Development Level

Tbio 516 | 10,625
Tchem 162 | 1,890
Tdark 150 | 7,003
Tclin 36 | 602

Collection

Eligible Ion Channel Proteins 30 | 117
Eligible non-olfactory GPCR Proteins 6 | 143
Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 22 | 633
preweaning lethality, incomple... 16 | 260
abnormal behavior 14 | 226
decreased lean body mass 13 | 195
decreased bone mineral content 11 | 157
abnormal lens morphology 10 | 73
decreased body weight 10 | 174
decreased bone mineral density 10 | 126
decreased total body fat amoun... 10 | 186
abnormal bone structure 9 | 131
increased circulating sodium l... 9 | 71
increased lean body mass 9 | 107
enlarged heart 8 | 111
increased bone mineral content 8 | 92
increased circulating alkaline... 8 | 119
abnormal retina morphology 7 | 100
decreased grip strength 7 | 123
embryonic lethality prior to t... 7 | 187
short tibia 7 | 82
abnormal retinal pigmentation 6 | 61
abnormal seminal vesicle morph... 6 | 47
decreased body length 6 | 108
decreased circulating glucose ... 6 | 121
decreased fasted circulating g... 6 | 49
decreased heart weight 6 | 44
hyperactivity 6 | 108
tremors 6 | 34
decreased circulating insulin ... 5 | 75
decreased prepulse inhibition 5 | 52
decreased rib number 5 | 59
increased circulating chloride... 5 | 43
increased grip strength 5 | 83
abnormal embryo size 4 | 112
abnormal gait 4 | 51
abnormal heart left ventricle ... 4 | 20
abnormal heart morphology 4 | 51
abnormal locomotor activation 4 | 26
abnormal spleen morphology 4 | 36
decreased circulating glycerol... 4 | 19
decreased circulating triglyce... 4 | 83
decreased startle reflex 4 | 48
enlarged spleen 4 | 26
hypoactivity 4 | 89
increased bone mineral density 4 | 52
increased mean corpuscular vol... 4 | 91
increased or absent threshold ... 4 | 128
increased startle reflex 4 | 38
increased total body fat amoun... 4 | 57
limb grasping 4 | 35
small thymus 4 | 11
abnormal coat/hair pigmentatio... 3 | 54
abnormal cornea morphology 3 | 24
abnormal cranium morphology 3 | 32
abnormal digit morphology 3 | 13
abnormal eye morphology 3 | 38
abnormal kidney morphology 3 | 30
abnormal optic disc morphology 3 | 10
abnormal retinal blood vessel ... 3 | 18
abnormal retinal vasculature m... 3 | 15
abnormal vibrissa morphology 3 | 17
abnormal vocalization 3 | 21
cardiovascular system phenotyp... 3 | 35
decreased circulating HDL chol... 3 | 77
decreased circulating alkaline... 3 | 41
decreased circulating amylase ... 3 | 24
decreased circulating calcium ... 3 | 33
decreased circulating choleste... 3 | 85
decreased circulating free fat... 3 | 39
decreased circulating serum al... 3 | 79
decreased circulating sodium l... 3 | 18
impaired glucose tolerance 3 | 52
increased circulating HDL chol... 3 | 63
increased mean corpuscular hem... 3 | 93
male infertility 3 | 62
oligodactyly 3 | 14
straub tail 3 | 26
thrombocytopenia 3 | 46
abnormal coat appearance 2 | 25
abnormal epididymis morphology 2 | 31
abnormal liver morphology 2 | 5
abnormal rib morphology 2 | 28
abnormal snout morphology 2 | 18
abnormal thoracic vertebrae mo... 2 | 16
corneal opacity 2 | 25
decreased circulating creatini... 2 | 31
decreased eosinophil cell numb... 2 | 41
decreased heart rate variabili... 2 | 11
decreased pulmonary respirator... 2 | 4
enlarged stomach 2 | 2
female infertility 2 | 34
impaired righting response 2 | 19
increased blood urea nitrogen ... 2 | 44
increased body weight 2 | 42
increased circulating choleste... 2 | 53
increased erythrocyte cell num... 2 | 26
increased fasted circulating g... 2 | 68
increased hemoglobin content 2 | 45
lethargy 2 | 5
persistence of hyaloid vascula... 2 | 22
prenatal lethality 2 | 16

Disease

ovarian cancer 362 | 8,484
psoriasis 362 | 6,685
glioblastoma 337 | 5,572
osteosarcoma 333 | 7,933
medulloblastoma, large-cell 318 | 6,234
atypical teratoid / rhabdoid tumor 263 | 4,369
lung carcinoma 246 | 2,844
lung cancer 242 | 4,466
Carcinoma 240 | 2,147
pilocytic astrocytoma 234 | 3,086
oligodendroglioma 198 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 193 | 3,289
lung adenocarcinoma 188 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 187 | 2,956
primitive neuroectodermal tumor 186 | 3,031
pediatric high grade glioma 179 | 2,712
Breast cancer 175 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 174 | 2,988
invasive ductal carcinoma 172 | 2,950
non-small cell lung cancer 169 | 2,798
pancreatic cancer 157 | 2,300
malignant mesothelioma 156 | 3,162
subependymal giant cell astrocytoma 149 | 2,287
interstitial cystitis 146 | 2,299
ulcerative colitis 141 | 2,087
ependymoma 139 | 2,514
Cancer 131 | 2,346
pituitary cancer 131 | 1,972
astrocytic glioma 126 | 2,241
cystic fibrosis 126 | 1,665
group 4 medulloblastoma 126 | 1,875
adult high grade glioma 121 | 2,148
posterior fossa group A ependymoma 117 | 1,511
Pick disease 112 | 1,893
colon cancer 105 | 1,475
primary pancreatic ductal adenocarcinoma 103 | 1,271
group 3 medulloblastoma 102 | 2,254
ductal carcinoma in situ 100 | 1,745
astrocytoma 97 | 1,493
adrenocortical carcinoma 94 | 1,427
breast carcinoma 90 | 1,614
sonic hedgehog group medulloblastoma 89 | 1,482
pancreatic ductal adenocarcinoma liver metastasis 88 | 1,795
medulloblastoma 87 | 1,524
posterior fossa group B ependymoma 80 | 1,530
diabetes mellitus 78 | 1,663
tuberculosis 77 | 1,557
nasopharyngeal carcinoma 72 | 1,056
atypical teratoid/rhabdoid tumor 71 | 1,095
Duchenne muscular dystrophy 68 | 602
active Crohn's disease 64 | 918
esophageal adenocarcinoma 64 | 737
juvenile dermatomyositis 64 | 1,189
cutaneous lupus erythematosus 63 | 1,056
gastric carcinoma 63 | 832
acute quadriplegic myopathy 62 | 1,157
Rheumatoid Arthritis 61 | 1,160
Atopic dermatitis 60 | 944
autosomal dominant Emery-Dreifuss muscular dystrophy 54 | 499
dermatomyositis 48 | 933
Alzheimer's disease 47 | 644
Schizophrenia 45 | 501
aldosterone-producing adenoma 45 | 664
mucosa-associated lymphoid tissue lymphoma 44 | 480
non primary Sjogren syndrome sicca 42 | 840
Endometriosis 41 | 535
Down syndrome 40 | 548
non-small cell lung carcinoma 40 | 413
primary Sjogren syndrome 39 | 789
spina bifida 38 | 1,064
Vascular disease 37 | 281
fibroadenoma 35 | 557
Epilepsy 34 | 346
Obesity 34 | 616
Atherosclerosis 32 | 275
Prostatic Neoplasms 31 | 471
Asthma 30 | 349
Becker muscular dystrophy 30 | 187
Autistic Disorder 29 | 320
Multiple myeloma 29 | 1,327
urothelial carcinoma 29 | 318
Amyotrophic Lateral Sclerosis 28 | 431
Intellectual disability 28 | 573
Kidney disease 28 | 396
Multiple Sclerosis 28 | 498
active ulcerative colitis 28 | 477
progressive supranuclear palsy 27 | 674
Cerebrovascular disease 26 | 231
Heart disease 26 | 279
head and neck cancer 26 | 270
interstitial lung disease 26 | 291
nephrosclerosis 26 | 329
pancreatic carcinoma 26 | 567
periodontitis 26 | 269
Arthritis 25 | 248
Kidney cancer 25 | 118
chronic rhinosinusitis 25 | 512
Osteoporosis 24 | 257
Waldenstrons macroglobulinemia 24 | 765
head and neck cancer and chronic obstructive pulmonary disease 24 | 237

Tissue

Female tissues 849 | 18,647
Digestive Tract 847 | 18,473
Nervous System 845 | 18,561
Endocrine System 843 | 18,512
Urinary Tract 842 | 18,444
Liver and Pancreas 841 | 18,136
Blood and immune system 839 | 17,995
Cardiovascular System 835 | 17,958
Male tissues 831 | 17,969
Skin and soft tissues 828 | 18,115
Respiratory system 822 | 17,484

Target Family

Non-IDG 517 | 11,971
Enzyme 204 | 4,146
Ion Channel 93 | 341
Transporter 23 | 473
Kinase 14 | 634
GPCR 12 | 406
Epigenetic 1 | 242

UniProt Keyword

Calcium 864 | 864
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.40066 23.4 60
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
Vesicular integral-membrane protein VIP36 LMAN2 Tbio Non-IDG -1.35463 24.9 101
Sodium/calcium exchanger 2 SLC8A2 Tbio Transporter -1.56223 31.9 51
Calumenin CALU Tbio Non-IDG -1.76431 61.4 157
Calcium/calmodulin-dependent protein kinase type 1D CAMK1D Tchem Kinase -1.06137 12.5 282