Development Level

Tbio 352 | 11,651
Tdark 76 | 6,593
Tchem 34 | 1,388
Tclin 20 | 612

Collection

RFA-RM-18-021 3 | 328
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 17 | 979
preweaning lethality, incomple... 13 | 499
abnormal behavior 11 | 298
decreased total body fat amoun... 10 | 207
decreased vertical activity 7 | 208
decreased grip strength 6 | 116
edema 6 | 59
impaired glucose tolerance 6 | 75
increased lean body mass 6 | 172
increased total body fat amoun... 6 | 134
abnormal bone structure 5 | 187
abnormal gait 5 | 69
decreased circulating choleste... 5 | 93
enlarged heart 5 | 210
improved glucose tolerance 5 | 79
increased circulating triglyce... 5 | 42
increased startle reflex 5 | 112
increased vertical activity 5 | 24
tremors 5 | 39
abnormal embryo size 4 | 220
abnormal sleep behavior 4 | 70
decreased body length 4 | 101
decreased fasted circulating g... 4 | 65
decreased lean body mass 4 | 135
hemorrhage 4 | 23
hyperactivity 4 | 148
increased bone mineral content 4 | 108
increased heart weight 4 | 62
increased hematocrit 4 | 46
persistence of hyaloid vascula... 4 | 33
short tibia 4 | 97
thrombocytopenia 4 | 56
abnormal heart morphology 3 | 162
abnormal locomotor behavior 3 | 24
decreased body weight 3 | 161
decreased circulating bilirubi... 3 | 19
decreased circulating glucose ... 3 | 126
decreased circulating insulin ... 3 | 76
decreased lymphocyte cell numb... 3 | 83
decreased startle reflex 3 | 75
hydrometra 3 | 53
hypoactivity 3 | 132
increased bone mineral density 3 | 72
increased circulating alkaline... 3 | 122
increased circulating chloride... 3 | 41
increased circulating sodium l... 3 | 71
increased hemoglobin content 3 | 45
increased red blood cell distr... 3 | 34
male infertility 3 | 123
small superior vagus ganglion 3 | 74
abnormal behavioral response t... 2 | 66
abnormal bone mineralization 2 | 38
abnormal coat-hair pigmentatio... 2 | 64
abnormal ear morphology 2 | 9
abnormal lens morphology 2 | 81
abnormal limb morphology 2 | 13
abnormal lung morphology 2 | 26
abnormal response to new envir... 2 | 10
abnormal skin morphology 2 | 50
abnormal spleen morphology 2 | 55
abnormal tail morphology 2 | 25
abnormal tooth morphology 2 | 24
corneal opacity 2 | 32
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased circulating creatini... 2 | 39
decreased circulating sodium l... 2 | 22
decreased circulating total pr... 2 | 49
decreased coping response 2 | 8
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
decreased prepulse inhibition 2 | 82
decreased pulmonary respirator... 2 | 5
embryonic growth retardation 2 | 106
enlarged spleen 2 | 41
enlarged stomach 2 | 2
impaired righting response 2 | 26
increased body weight 2 | 25
increased circulating amylase ... 2 | 25
increased circulating potassiu... 2 | 29
increased fasted circulating g... 2 | 76
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
small thymus 2 | 16
abnormal cornea morphology 1 | 31
abnormal head morphology 1 | 10
abnormal liver morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
embryonic lethality prior to t... 1 | 278
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
microphthalmia 1 | 26

Disease

Carcinoma 410 | 11,493
psoriasis 225 | 6,694
ovarian cancer 224 | 8,520
glioblastoma 221 | 5,792
osteosarcoma 212 | 7,950
Kidney cancer 197 | 2,613
medulloblastoma, large-cell 193 | 6,241
atypical teratoid / rhabdoid tumor 180 | 5,112
ependymoma 175 | 4,679
lung carcinoma 169 | 2,843
lung cancer 168 | 4,740
Breast cancer 166 | 3,578
adult high grade glioma 154 | 3,801
Astrocytoma, Pilocytic 139 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 137 | 2,955
invasive ductal carcinoma 136 | 2,951
non-small cell lung cancer 136 | 2,890
interstitial cystitis 135 | 2,312
malignant mesothelioma 134 | 3,232
lung adenocarcinoma 127 | 2,716
pancreatic cancer 127 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 124 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 124 | 3,291
group 3 medulloblastoma 122 | 4,104
Cancer 120 | 2,499
oligodendroglioma 107 | 2,850
primitive neuroectodermal tumor 98 | 3,035
pituitary cancer 90 | 1,972
subependymal giant cell astrocytoma 90 | 2,287
ulcerative colitis 90 | 1,819
cystic fibrosis 89 | 1,696
astrocytic glioma 82 | 2,597
ductal carcinoma in situ 80 | 1,745
group 4 medulloblastoma 80 | 1,855
breast carcinoma 78 | 1,638
tuberculosis 74 | 2,010
Liver cancer 72 | 604
primary pancreatic ductal adenocarcinoma 71 | 1,109
colon cancer 67 | 1,478
cutaneous lupus erythematosus 63 | 1,057
Melanoma 59 | 711
gastric carcinoma 59 | 807
Autosomal recessive predisposition 58 | 1,442
adrenocortical carcinoma 56 | 1,428
Pick disease 52 | 1,894
Skin cancer 52 | 469
Duchenne muscular dystrophy 50 | 601
Schizophrenia 49 | 1,160
astrocytoma 49 | 1,146
diabetes mellitus 49 | 1,728
nasopharyngeal carcinoma 48 | 1,058
pediatric high grade glioma 48 | 1,064
esophageal adenocarcinoma 46 | 737
juvenile dermatomyositis 46 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 44 | 1,962
autosomal dominant Emery-Dreifuss muscular dystrophy 43 | 510
Atopic dermatitis 40 | 952
Rheumatoid arthritis 37 | 1,191
dermatomyositis 36 | 966
Endometrial cancer 34 | 311
Intellectual disability 33 | 1,016
Multiple Sclerosis 33 | 540
Liver Cirrhosis, Experimental 32 | 769
Kidney disease 31 | 430
Autistic Disorder 30 | 364
acute quadriplegic myopathy 30 | 1,158
Down syndrome 28 | 499
fibroadenoma 28 | 559
primary Sjogren syndrome 28 | 735
spina bifida 28 | 1,074
Alzheimer's disease 27 | 658
medulloblastoma 27 | 720
Bipolar Disorder 25 | 666
Obesity 25 | 678
active ulcerative colitis 25 | 764
aldosterone-producing adenoma 25 | 665
urothelial carcinoma 25 | 318
Alcoholic Intoxication, Chronic 24 | 289
Atherosclerosis 24 | 291
interstitial lung disease 24 | 298
Becker muscular dystrophy 23 | 191
mucosa-associated lymphoid tissue lymphoma 23 | 484
Acquired metabolic disease 22 | 336
Asthma 22 | 385
Endometriosis 22 | 540
Epilepsy 22 | 792
Muscle hypotonia 22 | 571
Vascular disease 22 | 319
active Crohn's disease 22 | 922
non primary Sjogren syndrome sicca 22 | 891
progressive supranuclear palsy 22 | 676
Coronary artery disease 21 | 268
Breast Neoplasms 20 | 445
head and neck cancer 20 | 271
sonic hedgehog group medulloblastoma 20 | 467
Heart disease 19 | 306
Hypersensitivity reaction type II disease 19 | 253
Hypertension 19 | 396
limb girdle muscular dystrophy 2A 19 | 213
posterior fossa group A ependymoma 19 | 468

Tissue

Endocrine System 470 | 18,159
Digestive Tract 460 | 17,369
Female tissues 459 | 17,400
Male tissues 455 | 17,142
Nervous System 455 | 16,725
Skin and soft tissues 448 | 17,230
Blood and immune system 447 | 16,909
Liver and Pancreas 445 | 16,750
Urinary Tract 440 | 16,678
Respiratory system 437 | 16,393
Cardiovascular System 401 | 15,192

Target Family

Non-IDG 422 | 12,091
Enzyme 29 | 4,145
Kinase 20 | 634
GPCR 4 | 408
Ion Channel 3 | 344
Transporter 3 | 473
Transcription Factor 1 | 1,400

UniProt Keyword

Cell adhesion 482 | 482
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Contactin-associated protein-like 4 CNTNAP4 Tbio Non-IDG -0.73408 0.00000 148
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
Desmoglein-3 DSG3 Tbio Non-IDG -2.57795 402.0 381
Nephronectin NPNT Tbio Non-IDG -1.54450 37.2 104
Desmoglein-1 DSG1 Tbio Non-IDG -2.72159 516.2 406
Desmocollin-2 DSC2 Tbio Non-IDG -1.89689 79.7 173
EMILIN-1 EMILIN1 Tbio Non-IDG -1.54226 36.3 0
Integrin alpha-9 ITGA9 Tbio Non-IDG -1.46619 29.0 124