Development Level

Tbio 306 | 11,651
Tchem 45 | 1,388
Tdark 29 | 6,593
Tclin 3 | 612

Collection

Kinase: IDG Consortium (Comple... 5 | 37
Kinase: IDG Consortium (Target... 4 | 125
RFA-RM-18-021 4 | 328

IMPC Phenotype

preweaning lethality, complete... 52 | 979
preweaning lethality, incomple... 21 | 499
embryonic lethality prior to o... 16 | 239
embryonic lethality prior to t... 14 | 278
abnormal embryo size 10 | 220
increased fasted circulating g... 7 | 76
male infertility 7 | 123
embryonic growth retardation 6 | 106
abnormal seminal vesicle morph... 5 | 114
cataract 5 | 92
decreased body weight 5 | 161
increased circulating HDL chol... 5 | 80
increased circulating alkaline... 5 | 122
abnormal behavior 4 | 298
abnormal coat-hair pigmentatio... 4 | 64
abnormal lens morphology 4 | 81
decreased body length 4 | 101
decreased red blood cell distr... 4 | 41
impaired glucose tolerance 4 | 75
increased leukocyte cell numbe... 4 | 47
increased mean corpuscular vol... 4 | 92
thrombocytopenia 4 | 56
abnormal bone structure 3 | 187
abnormal heart morphology 3 | 162
abnormal kidney morphology 3 | 65
abnormal placenta size 3 | 20
abnormal skin morphology 3 | 50
decreased bone mineral content 3 | 151
decreased caudal vertebrae num... 3 | 53
decreased circulating choleste... 3 | 93
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
decreased total body fat amoun... 3 | 207
edema 3 | 59
female infertility 3 | 60
improved glucose tolerance 3 | 79
increased mean corpuscular hem... 3 | 96
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
microphthalmia 3 | 26
small spleen 3 | 19
small testis 3 | 58
abnormal behavioral response t... 2 | 66
abnormal craniofacial morpholo... 2 | 33
abnormal placenta morphology 2 | 5
abnormal retina morphology 2 | 71
abnormal skin coloration 2 | 25
abnormal snout morphology 2 | 23
abnormal tail morphology 2 | 25
abnormal testis morphology 2 | 43
anophthalmia 2 | 33
decreased circulating HDL chol... 2 | 68
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
hyperactivity 2 | 148
hypoactivity 2 | 132
increased body length 2 | 32
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating chloride... 2 | 41
increased circulating creatini... 2 | 38
increased mean platelet volume 2 | 45
increased or absent threshold ... 2 | 101
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
short tibia 2 | 97
syndactyly 2 | 23
thrombocytosis 2 | 27
tremors 2 | 39
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal retinal inner nuclear... 1 | 8
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
decreased IgG1 level 1 | 8
decreased circulating amylase ... 1 | 28
decreased circulating triglyce... 1 | 79
decreased fluid intake 1 | 3
enlarged spleen 1 | 41
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased heart weight 1 | 62
increased red blood cell distr... 1 | 34
long tibia 1 | 25
vertebral fusion 1 | 23

Disease

ovarian cancer 248 | 8,520
Carcinoma 241 | 11,493
medulloblastoma, large-cell 199 | 6,241
osteosarcoma 195 | 7,950
glioblastoma 187 | 5,792
group 3 medulloblastoma 170 | 4,104
atypical teratoid / rhabdoid tumor 169 | 5,112
psoriasis 167 | 6,694
lung cancer 149 | 4,740
primitive neuroectodermal tumor 147 | 3,035
Breast cancer 144 | 3,578
adult high grade glioma 124 | 3,801
ependymoma 122 | 4,679
non-small cell lung cancer 119 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 113 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 110 | 3,291
malignant mesothelioma 109 | 3,232
invasive ductal carcinoma 105 | 2,951
Cancer 96 | 2,499
adrenocortical carcinoma 94 | 1,428
lung adenocarcinoma 93 | 2,716
ductal carcinoma in situ 74 | 1,745
pancreatic cancer 73 | 2,398
oligodendroglioma 71 | 2,850
breast carcinoma 70 | 1,638
Kidney cancer 67 | 2,613
Astrocytoma, Pilocytic 66 | 3,081
Atopic dermatitis 62 | 952
colon cancer 62 | 1,478
nasopharyngeal carcinoma 59 | 1,058
Endometriosis 56 | 540
Multiple myeloma 52 | 1,332
Pick disease 51 | 1,894
astrocytic glioma 47 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 45 | 2,955
ulcerative colitis 42 | 1,819
subependymal giant cell astrocytoma 41 | 2,287
astrocytoma 39 | 1,146
tuberculosis 39 | 2,010
Waldenstrons macroglobulinemia 38 | 765
interstitial cystitis 37 | 2,312
Intellectual disability 35 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 35 | 1,962
pituitary cancer 35 | 1,972
group 4 medulloblastoma 32 | 1,855
Rheumatoid arthritis 31 | 1,191
pediatric high grade glioma 31 | 1,064
lung carcinoma 30 | 2,843
acute quadriplegic myopathy 29 | 1,158
dermatomyositis 29 | 966
Cognitive delay 28 | 608
Global developmental delay 28 | 608
Mental and motor retardation 28 | 608
juvenile dermatomyositis 26 | 1,187
Autosomal recessive predisposition 25 | 1,442
diabetes mellitus 25 | 1,728
progressive supranuclear palsy 25 | 676
primary Sjogren syndrome 24 | 735
Dull intelligence 23 | 645
Low intelligence 23 | 645
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
primary pancreatic ductal adenocarcinoma 23 | 1,109
Small head 22 | 374
Short stature 21 | 531
non primary Sjogren syndrome sicca 21 | 891
Hypoplastic mandible condyle 19 | 275
Mandibular hypoplasia 19 | 275
Microcephaly 19 | 166
Micrognathism 19 | 275
active Crohn's disease 19 | 922
posterior fossa group A ependymoma 19 | 468
acute myeloid leukemia 18 | 783
esophageal adenocarcinoma 18 | 737
medulloblastoma 18 | 720
spina bifida 18 | 1,074
Schizophrenia 16 | 1,160
cystic fibrosis 16 | 1,696
Polycystic ovary syndrome 15 | 360
Liver cancer 14 | 604
Amyotrophic lateral sclerosis 13 | 451
Liver Cirrhosis, Experimental 13 | 769
Type 2 diabetes mellitus 13 | 272
gastric carcinoma 13 | 807
Alzheimer's disease 12 | 658
Melanoma 12 | 711
pancreatic carcinoma 12 | 562
Acquired metabolic disease 11 | 336
Bipolar Disorder 11 | 666
Breast Neoplasms 11 | 445
Concave bridge of nose 11 | 195
Depressed nasal bridge 11 | 195
Depressed nasal root/bridge 11 | 195
Dilated ventricles (finding) 11 | 121
Fetal Growth Retardation 11 | 189
Infant, Small for Gestational Age 11 | 176
Intrauterine retardation 11 | 176
chronic rhinosinusitis 11 | 512
cutaneous lupus erythematosus 11 | 1,057

Tissue

Endocrine System 381 | 18,159
Male tissues 377 | 17,142
Skin and soft tissues 377 | 17,230
Digestive Tract 376 | 17,369
Female tissues 376 | 17,400
Respiratory system 376 | 16,393
Nervous System 375 | 16,725
Blood and immune system 374 | 16,909
Liver and Pancreas 374 | 16,750
Urinary Tract 373 | 16,678
Cardiovascular System 364 | 15,192

Target Family

Non-IDG 276 | 12,091
Enzyme 61 | 4,145
Kinase 37 | 634
Transcription Factor 4 | 1,400
Epigenetic 3 | 242
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

UniProt Keyword

Cell division 383 | 383
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive serine/threonine-protein kinase PLK5 PLK5 Tbio Kinase -0.60609 4.07 119
Fidgetin FIGN Tbio Enzyme -1.34015 21.2 103
Ankyrin repeat and LEM domain-containing protein 2 ANKLE2 Tbio Non-IDG -1.07238 11.8 76
Securin PTTG1 Tbio Non-IDG -2.42127 261.4 311
Nuclear-interacting partner of ALK ZC3HC1 Tbio Non-IDG -2.13812 136.0 171
F-box/LRR-repeat protein 7 FBXL7 Tbio Non-IDG -0.80631 6.84 53
BRISC and BRCA1-A complex member 1 BABAM1 Tbio Non-IDG -1.20557 16.7 162
BRISC and BRCA1-A complex member 2 BABAM2 Tbio Non-IDG -1.84649 70.2 156
Cytoplasmic dynein 1 light intermediate chain 1 DYNC1LI1 Tbio Non-IDG -1.67860 45.9 100
Serine/threonine-protein kinase VRK1 VRK1 Tbio Kinase -2.05267 119.8 168