Development Level

Tbio 18 | 11,445
Tchem 6 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 2 | 298
abnormal heart morphology 2 | 162
abnormal allantois morphology 1 | 8
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
anophthalmia 1 | 33
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased food intake 1 | 13
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased circulating bilirubi... 1 | 16
increased heart weight 1 | 62
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
small adrenal glands 1 | 16
thrombocytopenia 1 | 56

Disease

Carcinoma 18 | 11,493
ovarian cancer 14 | 8,520
Autosomal recessive predisposition 13 | 1,442
Cognitive delay 11 | 608
Epilepsy 11 | 792
Global developmental delay 11 | 608
Mental and motor retardation 11 | 608
Seizures 11 | 596
osteosarcoma 11 | 7,950
Intellectual disability 10 | 1,016
ependymoma 10 | 4,679
Dull intelligence 9 | 645
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
lung cancer 9 | 4,740
medulloblastoma, large-cell 9 | 6,241
non-small cell lung cancer 9 | 2,890
pancreatic cancer 9 | 2,398
psoriasis 9 | 6,694
Cancer 8 | 2,499
Failure to gain weight 8 | 365
Pediatric failure to thrive 8 | 365
group 3 medulloblastoma 8 | 4,104
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Astrocytoma, Pilocytic 7 | 3,081
adult high grade glioma 7 | 3,801
malignant mesothelioma 7 | 3,232
Breast cancer 6 | 3,578
Fetal Growth Retardation 6 | 189
Homocystinuria 6 | 21
Hyperhomocysteinemia 6 | 37
Small head 6 | 374
invasive ductal carcinoma 6 | 2,951
oligodendroglioma 6 | 2,850
spina bifida 6 | 1,074
Down syndrome 5 | 499
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
atypical teratoid / rhabdoid tumor 5 | 5,112
colon cancer 5 | 1,478
gastric carcinoma 5 | 807
glioblastoma 5 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
Acquired scoliosis 4 | 281
Argininosuccinic aciduria 4 | 17
Cleft Lip 4 | 141
Cleft Palate 4 | 271
Curvature of spine 4 | 282
Cutis Laxa 4 | 39
Infantile onset 4 | 238
Lethargy 4 | 77
Liver Cirrhosis, Experimental 4 | 769
Methylmalonic acidemia 4 | 37
Microcephaly 4 | 166
Multiple myeloma 4 | 1,332
Muscle hypotonia 4 | 571
Orbital separation excessive 4 | 244
Polycystic ovary syndrome 4 | 360
Schizophrenia 4 | 1,160
Serine deficiency 4 | 9
Vomiting 4 | 116
adrenocortical carcinoma 4 | 1,428
astrocytic glioma 4 | 2,597
cystic fibrosis 4 | 1,696
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
nasopharyngeal carcinoma 4 | 1,058
pancreatic carcinoma 4 | 562
subependymal giant cell astrocytoma 4 | 2,287
Atherosclerosis 3 | 291
Bipolar Disorder 3 | 666
Feeding difficulties in infancy 3 | 175
Gait abnormality 3 | 135
Hernia, Inguinal 3 | 89
Hyperammonemia 3 | 30
Hyperreflexia 3 | 209
Hypoplastic mandible condyle 3 | 275
Large auricle 3 | 87
Large dysplastic ears 3 | 87
Large pinnae 3 | 87
Large prominent ears 3 | 87
Large protruding ears 3 | 87
Large, floppy ears 3 | 87
Macrotia 3 | 87
Mandibular hypoplasia 3 | 275
Maple syrup urine disease 3 | 24
Melanoma 3 | 711
Neurodegenerative disease 3 | 414
Orotic aciduria 3 | 18
Sloping forehead 3 | 46
ductal carcinoma in situ 3 | 1,745
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung carcinoma 3 | 2,843
primary pancreatic ductal adenocarcinoma 3 | 1,109
progressive supranuclear palsy 3 | 676
tuberculosis 3 | 2,010
ulcerative colitis 3 | 1,819

Tissue

Blood and immune system 25 | 16,909
Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Liver and Pancreas 25 | 16,750
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Respiratory system 25 | 16,393
Skin and soft tissues 25 | 17,230
Urinary Tract 25 | 16,678
Cardiovascular System 24 | 15,192

Target Family

Enzyme 25 | 4,145
Non-IDG 1 | 12,091

UniProt Keyword

Amino-acid biosynthesis 26 | 26
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ornithine carbamoyltransferase, mitochondrial OTC Tchem Enzyme -2.21752 151.7 480
Cystathionine beta-synthase CBS Tchem Enzyme -3.25635 3246.1 391
Aspartate aminotransferase, cytoplasmic GOT1 Tbio Enzyme -2.25904 173.1 355
Argininosuccinate synthase ASS1 Tbio Enzyme -2.30801 186.1 322
D-3-phosphoglycerate dehydrogenase PHGDH Tbio Enzyme -3.17330 1408.2 293
Phosphoserine phosphatase PSPH Tbio Enzyme -1.56433 55.8 252
Cystathionine gamma-lyase CTH Tchem Enzyme -2.70857 467.8 252
Asparagine synthetase [glutamine-hydrolyzing] ASNS Tchem Enzyme -2.40144 244.3 223
Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 Tchem Enzyme -1.88659 78.1 216
Methylthioribulose-1-phosphate dehydratase APIP Tbio Enzyme -0.87551 9.29 210