Development Level

Tdark 12 | 7,003
Tchem 5 | 1,890
Tbio 4 | 10,625
Tclin 2 | 602

IMPC Term

premature death 1 | 5
preweaning lethality, incomple... 1 | 260
straub tail 1 | 26

Disease

lung cancer 5 | 4,466
Cancer 4 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
lung carcinoma 4 | 2,844
Alzheimer's disease 3 | 644
Amyotrophic lateral sclerosis type 3 3 | 15
diabetes mellitus 3 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
lung adenocarcinoma 3 | 2,713
medulloblastoma, large-cell 3 | 6,234
non-small cell lung cancer 3 | 2,798
osteosarcoma 3 | 7,933
ovarian cancer 3 | 8,484
pancreatic cancer 3 | 2,300
psoriasis 3 | 6,685
subependymal giant cell astrocytoma 3 | 2,287
Amyotrophic lateral sclerosis type 1 2 | 15
Down syndrome 2 | 548
Kidney Diseases 2 | 86
active Crohn's disease 2 | 918
breast carcinoma 2 | 1,614
glioblastoma 2 | 5,572
interstitial cystitis 2 | 2,299
interstitial lung disease 2 | 291
malignant mesothelioma 2 | 3,162
mucosa-associated lymphoid tissue lymphoma 2 | 480
primary pancreatic ductal adenocarcinoma 2 | 1,271
AMYOTROPHIC LATERAL SCLEROSIS 1 1 | 49
Acute chest syndrome 1 | 9
Adenoma 1 | 165
Adverse reaction to drug 1 | 54
Amyloidosis 1 | 68
Anemia 1 | 252
Atrophic gastritis 1 | 4
Barrett's esophagus 1 | 183
Bartter Disease 1 | 12
Brain disease 1 | 83
CD40 deficiency 1 | 3
Cardiomegaly 1 | 66
Cardiovascular system disease 1 | 194
Cerebrovascular disease 1 | 231
Conn's syndrome 1 | 22
Connective tissue disease 1 | 59
Cushing's syndrome 1 | 47
Degenerative polyarthritis 1 | 93
Dementia 1 | 129
Diabetes Mellitus, Experimental 1 | 106
Diabetic Retinopathy 1 | 53
Esophagitis 1 | 26
Fibrosis 1 | 40
Gastritis 1 | 44
Heart disease 1 | 279
Heart failure 1 | 80
Hyperaldosteronism 1 | 27
Hyperglycemia 1 | 120
Hyperinsulinism 1 | 63
Hyperparathyroidism 1 | 43
Hypertensive disease 1 | 193
Hypertensive disorder 1 | 58
Hypertensive retinopathy 1 | 9
Hyperthyroidism 1 | 50
Hyperuricemia 1 | 35
Hypoglycemia 1 | 81
Hypokalemia 1 | 40
Hypotension 1 | 53
Hypothyroidism 1 | 89
Ischemia 1 | 27
Kidney disease 1 | 396
Left Ventricular Hypertrophy 1 | 24
Liddle syndrome 1 | 14
Lipid metabolism disorder 1 | 102
Liver Cirrhosis 1 | 101
Liver carcinoma 1 | 217
Lung disease 1 | 132
Metabolic acidosis 1 | 49
Metabolic syndrome X 1 | 155
Muscle Weakness 1 | 92
Myocardial Infarction 1 | 126
Neoplasm Invasiveness 1 | 127
Neurodegenerative disease 1 | 383
Neuronal ceroid lipofuscinosis 1 | 28
Oligohydramnios 1 | 18
Osteoporosis 1 | 257
Ovarian hyperstimulation syndrome 1 | 15
Peripartum cardiomyopathy 1 | 4
Polycystic kidney disease 1 | 54
Portal hypertension 1 | 21
Proteinuria 1 | 63
Renal Cell Carcinoma 1 | 199
Substance Withdrawal Syndrome 1 | 52
Toxic encephalopathy 1 | 131
Vesicoureteral reflux 1 | 28
Weight Gain 1 | 87
X-linked cerebral adrenoleukodystrophy 1 | 115
active ulcerative colitis 1 | 477
atypical teratoid/rhabdoid tumor 1 | 1,095
inclusion-cell disease 1 | 15
pseudo-Hurler polydystrophy 1 | 6
sarcoidosis 1 | 358

Tissue

Blood and immune system 11 | 17,995
Cardiovascular System 11 | 17,958
Digestive Tract 11 | 18,473
Endocrine System 11 | 18,512
Female tissues 11 | 18,647
Liver and Pancreas 11 | 18,136
Male tissues 11 | 17,969
Nervous System 11 | 18,561
Skin and soft tissues 11 | 18,115
Urinary Tract 11 | 18,444
Respiratory system 10 | 17,484

Target Family

Enzyme 23 | 4,146

UniProt Keyword

Aspartyl protease 23 | 23
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

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