Development Level

Tchem 7 | 1,598
Tbio 4 | 11,445
Tclin 4 | 613
Tdark 1 | 6,588

IMPC Phenotype

decreased circulating glucose ... 4 | 126
increased total body fat amoun... 3 | 134
abnormal behavior 2 | 298
decreased body length 2 | 101
decreased body weight 2 | 161
increased fasted circulating g... 2 | 76
premature death 2 | 5
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal gait 1 | 69
abnormal limb morphology 1 | 13
abnormal rib morphology 1 | 10
abnormal snout morphology 1 | 23
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 36
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased circulating bilirubi... 1 | 19
decreased circulating glycerol... 1 | 16
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
hemorrhage 1 | 23
increased blood urea nitrogen ... 1 | 48
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating triglyce... 1 | 42
increased heart rate variabili... 1 | 7
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
limb grasping 1 | 41
polycystic kidney 1 | 15
preweaning lethality, complete... 1 | 979
respiratory system phenotype 1 | 2
vertebral fusion 1 | 23

Disease

Alzheimer's disease 16 | 658
Neurodegenerative disease 13 | 414
Carcinoma 12 | 11,493
Dementia 11 | 175
osteosarcoma 11 | 7,950
Amyloidosis 10 | 67
ovarian cancer 10 | 8,520
Alzheimer Disease 9 | 83
medulloblastoma, large-cell 9 | 6,241
Cancer 8 | 2,499
glioblastoma 8 | 5,792
psoriasis 8 | 6,694
Bipolar Disorder 7 | 666
Depressive disorder 7 | 409
malignant mesothelioma 7 | 3,232
Toxic encephalopathy 6 | 141
atypical teratoid / rhabdoid tumor 6 | 5,112
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
invasive ductal carcinoma 6 | 2,951
lung cancer 6 | 4,740
oligodendroglioma 6 | 2,850
Breast cancer 5 | 3,578
Cognition Disorders 5 | 32
Parkinson's disease 5 | 392
Parkinsonian Disorders 5 | 56
Pick disease 5 | 1,894
Schizophrenia 5 | 1,160
diabetes mellitus 5 | 1,728
ependymoma 5 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
ALZHEIMER DISEASE 2 4 | 5
Amyotrophic lateral sclerosis 4 | 451
Brain disease 4 | 96
Cerebrovascular disease 4 | 238
Deglutition Disorders 4 | 132
Disease Models, Animal 4 | 155
Down syndrome 4 | 499
Dystonia 4 | 164
Dystonic disease 4 | 106
Forgetful 4 | 40
Heart failure 4 | 162
Kidney cancer 4 | 2,613
Memory Loss 4 | 40
Memory impairment 4 | 40
Nerve Degeneration 4 | 121
Neurodegenerative Diseases 4 | 38
Neurodegenerative Disorders 4 | 79
Neurofibrillary degeneration (morphologic abnormality) 4 | 9
Rheumatoid arthritis 4 | 1,191
Splenomegaly 4 | 190
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
juvenile dermatomyositis 4 | 1,187
lung carcinoma 4 | 2,843
Abnormal vision 3 | 52
Alzheimer Disease 4 3 | 3
Anxiety 3 | 136
Anxiety disease 3 | 113
Aphasia 3 | 26
Astrocytoma, Pilocytic 3 | 3,081
Atopic dermatitis 3 | 952
Blurred vision 3 | 19
Cerebellar Ataxia 3 | 304
Cerebral amyloid angiopathy 3 | 13
Cerebral atrophy 3 | 178
Congestive heart failure 3 | 113
Dysarthria 3 | 192
Epilepsy 3 | 792
Frontotemporal dementia 3 | 51
Hypertensive disease 3 | 292
Learning Disorders 3 | 29
Memory Disorders 3 | 40
Mental Depression 3 | 333
Muscle Rigidity 3 | 49
Myoclonus 3 | 74
Neuronal loss 3 | 25
Onset in middle age 3 | 4
Optic Atrophy 3 | 242
Osteoarthritis 3 | 184
PARKINSON DISEASE, LATE-ONSET 3 | 20
Pick's disease 3 | 15
Seizures 3 | 596
acute quadriplegic myopathy 3 | 1,158
dermatomyositis 3 | 966
head and neck cancer and chronic obstructive pulmonary disease 3 | 239
non primary Sjogren syndrome sicca 3 | 891
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primitive neuroectodermal tumor 3 | 3,035
progressive supranuclear palsy 3 | 676
Dysgraphia 2 | 20
Intermittent migraine headaches 2 | 68
Language Disorders 2 | 13
Leigh disease 2 | 100
Peripheral Neuropathy 2 | 134
Social disinhibition 2 | 14

Tissue

Blood and immune system 16 | 16,909
Cardiovascular System 16 | 15,192
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678

Target Family

Enzyme 7 | 4,145
Non-IDG 6 | 12,091
Kinase 2 | 634
Transporter 1 | 473

UniProt Keyword

Alzheimer disease 16 | 16
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Presenilin-1 PSEN1 Tchem Enzyme -3.53128 3394.7 677
Disintegrin and metalloproteinase domain-containing protein 10 ADAM10 Tchem Enzyme -2.64652 422.4 384
Cathepsin D CTSD Tchem Enzyme -3.47061 2866.8 779
Serine/threonine-protein phosphatase 5 PPP5C Tbio Enzyme -1.59075 41.9 338
Ras-specific guanine nucleotide-releasing factor RalGPS2 RALGPS2 Tdark Non-IDG -0.16734 2.43 84
Presenilin-2 PSEN2 Tchem Enzyme -2.78856 585.9 310
Glycogen synthase kinase-3 alpha GSK3A Tclin Kinase -1.82880 53.1 840
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -3.00390 610.8 955
ATP-binding cassette sub-family A member 7 ABCA7 Tbio Transporter -2.20287 157.0 138
Alpha-synuclein SNCA Tchem Non-IDG -3.63937 4224.9 1813