Development Level

Tbio 6,252 | 10,625
Tdark 2,773 | 7,003
Tchem 1,146 | 1,890
Tclin 341 | 602

Collection

Eligible Kinase Proteins 86 | 134
Eligible Ion Channel Proteins 66 | 117
Eligible non-olfactory GPCR Proteins 24 | 143

IMPC Term

preweaning lethality, complete... 405 | 633
preweaning lethality, incomple... 163 | 260
abnormal behavior 152 | 226
decreased lean body mass 127 | 195
decreased total body fat amoun... 124 | 186
decreased body weight 112 | 174
embryonic lethality prior to t... 107 | 187
decreased bone mineral content 105 | 157
embryonic lethality prior to o... 90 | 148
increased or absent threshold ... 90 | 128
decreased grip strength 87 | 123
decreased bone mineral density 81 | 126
abnormal bone structure 80 | 131
increased lean body mass 78 | 107
increased circulating alkaline... 76 | 119
abnormal embryo size 74 | 112
abnormal retina morphology 72 | 100
decreased body length 71 | 108
hyperactivity 69 | 108
decreased circulating glucose ... 65 | 121
increased bone mineral content 64 | 92
decreased circulating choleste... 62 | 85
decreased circulating triglyce... 60 | 83
hypoactivity 59 | 89
increased mean corpuscular vol... 59 | 91
enlarged heart 58 | 111
decreased circulating HDL chol... 55 | 77
decreased circulating serum al... 55 | 79
increased grip strength 55 | 83
short tibia 55 | 82
increased mean corpuscular hem... 54 | 93
abnormal lens morphology 46 | 73
abnormal retinal pigmentation 46 | 61
decreased circulating insulin ... 45 | 75
increased circulating sodium l... 44 | 71
male infertility 44 | 62
increased sacral vertebrae num... 42 | 62
decreased hemoglobin content 40 | 53
decreased lumbar vertebrae num... 40 | 62
decreased rib number 39 | 59
increased circulating HDL chol... 39 | 63
decreased prepulse inhibition 38 | 52
impaired glucose tolerance 38 | 52
abnormal bone mineralization 37 | 55
abnormal sleep behavior 37 | 63
prenatal lethality prior to he... 37 | 64
increased fasted circulating g... 36 | 68
increased total body fat amoun... 36 | 57
decreased leukocyte cell numbe... 35 | 54
decreased circulating total pr... 34 | 41
increased blood urea nitrogen ... 34 | 44
thrombocytopenia 34 | 46
abnormal gait 33 | 51
decreased mean corpuscular vol... 33 | 50
increased body weight 33 | 42
increased circulating choleste... 33 | 53
decreased caudal vertebrae num... 32 | 49
increased exploration in new e... 32 | 56
abnormal behavioral response t... 31 | 52
abnormal coat/hair pigmentatio... 31 | 54
decreased startle reflex 31 | 48
decreased circulating alanine ... 30 | 53
decreased eosinophil cell numb... 30 | 41
increased bone mineral density 30 | 52
increased hemoglobin content 30 | 45
decreased circulating alkaline... 29 | 41
decreased circulating free fat... 29 | 39
decreased neutrophil cell numb... 29 | 37
abnormal heart morphology 28 | 51
decreased fasted circulating g... 28 | 49
decreased heart weight 28 | 44
increased circulating chloride... 28 | 43
abnormal cranium morphology 27 | 32
decreased erythrocyte cell num... 27 | 43
increased hematocrit 27 | 36
tremors 27 | 34
improved glucose tolerance 26 | 56
small testis 26 | 37
cardiovascular system phenotyp... 25 | 35
decreased circulating LDL chol... 25 | 37
decreased mean corpuscular hem... 25 | 34
increased startle reflex 25 | 38
abnormal neural tube closure 24 | 37
abnormal seminal vesicle morph... 24 | 47
decreased T cell number 24 | 31
female infertility 24 | 34
increased heart weight 24 | 37
increased rib number 24 | 41
abnormal spleen morphology 23 | 36
limb grasping 22 | 35
abnormal eye morphology 21 | 38
increased circulating calcium ... 21 | 32
increased leukocyte cell numbe... 21 | 37
decreased circulating fructosa... 20 | 31
abnormal locomotor activation 19 | 26
decreased blood urea nitrogen ... 19 | 31
decreased circulating chloride... 19 | 32
embryonic growth retardation 19 | 28
increased circulating creatini... 19 | 29
increased erythrocyte cell num... 19 | 26

Disease

ovarian cancer 5,251 | 8,484
osteosarcoma 5,059 | 7,933
medulloblastoma, large-cell 3,975 | 6,234
psoriasis 3,812 | 6,685
glioblastoma 3,533 | 5,572
atypical teratoid / rhabdoid tumor 2,808 | 4,369
lung cancer 2,748 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 2,009 | 3,289
malignant mesothelioma 1,996 | 3,162
primitive neuroectodermal tumor 1,976 | 3,031
pilocytic astrocytoma 1,912 | 3,086
Breast cancer 1,899 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 1,862 | 2,956
oligodendroglioma 1,852 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 1,849 | 2,988
invasive ductal carcinoma 1,827 | 2,950
pediatric high grade glioma 1,714 | 2,712
lung carcinoma 1,703 | 2,844
ependymoma 1,678 | 2,514
non-small cell lung cancer 1,678 | 2,798
lung adenocarcinoma 1,613 | 2,713
Carcinoma 1,520 | 2,147
subependymal giant cell astrocytoma 1,478 | 2,287
astrocytic glioma 1,463 | 2,241
group 3 medulloblastoma 1,423 | 2,254
interstitial cystitis 1,377 | 2,299
Cancer 1,344 | 2,346
Pick disease 1,328 | 1,893
adult high grade glioma 1,327 | 2,148
pancreatic cancer 1,321 | 2,300
ulcerative colitis 1,247 | 2,087
pituitary cancer 1,195 | 1,972
group 4 medulloblastoma 1,174 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,085 | 1,795
ductal carcinoma in situ 1,081 | 1,745
posterior fossa group B ependymoma 985 | 1,530
cystic fibrosis 976 | 1,665
medulloblastoma 974 | 1,524
tuberculosis 974 | 1,557
astrocytoma 951 | 1,493
sonic hedgehog group medulloblastoma 938 | 1,482
breast carcinoma 934 | 1,614
colon cancer 925 | 1,475
posterior fossa group A ependymoma 881 | 1,511
adrenocortical carcinoma 863 | 1,427
Multiple myeloma 801 | 1,327
diabetes mellitus 769 | 1,663
juvenile dermatomyositis 764 | 1,189
primary pancreatic ductal adenocarcinoma 753 | 1,271
acute quadriplegic myopathy 732 | 1,157
Rheumatoid Arthritis 707 | 1,160
spina bifida 681 | 1,064
atypical teratoid/rhabdoid tumor 668 | 1,095
nasopharyngeal carcinoma 650 | 1,056
cutaneous lupus erythematosus 641 | 1,056
dermatomyositis 605 | 933
active Crohn's disease 530 | 918
non primary Sjogren syndrome sicca 518 | 840
progressive supranuclear palsy 518 | 674
Atopic dermatitis 516 | 944
primary Sjogren syndrome 505 | 789
gastric carcinoma 491 | 832
Waldenstrons macroglobulinemia 477 | 765
tuberculosis and treatment for 6 months 464 | 686
acute myeloid leukemia 446 | 780
Alzheimer's disease 435 | 644
aldosterone-producing adenoma 410 | 664
Intellectual disability 409 | 573
esophageal adenocarcinoma 407 | 737
Obesity 359 | 616
Down syndrome 351 | 548
chronic rhinosinusitis 351 | 512
Duchenne muscular dystrophy 338 | 602
pancreatic carcinoma 332 | 567
fibroadenoma 330 | 557
Schizophrenia 317 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 299 | 499
Endometriosis 295 | 535
Amyotrophic Lateral Sclerosis 293 | 431
hepatocellular carcinoma 289 | 532
IGA Glomerulonephritis 278 | 454
Prostatic Neoplasms 276 | 471
active ulcerative colitis 276 | 477
Neurodegenerative disease 264 | 383
gastric cancer 263 | 430
mucosa-associated lymphoid tissue lymphoma 259 | 480
Multiple Sclerosis 258 | 498
non-small cell lung carcinoma 256 | 413
Mammary Neoplasms 240 | 410
inflammatory breast cancer 232 | 404
Epilepsy 228 | 346
Parkinson's disease 221 | 364
hereditary spastic paraplegia 221 | 313
Kidney disease 219 | 396
glioblastoma multiforme 211 | 347
Autistic Disorder 209 | 320
Polycystic Ovary Syndrome 208 | 332
tuberculosis and treatment for 3 months 205 | 327
sarcoidosis 200 | 358
interstitial lung disease 198 | 291

Tissue

Female tissues 10,343 | 18,647
Nervous System 10,335 | 18,561
Digestive Tract 10,334 | 18,473
Endocrine System 10,326 | 18,512
Urinary Tract 10,304 | 18,444
Liver and Pancreas 10,273 | 18,136
Blood and immune system 10,247 | 17,995
Male tissues 10,247 | 17,969
Cardiovascular System 10,232 | 17,958
Skin and soft tissues 10,225 | 18,115
Respiratory system 10,101 | 17,484

Target Family

Non-IDG 6,053 | 11,971
Enzyme 2,393 | 4,146
Transcription Factor 726 | 1,400
Kinase 445 | 634
Transporter 308 | 473
Ion Channel 205 | 341
Epigenetic 193 | 242
GPCR 119 | 406
Nuclear Receptor 39 | 48
TF/Epigenetic 31 | 38

UniProt Keyword

Alternative splicing 10,512 | 10,512
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108