Development Level

Tbio 26 | 11,445
Tchem 12 | 1,598

IMPC Phenotype

preweaning lethality, complete... 15 | 979
embryonic lethality prior to o... 5 | 239
decreased grip strength 3 | 116
embryonic lethality prior to t... 3 | 278
abnormal embryo size 2 | 220
decreased fasted circulating g... 2 | 65
impaired glucose tolerance 2 | 75
increased total body fat amoun... 2 | 134
abnormal QT variability 1 | 10
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal spinal cord morpholog... 1 | 9
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased circulating sodium l... 1 | 22
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
decreased urine magnesium leve... 1 | 3
embryonic growth retardation 1 | 106
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased erythrocyte cell num... 1 | 39
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased red blood cell distr... 1 | 34
increased thermal nociceptive ... 1 | 9

Disease

Carcinoma 36 | 11,493
ovarian cancer 27 | 8,520
Autosomal recessive predisposition 15 | 1,442
lung cancer 15 | 4,740
psoriasis 14 | 6,694
Multiple myeloma 12 | 1,332
osteosarcoma 12 | 7,950
medulloblastoma, large-cell 11 | 6,241
Myositis 9 | 30
Neurodegenerative disease 9 | 414
diabetes mellitus 8 | 1,728
Distal sensory impairment 7 | 52
Epilepsy 7 | 792
Neuropathy 7 | 261
glioblastoma 7 | 5,792
Cancer 6 | 2,499
Charcot-Marie-Tooth disease 6 | 62
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Muscle hypotonia 6 | 571
Nystagmus 6 | 317
dermatomyositis 6 | 966
tuberculosis 6 | 2,010
Anemia 5 | 365
Breast cancer 5 | 3,578
Failure to gain weight 5 | 365
Kidney cancer 5 | 2,613
Leigh disease 5 | 100
Pediatric failure to thrive 5 | 365
Small head 5 | 374
Waldenstrons macroglobulinemia 5 | 765
astrocytoma 5 | 1,146
atypical teratoid / rhabdoid tumor 5 | 5,112
group 3 medulloblastoma 5 | 4,104
juvenile dermatomyositis 5 | 1,187
malignant mesothelioma 5 | 3,232
non-small cell lung cancer 5 | 2,890
Alpers syndrome 4 | 9
Autosomal recessive Robinow syndrome 4 | 27
Congenital pes cavus 4 | 88
Decreased tendon reflex 4 | 122
Hemoglobin low 4 | 124
Highly variable severity 4 | 157
Pick disease 4 | 1,894
Progressive disorder 4 | 142
Variable expressivity 4 | 157
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
colon cancer 4 | 1,478
ependymoma 4 | 4,679
interstitial lung disease 4 | 298
lung adenocarcinoma 4 | 2,716
oligodendroglioma 4 | 2,850
sonic hedgehog group medulloblastoma 4 | 467
Absent reflex 3 | 92
Absent tendon reflex 3 | 92
Acidosis, Lactic 3 | 97
Acquired scoliosis 3 | 281
Axonal neuropathy 3 | 27
CNS hypomyelination 3 | 17
Cerebral atrophy 3 | 178
Combined oxidative phosphorylation deficiency 3 | 14
Curvature of spine 3 | 282
Degenerative brain disorder 3 | 100
Distal limb muscle weakness due to peripheral neuropathy 3 | 62
Distal muscle weakness 3 | 62
Foot dorsiflexor weakness 3 | 27
Foot-drop 3 | 27
Gait, Drop Foot 3 | 24
Hammer Toe 3 | 23
Hyperreflexia 3 | 209
Hypomyelination 3 | 17
Hypoplasia of corpus callosum 3 | 90
Lactic acidemia 3 | 95
Motor delay 3 | 147
Muscle Spasticity 3 | 195
No development of motor milestones 3 | 147
Peripheral axonal neuropathy 3 | 18
Perrault syndrome 3 | 19
Reflex, Deep Tendon, Absent 3 | 92
Sensorineural Hearing Loss (disorder) 3 | 284
Slow progression 3 | 89
Supratentorial atrophy 3 | 94
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
pancreatic cancer 3 | 2,398
pediatric high grade glioma 3 | 1,064
primitive neuroectodermal tumor 3 | 3,035
Elevated hepatic transaminases 2 | 81
Hepatic enzyme increased 2 | 81
Lactic acidosis 2 | 51
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Long philtrum 2 | 137
Subclinical abnormal liver function tests 2 | 81
Transaminases increased 2 | 81
active Crohn's disease 2 | 922
posterior fossa group B ependymoma 2 | 416

Tissue

Blood and immune system 38 | 16,909
Cardiovascular System 38 | 15,192
Digestive Tract 38 | 17,369
Endocrine System 38 | 18,159
Female tissues 38 | 17,400
Liver and Pancreas 38 | 16,750
Male tissues 38 | 17,142
Nervous System 38 | 16,725
Respiratory system 38 | 16,393
Skin and soft tissues 38 | 17,230
Urinary Tract 38 | 16,678

Target Family

Enzyme 38 | 4,145

UniProt Keyword

Aminoacyl-tRNA synthetase 38 | 38
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Isoleucine--tRNA ligase, cytoplasmic IARS Tchem Enzyme -3.11190 1198.0 95
Tyrosine--tRNA ligase, cytoplasmic YARS Tchem Enzyme -2.45633 272.6 180
Glycine--tRNA ligase GARS Tbio Enzyme -2.62899 412.8 178
Aspartate--tRNA ligase, cytoplasmic DARS Tbio Enzyme -1.93573 78.1 128
Alanine--tRNA ligase, cytoplasmic AARS Tbio Enzyme -2.49617 295.2 140
Cysteine--tRNA ligase, cytoplasmic CARS Tbio Enzyme -3.00492 954.7 154
Tryptophan--tRNA ligase, cytoplasmic WARS Tbio Enzyme -2.74520 518.6 163
Threonine--tRNA ligase, cytoplasmic TARS Tchem Enzyme -2.61174 405.9 120
Valine--tRNA ligase VARS Tchem Enzyme -1.98726 93.0 112
Histidine--tRNA ligase, cytoplasmic HARS Tchem Enzyme -1.85612 66.8 212