Development Level

Tbio 67 | 11,651
Tchem 9 | 1,388
Tdark 3 | 6,593
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
decreased total body fat amoun... 3 | 207
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal behavior 2 | 298
abnormal embryo turning 2 | 31
abnormal neural tube closure 2 | 46
decreased body weight 2 | 161
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
hypoactivity 2 | 132
increased startle reflex 2 | 112
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal coat- hair morphology 1 | 19
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal social-conspecific in... 1 | 3
abnormal tail bud morphology 1 | 8
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased circulating amylase ... 1 | 28
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased heart rate variabili... 1 | 13
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
enlarged seminal vesicle 1 | 10
enlarged uterus 1 | 11
hydrometra 1 | 53
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased aggression 1 | 4
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased coping response 1 | 4
increased erythrocyte cell num... 1 | 39
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased granulocyte number 1 | 1
increased grip strength 1 | 41
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
prolonged RR interval 1 | 8
shortened ST segment 1 | 10
small epididymis 1 | 3
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Cataract 80 | 297
Carcinoma 46 | 11,493
Lens Opacities 42 | 231
Autosomal recessive predisposition 37 | 1,442
ovarian cancer 33 | 8,519
osteosarcoma 31 | 7,950
Congenital Bilateral Cataracts 26 | 50
Congenital cataract 26 | 50
lung cancer 26 | 4,740
Intellectual disability 23 | 1,016
psoriasis 22 | 6,694
Breast cancer 19 | 3,577
Dull intelligence 19 | 645
Low intelligence 19 | 645
Mental Retardation 19 | 645
Mental deficiency 19 | 645
Nuclear cataract 19 | 19
Nystagmus 19 | 317
Poor school performance 19 | 645
medulloblastoma, large-cell 19 | 6,241
Nuclear non-senile cataract 18 | 18
Short stature 18 | 531
atypical teratoid / rhabdoid tumor 18 | 5,112
Epilepsy 16 | 792
Kidney cancer 16 | 2,613
Myopia 16 | 176
CATARACT 16, MULTIPLE TYPES 15 | 15
Congenital total cataract 15 | 15
Corneal diameter decreased 15 | 47
Glaucoma 15 | 239
Microcornea 15 | 47
Muscle hypotonia 15 | 571
Sensorineural Hearing Loss (disorder) 15 | 284
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,290
invasive ductal carcinoma 15 | 2,950
Abnormally small eyeball 14 | 97
Cerebellar Ataxia 14 | 304
Cognitive delay 14 | 608
Decreased size of eyeball 14 | 97
Global developmental delay 14 | 608
Mental and motor retardation 14 | 608
Microphthalmos 14 | 100
glioblastoma 14 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,954
malignant mesothelioma 14 | 3,232
Seizures 13 | 596
diabetes mellitus 13 | 1,728
group 3 medulloblastoma 13 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
pituitary cancer 13 | 1,972
Hypoplastic mandible condyle 12 | 275
Low Vision 12 | 174
Mandibular hypoplasia 12 | 275
Micrognathism 12 | 275
Optic Atrophy 12 | 242
Visual Impairment 12 | 174
lung adenocarcinoma 12 | 2,716
lung carcinoma 12 | 2,843
Astrocytoma, Pilocytic 11 | 3,081
Cancer 11 | 2,499
Cerebral atrophy 11 | 178
Microphthalmia 11 | 76
Small head 11 | 374
ductal carcinoma in situ 11 | 1,744
pancreatic cancer 11 | 2,398
Cataract, Pulverulent 10 | 11
breast carcinoma 10 | 1,637
Blindness 9 | 88
Concave bridge of nose 9 | 195
Depressed nasal bridge 9 | 195
Depressed nasal root/bridge 9 | 195
Failure to gain weight 9 | 365
Frontal bossing 9 | 157
Pediatric failure to thrive 9 | 365
adult high grade glioma 9 | 3,801
cataract 2 multiple types 9 | 9
ependymoma 9 | 4,679
group 4 medulloblastoma 9 | 1,855
non-small cell lung cancer 9 | 2,890
Acquired scoliosis 8 | 281
Broad flat nasal bridge 8 | 236
Cataract microcornea syndrome 8 | 8
Cataract-microcornea syndrome 8 | 8
Curvature of spine 8 | 282
Hypotrophic malar bone 8 | 129
Malar flattening 8 | 129
Muscle Spasticity 8 | 195
Nasal bridge wide 8 | 236
Neuropathy 8 | 261
Peripheral Neuropathy 8 | 134
acute quadriplegic myopathy 8 | 1,158
colon cancer 8 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
subependymal giant cell astrocytoma 8 | 2,287
Feeding difficulties in infancy 7 | 175
Strabismus 7 | 270
cystic fibrosis 7 | 1,695
juvenile dermatomyositis 7 | 1,187
tuberculosis 7 | 2,010
ulcerative colitis 7 | 1,819

Tissue

Endocrine System 77 | 18,159
Digestive Tract 73 | 17,369
Male tissues 68 | 17,142
Nervous System 68 | 16,725
Blood and immune system 67 | 16,909
Urinary Tract 67 | 16,678
Female tissues 66 | 17,400
Liver and Pancreas 66 | 16,750
Skin and soft tissues 66 | 17,230
Respiratory system 61 | 16,393
Cardiovascular System 59 | 15,192

Target Family

Non-IDG 39 | 12,091
Enzyme 25 | 4,145
Transcription Factor 7 | 1,400
Kinase 4 | 634
Transporter 3 | 473
Epigenetic 1 | 242
Ion Channel 1 | 344

UniProt Keyword

Cataract 80 | 80
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Homeobox protein SIX6 SIX6 Tbio Transcription Factor -2.23077 163.2 112
Beta-crystallin A4 CRYBA4 Tbio Non-IDG -1.25788 15.5 105
Inositol polyphosphate 5-phosphatase OCRL-1 OCRL Tbio Enzyme -2.20394 172.2 226
Alpha-crystallin A chain CRYAA Tbio Non-IDG -2.84905 682.1 234
Collagen alpha-1(II) chain COL2A1 Tbio Non-IDG -2.89229 724.4 424
Inositol polyphosphate 5-phosphatase K INPP5K Tbio Enzyme -0.93536 10.1 92
FYVE and coiled-coil domain-containing protein 1 FYCO1 Tbio Non-IDG -0.88002 9.75 92
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 ABHD5 Tbio Enzyme -1.95524 94.8 243
Phakinin BFSP2 Tbio Non-IDG -2.51557 325.7 81
Hyccin FAM126A Tbio Non-IDG -0.95309 9.49 51