Development Level

Tbio 111 | 11,445
Tchem 17 | 1,598
Tdark 10 | 6,588
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 15 | 979
increased lean body mass 6 | 172
abnormal behavior 5 | 298
abnormal bone structure 3 | 187
decreased body weight 3 | 161
preweaning lethality, incomple... 3 | 499
decreased bone mineral content 2 | 151
decreased circulating aspartat... 2 | 34
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
decreased mean platelet volume 2 | 25
decreased prepulse inhibition 2 | 82
decreased red blood cell distr... 2 | 41
embryonic lethality prior to t... 2 | 278
hypoactivity 2 | 132
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
long tibia 2 | 25
prolonged QT interval 2 | 38
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal optic disc morphology 1 | 10
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
aorta dilation 1 | 3
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating lactate ... 1 | 3
decreased circulating magnesiu... 1 | 13
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
increased B cell number 1 | 9
increased body length 1 | 32
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
macrophthalmia 1 | 2
mammalian phenotype 1 | 17
polycystic kidney 1 | 15
prenatal lethality 1 | 28
prolonged ST segment 1 | 36
short tibia 1 | 97
shortened QT interval 1 | 4
thrombocytopenia 1 | 56
vertebral fusion 1 | 23

Disease

Carcinoma 87 | 11,493
ovarian cancer 84 | 8,520
osteosarcoma 76 | 7,950
medulloblastoma, large-cell 56 | 6,241
glioblastoma 49 | 5,792
psoriasis 42 | 6,694
atypical teratoid / rhabdoid tumor 40 | 5,112
lung cancer 38 | 4,740
ependymoma 32 | 4,679
Cancer 29 | 2,499
adult high grade glioma 28 | 3,801
Breast cancer 24 | 3,578
Neurodegenerative disease 24 | 414
astrocytic glioma 22 | 2,597
malignant mesothelioma 21 | 3,232
primitive neuroectodermal tumor 21 | 3,035
tuberculosis 21 | 2,010
Multiple myeloma 20 | 1,332
group 3 medulloblastoma 19 | 4,104
group 4 medulloblastoma 19 | 1,855
subependymal giant cell astrocytoma 19 | 2,287
Astrocytoma, Pilocytic 18 | 3,081
Kidney cancer 18 | 2,613
diabetes mellitus 18 | 1,728
oligodendroglioma 18 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
acute quadriplegic myopathy 16 | 1,158
astrocytoma 16 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
invasive ductal carcinoma 16 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
lung adenocarcinoma 15 | 2,716
Schizophrenia 14 | 1,160
juvenile dermatomyositis 14 | 1,187
lung carcinoma 14 | 2,843
Pick disease 13 | 1,894
breast carcinoma 13 | 1,638
pituitary cancer 13 | 1,972
Rheumatoid arthritis 12 | 1,191
dermatomyositis 12 | 966
ductal carcinoma in situ 12 | 1,745
non-small cell lung cancer 12 | 2,890
pancreatic cancer 12 | 2,398
Amyotrophic lateral sclerosis 11 | 451
Waldenstrons macroglobulinemia 11 | 765
spina bifida 11 | 1,074
ulcerative colitis 11 | 1,819
Vici syndrome 10 | 14
pediatric high grade glioma 10 | 1,064
Alzheimer's disease 9 | 658
Autosomal recessive predisposition 9 | 1,442
Parkinson's disease 9 | 392
hepatocellular carcinoma 9 | 547
interstitial cystitis 9 | 2,312
primary pancreatic ductal adenocarcinoma 9 | 1,109
Nerve Degeneration 8 | 121
active Crohn's disease 8 | 922
acute myeloid leukemia 8 | 783
colon cancer 8 | 1,478
cutaneous lupus erythematosus 8 | 1,057
esophageal adenocarcinoma 8 | 737
medulloblastoma 8 | 720
non primary Sjogren syndrome sicca 8 | 891
Frontotemporal dementia 7 | 51
Neuropathy 7 | 261
adrenocortical carcinoma 7 | 1,428
mucosa-associated lymphoid tissue lymphoma 7 | 484
posterior fossa group A ependymoma 7 | 468
Atopic dermatitis 6 | 952
Crohn's disease 6 | 321
Dementia 6 | 175
Depressive disorder 6 | 409
Dysarthria 6 | 192
Fatigue 6 | 182
Vascular disease 6 | 319
active ulcerative colitis 6 | 764
cystic fibrosis 6 | 1,696
gastric cancer 6 | 459
progressive supranuclear palsy 6 | 676
Absent reflex 5 | 92
Absent tendon reflex 5 | 92
Anxiety 5 | 136
Anxiety disease 5 | 113
Decreased tendon reflex 5 | 122
Down syndrome 5 | 499
Glaucoma 5 | 239
Huntington's disease 5 | 76
Intellectual disability 5 | 1,016
Muscle Spasticity 5 | 195
Neurodegenerative Disorders 5 | 79
Neurogenic Muscular Atrophy 5 | 139
Neurogenic muscle atrophy, especially in the lower limbs 5 | 139
Reflex, Deep Tendon, Absent 5 | 92
Skeletal muscle atrophy 5 | 139
Systemic lupus erythematosus 5 | 194
gastric carcinoma 5 | 807
muscle degeneration 5 | 139
pancreatic carcinoma 5 | 562
primary Sjogren syndrome 5 | 735

Tissue

Blood and immune system 138 | 16,909
Digestive Tract 138 | 17,369
Endocrine System 138 | 18,159
Female tissues 138 | 17,400
Liver and Pancreas 138 | 16,750
Male tissues 138 | 17,142
Nervous System 138 | 16,725
Respiratory system 138 | 16,393
Skin and soft tissues 138 | 17,230
Urinary Tract 138 | 16,678
Cardiovascular System 135 | 15,192

Target Family

Non-IDG 95 | 12,091
Enzyme 26 | 4,145
Kinase 11 | 634
Transcription Factor 5 | 1,400
Epigenetic 3 | 242

UniProt Keyword

Autophagy 140 | 140
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Ras-related protein Rab-39A RAB39A Tdark Enzyme -0.57787 3.49 68
Beclin-2 BECN2 Tbio Non-IDG 0.00000 87
GATOR complex protein WDR24 WDR24 Tdark Non-IDG 0.16 1.02 28
Cysteine protease ATG4B ATG4B Tbio Enzyme -1.79492 58.3 416
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Endophilin-B1 SH3GLB1 Tbio Non-IDG -1.10096 14.5 386
Transmembrane protein 74 TMEM74 Tdark Non-IDG -0.72496 3.54 52
Pleckstrin homology domain-containing family M member 1 PLEKHM1 Tbio Non-IDG -1.44998 27.9 116
Zinc finger protein with KRAB and SCAN domains 3 ZKSCAN3 Tbio Transcription Factor -0.90118 10.2 101