Development Level

Tbio 70 | 11,651
Tclin 9 | 612
Tchem 4 | 1,388
Tdark 1 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 12 | 979
increased heart weight 5 | 62
decreased body weight 4 | 161
edema 3 | 59
abnormal embryo size 2 | 220
abnormal retina morphology 2 | 71
decreased cardiac muscle contr... 2 | 11
decreased circulating amylase ... 2 | 28
decreased lean body mass 2 | 135
dilated heart left ventricle 2 | 11
increased startle reflex 2 | 112
tremors 2 | 39
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal response to new envir... 1 | 10
abnormal skin morphology 1 | 50
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
abnormal whole-body plethysmog... 1 | 4
cataract 1 | 92
corneal opacity 1 | 32
corneal vascularization 1 | 6
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased heart left ventricle... 1 | 4
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased or absent threshold ... 1 | 101
increased vertical activity 1 | 24
narrow eye opening 1 | 12
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
respiratory system phenotype 1 | 2
small adrenal glands 1 | 16
thick ventricular wall 1 | 7

Disease

Cardiomyopathy 84 | 116
Carcinoma 60 | 11,493
Dilated cardiomyopathy 42 | 56
ovarian cancer 42 | 8,520
Cardiomyopathy, Dilated 38 | 83
psoriasis 38 | 6,694
Hypertrophic Cardiomyopathy 37 | 117
Familial isolated dilated cardiomyopathy 36 | 41
LEFT VENTRICULAR NONCOMPACTION 10 36 | 40
LEFT VENTRICULAR NONCOMPACTION 8 36 | 40
lung cancer 31 | 4,740
atypical teratoid / rhabdoid tumor 29 | 5,112
Autosomal recessive predisposition 27 | 1,442
ependymoma 26 | 4,679
glioblastoma 26 | 5,792
osteosarcoma 26 | 7,950
medulloblastoma, large-cell 25 | 6,241
lung adenocarcinoma 24 | 2,716
Kidney cancer 23 | 2,613
Myopathy 23 | 185
malignant mesothelioma 23 | 3,232
Breast cancer 22 | 3,578
Congestive heart failure 20 | 113
lung carcinoma 20 | 2,843
Heart failure 19 | 162
pancreatic cancer 19 | 2,398
Cardiac Arrhythmia 17 | 103
acute quadriplegic myopathy 16 | 1,158
adult high grade glioma 16 | 3,801
group 3 medulloblastoma 16 | 4,104
Cardiac conduction abnormalities 15 | 78
Conduction disorder of the heart 15 | 79
EKG abnormalities 15 | 78
Electrocardiogram abnormal 15 | 81
Electrocardiogram change 15 | 78
Sudden Cardiac Death 15 | 29
colon cancer 15 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
non-small cell lung cancer 15 | 2,890
primitive neuroectodermal tumor 15 | 3,035
Arrhythmogenic right ventricular cardiomyopathy 14 | 30
Creatine phosphokinase serum increased 14 | 110
Elevated creatine kinase 14 | 110
Heart disease 14 | 306
Left ventricular noncompaction 14 | 26
Melanoma 14 | 711
Muscle hypotonia 14 | 571
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
subependymal giant cell astrocytoma 14 | 2,287
Astrocytoma, Pilocytic 13 | 3,081
Cardiomyopathies 13 | 110
Cognitive delay 13 | 608
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
group 4 medulloblastoma 13 | 1,855
Epilepsy 12 | 792
Muscular dystrophy 12 | 75
Tachycardia, Ventricular 12 | 22
ductal carcinoma in situ 12 | 1,745
interstitial cystitis 12 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
oligodendroglioma 12 | 2,850
Atrial Septal Defects 11 | 85
Blepharoptosis 11 | 231
Cancer 11 | 2,499
Liver cancer 11 | 604
Seizures 11 | 596
cystic fibrosis 11 | 1,696
invasive ductal carcinoma 11 | 2,951
tuberculosis 11 | 2,010
Acquired scoliosis 10 | 281
Atrial Fibrillation 10 | 124
Cardiomegaly 10 | 116
Curvature of spine 10 | 282
Intellectual disability 10 | 1,016
Muscle Weakness 10 | 170
Muscle biopsy shows dystrophic changes 10 | 39
Strabismus 10 | 270
diabetes mellitus 10 | 1,728
pituitary cancer 10 | 1,972
Amyotrophic lateral sclerosis 9 | 451
Byzanthine arch palate 9 | 194
Dull intelligence 9 | 645
Failure to gain weight 9 | 365
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Myocardial Infarction 9 | 151
Nystagmus 9 | 317
Pectus excavatum 9 | 100
Pediatric failure to thrive 9 | 365
Pick disease 9 | 1,894
Poor school performance 9 | 645
Short stature 9 | 531
Skin cancer 9 | 469
Ventricular arrhythmia 9 | 27
astrocytic glioma 9 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
astrocytoma 8 | 1,146
juvenile dermatomyositis 8 | 1,187

Tissue

Endocrine System 84 | 18,159
Female tissues 84 | 17,400
Digestive Tract 83 | 17,369
Liver and Pancreas 83 | 16,750
Male tissues 83 | 17,142
Cardiovascular System 82 | 15,192
Blood and immune system 81 | 16,909
Skin and soft tissues 81 | 17,230
Urinary Tract 80 | 16,678
Nervous System 78 | 16,725
Respiratory system 76 | 16,393

Target Family

Non-IDG 53 | 12,091
Enzyme 13 | 4,145
Kinase 8 | 634
Transcription Factor 5 | 1,400
Ion Channel 2 | 344
Transporter 2 | 473
TF/Epigenetic 1 | 38

UniProt Keyword

Cardiomyopathy 84 | 84
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lamina-associated polypeptide 2, isoform alpha TMPO Tbio Non-IDG -2.11834 246.0 283
Desmocollin-2 DSC2 Tbio Non-IDG -1.89689 79.7 173
Transmembrane protein 43 TMEM43 Tbio Non-IDG -1.19270 17.2 71
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial NDUFB11 Tclin Enzyme -2.18376 150.2 86
T-box transcription factor TBX20 TBX20 Tbio Transcription Factor -1.74657 63.3 109
Natriuretic peptides A NPPA Tchem Non-IDG -3.25145 1788.9 509
Unconventional myosin-VI MYO6 Tbio Non-IDG -1.72509 54.2 108
Troponin C, slow skeletal and cardiac muscles TNNC1 Tclin Non-IDG -1.15127 12.7 281
Myosin-binding protein C, cardiac-type MYBPC3 Tbio Non-IDG -2.45618 287.6 139
Elongation factor Ts, mitochondrial TSFM Tbio Non-IDG -2.30763 199.4 123