Development Level

Tbio 524 | 11,651
Tclin 73 | 612
Tdark 57 | 6,593
Tchem 55 | 1,388

Collection

RFA-RM-18-021 19 | 328
Ion Channel: IDG Consortium (T... 18 | 99
Kinase: IDG Consortium (Comple... 3 | 37
GPCR: IDG Consortium (Complete... 2 | 25
Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 45 | 979
preweaning lethality, incomple... 28 | 499
abnormal behavior 18 | 298
decreased total body fat amoun... 16 | 207
decreased vertical activity 14 | 208
embryonic lethality prior to t... 14 | 278
abnormal embryo size 13 | 220
decreased body weight 12 | 161
increased total body fat amoun... 11 | 134
abnormal bone structure 10 | 187
enlarged heart 10 | 210
hyperactivity 10 | 148
increased lean body mass 10 | 172
abnormal sleep behavior 9 | 70
decreased circulating choleste... 9 | 93
decreased lymphocyte cell numb... 9 | 83
embryonic lethality prior to o... 9 | 239
increased or absent threshold ... 9 | 101
abnormal heart morphology 8 | 162
abnormal retina morphology 8 | 71
decreased bone mineral content 8 | 151
decreased grip strength 7 | 116
decreased lean body mass 7 | 135
decreased startle reflex 7 | 75
embryonic growth retardation 7 | 106
hypoactivity 7 | 132
increased mean corpuscular vol... 7 | 92
increased startle reflex 7 | 112
decreased body length 6 | 101
decreased circulating HDL chol... 6 | 68
decreased fasted circulating g... 6 | 65
improved glucose tolerance 6 | 79
increased bone mineral content 6 | 108
increased circulating chloride... 6 | 41
increased heart weight 6 | 62
abnormal pericardium morpholog... 5 | 26
abnormal testis morphology 5 | 43
decreased circulating glucose ... 5 | 126
edema 5 | 59
increased circulating alkaline... 5 | 122
increased monocyte cell number 5 | 63
small superior vagus ganglion 5 | 74
small testis 5 | 58
abnormal behavioral response t... 4 | 66
abnormal coat appearance 4 | 31
abnormal cornea morphology 4 | 31
abnormal locomotor behavior 4 | 24
abnormal seminal vesicle morph... 4 | 114
abnormal skin morphology 4 | 50
decreased bone mineral density 4 | 126
decreased circulating serum al... 4 | 82
decreased mean corpuscular vol... 4 | 79
hydrometra 4 | 53
impaired glucose tolerance 4 | 75
increased body weight 4 | 25
increased bone mineral density 4 | 72
increased circulating sodium l... 4 | 71
increased vertical activity 4 | 24
persistence of hyaloid vascula... 4 | 33
prenatal lethality prior to he... 4 | 87
tremors 4 | 39
abnormal bone mineralization 3 | 38
abnormal epididymis morphology 3 | 42
abnormal gait 3 | 69
abnormal joint morphology 3 | 23
abnormal kidney morphology 3 | 65
abnormal neural tube closure 3 | 46
abnormal spleen morphology 3 | 55
brachydactyly 3 | 19
decreased circulating aspartat... 3 | 34
decreased circulating insulin ... 3 | 76
decreased circulating triglyce... 3 | 79
decreased neutrophil cell numb... 3 | 42
decreased threshold for audito... 3 | 26
hemorrhage 3 | 23
increased blood urea nitrogen ... 3 | 48
increased fasted circulating g... 3 | 76
increased neutrophil cell numb... 3 | 46
increased red blood cell distr... 3 | 34
limb grasping 3 | 41
male infertility 3 | 123
short tibia 3 | 97
syndactyly 3 | 23
abnormal coat-hair pigmentatio... 2 | 64
abnormal liver morphology 2 | 17
abnormal retinal vasculature m... 2 | 27
absent startle reflex 2 | 24
absent vibrissae 2 | 12
decreased caudal vertebrae num... 2 | 53
decreased eosinophil cell numb... 2 | 24
decreased pulmonary respirator... 2 | 5
increased circulating amylase ... 2 | 25
increased circulating calcium ... 2 | 34
increased circulating choleste... 2 | 66
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
increased circulating potassiu... 2 | 29
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96

Disease

Carcinoma 551 | 11,493
medulloblastoma, large-cell 372 | 6,241
glioblastoma 360 | 5,792
ovarian cancer 347 | 8,520
atypical teratoid / rhabdoid tumor 339 | 5,112
osteosarcoma 320 | 7,950
ependymoma 311 | 4,679
psoriasis 309 | 6,694
adult high grade glioma 271 | 3,801
group 3 medulloblastoma 246 | 4,104
Astrocytoma, Pilocytic 239 | 3,081
oligodendroglioma 223 | 2,850
primitive neuroectodermal tumor 223 | 3,035
lung cancer 212 | 4,740
lung carcinoma 194 | 2,843
Kidney cancer 191 | 2,613
astrocytic glioma 191 | 2,597
Breast cancer 182 | 3,578
non-small cell lung cancer 177 | 2,890
subependymal giant cell astrocytoma 167 | 2,287
invasive ductal carcinoma 166 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 160 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 160 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 156 | 2,989
malignant mesothelioma 155 | 3,232
interstitial cystitis 151 | 2,312
lung adenocarcinoma 144 | 2,716
Schizophrenia 142 | 1,160
Pick disease 139 | 1,894
pancreatic cancer 132 | 2,398
pituitary cancer 125 | 1,972
Cancer 115 | 2,499
ductal carcinoma in situ 106 | 1,745
cystic fibrosis 99 | 1,696
breast carcinoma 93 | 1,638
group 4 medulloblastoma 88 | 1,855
ulcerative colitis 83 | 1,819
Bipolar Disorder 82 | 666
colon cancer 79 | 1,478
tuberculosis 79 | 2,010
Intellectual disability 75 | 1,016
spina bifida 75 | 1,074
Epilepsy 74 | 792
Liver cancer 68 | 604
pancreatic ductal adenocarcinoma liver metastasis 68 | 1,962
adrenocortical carcinoma 67 | 1,428
Autosomal recessive predisposition 66 | 1,442
primary pancreatic ductal adenocarcinoma 65 | 1,109
astrocytoma 64 | 1,146
Autistic Disorder 61 | 364
diabetes mellitus 58 | 1,728
Melanoma 55 | 711
pediatric high grade glioma 54 | 1,064
Skin cancer 47 | 469
acute quadriplegic myopathy 47 | 1,158
juvenile dermatomyositis 47 | 1,187
active Crohn's disease 46 | 922
esophageal adenocarcinoma 46 | 737
gastric carcinoma 46 | 807
Alcoholic Intoxication, Chronic 45 | 289
Alzheimer's disease 45 | 658
medulloblastoma 45 | 720
cutaneous lupus erythematosus 44 | 1,057
nasopharyngeal carcinoma 43 | 1,058
Muscle hypotonia 42 | 571
Parkinson's disease 41 | 392
dermatomyositis 41 | 966
General anesthesia 40 | 53
Depressive disorder 39 | 409
Rheumatoid arthritis 38 | 1,191
Down syndrome 37 | 499
Dull intelligence 37 | 645
Low intelligence 37 | 645
Mental Depression 37 | 333
Mental Retardation 37 | 645
Mental deficiency 37 | 645
Poor school performance 37 | 645
Seizures 37 | 596
active ulcerative colitis 37 | 764
Atopic dermatitis 36 | 952
aldosterone-producing adenoma 35 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 35 | 510
Amyotrophic lateral sclerosis 33 | 451
Major Depressive Disorder 33 | 301
non primary Sjogren syndrome sicca 33 | 891
Neurodegenerative disease 32 | 414
Duchenne muscular dystrophy 31 | 601
acute myeloid leukemia 31 | 783
progressive supranuclear palsy 30 | 676
Multiple myeloma 29 | 1,332
Cognitive delay 28 | 608
Global developmental delay 28 | 608
Liver Cirrhosis, Experimental 28 | 769
Mental and motor retardation 28 | 608
Prostatic Neoplasms 28 | 495
fibroadenoma 28 | 559
mucosa-associated lymphoid tissue lymphoma 28 | 484
Multiple Sclerosis 26 | 540
Obesity 25 | 678
sonic hedgehog group medulloblastoma 25 | 467

Tissue

Endocrine System 696 | 18,159
Digestive Tract 680 | 17,369
Female tissues 678 | 17,400
Nervous System 677 | 16,725
Skin and soft tissues 672 | 17,230
Male tissues 667 | 17,142
Urinary Tract 654 | 16,678
Blood and immune system 647 | 16,909
Liver and Pancreas 645 | 16,750
Respiratory system 624 | 16,393
Cardiovascular System 580 | 15,192

Target Family

Non-IDG 503 | 12,091
Ion Channel 79 | 344
Enzyme 64 | 4,145
Kinase 33 | 634
GPCR 14 | 408
Transporter 11 | 473
Epigenetic 4 | 242
Transcription Factor 1 | 1,400

UniProt Keyword

Cell junction 709 | 709
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
Stonin-2 STON2 Tbio Non-IDG -1.43585 30.0 11
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Contactin-associated protein-like 4 CNTNAP4 Tbio Non-IDG -0.73408 0.00000 148
Synaptic vesicle 2-related protein SVOP Tdark Non-IDG -0.57678 4.35 90
Desmoglein-3 DSG3 Tbio Non-IDG -2.57795 402.0 381
Gap junction beta-6 protein GJB6 Tbio Non-IDG -2.99235 908.9 170
Phosphatase and actin regulator 1 PHACTR1 Tbio Enzyme -1.79171 63.2 41
Protein TANC1 TANC1 Tdark Non-IDG -1.18264 15.5 31
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060