Development Level

Tbio 43 | 11,445
Tchem 36 | 1,598
Tclin 13 | 613
Tdark 9 | 6,588

Collection

Ion Channel: IDG Consortium (T... 17 | 99

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 8 | 499
increased startle reflex 6 | 112
abnormal embryo size 4 | 220
decreased prepulse inhibition 4 | 82
embryonic lethality prior to t... 4 | 278
abnormal behavior 3 | 298
decreased circulating glucose ... 3 | 126
decreased fasted circulating g... 3 | 65
increased circulating sodium l... 3 | 71
increased total body fat amoun... 3 | 134
abnormal gait 2 | 69
abnormal sleep behavior 2 | 70
absent vibrissae 2 | 12
decreased body weight 2 | 161
decreased circulating amylase ... 2 | 28
decreased grip strength 2 | 116
decreased mean platelet volume 2 | 25
decreased neutrophil cell numb... 2 | 42
edema 2 | 59
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
impaired righting response 2 | 26
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
prenatal lethality 2 | 28
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal iris transilluminatio... 1 | 2
abnormal locomotor activation 1 | 16
abnormal pancreas morphology 1 | 13
abnormal placenta vasculature 1 | 2
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal spine curvature 1 | 9
abnormal spleen morphology 1 | 55
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
corneal vascularization 1 | 6
cyanosis 1 | 7
decreased cardiac stroke volum... 1 | 6
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
enlarged testis 1 | 6
enlarged thymus 1 | 5
hemorrhage 1 | 23
hydrometra 1 | 53
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased respiratory quotient 1 | 2
increased spleen weight 1 | 10
limb grasping 1 | 41
long tibia 1 | 25
male infertility 1 | 123
mammalian phenotype 1 | 17
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
respiratory system phenotype 1 | 2
small epididymis 1 | 3
small heart 1 | 10
small liver 1 | 8
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74

Disease

Carcinoma 84 | 11,493
medulloblastoma, large-cell 48 | 6,241
glioblastoma 47 | 5,792
osteosarcoma 47 | 7,950
ovarian cancer 45 | 8,520
atypical teratoid / rhabdoid tumor 43 | 5,112
Kidney cancer 42 | 2,613
adult high grade glioma 40 | 3,801
ependymoma 36 | 4,679
psoriasis 36 | 6,694
Astrocytoma, Pilocytic 28 | 3,081
group 3 medulloblastoma 28 | 4,104
primitive neuroectodermal tumor 28 | 3,035
oligodendroglioma 26 | 2,850
lung carcinoma 24 | 2,843
Breast cancer 22 | 3,578
lung cancer 22 | 4,740
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
pituitary cancer 21 | 1,972
subependymal giant cell astrocytoma 21 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
astrocytic glioma 19 | 2,597
Pick disease 18 | 1,894
invasive ductal carcinoma 17 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
Hypertension 14 | 396
lung adenocarcinoma 14 | 2,716
Bipolar Disorder 13 | 666
malignant mesothelioma 13 | 3,232
pancreatic cancer 13 | 2,398
Endometrial cancer 12 | 311
Liver cancer 12 | 604
group 4 medulloblastoma 12 | 1,855
colon cancer 11 | 1,478
cystic fibrosis 11 | 1,696
Epilepsy 10 | 792
Melanoma 10 | 711
tuberculosis 10 | 2,010
Hypertensive disease 9 | 292
Schizophrenia 9 | 1,160
Skin cancer 9 | 469
ductal carcinoma in situ 9 | 1,745
ulcerative colitis 9 | 1,819
Autosomal recessive predisposition 8 | 1,442
Intellectual disability 8 | 1,016
Malignant hyperthermia 8 | 26
Cancer 7 | 2,499
Hypertensive disorder 7 | 56
Neurodegenerative disease 7 | 414
cutaneous lupus erythematosus 7 | 1,057
interstitial cystitis 7 | 2,312
Cerebellar Ataxia 6 | 304
Endometriosis 6 | 540
Myopathy 6 | 185
Schnyder Corneal Dystrophy 6 | 23
astrocytoma 6 | 1,146
breast carcinoma 6 | 1,638
medulloblastoma 6 | 720
non-small cell lung cancer 6 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
pediatric high grade glioma 6 | 1,064
Amenorrhea Secondary to Ovarian Dysfunction 5 | 8
Angina Pectoris 5 | 32
Atrophic vaginitis 5 | 14
Brain Ischemia 5 | 110
Contraception 5 | 15
Corpus Luteum Insufficiency Syndrome 5 | 8
Dentin sensitivity 5 | 14
Dysfunctional uterine bleeding 5 | 9
Endometrial Hyperplasia Prevention 5 | 9
Endometrial carcinoma 5 | 15
Infertility Secondary to Progesterone Deficiency 5 | 8
Menopausal flushing 5 | 17
Obesity 5 | 678
Postmenopausal osteoporosis 5 | 19
Prevention of Premature Labor 5 | 9
Secondary malignant neoplasm of kidney 5 | 9
Secondary physiologic amenorrhea 5 | 32
Seizures 5 | 596
active Crohn's disease 5 | 922
adrenocortical carcinoma 5 | 1,428
aldosterone-producing adenoma 5 | 665
dermatomyositis 5 | 966
primary pancreatic ductal adenocarcinoma 5 | 1,109
Adenoma 4 | 167
Heart disease 4 | 306
Male infertility 4 | 206
Muscle hypotonia 4 | 571
Neuropathy 4 | 261
Parkinson's disease 4 | 392
Rheumatoid arthritis 4 | 1,191
Type 2 diabetes mellitus 4 | 272
acute myeloid leukemia 4 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
diabetes mellitus 4 | 1,728
fibroadenoma 4 | 559
head and neck cancer 4 | 271
non primary Sjogren syndrome sicca 4 | 891
pancreatic carcinoma 4 | 562
progressive supranuclear palsy 4 | 676

Tissue

Endocrine System 99 | 18,159
Nervous System 94 | 16,725
Digestive Tract 93 | 17,369
Female tissues 92 | 17,400
Skin and soft tissues 92 | 17,230
Blood and immune system 90 | 16,909
Urinary Tract 90 | 16,678
Male tissues 89 | 17,142
Liver and Pancreas 88 | 16,750
Respiratory system 84 | 16,393
Cardiovascular System 72 | 15,192

Target Family

Ion Channel 69 | 344
Transporter 18 | 473
Non-IDG 13 | 12,091
Kinase 1 | 634

UniProt Keyword

Calcium transport 101 | 101
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transient receptor potential cation channel subfamily V member 2 TRPV2 Tchem Ion Channel -2.28525 197.9 203
Pannexin-1 PANX1 Tbio Ion Channel -2.59888 418.5 154
Calcium-activated chloride channel regulator family member 3 CLCA3P Tdark Ion Channel 0.00000 0
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.87498 737.3 295
Transient receptor potential cation channel subfamily M member 2 TRPM2 Tchem Ion Channel -1.34318 25.1 209
Transient receptor potential cation channel subfamily M member 7 TRPM7 Tchem Ion Channel -2.53154 365.5 317
Voltage-dependent calcium channel gamma-like subunit TMEM37 Tbio Ion Channel -2.84704 668.1 56
Short transient receptor potential channel 7 TRPC7 Tchem Ion Channel -2.43775 199.8 220
Transient receptor potential cation channel subfamily M member 3 TRPM3 Tchem Ion Channel -2.19236 141.8 121
Sodium/potassium/calcium exchanger 3 SLC24A3 Tbio Transporter -1.12274 13.0 86