Development Level

Tbio 6,555 | 11,178
Tdark 2,483 | 6,569
Tchem 1,144 | 1,885
Tclin 346 | 612

Collection

Kinase: IDG Consortium (Target... 81 | 125
Ion Channel: IDG Consortium (T... 56 | 99
Kinase: IDG Consortium (Comple... 28 | 37
GPCR: IDG Consortium (Targets) 22 | 126
GPCR: IDG Consortium (Complete... 8 | 25

IMPC Phenotype

preweaning lethality, complete... 618 | 979
preweaning lethality, incomple... 316 | 499
abnormal behavior 200 | 298
embryonic lethality prior to t... 159 | 278
abnormal embryo size 145 | 220
decreased total body fat amoun... 142 | 207
embryonic lethality prior to o... 137 | 239
increased lean body mass 122 | 172
decreased vertical activity 115 | 208
abnormal bone structure 114 | 187
enlarged heart 114 | 210
decreased body weight 107 | 161
decreased bone mineral content 98 | 151
hyperactivity 90 | 148
abnormal heart morphology 87 | 162
decreased lean body mass 87 | 135
increased total body fat amoun... 86 | 134
decreased grip strength 83 | 116
hypoactivity 82 | 132
male infertility 82 | 123
increased circulating alkaline... 79 | 122
decreased bone mineral density 77 | 126
decreased circulating glucose ... 76 | 126
increased startle reflex 69 | 112
decreased circulating choleste... 68 | 93
embryonic growth retardation 68 | 106
increased bone mineral content 68 | 108
increased or absent threshold ... 66 | 101
increased mean corpuscular hem... 61 | 96
short tibia 61 | 97
decreased body length 58 | 101
decreased circulating serum al... 57 | 82
increased mean corpuscular vol... 57 | 92
abnormal seminal vesicle morph... 56 | 114
decreased lymphocyte cell numb... 56 | 83
impaired glucose tolerance 55 | 75
decreased prepulse inhibition 54 | 82
cataract 53 | 92
decreased leukocyte cell numbe... 53 | 73
decreased circulating triglyce... 52 | 79
decreased startle reflex 52 | 75
prenatal lethality prior to he... 52 | 87
abnormal retina morphology 51 | 71
decreased mean corpuscular vol... 51 | 79
increased circulating HDL chol... 48 | 80
abnormal lens morphology 47 | 81
abnormal gait 46 | 69
decreased circulating HDL chol... 46 | 68
decreased circulating insulin ... 46 | 76
increased heart weight 46 | 62
increased fasted circulating g... 45 | 76
decreased hemoglobin content 44 | 68
increased circulating sodium l... 43 | 71
decreased circulating total pr... 42 | 49
decreased erythrocyte cell num... 42 | 62
edema 42 | 59
thrombocytopenia 42 | 56
abnormal behavioral response t... 41 | 66
female infertility 41 | 60
increased bone mineral density 41 | 72
increased circulating choleste... 41 | 66
small superior vagus ganglion 41 | 74
abnormal sleep behavior 40 | 70
decreased fasted circulating g... 40 | 65
improved glucose tolerance 40 | 79
abnormal eye morphology 38 | 68
abnormal coat-hair pigmentatio... 37 | 64
small testis 37 | 58
increased blood urea nitrogen ... 36 | 48
decreased mean corpuscular hem... 35 | 50
abnormal spleen morphology 34 | 55
increased hematocrit 34 | 46
increased monocyte cell number 34 | 63
decreased blood urea nitrogen ... 32 | 51
decreased caudal vertebrae num... 32 | 53
decreased circulating alkaline... 32 | 46
decreased neutrophil cell numb... 32 | 42
abnormal cranium morphology 31 | 36
abnormal kidney morphology 31 | 65
increased grip strength 31 | 41
increased hemoglobin content 30 | 45
increased leukocyte cell numbe... 30 | 47
decreased red blood cell distr... 29 | 41
increased erythrocyte cell num... 29 | 39
tremors 29 | 39
abnormal skin morphology 28 | 50
decreased circulating LDL chol... 28 | 38
decreased circulating alanine ... 28 | 47
hydrometra 28 | 53
increased circulating chloride... 28 | 41
increased mean platelet volume 28 | 45
increased neutrophil cell numb... 28 | 46
abnormal neural tube closure 27 | 46
decreased hematocrit 27 | 46
increased circulating creatini... 27 | 38
abnormal bone mineralization 26 | 38
cardiovascular system phenotyp... 26 | 36
increased circulating triglyce... 26 | 42
increased prepulse inhibition 26 | 32
persistence of hyaloid vascula... 26 | 33

Disease

Carcinoma 6,978 | 11,192
ovarian cancer 5,132 | 8,297
osteosarcoma 4,948 | 7,766
medulloblastoma, large-cell 3,877 | 6,086
psoriasis 3,711 | 6,514
glioblastoma 3,573 | 5,635
atypical teratoid / rhabdoid tumor 3,173 | 4,971
ependymoma 2,925 | 4,559
lung cancer 2,815 | 4,607
group 3 medulloblastoma 2,531 | 4,002
adult high grade glioma 2,317 | 3,701
Breast cancer 2,124 | 3,469
malignant mesothelioma 1,978 | 3,135
intraductal papillary-mucinous neoplasm (IPMN) 1,963 | 3,204
primitive neuroectodermal tumor 1,922 | 2,957
Astrocytoma, Pilocytic 1,860 | 3,006
Kidney cancer 1,823 | 2,548
intraductal papillary-mucinous adenoma (IPMA) 1,815 | 2,872
oligodendroglioma 1,801 | 2,768
intraductal papillary-mucinous carcinoma (IPMC) 1,798 | 2,902
invasive ductal carcinoma 1,784 | 2,867
non-small cell lung cancer 1,682 | 2,799
lung carcinoma 1,656 | 2,755
astrocytic glioma 1,645 | 2,530
lung adenocarcinoma 1,567 | 2,627
subependymal giant cell astrocytoma 1,441 | 2,230
Cancer 1,370 | 2,388
pancreatic cancer 1,359 | 2,322
interstitial cystitis 1,339 | 2,237
Pick disease 1,300 | 1,856
tuberculosis 1,221 | 1,963
pituitary cancer 1,161 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 1,157 | 1,911
group 4 medulloblastoma 1,137 | 1,806
ulcerative colitis 1,065 | 1,765
ductal carcinoma in situ 1,053 | 1,686
cystic fibrosis 968 | 1,629
breast carcinoma 927 | 1,589
colon cancer 896 | 1,428
Autosomal recessive predisposition 859 | 1,407
adrenocortical carcinoma 831 | 1,385
Multiple myeloma 779 | 1,296
diabetes mellitus 770 | 1,683
juvenile dermatomyositis 735 | 1,147
acute quadriplegic myopathy 718 | 1,133
astrocytoma 714 | 1,113
Schizophrenia 713 | 1,136
Rheumatoid arthritis 703 | 1,156
Intellectual disability 681 | 998
spina bifida 672 | 1,053
pediatric high grade glioma 651 | 1,035
primary pancreatic ductal adenocarcinoma 635 | 1,071
nasopharyngeal carcinoma 633 | 1,024
cutaneous lupus erythematosus 615 | 1,016
dermatomyositis 588 | 941
non primary Sjogren syndrome sicca 531 | 861
active Crohn's disease 506 | 882
Epilepsy 504 | 775
progressive supranuclear palsy 503 | 656
Atopic dermatitis 502 | 915
gastric carcinoma 466 | 781
Waldenstrons macroglobulinemia 461 | 742
Melanoma 455 | 689
primary Sjogren syndrome 452 | 710
medulloblastoma 444 | 702
acute myeloid leukemia 435 | 760
Liver cancer 431 | 589
Dull intelligence 427 | 634
Low intelligence 427 | 634
Mental Retardation 427 | 634
Mental deficiency 427 | 634
Poor school performance 427 | 634
Alzheimer's disease 426 | 640
active ulcerative colitis 413 | 736
Bipolar Disorder 410 | 646
Liver Cirrhosis, Experimental 410 | 733
Cognitive delay 398 | 596
Global developmental delay 398 | 596
Mental and motor retardation 398 | 596
aldosterone-producing adenoma 398 | 646
esophageal adenocarcinoma 383 | 696
Muscle hypotonia 379 | 562
Seizures 377 | 584
Obesity 373 | 655
chronic rhinosinusitis 346 | 505
Duchenne muscular dystrophy 331 | 587
Short stature 326 | 514
fibroadenoma 324 | 538
pancreatic carcinoma 323 | 555
Skin cancer 315 | 451
Down syndrome 312 | 480
Amyotrophic lateral sclerosis 301 | 437
autosomal dominant Emery-Dreifuss muscular dystrophy 295 | 492
sonic hedgehog group medulloblastoma 292 | 459
Endometriosis 289 | 521
hepatocellular carcinoma 286 | 536
Multiple Sclerosis 284 | 527
Prostatic Neoplasms 280 | 472
Neurodegenerative disease 277 | 402
tuberculosis and treatment for 6 months 270 | 399

Tissue

Endocrine System 10,272 | 18,159
Female tissues 10,087 | 17,400
Digestive Tract 10,072 | 17,369
Skin and soft tissues 10,009 | 17,230
Male tissues 9,993 | 17,142
Blood and immune system 9,881 | 16,909
Liver and Pancreas 9,855 | 16,750
Urinary Tract 9,829 | 16,678
Nervous System 9,818 | 16,725
Respiratory system 9,710 | 16,393
Cardiovascular System 9,167 | 15,192

Target Family

Non-IDG 6,062 | 12,091
Enzyme 2,395 | 4,145
Transcription Factor 729 | 1,400
Kinase 445 | 634
Transporter 308 | 473
Ion Channel 206 | 344
Epigenetic 193 | 242
GPCR 120 | 408
Nuclear Receptor 39 | 48
TF/Epigenetic 31 | 38

UniProt Keyword

Alternative splicing 10,528 | 10,528
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Probable gluconokinase IDNK Tbio Kinase -1.00330 9.91 94
Hydroxyacylglutathione hydrolase, mitochondrial HAGH Tbio Enzyme -1.95974 82.6 162
Nidogen-2 NID2 Tbio Non-IDG -1.62355 40.1 116
Kazal-type serine protease inhibitor domain-containing protein 1 KAZALD1 Tdark Enzyme -0.50068 4.33 42
LIM homeobox transcription factor 1-alpha LMX1A Tbio Transcription Factor -1.82498 66.0 175