 8 | 26
increased circulating calcium ... 8 | 34
increased mean platelet volume 8 | 45
pallor 8 | 34
prenatal lethality 8 | 28
thrombocytopenia 8 | 56

Disease

Carcinoma 2,273 | 11,493
osteosarcoma 1,260 | 7,950
ovarian cancer 1,226 | 8,520
psoriasis 1,153 | 6,694
medulloblastoma, large-cell 1,112 | 6,241
glioblastoma 1,052 | 5,792
atypical teratoid / rhabdoid tumor 921 | 5,112
ependymoma 877 | 4,679
lung cancer 822 | 4,740
adult high grade glioma 756 | 3,801
lung carcinoma 713 | 2,843
Astrocytoma, Pilocytic 700 | 3,081
Breast cancer 632 | 3,578
group 3 medulloblastoma 628 | 4,104
Kidney cancer 618 | 2,613
non-small cell lung cancer 588 | 2,890
interstitial cystitis 584 | 2,312
invasive ductal carcinoma 576 | 2,951
oligodendroglioma 565 | 2,850
lung adenocarcinoma 560 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 550 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 541 | 2,955
primitive neuroectodermal tumor 537 | 3,035
malignant mesothelioma 521 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 519 | 2,989
Cancer 512 | 2,499
subependymal giant cell astrocytoma 474 | 2,287
astrocytic glioma 473 | 2,597
pancreatic cancer 466 | 2,398
tuberculosis 412 | 2,010
ulcerative colitis 405 | 1,819
pituitary cancer 403 | 1,972
ductal carcinoma in situ 364 | 1,745
diabetes mellitus 360 | 1,728
cystic fibrosis 338 | 1,696
Schizophrenia 337 | 1,160
group 4 medulloblastoma 330 | 1,855
breast carcinoma 307 | 1,638
Pick disease 305 | 1,894
colon cancer 284 | 1,478
Autosomal recessive predisposition 268 | 1,442
cutaneous lupus erythematosus 265 | 1,057
pancreatic ductal adenocarcinoma liver metastasis 264 | 1,962
adrenocortical carcinoma 251 | 1,428
Rheumatoid arthritis 225 | 1,191
primary pancreatic ductal adenocarcinoma 216 | 1,109
astrocytoma 212 | 1,146
Bipolar Disorder 203 | 666
pediatric high grade glioma 191 | 1,064
Melanoma 190 | 711
active Crohn's disease 190 | 922
Epilepsy 188 | 792
juvenile dermatomyositis 182 | 1,187
spina bifida 181 | 1,074
Liver cancer 177 | 604
nasopharyngeal carcinoma 172 | 1,058
active ulcerative colitis 170 | 764
primary Sjogren syndrome 168 | 735
acute quadriplegic myopathy 166 | 1,158
Intellectual disability 163 | 1,016
gastric carcinoma 163 | 807
Obesity 159 | 678
esophageal adenocarcinoma 156 | 737
Skin cancer 154 | 469
Alzheimer's disease 152 | 658
Atopic dermatitis 152 | 952
Multiple Sclerosis 147 | 540
Liver Cirrhosis, Experimental 146 | 769
Duchenne muscular dystrophy 139 | 601
dermatomyositis 138 | 966
Depressive disorder 136 | 409
Multiple myeloma 133 | 1,332
mucosa-associated lymphoid tissue lymphoma 130 | 484
Down syndrome 127 | 499
Alcoholic Intoxication, Chronic 126 | 289
Hypertension 126 | 396
aldosterone-producing adenoma 126 | 665
non primary Sjogren syndrome sicca 124 | 891
fibroadenoma 121 | 559
Autistic Disorder 117 | 364
Mental Depression 116 | 333
Seizures 116 | 596
medulloblastoma 114 | 720
Kidney disease 109 | 430
Asthma 106 | 385
Parkinson's disease 106 | 392
acute myeloid leukemia 103 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 103 | 510
Dull intelligence 101 | 645
Low intelligence 101 | 645
Mental Retardation 101 | 645
Mental deficiency 101 | 645
Poor school performance 101 | 645
Major Depressive Disorder 96 | 301
pancreatic carcinoma 96 | 562
Breast Neoplasms 95 | 445
Prostatic Neoplasms 95 | 495
Waldenstrons macroglobulinemia 94 | 765
progressive supranuclear palsy 94 | 676
Endometriosis 93 | 540

Tissue

Endocrine System 2,769 | 18,159
Female tissues 2,613 | 17,400
Digestive Tract 2,605 | 17,369
Skin and soft tissues 2,565 | 17,230
Male tissues 2,554 | 17,142
Nervous System 2,534 | 16,725
Blood and immune system 2,515 | 16,909
Urinary Tract 2,501 | 16,678
Liver and Pancreas 2,491 | 16,750
Respiratory system 2,418 | 16,393
Cardiovascular System 2,168 | 15,192

Target Family

Non-IDG 1,677 | 12,091
oGPCR 420 | 421
GPCR 366 | 408
Enzyme 357 | 4,145
Ion Channel 219 | 344
Transporter 193 | 473
Kinase 146 | 634
Transcription Factor 7 | 1,400
Epigenetic 4 | 242
Nuclear Receptor 1 | 48

UniProt Keyword

Cell membrane 3,390 | 3,390
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
Shadow of prion protein SPRN Tbio Non-IDG -2.49698 315.1 88
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Protocadherin gamma-A9 PCDHGA9 Tdark Non-IDG 0.51 0.72 31
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Neuromodulin GAP43 Tbio Non-IDG -2.93905 762.9 597