Development Level

Tbio 102 | 11,651
Tchem 33 | 1,388
Tclin 13 | 612
Tdark 5 | 6,593

Collection

RFA-RM-18-021 9 | 328
Kinase: IDG Consortium (Target... 8 | 125
Kinase: IDG Consortium (Comple... 2 | 37
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 12 | 979
abnormal behavior 5 | 298
edema 5 | 59
hyperactivity 5 | 148
preweaning lethality, incomple... 5 | 499
abnormal bone structure 4 | 187
decreased body weight 4 | 161
increased or absent threshold ... 4 | 101
abnormal embryo size 3 | 220
decreased bone mineral content 3 | 151
embryonic lethality prior to t... 3 | 278
hemorrhage 3 | 23
increased total body fat amoun... 3 | 134
abnormal coat-hair pigmentatio... 2 | 64
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating amylase ... 2 | 28
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating magnesiu... 2 | 13
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 39
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased startle reflex 2 | 112
persistence of hyaloid vascula... 2 | 33
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
absent vibrissae 1 | 12
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
convulsive seizures 1 | 13
corneal opacity 1 | 32
cyanosis 1 | 7
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating potassiu... 1 | 29
increased heart rate 1 | 23
increased heart rate variabili... 1 | 7
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased vertical activity 1 | 24
prenatal lethality 1 | 28
shortened RR interval 1 | 17
stereotypic behavior 1 | 3
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 128 | 11,493
glioblastoma 76 | 5,792
ovarian cancer 75 | 8,520
osteosarcoma 74 | 7,950
ependymoma 73 | 4,679
medulloblastoma, large-cell 73 | 6,241
atypical teratoid / rhabdoid tumor 66 | 5,112
Kidney cancer 65 | 2,613
psoriasis 65 | 6,694
adult high grade glioma 60 | 3,801
Astrocytoma, Pilocytic 56 | 3,081
primitive neuroectodermal tumor 54 | 3,035
oligodendroglioma 51 | 2,850
group 3 medulloblastoma 49 | 4,104
astrocytic glioma 48 | 2,597
Breast cancer 43 | 3,578
malignant mesothelioma 41 | 3,232
lung cancer 40 | 4,740
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,291
pancreatic cancer 37 | 2,398
lung carcinoma 36 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
subependymal giant cell astrocytoma 33 | 2,287
invasive ductal carcinoma 31 | 2,951
lung adenocarcinoma 31 | 2,716
Pick disease 30 | 1,894
non-small cell lung cancer 30 | 2,890
ulcerative colitis 29 | 1,819
pituitary cancer 26 | 1,972
Melanoma 25 | 711
acute quadriplegic myopathy 25 | 1,158
Autosomal recessive predisposition 24 | 1,442
colon cancer 24 | 1,478
Cancer 23 | 2,499
cystic fibrosis 23 | 1,696
group 4 medulloblastoma 23 | 1,855
Liver cancer 20 | 604
interstitial cystitis 20 | 2,312
tuberculosis 20 | 2,010
Schizophrenia 18 | 1,160
Skin cancer 18 | 469
diabetes mellitus 18 | 1,728
Duchenne muscular dystrophy 17 | 601
pediatric high grade glioma 16 | 1,064
primary pancreatic ductal adenocarcinoma 16 | 1,109
adrenocortical carcinoma 15 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 510
ductal carcinoma in situ 15 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
breast carcinoma 14 | 1,638
Amyotrophic lateral sclerosis 13 | 451
Endometrial cancer 13 | 311
Seizures 13 | 596
juvenile dermatomyositis 13 | 1,187
Hypertension 12 | 396
gastric carcinoma 12 | 807
nasopharyngeal carcinoma 12 | 1,058
Bipolar Disorder 11 | 666
Epilepsy 11 | 792
Hepatomegaly 11 | 285
Hypertensive disease 11 | 292
spina bifida 11 | 1,074
Atrial Fibrillation 10 | 124
Intellectual disability 10 | 1,016
Liver Cirrhosis, Experimental 10 | 769
Rheumatoid arthritis 10 | 1,191
Sensorineural hearing loss 10 | 106
esophageal adenocarcinoma 10 | 737
Cardiomyopathy 9 | 116
Cognitive delay 9 | 608
Down syndrome 9 | 499
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
Muscle hypotonia 9 | 571
Short stature 9 | 531
dermatomyositis 9 | 966
interstitial lung disease 9 | 298
medulloblastoma 9 | 720
Brain Ischemia 8 | 110
Depressive disorder 8 | 409
Infantile onset 8 | 238
Kidney disease 8 | 430
Mental Depression 8 | 333
Myocardial Infarction 8 | 151
Myopathy 8 | 185
Nonsyndromic deafness 8 | 142
Polycystic ovary syndrome 8 | 360
aldosterone-producing adenoma 8 | 665
astrocytoma 8 | 1,146
cutaneous lupus erythematosus 8 | 1,057
progressive supranuclear palsy 8 | 676
Atopic dermatitis 7 | 952
Cataract 7 | 297
Heart conduction disease 7 | 83
Multiple Sclerosis 7 | 540
Parkinson's disease 7 | 392
Status Epilepticus 7 | 98
mucosa-associated lymphoid tissue lymphoma 7 | 484
pancreatic carcinoma 7 | 562

Tissue

Endocrine System 153 | 18,159
Skin and soft tissues 151 | 17,230
Digestive Tract 149 | 17,369
Male tissues 148 | 17,142
Nervous System 147 | 16,725
Female tissues 144 | 17,400
Liver and Pancreas 143 | 16,750
Blood and immune system 142 | 16,909
Urinary Tract 141 | 16,678
Respiratory system 139 | 16,393
Cardiovascular System 136 | 15,192

Target Family

Non-IDG 68 | 12,091
Enzyme 29 | 4,145
Kinase 28 | 634
Ion Channel 19 | 344
Transporter 8 | 473
Transcription Factor 1 | 1,400

UniProt Keyword

Calmodulin-binding 153 | 153
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S Tclin Ion Channel -2.21321 163.9 114
Unconventional myosin-Va MYO5A Tbio Non-IDG -1.77097 54.9 83
Unconventional myosin-Vb MYO5B Tbio Non-IDG -1.96052 93.4 42
Unconventional myosin-Id MYO1D Tbio Non-IDG -1.39704 23.1 63
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.32299 2090.2 2060
Plasma membrane calcium-transporting ATPase 2 ATP2B2 Tbio Transporter -2.07505 125.1 76
Sphingosine kinase 1 SPHK1 Tchem Kinase -2.72994 583.6 518