Development Level

Tbio 364 | 11,178
Tchem 127 | 1,885
Tdark 26 | 6,569
Tclin 16 | 612

Collection

Kinase: IDG Consortium (Target... 9 | 125
Kinase: IDG Consortium (Comple... 6 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 31 | 979
preweaning lethality, incomple... 16 | 499
abnormal behavior 13 | 298
hypoactivity 12 | 132
decreased vertical activity 11 | 208
abnormal bone structure 10 | 187
hyperactivity 9 | 148
increased lean body mass 8 | 172
decreased bone mineral content 7 | 151
abnormal embryo size 6 | 220
abnormal gait 6 | 69
decreased bone mineral density 6 | 126
decreased mean corpuscular vol... 6 | 79
decreased total body fat amoun... 6 | 207
increased circulating alkaline... 6 | 122
increased startle reflex 6 | 112
decreased body weight 5 | 161
decreased prepulse inhibition 5 | 82
embryonic lethality prior to t... 5 | 278
enlarged heart 5 | 210
increased leukocyte cell numbe... 5 | 47
increased mean corpuscular hem... 5 | 96
thrombocytopenia 5 | 56
abnormal bone mineralization 4 | 38
abnormal coat-hair pigmentatio... 4 | 64
abnormal lens morphology 4 | 81
abnormal retina morphology 4 | 71
abnormal seminal vesicle morph... 4 | 114
decreased circulating choleste... 4 | 93
decreased circulating glucose ... 4 | 126
decreased erythrocyte cell num... 4 | 62
decreased mean corpuscular hem... 4 | 50
embryonic growth retardation 4 | 106
embryonic lethality prior to o... 4 | 239
impaired glucose tolerance 4 | 75
increased circulating sodium l... 4 | 71
increased mean corpuscular vol... 4 | 92
increased or absent threshold ... 4 | 101
increased total body fat amoun... 4 | 134
male infertility 4 | 123
tremors 4 | 39
abnormal limb morphology 3 | 13
cataract 3 | 92
decreased T cell number 3 | 15
decreased circulating creatini... 3 | 39
decreased circulating triglyce... 3 | 79
decreased hematocrit 3 | 46
decreased lean body mass 3 | 135
decreased neutrophil cell numb... 3 | 42
edema 3 | 59
increased blood urea nitrogen ... 3 | 48
increased bone mineral density 3 | 72
increased circulating amylase ... 3 | 25
increased circulating choleste... 3 | 66
increased grip strength 3 | 41
increased heart weight 3 | 62
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 36
limb grasping 3 | 41
prenatal lethality prior to he... 3 | 87
abnormal behavioral response t... 2 | 66
abnormal heart left ventricle ... 2 | 16
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
abnormal tail morphology 2 | 25
cyanosis 2 | 7
decreased CD4-positive, alpha ... 2 | 7
decreased IgG1 level 2 | 8
decreased basophil cell number 2 | 16
decreased blood urea nitrogen ... 2 | 51
decreased circulating HDL chol... 2 | 68
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased circulating bilirubi... 2 | 19
decreased circulating calcium ... 2 | 36
decreased circulating insulin ... 2 | 76
decreased circulating potassiu... 2 | 20
decreased circulating serum al... 2 | 82
decreased granulocyte number 2 | 6
decreased heart left ventricle... 2 | 28
decreased red blood cell distr... 2 | 41
decreased startle reflex 2 | 75
dilated heart left ventricle 2 | 11
enlarged spleen 2 | 41
female infertility 2 | 60
hemorrhage 2 | 23
increased bone mineral content 2 | 108
increased circulating calcium ... 2 | 34
increased circulating free fat... 2 | 20
increased circulating triglyce... 2 | 42
increased eosinophil cell numb... 2 | 11
increased hematocrit 2 | 46
increased large unstained cell... 2 | 5
increased lymphocyte cell numb... 2 | 32
increased mean platelet volume 2 | 45
increased red blood cell distr... 2 | 34
small superior vagus ganglion 2 | 74
abnormal craniofacial morpholo... 1 | 33
decreased mean corpuscular hem... 1 | 31
vertebral fusion 1 | 23

Disease

ovarian cancer 308 | 8,297
Carcinoma 296 | 11,192
osteosarcoma 248 | 7,766
psoriasis 220 | 6,514
glioblastoma 205 | 5,635
medulloblastoma, large-cell 200 | 6,086
lung cancer 199 | 4,607
Cancer 197 | 2,388
atypical teratoid / rhabdoid tumor 152 | 4,971
ependymoma 135 | 4,559
malignant mesothelioma 129 | 3,135
Breast cancer 124 | 3,469
group 3 medulloblastoma 122 | 4,002
non-small cell lung cancer 122 | 2,799
adult high grade glioma 121 | 3,701
intraductal papillary-mucinous neoplasm (IPMN) 117 | 3,204
invasive ductal carcinoma 111 | 2,867
lung carcinoma 110 | 2,755
intraductal papillary-mucinous carcinoma (IPMC) 109 | 2,902
Astrocytoma, Pilocytic 106 | 3,006
pancreatic cancer 106 | 2,322
lung adenocarcinoma 103 | 2,627
subependymal giant cell astrocytoma 96 | 2,230
intraductal papillary-mucinous adenoma (IPMA) 94 | 2,872
oligodendroglioma 94 | 2,768
primitive neuroectodermal tumor 90 | 2,957
tuberculosis 88 | 1,963
interstitial cystitis 87 | 2,237
pituitary cancer 81 | 1,915
astrocytic glioma 80 | 2,530
pancreatic ductal adenocarcinoma liver metastasis 78 | 1,911
breast carcinoma 74 | 1,589
diabetes mellitus 74 | 1,683
ulcerative colitis 73 | 1,765
Multiple myeloma 69 | 1,296
group 4 medulloblastoma 69 | 1,806
Kidney cancer 68 | 2,548
Pick disease 65 | 1,856
cystic fibrosis 64 | 1,629
ductal carcinoma in situ 62 | 1,686
colon cancer 59 | 1,428
cutaneous lupus erythematosus 58 | 1,016
adrenocortical carcinoma 54 | 1,385
Schizophrenia 51 | 1,136
juvenile dermatomyositis 49 | 1,147
Alzheimer's disease 45 | 640
Rheumatoid arthritis 45 | 1,156
primary pancreatic ductal adenocarcinoma 45 | 1,071
spina bifida 45 | 1,053
acute quadriplegic myopathy 44 | 1,133
Waldenstrons macroglobulinemia 42 | 742
astrocytoma 42 | 1,113
dermatomyositis 41 | 941
nasopharyngeal carcinoma 41 | 1,024
esophageal adenocarcinoma 40 | 696
primary Sjogren syndrome 39 | 710
active Crohn's disease 38 | 882
aldosterone-producing adenoma 38 | 646
Prostatic Neoplasms 37 | 472
Vascular disease 37 | 294
active ulcerative colitis 37 | 736
gastric carcinoma 37 | 781
pediatric high grade glioma 37 | 1,035
Autosomal recessive predisposition 35 | 1,407
Breast Neoplasms 35 | 423
Mammary Neoplasms 33 | 403
Liver Cirrhosis, Experimental 32 | 733
acute myeloid leukemia 31 | 760
Bipolar Disorder 30 | 646
Lung Neoplasms 30 | 217
Atopic dermatitis 29 | 915
non primary Sjogren syndrome sicca 29 | 861
hepatocellular carcinoma 28 | 536
Melanoma 27 | 689
Multiple Sclerosis 27 | 527
Intellectual disability 26 | 998
Neurodegenerative disease 26 | 402
Obesity 26 | 655
pancreatic carcinoma 26 | 555
Liver cancer 25 | 589
Stomach Neoplasms 24 | 287
sonic hedgehog group medulloblastoma 24 | 459
Amyotrophic lateral sclerosis 23 | 437
Down syndrome 23 | 480
Kidney disease 23 | 411
Renal Cell Carcinoma 23 | 211
gastric cancer 22 | 445
medulloblastoma 21 | 702
mucosa-associated lymphoid tissue lymphoma 21 | 473
sarcoidosis 21 | 357
Duchenne muscular dystrophy 20 | 587
fibroadenoma 20 | 538
progressive supranuclear palsy 20 | 656
non-small cell lung carcinoma 19 | 302
tuberculosis and treatment for 6 months 19 | 399
Epilepsy 18 | 775
Hypersensitivity reaction type II disease 18 | 245
Parkinson's disease 18 | 378
Splenomegaly 18 | 186
Toxic encephalopathy 18 | 139

Tissue

Endocrine System 520 | 18,159
Female tissues 519 | 17,400
Digestive Tract 517 | 17,369
Skin and soft tissues 516 | 17,230
Male tissues 514 | 17,142
Nervous System 514 | 16,725
Blood and immune system 512 | 16,909
Liver and Pancreas 512 | 16,750
Urinary Tract 512 | 16,678
Respiratory system 511 | 16,393
Cardiovascular System 492 | 15,192

Target Family

Non-IDG 325 | 12,091
Enzyme 94 | 4,145
Kinase 75 | 634
Transcription Factor 19 | 1,400
Epigenetic 8 | 242
GPCR 4 | 408
Ion Channel 3 | 344
Transporter 3 | 473
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

UniProt Keyword

Apoptosis 533 | 533
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase D1 PRKD1 Tchem Kinase -2.88440 775.2 667
Neutrophil gelatinase-associated lipocalin LCN2 Tbio Enzyme -3.35178 2368.1 847
Serine/threonine-protein kinase N2 PKN2 Tchem Kinase -2.01264 103.6 159
Tumor necrosis factor receptor superfamily member 1B TNFRSF1B Tchem Non-IDG -3.67481 4484.7 712
Bcl-2 homologous antagonist/killer BAK1 Tchem Non-IDG -2.29199 175.9 554
Histone-lysine N-methyltransferase 2A KMT2A Tchem Epigenetic -2.88228 736.0 334
Dynamin-like 120 kDa protein, mitochondrial OPA1 Tbio Non-IDG -2.51554 307.1 210
Protein shisa-5 SHISA5 Tbio Non-IDG -0.48079 3.93 94
Placental protein 13-like LGALS14 Tdark Non-IDG -1.02743 10.4 40
Mitogen-activated protein kinase kinase kinase 9 MAP3K9 Tchem Kinase -1.42881 24.7 265