Development Level

Tbio 462 | 10,625
Tchem 111 | 1,890
Tdark 59 | 7,003
Tclin 5 | 602

Collection

Eligible Kinase Proteins 12 | 134

IMPC Term

preweaning lethality, complete... 47 | 633
preweaning lethality, incomple... 17 | 260
embryonic lethality prior to t... 13 | 187
embryonic lethality prior to o... 11 | 148
abnormal behavior 8 | 226
decreased body weight 8 | 174
increased fasted circulating g... 8 | 68
decreased lean body mass 7 | 195
abnormal coat/hair pigmentatio... 6 | 54
abnormal embryo size 6 | 112
decreased bone mineral content 6 | 157
decreased total body fat amoun... 6 | 186
increased lean body mass 6 | 107
thrombocytopenia 6 | 46
abnormal retina morphology 5 | 100
embryonic growth retardation 5 | 28
improved glucose tolerance 5 | 56
increased bone mineral density 5 | 52
increased leukocyte cell numbe... 5 | 37
male infertility 5 | 62
abnormal bone structure 4 | 131
abnormal gait 4 | 51
abnormal lens morphology 4 | 73
cataract 4 | 26
decreased circulating glucose ... 4 | 121
decreased circulating serum al... 4 | 79
decreased grip strength 4 | 123
decreased lumbar vertebrae num... 4 | 62
hypoactivity 4 | 89
increased bone mineral content 4 | 92
increased mean corpuscular vol... 4 | 91
increased or absent threshold ... 4 | 128
tremors 4 | 34
decreased circulating LDL chol... 3 | 37
decreased circulating alanine ... 3 | 53
decreased circulating choleste... 3 | 85
decreased mean corpuscular vol... 3 | 50
female infertility 3 | 34
hyperactivity 3 | 108
increased circulating HDL chol... 3 | 63
increased circulating alkaline... 3 | 119
increased circulating chloride... 3 | 43
increased circulating sodium l... 3 | 71
increased grip strength 3 | 83
increased mean corpuscular hem... 3 | 93
increased rib number 3 | 41
increased sacral vertebrae num... 3 | 62
prenatal lethality 3 | 16
small testis 3 | 37
abnormal behavioral response t... 2 | 52
abnormal craniofacial morpholo... 2 | 12
abnormal cranium morphology 2 | 32
abnormal heart left ventricle ... 2 | 20
abnormal kidney morphology 2 | 30
abnormal optic disc morphology 2 | 10
abnormal placenta morphology 2 | 4
abnormal placenta size 2 | 10
abnormal seminal vesicle morph... 2 | 47
abnormal snout morphology 2 | 18
abnormal spleen morphology 2 | 36
abnormal testis morphology 2 | 30
anophthalmia 2 | 20
decreased CD8-positive, alpha-... 2 | 26
decreased basophil cell number 2 | 11
decreased blood urea nitrogen ... 2 | 31
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased circulating aspartat... 2 | 27
decreased circulating chloride... 2 | 32
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased eosinophil cell numb... 2 | 41
decreased erythrocyte cell num... 2 | 43
decreased fasted circulating g... 2 | 49
decreased mean corpuscular hem... 2 | 34
decreased rib number 2 | 59
decreased spleen weight 2 | 13
enlarged spleen 2 | 26
hydrops fetalis 2 | 22
impaired glucose tolerance 2 | 52
increased B cell number 2 | 23
increased blood urea nitrogen ... 2 | 44
increased circulating choleste... 2 | 53
increased circulating triglyce... 2 | 24
increased exploration in new e... 2 | 56
increased heart weight 2 | 37
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
microphthalmia 2 | 15
prenatal lethality prior to he... 2 | 64
short tibia 2 | 82
small spleen 2 | 11
vertebral fusion 2 | 23
abnormal heart morphology 1 | 51
abnormal neural tube closure 1 | 37
abnormal rib morphology 1 | 28
abnormal thoracic vertebrae mo... 1 | 16
decreased effector memory CD8-... 1 | 24
decreased thoracic vertebrae n... 1 | 7
increased CD4-positive, CD25-p... 1 | 18

Disease

ovarian cancer 390 | 8,484
osteosarcoma 318 | 7,933
medulloblastoma, large-cell 306 | 6,234
psoriasis 274 | 6,685
glioblastoma 270 | 5,572
lung cancer 227 | 4,466
primitive neuroectodermal tumor 210 | 3,031
Breast cancer 200 | 3,094
atypical teratoid / rhabdoid tumor 196 | 4,369
Cancer 189 | 2,346
malignant mesothelioma 177 | 3,162
non-small cell lung cancer 173 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 163 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 160 | 2,988
pediatric high grade glioma 156 | 2,712
group 3 medulloblastoma 151 | 2,254
invasive ductal carcinoma 147 | 2,950
lung adenocarcinoma 141 | 2,713
adrenocortical carcinoma 139 | 1,427
ductal carcinoma in situ 112 | 1,745
oligodendroglioma 109 | 2,849
pancreatic cancer 108 | 2,300
colon cancer 98 | 1,475
breast carcinoma 96 | 1,614
nasopharyngeal carcinoma 89 | 1,056
pilocytic astrocytoma 89 | 3,086
Carcinoma 87 | 2,147
ependymoma 85 | 2,514
posterior fossa group A ependymoma 85 | 1,511
Atopic dermatitis 83 | 944
Multiple myeloma 82 | 1,327
intraductal papillary-mucinous adenoma (IPMA) 79 | 2,956
sonic hedgehog group medulloblastoma 79 | 1,482
Endometriosis 77 | 535
Pick disease 70 | 1,893
atypical teratoid/rhabdoid tumor 69 | 1,095
astrocytoma 68 | 1,493
ulcerative colitis 67 | 2,087
adult high grade glioma 66 | 2,148
astrocytic glioma 64 | 2,241
medulloblastoma 64 | 1,524
subependymal giant cell astrocytoma 63 | 2,287
interstitial cystitis 59 | 2,299
Waldenstrons macroglobulinemia 55 | 765
group 4 medulloblastoma 55 | 1,875
Rheumatoid Arthritis 53 | 1,160
lung carcinoma 53 | 2,844
IGA Glomerulonephritis 52 | 454
pituitary cancer 52 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,795
tuberculosis 51 | 1,557
acute quadriplegic myopathy 49 | 1,157
juvenile dermatomyositis 48 | 1,189
posterior fossa group B ependymoma 47 | 1,530
diabetes mellitus 46 | 1,663
dermatomyositis 44 | 933
primary pancreatic ductal adenocarcinoma 42 | 1,271
primary Sjogren syndrome 39 | 789
non primary Sjogren syndrome sicca 38 | 840
acute myeloid leukemia 34 | 780
Mammary Neoplasms 33 | 410
cystic fibrosis 31 | 1,665
progressive supranuclear palsy 31 | 674
Intellectual disability 30 | 573
active Crohn's disease 29 | 918
inflammatory breast cancer 28 | 404
spina bifida 27 | 1,064
Microcephaly 26 | 149
pancreatic carcinoma 25 | 567
tuberculosis and treatment for 6 months 25 | 686
gastric carcinoma 24 | 832
cutaneous lupus erythematosus 23 | 1,056
Peripheral Neuropathy 22 | 303
Stomach Neoplasms 22 | 282
esophageal adenocarcinoma 22 | 737
Prostatic Neoplasms 21 | 471
Amyotrophic Lateral Sclerosis 19 | 431
Down syndrome 19 | 548
chronic rhinosinusitis 19 | 512
Lung Neoplasms 18 | 171
Polycystic Ovary Syndrome 18 | 332
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 499
Alzheimer's disease 17 | 644
Melanoma 17 | 261
Liver carcinoma 16 | 217
Vascular disease 16 | 281
hepatocellular carcinoma 16 | 532
Bladder Neoplasm 15 | 109
aldosterone-producing adenoma 15 | 664
fibroadenoma 15 | 557
gastric cancer 15 | 430
non-small cell lung carcinoma 15 | 413
ovarian neoplasm 15 | 97
Duchenne muscular dystrophy 14 | 602
Type 2 diabetes mellitus 14 | 189
cystic fibrosis and chronic rhinosinusitis 14 | 213
hereditary spastic paraplegia 14 | 313
Adenoma 13 | 165
Neurodegenerative disease 13 | 383
tuberculosis and treatment for 3 months 13 | 327

Tissue

Digestive Tract 631 | 18,473
Female tissues 631 | 18,647
Liver and Pancreas 630 | 18,136
Male tissues 630 | 17,969
Blood and immune system 629 | 17,995
Cardiovascular System 629 | 17,958
Endocrine System 629 | 18,512
Nervous System 629 | 18,561
Urinary Tract 628 | 18,444
Skin and soft tissues 625 | 18,115
Respiratory system 623 | 17,484

Target Family

Non-IDG 407 | 11,971
Enzyme 100 | 4,146
Kinase 78 | 634
Transcription Factor 32 | 1,400
Epigenetic 17 | 242
GPCR 1 | 406
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

UniProt Keyword

Cell cycle 637 | 637
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Microtubule-associated protein RP/EB family member 3 MAPRE3 Tbio Non-IDG -2.14681 132.5 161
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Multicilin MCIDAS Tbio Non-IDG -2.00076 101.0 59
Kinetochore protein Nuf2 NUF2 Tbio Non-IDG -1.66072 48.8 98
Host cell factor 1 HCFC1 Tbio Non-IDG -2.50024 341.6 160
Nuclear autoantigenic sperm protein NASP Tbio Non-IDG -1.72078 58.3 103