Development Level

Tbio 499 | 11,445
Tchem 99 | 1,598
Tdark 44 | 6,588
Tclin 5 | 613

Collection

Kinase: IDG Consortium (Target... 11 | 125
Kinase: IDG Consortium (Comple... 7 | 37

IMPC Phenotype

preweaning lethality, complete... 67 | 979
preweaning lethality, incomple... 32 | 499
embryonic lethality prior to o... 20 | 239
embryonic lethality prior to t... 20 | 278
abnormal embryo size 14 | 220
abnormal behavior 12 | 298
male infertility 11 | 123
increased fasted circulating g... 9 | 76
cataract 8 | 92
decreased body weight 8 | 161
decreased total body fat amoun... 8 | 207
embryonic growth retardation 8 | 106
abnormal bone structure 7 | 187
abnormal lens morphology 7 | 81
decreased body length 7 | 101
abnormal seminal vesicle morph... 6 | 114
decreased mean corpuscular vol... 6 | 79
decreased red blood cell distr... 6 | 41
impaired glucose tolerance 6 | 75
increased mean corpuscular vol... 6 | 92
small testis 6 | 58
abnormal coat-hair pigmentatio... 5 | 64
abnormal heart morphology 5 | 162
decreased bone mineral content 5 | 151
decreased circulating choleste... 5 | 93
edema 5 | 59
female infertility 5 | 60
hyperactivity 5 | 148
hypoactivity 5 | 132
improved glucose tolerance 5 | 79
increased circulating HDL chol... 5 | 80
increased circulating alkaline... 5 | 122
increased leukocyte cell numbe... 5 | 47
increased startle reflex 5 | 112
increased total body fat amoun... 5 | 134
thrombocytopenia 5 | 56
decreased lean body mass 4 | 135
decreased threshold for audito... 4 | 26
increased bone mineral content 4 | 108
increased bone mineral density 4 | 72
syndactyly 4 | 23
abnormal behavioral response t... 3 | 66
abnormal kidney morphology 3 | 65
abnormal placenta size 3 | 20
abnormal skin morphology 3 | 50
abnormal testis morphology 3 | 43
brachydactyly 3 | 19
decreased bone mineral density 3 | 126
decreased caudal vertebrae num... 3 | 53
decreased circulating HDL chol... 3 | 68
decreased circulating LDL chol... 3 | 38
decreased circulating alanine ... 3 | 47
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased grip strength 3 | 116
decreased mean corpuscular hem... 3 | 50
enlarged heart 3 | 210
increased body length 3 | 32
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
microphthalmia 3 | 26
prenatal lethality 3 | 28
prenatal lethality prior to he... 3 | 87
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
small spleen 3 | 19
tremors 3 | 39
abnormal craniofacial morpholo... 2 | 33
abnormal embryo turning 2 | 31
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal joint morphology 2 | 23
abnormal lung morphology 2 | 26
abnormal optic disc morphology 2 | 10
abnormal retina morphology 2 | 71
abnormal skin coloration 2 | 25
abnormal snout morphology 2 | 23
abnormal spleen morphology 2 | 55
anophthalmia 2 | 33
decreased blood urea nitrogen ... 2 | 51
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
decreased vertical activity 2 | 208
enlarged epididymis 2 | 31
enlarged lymph nodes 2 | 37
enlarged spleen 2 | 41
increased blood urea nitrogen ... 2 | 48
increased circulating calcium ... 2 | 34
increased circulating chloride... 2 | 41
increased circulating creatini... 2 | 38
increased circulating sodium l... 2 | 71
increased heart weight 2 | 62
increased mean platelet volume 2 | 45
increased or absent threshold ... 2 | 101
short tibia 2 | 97
thrombocytosis 2 | 27
vertebral fusion 2 | 23

Disease

Carcinoma 413 | 11,493
ovarian cancer 400 | 8,520
osteosarcoma 327 | 7,950
medulloblastoma, large-cell 312 | 6,241
glioblastoma 284 | 5,792
psoriasis 276 | 6,694
group 3 medulloblastoma 257 | 4,104
atypical teratoid / rhabdoid tumor 255 | 5,112
lung cancer 243 | 4,740
Breast cancer 231 | 3,578
primitive neuroectodermal tumor 214 | 3,035
Cancer 197 | 2,499
ependymoma 187 | 4,679
adult high grade glioma 181 | 3,801
malignant mesothelioma 180 | 3,232
non-small cell lung cancer 178 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 166 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 163 | 2,989
invasive ductal carcinoma 151 | 2,951
lung adenocarcinoma 144 | 2,716
adrenocortical carcinoma 140 | 1,428
Kidney cancer 119 | 2,613
ductal carcinoma in situ 115 | 1,745
pancreatic cancer 112 | 2,398
oligodendroglioma 110 | 2,850
breast carcinoma 107 | 1,638
colon cancer 99 | 1,478
Astrocytoma, Pilocytic 95 | 3,081
nasopharyngeal carcinoma 90 | 1,058
Atopic dermatitis 84 | 952
Multiple myeloma 83 | 1,332
intraductal papillary-mucinous adenoma (IPMA) 81 | 2,955
Endometriosis 77 | 540
astrocytic glioma 75 | 2,597
Pick disease 72 | 1,894
tuberculosis 64 | 2,010
ulcerative colitis 64 | 1,819
subependymal giant cell astrocytoma 63 | 2,287
astrocytoma 60 | 1,146
interstitial cystitis 60 | 2,312
Waldenstrons macroglobulinemia 57 | 765
lung carcinoma 57 | 2,843
Intellectual disability 56 | 1,016
group 4 medulloblastoma 56 | 1,855
pituitary cancer 56 | 1,972
Rheumatoid arthritis 54 | 1,191
pancreatic ductal adenocarcinoma liver metastasis 54 | 1,962
juvenile dermatomyositis 52 | 1,187
acute quadriplegic myopathy 51 | 1,158
diabetes mellitus 49 | 1,728
dermatomyositis 45 | 966
pediatric high grade glioma 44 | 1,064
primary pancreatic ductal adenocarcinoma 41 | 1,109
Autosomal recessive predisposition 40 | 1,442
primary Sjogren syndrome 39 | 735
Dull intelligence 38 | 645
Low intelligence 38 | 645
Mental Retardation 38 | 645
Mental deficiency 38 | 645
Poor school performance 38 | 645
non primary Sjogren syndrome sicca 38 | 891
Breast Neoplasms 37 | 445
Short stature 36 | 531
acute myeloid leukemia 36 | 783
Cognitive delay 35 | 608
Global developmental delay 35 | 608
Mental and motor retardation 35 | 608
Small head 35 | 374
cystic fibrosis 35 | 1,696
Mammary Neoplasms 33 | 425
medulloblastoma 33 | 720
progressive supranuclear palsy 33 | 676
Schizophrenia 31 | 1,160
active Crohn's disease 31 | 922
Liver cancer 30 | 604
spina bifida 29 | 1,074
Melanoma 28 | 711
Microcephaly 27 | 166
posterior fossa group A ependymoma 27 | 468
Stomach Neoplasms 26 | 300
gastric carcinoma 26 | 807
Liver Cirrhosis, Experimental 25 | 769
esophageal adenocarcinoma 24 | 737
Hypoplastic mandible condyle 23 | 275
Mandibular hypoplasia 23 | 275
Micrognathism 23 | 275
cutaneous lupus erythematosus 23 | 1,057
Alzheimer's disease 22 | 658
Lung Neoplasms 22 | 232
Prostatic Neoplasms 22 | 495
pancreatic carcinoma 22 | 562
Amyotrophic lateral sclerosis 21 | 451
Polycystic ovary syndrome 20 | 360
tuberculosis and treatment for 6 months 20 | 409
Epilepsy 19 | 792
autosomal dominant Emery-Dreifuss muscular dystrophy 19 | 510
chronic rhinosinusitis 19 | 512
hepatocellular carcinoma 19 | 547
Fetal Growth Retardation 18 | 189
Infant, Small for Gestational Age 18 | 176

Tissue

Endocrine System 639 | 18,159
Male tissues 633 | 17,142
Female tissues 632 | 17,400
Skin and soft tissues 632 | 17,230
Digestive Tract 631 | 17,369
Blood and immune system 629 | 16,909
Liver and Pancreas 629 | 16,750
Nervous System 626 | 16,725
Respiratory system 626 | 16,393
Urinary Tract 625 | 16,678
Cardiovascular System 604 | 15,192

Target Family

Non-IDG 417 | 12,091
Enzyme 100 | 4,145
Kinase 78 | 634
Transcription Factor 32 | 1,400
Epigenetic 17 | 242
GPCR 1 | 408
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

UniProt Keyword

Cell cycle 647 | 647
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase tousled-like 1 TLK1 Tchem Kinase -1.25235 19.2 305
CDK2-associated and cullin domain-containing protein 1 CACUL1 Tbio Non-IDG -0.58734 5.65 98
Kinesin-like protein KIF18B KIF18B Tbio Non-IDG -0.83463 5.23 17
Transforming acidic coiled-coil-containing protein 3 TACC3 Tbio Non-IDG -1.99617 101.2 222
CDK5 and ABL1 enzyme substrate 2 CABLES2 Tdark Non-IDG 0.08 1.29 75
CASP8-associated protein 2 CASP8AP2 Tbio Non-IDG 0.00000 0
Inactive serine/threonine-protein kinase PLK5 PLK5 Tbio Kinase -0.60609 4.07 119
Nuclear distribution protein nudE homolog 1 NDE1 Tbio Non-IDG -2.01711 96.0 192
Condensin-2 complex subunit G2 NCAPG2 Tbio Non-IDG -0.75957 5.48 110
HAUS augmin-like complex subunit 2 HAUS2 Tbio Non-IDG 0.71 0.12 44