Development Level

Tbio 371 | 11,445
Tchem 120 | 1,598
Tdark 26 | 6,588
Tclin 16 | 613

Collection

Kinase: IDG Consortium (Target... 9 | 125
Kinase: IDG Consortium (Comple... 6 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 31 | 979
preweaning lethality, incomple... 16 | 499
abnormal behavior 13 | 298
hypoactivity 12 | 132
decreased vertical activity 11 | 208
abnormal bone structure 10 | 187
hyperactivity 9 | 148
increased lean body mass 8 | 172
decreased bone mineral content 7 | 151
abnormal embryo size 6 | 220
abnormal gait 6 | 69
decreased bone mineral density 6 | 126
decreased mean corpuscular vol... 6 | 79
decreased total body fat amoun... 6 | 207
increased circulating alkaline... 6 | 122
increased startle reflex 6 | 112
decreased body weight 5 | 161
decreased prepulse inhibition 5 | 82
embryonic lethality prior to t... 5 | 278
enlarged heart 5 | 210
increased leukocyte cell numbe... 5 | 47
increased mean corpuscular hem... 5 | 96
thrombocytopenia 5 | 56
abnormal bone mineralization 4 | 38
abnormal coat-hair pigmentatio... 4 | 64
abnormal lens morphology 4 | 81
abnormal retina morphology 4 | 71
abnormal seminal vesicle morph... 4 | 114
decreased circulating choleste... 4 | 93
decreased circulating glucose ... 4 | 126
decreased erythrocyte cell num... 4 | 62
decreased mean corpuscular hem... 4 | 50
embryonic growth retardation 4 | 106
embryonic lethality prior to o... 4 | 239
impaired glucose tolerance 4 | 75
increased circulating sodium l... 4 | 71
increased mean corpuscular vol... 4 | 92
increased or absent threshold ... 4 | 101
increased total body fat amoun... 4 | 134
male infertility 4 | 123
tremors 4 | 39
abnormal limb morphology 3 | 13
cataract 3 | 92
decreased T cell number 3 | 15
decreased circulating creatini... 3 | 39
decreased circulating triglyce... 3 | 79
decreased hematocrit 3 | 46
decreased lean body mass 3 | 135
decreased neutrophil cell numb... 3 | 42
edema 3 | 59
increased blood urea nitrogen ... 3 | 48
increased bone mineral density 3 | 72
increased circulating amylase ... 3 | 25
increased circulating choleste... 3 | 66
increased grip strength 3 | 41
increased heart weight 3 | 62
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 36
limb grasping 3 | 41
prenatal lethality prior to he... 3 | 87
abnormal behavioral response t... 2 | 66
abnormal heart left ventricle ... 2 | 16
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
abnormal tail morphology 2 | 25
cyanosis 2 | 7
decreased CD4-positive, alpha ... 2 | 7
decreased IgG1 level 2 | 8
decreased basophil cell number 2 | 16
decreased blood urea nitrogen ... 2 | 51
decreased circulating HDL chol... 2 | 68
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased circulating bilirubi... 2 | 19
decreased circulating calcium ... 2 | 36
decreased circulating insulin ... 2 | 76
decreased circulating potassiu... 2 | 20
decreased circulating serum al... 2 | 82
decreased granulocyte number 2 | 6
decreased heart left ventricle... 2 | 28
decreased red blood cell distr... 2 | 41
decreased startle reflex 2 | 75
dilated heart left ventricle 2 | 11
enlarged spleen 2 | 41
female infertility 2 | 60
hemorrhage 2 | 23
increased bone mineral content 2 | 108
increased circulating calcium ... 2 | 34
increased circulating free fat... 2 | 20
increased circulating triglyce... 2 | 42
increased eosinophil cell numb... 2 | 11
increased hematocrit 2 | 46
increased large unstained cell... 2 | 5
increased lymphocyte cell numb... 2 | 32
increased mean platelet volume 2 | 45
increased red blood cell distr... 2 | 34
small superior vagus ganglion 2 | 74
abnormal craniofacial morpholo... 1 | 33
decreased mean corpuscular hem... 1 | 31
vertebral fusion 1 | 23

Disease

ovarian cancer 315 | 8,520
Carcinoma 309 | 11,493
osteosarcoma 253 | 7,950
psoriasis 227 | 6,694
glioblastoma 212 | 5,792
medulloblastoma, large-cell 208 | 6,241
lung cancer 205 | 4,740
Cancer 201 | 2,499
atypical teratoid / rhabdoid tumor 158 | 5,112
ependymoma 142 | 4,679
malignant mesothelioma 131 | 3,232
Breast cancer 128 | 3,578
adult high grade glioma 127 | 3,801
group 3 medulloblastoma 127 | 4,104
non-small cell lung cancer 125 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 120 | 3,291
invasive ductal carcinoma 114 | 2,951
lung carcinoma 113 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 112 | 2,989
pancreatic cancer 109 | 2,398
Astrocytoma, Pilocytic 108 | 3,081
lung adenocarcinoma 107 | 2,716
oligodendroglioma 99 | 2,850
subependymal giant cell astrocytoma 98 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 95 | 2,955
primitive neuroectodermal tumor 94 | 3,035
tuberculosis 91 | 2,010
interstitial cystitis 88 | 2,312
astrocytic glioma 83 | 2,597
pituitary cancer 82 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 80 | 1,962
breast carcinoma 76 | 1,638
diabetes mellitus 76 | 1,728
ulcerative colitis 74 | 1,819
Kidney cancer 71 | 2,613
Multiple myeloma 70 | 1,332
group 4 medulloblastoma 70 | 1,855
Pick disease 66 | 1,894
cystic fibrosis 64 | 1,696
ductal carcinoma in situ 63 | 1,745
colon cancer 61 | 1,478
cutaneous lupus erythematosus 59 | 1,057
adrenocortical carcinoma 56 | 1,428
Schizophrenia 52 | 1,160
juvenile dermatomyositis 51 | 1,187
Rheumatoid arthritis 48 | 1,191
Alzheimer's disease 47 | 658
primary pancreatic ductal adenocarcinoma 46 | 1,109
acute quadriplegic myopathy 45 | 1,158
spina bifida 45 | 1,074
dermatomyositis 44 | 966
nasopharyngeal carcinoma 44 | 1,058
Waldenstrons macroglobulinemia 43 | 765
astrocytoma 43 | 1,146
primary Sjogren syndrome 42 | 735
esophageal adenocarcinoma 41 | 737
active Crohn's disease 40 | 922
active ulcerative colitis 39 | 764
aldosterone-producing adenoma 39 | 665
Prostatic Neoplasms 38 | 495
Vascular disease 38 | 319
gastric carcinoma 38 | 807
pediatric high grade glioma 38 | 1,064
Breast Neoplasms 36 | 445
Autosomal recessive predisposition 35 | 1,442
Liver Cirrhosis, Experimental 35 | 769
Mammary Neoplasms 34 | 425
Bipolar Disorder 31 | 666
Lung Neoplasms 31 | 232
acute myeloid leukemia 31 | 783
Atopic dermatitis 30 | 952
Intellectual disability 29 | 1,016
non primary Sjogren syndrome sicca 29 | 891
Neurodegenerative disease 28 | 414
hepatocellular carcinoma 28 | 547
Liver cancer 27 | 604
Melanoma 27 | 711
Multiple Sclerosis 27 | 540
Obesity 27 | 678
Stomach Neoplasms 26 | 300
pancreatic carcinoma 26 | 562
Amyotrophic lateral sclerosis 24 | 451
Down syndrome 24 | 499
Kidney disease 24 | 430
Renal Cell Carcinoma 24 | 214
sonic hedgehog group medulloblastoma 24 | 467
gastric cancer 23 | 459
medulloblastoma 22 | 720
sarcoidosis 22 | 370
Duchenne muscular dystrophy 21 | 601
Parkinson's disease 21 | 392
mucosa-associated lymphoid tissue lymphoma 21 | 484
Epilepsy 20 | 792
fibroadenoma 20 | 559
non-small cell lung carcinoma 20 | 317
progressive supranuclear palsy 20 | 676
Seizures 19 | 596
Splenomegaly 19 | 190
Toxic encephalopathy 19 | 141
tuberculosis and treatment for 6 months 19 | 409

Tissue

Endocrine System 520 | 18,159
Female tissues 519 | 17,400
Digestive Tract 517 | 17,369
Skin and soft tissues 516 | 17,230
Male tissues 514 | 17,142
Nervous System 514 | 16,725
Blood and immune system 512 | 16,909
Liver and Pancreas 512 | 16,750
Urinary Tract 512 | 16,678
Respiratory system 511 | 16,393
Cardiovascular System 492 | 15,192

Target Family

Non-IDG 325 | 12,091
Enzyme 94 | 4,145
Kinase 75 | 634
Transcription Factor 19 | 1,400
Epigenetic 8 | 242
GPCR 4 | 408
Ion Channel 3 | 344
Transporter 3 | 473
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

UniProt Keyword

Apoptosis 533 | 533
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Ras association domain-containing protein 5 RASSF5 Tbio Non-IDG -1.81149 71.3 155
Phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 Tbio Non-IDG -2.70122 462.2 347
E3 ubiquitin-protein ligase TRAF7 TRAF7 Tbio Enzyme -1.09531 13.0 112
Huntingtin HTT Tchem Non-IDG -3.36282 2294.8 599
Apoptotic chromatin condensation inducer in the nucleus ACIN1 Tbio Non-IDG -1.51987 31.1 429
MAP kinase-activating death domain protein MADD Tbio Enzyme -1.86555 79.6 121
CASP8-associated protein 2 CASP8AP2 Tbio Non-IDG 0.00000 0
Ubiquitin carboxyl-terminal hydrolase 17-like protein 3 USP17L3 Tdark Enzyme -0.71476 13.1 15