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Development Level

Tbio 22 | 11,445
Tchem 5 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
absent startle reflex 1 | 24
corneal opacity 1 | 32
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased grip strength 1 | 116
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
fused cornea and lens 1 | 5
increased body length 1 | 32
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating creatini... 1 | 38
increased fasted circulating g... 1 | 76
increased lymphocyte cell numb... 1 | 32
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
male infertility 1 | 123
small testis 1 | 58

Disease

Amyotrophic lateral sclerosis 29 | 451
Neurodegenerative disease 29 | 414
ovarian cancer 24 | 8,520
Carcinoma 20 | 11,493
Muscle Spasticity 20 | 195
Pain 20 | 103
Paralysed 20 | 42
Anxiety 19 | 136
Anxiety disease 19 | 113
Depressive disorder 19 | 409
Dyspnea 19 | 76
Fatigable weakness of respiratory muscles 19 | 28
Fatigable weakness of swallowing muscles 19 | 28
Fatigue 19 | 182
Generalized muscle weakness 19 | 57
Mood swings 19 | 77
Muscle Cramp 19 | 55
Nerve Degeneration 19 | 121
Neuro-degenerative disease 19 | 43
Neurodegenerative Disorders 19 | 79
Neurogenic Muscular Atrophy 19 | 139
Neurogenic muscle atrophy, especially in the lower limbs 19 | 139
Respiratory Failure 19 | 104
Skeletal muscle atrophy 19 | 139
Xerostomia 19 | 42
muscle degeneration 19 | 139
Frontotemporal dementia 15 | 51
medulloblastoma, large-cell 15 | 6,241
Dysarthria 14 | 192
glioblastoma 14 | 5,792
osteosarcoma 13 | 7,950
atypical teratoid / rhabdoid tumor 11 | 5,112
Cancer 10 | 2,499
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
psoriasis 10 | 6,694
Deglutition Disorders 9 | 132
Dementia 9 | 175
Multiple myeloma 9 | 1,332
Muscular fasciculation 9 | 22
astrocytic glioma 9 | 2,597
ependymoma 9 | 4,679
Decreased tendon reflex 8 | 122
Hyperreflexia 8 | 209
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
lung cancer 8 | 4,740
Distal limb muscle weakness due to peripheral neuropathy 7 | 62
Distal muscle weakness 7 | 62
Kidney cancer 7 | 2,613
Lateral sclerosis 7 | 15
Neuropathy 7 | 261
Pick disease 7 | 1,894
adult high grade glioma 7 | 3,801
dermatomyositis 7 | 966
group 3 medulloblastoma 7 | 4,104
progressive supranuclear palsy 7 | 676
Abnormal lower motor neuron morphology 6 | 6
Adult onset 6 | 82
Progressive disorder 6 | 142
Waldenstrons macroglobulinemia 6 | 765
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
malignant mesothelioma 6 | 3,232
oligodendroglioma 6 | 2,850
Amyotrophic lateral sclerosis type 1 5 | 23
Apathy 5 | 16
Aphasia 5 | 26
Babinski Reflex 5 | 100
Distal amyotrophy 5 | 51
Frontotemporal Lobar Degeneration 5 | 6
Gait abnormality 5 | 135
Parkinson's disease 5 | 392
Schizophrenia 5 | 1,160
Social disinhibition 5 | 14
acute quadriplegic myopathy 5 | 1,158
astrocytoma 5 | 1,146
colon cancer 5 | 1,478
hepatocellular carcinoma 5 | 547
non-small cell lung cancer 5 | 2,890
pediatric high grade glioma 5 | 1,064
primitive neuroectodermal tumor 5 | 3,035
AMYOTROPHIC LATERAL SCLEROSIS 1 4 | 49
Abnormal upper motor neuron morphology 4 | 11
Aggressive behavior 4 | 75
Aggressive reaction 4 | 75
Alzheimer's disease 4 | 658
Astrocytoma, Pilocytic 4 | 3,081
Autosomal recessive predisposition 4 | 1,442
Charcot-Marie-Tooth disease 4 | 62
Huntington's disease 4 | 76
Liver cancer 4 | 604
Muscle Weakness 4 | 170
Myopathy 4 | 185
Personality change 4 | 23
Physical aggression 4 | 76
Stereotyped Behavior 4 | 37
Stereotypic Movement Disorder 4 | 42
cystic fibrosis 4 | 1,696
lung adenocarcinoma 4 | 2,716
spina bifida 4 | 1,074
subependymal giant cell astrocytoma 4 | 2,287

Tissue

Blood and immune system 29 | 16,909
Cardiovascular System 29 | 15,192
Digestive Tract 29 | 17,369
Endocrine System 29 | 18,159
Female tissues 29 | 17,400
Liver and Pancreas 29 | 16,750
Male tissues 29 | 17,142
Nervous System 29 | 16,725
Respiratory system 29 | 16,393
Skin and soft tissues 29 | 17,230
Urinary Tract 29 | 16,678

Target Family

Non-IDG 20 | 12,091
Enzyme 5 | 4,145
Kinase 3 | 634
Ion Channel 1 | 344

UniProt Keyword

Amyotrophic lateral sclerosis 29 | 29
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transient receptor potential cation channel subfamily M member 7 TRPM7 Tchem Ion Channel -2.53154 365.5 317
Sigma non-opioid intracellular receptor 1 SIGMAR1 Tclin Non-IDG -2.28907 210.0 143
Transmembrane protein 106B TMEM106B Tbio Non-IDG -1.54017 36.2 87
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.71624 54.4 193
Profilin-1 PFN1 Tbio Non-IDG -2.31736 223.5 260
Matrin-3 MATR3 Tbio Non-IDG -1.74141 55.1 167
Receptor tyrosine-protein kinase erbB-4 ERBB4 Tclin Kinase -2.78704 558.2 1072
Alsin ALS2 Tbio Non-IDG -2.20492 161.9 180
Sequestosome-1 SQSTM1 Tbio Non-IDG -2.78728 635.1 766
Serine/threonine-protein kinase TBK1 TBK1 Tchem Kinase -2.76728 569.1 455