Development Level

Tbio 468 | 10,625
Tchem 73 | 1,890
Tclin 72 | 602
Tdark 59 | 7,003

Collection

Eligible Ion Channel Proteins 26 | 117
Eligible non-olfactory GPCR Proteins 2 | 143
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 31 | 633
preweaning lethality, incomple... 16 | 260
abnormal behavior 14 | 226
decreased body weight 11 | 174
decreased circulating choleste... 11 | 85
decreased grip strength 11 | 123
decreased total body fat amoun... 11 | 186
abnormal bone structure 10 | 131
embryonic lethality prior to t... 10 | 187
decreased lean body mass 9 | 195
abnormal embryo size 8 | 112
abnormal retina morphology 8 | 100
decreased bone mineral content 8 | 157
decreased circulating HDL chol... 8 | 77
enlarged heart 7 | 111
increased lean body mass 7 | 107
increased or absent threshold ... 7 | 128
abnormal retinal pigmentation 6 | 61
abnormal sleep behavior 6 | 63
hypoactivity 6 | 89
increased mean corpuscular vol... 6 | 91
decreased circulating glucose ... 5 | 121
decreased fasted circulating g... 5 | 49
hyperactivity 5 | 108
increased mean corpuscular hem... 5 | 93
increased total body fat amoun... 5 | 57
abnormal neural tube closure 4 | 37
decreased bone mineral density 4 | 126
decreased circulating alanine ... 4 | 53
decreased circulating free fat... 4 | 39
decreased circulating insulin ... 4 | 75
decreased startle reflex 4 | 48
decreased vertical activity 4 | 22
embryonic lethality prior to o... 4 | 148
improved glucose tolerance 4 | 56
increased blood urea nitrogen ... 4 | 44
increased body weight 4 | 42
increased circulating alkaline... 4 | 119
increased grip strength 4 | 83
increased vertical activity 4 | 18
prenatal lethality prior to he... 4 | 64
short tibia 4 | 82
shortened RR interval 4 | 19
tremors 4 | 34
abnormal bone mineralization 3 | 55
abnormal coat appearance 3 | 25
abnormal cornea morphology 3 | 24
abnormal gait 3 | 51
abnormal heart left ventricle ... 3 | 20
abnormal heart morphology 3 | 51
abnormal locomotor activation 3 | 26
abnormal pericardium morpholog... 3 | 11
cardiovascular system phenotyp... 3 | 35
decreased body length 3 | 108
decreased circulating aspartat... 3 | 27
decreased circulating triglyce... 3 | 83
decreased mean corpuscular vol... 3 | 50
impaired glucose tolerance 3 | 52
increased bone mineral content 3 | 92
increased circulating HDL chol... 3 | 63
increased circulating chloride... 3 | 43
increased circulating choleste... 3 | 53
increased circulating phosphat... 3 | 24
increased circulating potassiu... 3 | 31
increased circulating sodium l... 3 | 71
increased heart rate 3 | 17
increased heart weight 3 | 37
increased startle reflex 3 | 38
persistence of hyaloid vascula... 3 | 22
abnormal behavioral response t... 2 | 52
abnormal coat/hair pigmentatio... 2 | 54
abnormal head morphology 2 | 10
abnormal lens morphology 2 | 73
abnormal skin morphology 2 | 23
abnormal testis morphology 2 | 30
absent startle reflex 2 | 15
decreased T cell number 2 | 31
decreased circulating LDL chol... 2 | 37
decreased circulating serum al... 2 | 79
decreased effector memory CD8-... 2 | 24
decreased eosinophil cell numb... 2 | 41
decreased exploration in new e... 2 | 9
decreased heart weight 2 | 44
decreased lumbar vertebrae num... 2 | 62
decreased prepulse inhibition 2 | 52
decreased pulmonary respirator... 2 | 4
decreased rib number 2 | 59
enlarged stomach 2 | 2
hydrometra 2 | 13
increased bone mineral density 2 | 52
increased circulating calcium ... 2 | 32
increased exploration in new e... 2 | 56
increased hemoglobin content 2 | 45
lethargy 2 | 5
limb grasping 2 | 35
male infertility 2 | 62
small testis 2 | 37
small thymus 2 | 11
straub tail 2 | 26
thrombocytopenia 2 | 46

Disease

medulloblastoma, large-cell 354 | 6,234
glioblastoma 328 | 5,572
ovarian cancer 324 | 8,484
osteosarcoma 299 | 7,933
psoriasis 292 | 6,685
atypical teratoid / rhabdoid tumor 283 | 4,369
pilocytic astrocytoma 230 | 3,086
primitive neuroectodermal tumor 213 | 3,031
oligodendroglioma 210 | 2,849
pediatric high grade glioma 188 | 2,712
lung cancer 184 | 4,466
lung carcinoma 182 | 2,844
Carcinoma 171 | 2,147
non-small cell lung cancer 161 | 2,798
subependymal giant cell astrocytoma 160 | 2,287
ependymoma 152 | 2,514
invasive ductal carcinoma 151 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 147 | 3,289
Breast cancer 146 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 146 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 146 | 2,988
malignant mesothelioma 146 | 3,162
interstitial cystitis 142 | 2,299
lung adenocarcinoma 135 | 2,713
astrocytic glioma 132 | 2,241
Pick disease 128 | 1,893
adult high grade glioma 122 | 2,148
medulloblastoma 121 | 1,524
pituitary cancer 114 | 1,972
astrocytoma 112 | 1,493
pancreatic cancer 112 | 2,300
posterior fossa group A ependymoma 105 | 1,511
Cancer 100 | 2,346
ductal carcinoma in situ 97 | 1,745
group 4 medulloblastoma 95 | 1,875
cystic fibrosis 91 | 1,665
breast carcinoma 86 | 1,614
ulcerative colitis 85 | 2,087
group 3 medulloblastoma 83 | 2,254
sonic hedgehog group medulloblastoma 80 | 1,482
colon cancer 78 | 1,475
posterior fossa group B ependymoma 77 | 1,530
Schizophrenia 72 | 501
primary pancreatic ductal adenocarcinoma 72 | 1,271
spina bifida 70 | 1,064
Epilepsy 61 | 346
tuberculosis 61 | 1,557
adrenocortical carcinoma 59 | 1,427
atypical teratoid/rhabdoid tumor 56 | 1,095
Autistic Disorder 53 | 320
pancreatic ductal adenocarcinoma liver metastasis 53 | 1,795
diabetes mellitus 51 | 1,663
Alzheimer's disease 46 | 644
Intellectual disability 46 | 573
esophageal adenocarcinoma 45 | 737
juvenile dermatomyositis 45 | 1,189
Down syndrome 43 | 548
acute quadriplegic myopathy 43 | 1,157
active Crohn's disease 42 | 918
gastric carcinoma 42 | 832
dermatomyositis 41 | 933
General anesthesia 40 | 53
cutaneous lupus erythematosus 40 | 1,056
Parkinson's disease 38 | 364
nasopharyngeal carcinoma 37 | 1,056
Rheumatoid Arthritis 35 | 1,160
Atopic dermatitis 34 | 944
autosomal dominant Emery-Dreifuss muscular dystrophy 34 | 499
Amyotrophic Lateral Sclerosis 31 | 431
Duchenne muscular dystrophy 31 | 602
aldosterone-producing adenoma 31 | 664
non primary Sjogren syndrome sicca 31 | 840
Bipolar Disorder 29 | 266
active ulcerative colitis 28 | 477
Multiple myeloma 27 | 1,327
Prostatic Neoplasms 27 | 471
acute myeloid leukemia 27 | 780
fibroadenoma 27 | 557
progressive supranuclear palsy 27 | 674
Neurodegenerative disease 26 | 383
Obesity 26 | 616
Tonic-clonic epilepsy 25 | 47
mucosa-associated lymphoid tissue lymphoma 25 | 480
Neuropathy 24 | 210
Multiple Sclerosis 23 | 498
primary Sjogren syndrome 23 | 789
urothelial carcinoma 23 | 318
Alcohol dependence 22 | 107
Cerebrovascular disease 21 | 231
Local anesthesia 20 | 40
Nicotine dependence 20 | 53
glioblastoma multiforme 20 | 347
hereditary spastic paraplegia 20 | 313
Kidney disease 19 | 396
nephrosclerosis 19 | 329
tuberculosis and treatment for 3 months 19 | 327
Cocaine-Related Disorders 18 | 88
Mammary Neoplasms 18 | 410
non-small cell lung carcinoma 18 | 413
pancreatic carcinoma 18 | 567

Tissue

Female tissues 666 | 18,647
Nervous System 666 | 18,561
Endocrine System 665 | 18,512
Digestive Tract 663 | 18,473
Liver and Pancreas 661 | 18,136
Urinary Tract 660 | 18,444
Cardiovascular System 656 | 17,958
Skin and soft tissues 656 | 18,115
Blood and immune system 655 | 17,995
Male tissues 655 | 17,969
Respiratory system 648 | 17,484

Target Family

Non-IDG 475 | 11,971
Ion Channel 77 | 341
Enzyme 61 | 4,146
Kinase 33 | 634
GPCR 13 | 406
Transporter 8 | 473
Epigenetic 4 | 242
Transcription Factor 1 | 1,400

UniProt Keyword

Cell junction 672 | 672
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 Tchem Ion Channel -1.68717 47.7 33
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.80380 77.2 248
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167
Receptor-type tyrosine-protein phosphatase eta PTPRJ Tbio Enzyme -1.94494 110.6 235
Cytoplasmic polyadenylation element-binding protein 1 CPEB1 Tbio Non-IDG -2.20580 171.1 185
Gamma-aminobutyric acid receptor subunit rho-1 GABRR1 Tchem Ion Channel -1.70715 50.4 134
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Keratinocyte differentiation factor 1 KDF1 Tbio Non-IDG -0.24304 2.16 71
Acetylcholine receptor subunit delta CHRND Tclin Ion Channel -1.23749 17.4 128