Development Level

Tbio 98 | 10,625
Tchem 36 | 1,890
Tclin 12 | 602
Tdark 5 | 7,003

Collection

Kinase: IDG Consortium (Targets) 8 | 125
Kinase: IDG Consortium (Complete/Control) 2 | 37
Ion Channel: IDG Consortium (Targets) 1 | 102

IMPC Phenotype

abnormal behavior 6 | 226
preweaning lethality, complete... 5 | 633
decreased body weight 4 | 174
decreased lean body mass 4 | 195
increased circulating alkaline... 4 | 119
hyperactivity 3 | 108
increased or absent threshold ... 3 | 128
preweaning lethality, incomple... 3 | 260
abnormal bone structure 2 | 131
abnormal coat-hair pigmentatio... 2 | 54
abnormal retina morphology 2 | 100
decreased body length 2 | 108
decreased bone mineral content 2 | 157
decreased circulating HDL chol... 2 | 77
decreased circulating amylase ... 2 | 24
decreased circulating choleste... 2 | 85
decreased circulating magnesiu... 2 | 11
decreased grip strength 2 | 123
decreased leukocyte cell numbe... 2 | 54
edema 2 | 11
hemorrhage 2 | 12
increased circulating chloride... 2 | 43
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 26
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased startle reflex 2 | 38
persistence of hyaloid vascula... 2 | 22
short tibia 2 | 82
abnormal behavioral response t... 1 | 52
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal digit morphology 1 | 13
abnormal epididymis morphology 1 | 31
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal lumbar vertebrae morp... 1 | 6
abnormal respiratory quotient 1 | 9
abnormal skin coloration 1 | 18
abnormal sleep behavior 1 | 63
abnormal vibrissa morphology 1 | 17
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
absent startle reflex 1 | 15
absent vibrissae 1 | 14
convulsive seizures 1 | 11
corneal opacity 1 | 25
decreased CD8-positive, alpha-... 1 | 26
decreased Ly6C low monocyte nu... 1 | 23
decreased anxiety-related resp... 1 | 12
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating free fat... 1 | 39
decreased circulating glycerol... 1 | 19
decreased circulating iron lev... 1 | 25
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased exploration in new e... 1 | 9
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased lactate dehydrogenas... 1 | 14
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased startle reflex 1 | 48
decreased vertical activity 1 | 22
embryonic lethality prior to t... 1 | 187
fused cornea and lens 1 | 4
fused phalanges 1 | 1
hydrops fetalis 1 | 22
hypoactivity 1 | 89
impaired pupillary reflex 1 | 14
impaired righting response 1 | 19
improved glucose tolerance 1 | 56
increased Ly6C high monocyte n... 1 | 12
increased Ly6C low monocyte nu... 1 | 8
increased NK T cell number 1 | 11
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased caudal vertebrae num... 1 | 8
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased heart rate 1 | 17
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased rib number 1 | 41
male infertility 1 | 62
prenatal lethality prior to he... 1 | 64
shortened RR interval 1 | 19
shortened ST segment 1 | 9
stereotypic behavior 1 | 3
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

osteosarcoma 74 | 7,933
glioblastoma 73 | 5,572
medulloblastoma, large-cell 72 | 6,234
ovarian cancer 72 | 8,491
psoriasis 63 | 6,685
Carcinoma 60 | 2,147
atypical teratoid / rhabdoid tumor 56 | 4,369
pilocytic astrocytoma 54 | 3,086
primitive neuroectodermal tumor 54 | 3,031
oligodendroglioma 51 | 2,849
pediatric high grade glioma 47 | 2,712
ependymoma 43 | 2,514
malignant mesothelioma 39 | 3,163
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,289
astrocytic glioma 36 | 2,241
lung cancer 36 | 4,473
lung carcinoma 35 | 2,844
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,988
subependymal giant cell astrocytoma 32 | 2,287
invasive ductal carcinoma 31 | 2,950
lung adenocarcinoma 31 | 2,714
pancreatic cancer 31 | 2,300
Pick disease 30 | 1,893
ulcerative colitis 29 | 2,087
Breast cancer 28 | 3,098
adult high grade glioma 28 | 2,148
non-small cell lung cancer 28 | 2,798
medulloblastoma 27 | 1,524
pituitary cancer 25 | 1,972
acute quadriplegic myopathy 24 | 1,157
colon cancer 23 | 1,475
cystic fibrosis 23 | 1,670
group 3 medulloblastoma 22 | 2,254
Cancer 21 | 2,346
astrocytoma 20 | 1,493
sonic hedgehog group medulloblastoma 20 | 1,482
diabetes mellitus 18 | 1,663
interstitial cystitis 18 | 2,299
primary pancreatic ductal adenocarcinoma 18 | 1,271
Duchenne muscular dystrophy 17 | 602
posterior fossa group A ependymoma 17 | 1,511
group 4 medulloblastoma 16 | 1,875
posterior fossa group B ependymoma 16 | 1,530
tuberculosis 16 | 1,563
adrenocortical carcinoma 15 | 1,427
ductal carcinoma in situ 15 | 1,745
Amyotrophic Lateral Sclerosis 14 | 432
autosomal dominant Emery-Dreifuss muscular dystrophy 14 | 499
breast carcinoma 14 | 1,614
atypical teratoid/rhabdoid tumor 13 | 1,095
juvenile dermatomyositis 13 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
Sensorineural hearing loss 11 | 107
gastric carcinoma 11 | 832
nasopharyngeal carcinoma 11 | 1,056
spina bifida 11 | 1,064
Hypertension 10 | 293
Rheumatoid Arthritis 10 | 1,170
esophageal adenocarcinoma 10 | 737
Down syndrome 9 | 548
dermatomyositis 9 | 966
interstitial lung disease 9 | 292
Brain Ischemia 8 | 87
Kidney disease 8 | 397
Nonsyndromic deafness 8 | 121
aldosterone-producing adenoma 8 | 664
cutaneous lupus erythematosus 8 | 1,056
non-small cell lung carcinoma 8 | 413
progressive supranuclear palsy 8 | 674
Atopic dermatitis 7 | 944
Atrial Fibrillation 7 | 110
Cardiomyopathy 7 | 110
Heart disease 7 | 279
Hypertensive disease 7 | 193
Myocardial Infarction 7 | 126
Myopathy 7 | 128
Polycystic Ovary Syndrome 7 | 334
Status Epilepticus 7 | 85
mucosa-associated lymphoid tissue lymphoma 7 | 480
pancreatic carcinoma 7 | 567
Alzheimer's disease 6 | 644
Cerebrovascular disease 6 | 231
Heart conduction disease 6 | 65
IGA Glomerulonephritis 6 | 454
Intellectual disability 6 | 573
Kidney cancer 6 | 121
Long QT syndrome 6 | 53
Multiple Sclerosis 6 | 498
Neurodegenerative disease 6 | 383
Obesity 6 | 616
Parkinson's disease 6 | 364
Renal Cell Carcinoma 6 | 199
Schizophrenia 6 | 503
Schnyder Corneal Dystrophy 6 | 24
Waldenstrons macroglobulinemia 6 | 764
acute myeloid leukemia 6 | 785
hepatocellular carcinoma 6 | 550
chronic lymphocytic leukemia 5 | 244
chronic rhinosinusitis 5 | 512

Tissue

Blood and immune system 151 | 17,994
Cardiovascular System 151 | 17,957
Female tissues 151 | 18,646
Liver and Pancreas 151 | 18,135
Nervous System 151 | 18,560
Digestive Tract 150 | 18,472
Endocrine System 150 | 18,511
Male tissues 150 | 17,968
Urinary Tract 150 | 18,443
Respiratory system 149 | 17,483
Skin and soft tissues 148 | 18,114

Target Family

Non-IDG 67 | 11,969
Enzyme 29 | 4,146
Kinase 28 | 634
Ion Channel 18 | 341
Transporter 8 | 473
Transcription Factor 1 | 1,400

UniProt Keyword

Calmodulin-binding 151 | 151
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine-threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myristoylated alanine-rich C-kinase substrate MARCKS Tbio Enzyme -2.67051 512.2 639
Calcium/calmodulin-dependent protein kinase kinase 2 CAMKK2 Tchem Kinase -2.07114 116.8 211
Synaptotagmin-7 SYT7 Tbio Non-IDG -1.72363 48.4 144
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.87621 876.7 339
Beta-1-syntrophin SNTB1 Tbio Non-IDG -1.04336 8.71 102
Sphingosine kinase 1 SPHK1 Tchem Kinase -2.67625 514.1 477
Unconventional myosin-Vb MYO5B Tbio Non-IDG -1.93054 87.2 28
Spectrin alpha chain, non-erythrocytic 1 SPTAN1 Tbio Non-IDG -2.41058 258.0 266
Unconventional myosin-VI MYO6 Tbio Non-IDG -1.66390 49.9 93
Unconventional myosin-Id MYO1D Tbio Non-IDG -1.35309 22.2 57