Development Level

Tbio 73 | 11,445
Tchem 17 | 1,598
Tclin 7 | 613
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal bone structure 5 | 187
increased total body fat amoun... 5 | 134
decreased circulating HDL chol... 4 | 68
decreased lymphocyte cell numb... 4 | 83
decreased prepulse inhibition 4 | 82
increased circulating amylase ... 4 | 25
increased lean body mass 4 | 172
abnormal embryo size 3 | 220
decreased body weight 3 | 161
decreased circulating choleste... 3 | 93
decreased circulating iron lev... 3 | 32
decreased lean body mass 3 | 135
increased startle reflex 3 | 112
preweaning lethality, incomple... 3 | 499
abnormal coat-hair pigmentatio... 2 | 64
abnormal locomotor activation 2 | 16
abnormal locomotor behavior 2 | 24
abnormal startle reflex 2 | 15
decreased bone mineral content 2 | 151
decreased circulating alkaline... 2 | 46
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased mean corpuscular vol... 2 | 79
decreased pulmonary respirator... 2 | 5
decreased total body fat amoun... 2 | 207
enlarged stomach 2 | 2
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating chloride... 2 | 41
increased or absent threshold ... 2 | 101
increased red blood cell distr... 2 | 34
limb grasping 2 | 41
short tibia 2 | 97
small thymus 2 | 16
syndactyly 2 | 23
tremors 2 | 39
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal forelimb morphology 1 | 2
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
absent teeth 1 | 3
brachydactyly 1 | 19
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
female infertility 1 | 60
fused cornea and lens 1 | 5
fused phalanges 1 | 1
impaired pupillary reflex 1 | 26
increased B cell number 1 | 9
increased CD4-positive, alpha ... 1 | 4
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased hematocrit 1 | 46
increased lactate dehydrogenas... 1 | 3
increased monocyte cell number 1 | 63
increased total retina thickne... 1 | 4
increased vertical activity 1 | 24
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33

Disease

Carcinoma 79 | 11,493
ovarian cancer 57 | 8,520
osteosarcoma 45 | 7,950
glioblastoma 42 | 5,792
ependymoma 39 | 4,679
medulloblastoma, large-cell 39 | 6,241
lung cancer 38 | 4,740
atypical teratoid / rhabdoid tumor 37 | 5,112
malignant mesothelioma 37 | 3,232
psoriasis 36 | 6,694
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,291
Kidney cancer 34 | 2,613
Cancer 31 | 2,499
adult high grade glioma 30 | 3,801
interstitial cystitis 30 | 2,312
lung adenocarcinoma 30 | 2,716
non-small cell lung cancer 30 | 2,890
Astrocytoma, Pilocytic 29 | 3,081
Breast cancer 28 | 3,578
oligodendroglioma 25 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
group 3 medulloblastoma 23 | 4,104
pituitary cancer 22 | 1,972
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
invasive ductal carcinoma 21 | 2,951
primitive neuroectodermal tumor 21 | 3,035
Schizophrenia 20 | 1,160
subependymal giant cell astrocytoma 20 | 2,287
astrocytic glioma 19 | 2,597
colon cancer 19 | 1,478
lung carcinoma 18 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
astrocytoma 17 | 1,146
breast carcinoma 16 | 1,638
pancreatic cancer 16 | 2,398
tuberculosis 16 | 2,010
ulcerative colitis 16 | 1,819
Pick disease 15 | 1,894
diabetes mellitus 15 | 1,728
ductal carcinoma in situ 15 | 1,745
Autosomal recessive predisposition 14 | 1,442
Bipolar Disorder 14 | 666
Liver cancer 14 | 604
group 4 medulloblastoma 14 | 1,855
Intellectual disability 13 | 1,016
Obesity 13 | 678
Amyotrophic lateral sclerosis 12 | 451
Autistic Disorder 11 | 364
Melanoma 11 | 711
acute quadriplegic myopathy 11 | 1,158
adrenocortical carcinoma 11 | 1,428
cutaneous lupus erythematosus 11 | 1,057
cystic fibrosis 11 | 1,696
dermatomyositis 11 | 966
esophageal adenocarcinoma 11 | 737
pediatric high grade glioma 11 | 1,064
Atopic dermatitis 10 | 952
Rheumatoid arthritis 10 | 1,191
juvenile dermatomyositis 10 | 1,187
Breast Neoplasms 9 | 445
Endometrial cancer 9 | 311
Neuropathy 9 | 261
chronic rhinosinusitis 9 | 512
Acquired metabolic disease 8 | 336
Depressive disorder 8 | 409
Epilepsy 8 | 792
Hypertension 8 | 396
Kidney disease 8 | 430
Multiple myeloma 8 | 1,332
Osteoporosis 8 | 363
Prostatic Neoplasms 8 | 495
nasopharyngeal carcinoma 8 | 1,058
primary pancreatic ductal adenocarcinoma 8 | 1,109
Adenocarcinoma 7 | 122
Alzheimer's disease 7 | 658
Animal Mammary Neoplasms 7 | 136
Asthma 7 | 385
Carcinoma, Hepatocellular 7 | 228
Dull intelligence 7 | 645
Endometriosis 7 | 540
Liver carcinoma 7 | 240
Low intelligence 7 | 645
Lung Neoplasms 7 | 232
Lymphoid leukemia 7 | 160
Mammary Neoplasms, Animal 7 | 136
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Skin cancer 7 | 469
gastric carcinoma 7 | 807
hepatocellular carcinoma 7 | 547
nephrosclerosis 7 | 333
primary Sjogren syndrome 7 | 735
spina bifida 7 | 1,074
Down syndrome 6 | 499
Mental Depression 6 | 333
Vascular disease 6 | 319
Waldenstrons macroglobulinemia 6 | 765
mucosa-associated lymphoid tissue lymphoma 6 | 484
progressive supranuclear palsy 6 | 676

Tissue

Digestive Tract 93 | 17,369
Endocrine System 93 | 18,159
Female tissues 93 | 17,400
Skin and soft tissues 93 | 17,230
Blood and immune system 92 | 16,909
Male tissues 92 | 17,142
Liver and Pancreas 91 | 16,750
Nervous System 91 | 16,725
Respiratory system 91 | 16,393
Urinary Tract 91 | 16,678
Cardiovascular System 86 | 15,192

Target Family

Non-IDG 52 | 12,091
Enzyme 21 | 4,145
Kinase 7 | 634
Nuclear Receptor 7 | 48
Transcription Factor 6 | 1,400
Transporter 3 | 473
TF/Epigenetic 2 | 38
Epigenetic 1 | 242
GPCR 1 | 408

UniProt Keyword

Alternative promoter usage 100 | 100
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
L-amino-acid oxidase IL4I1 Tbio Enzyme -2.79074 622.3 53
Neurexin-1 NRXN1 Tbio Non-IDG -1.88807 125.1 174
Tyrosine-protein kinase Fer FER Tchem Kinase -1.86307 55.4 414
Serine/threonine-protein kinase MARK2 MARK2 Tchem Kinase -2.49873 272.3 322
A disintegrin and metalloproteinase with thrombospondin motifs 14 ADAMTS14 Tbio Enzyme -0.89572 7.58 29
Neurexin-3 NRXN3 Tbio Non-IDG -1.34072 34.8 172
Plakophilin-3 PKP3 Tbio Non-IDG -1.37372 26.0 200
Dual specificity protein phosphatase 13 isoform B DUSP13 Tbio Enzyme -1.26330 34.4 180
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Solute carrier family 12 member 6 SLC12A6 Tbio Transporter -1.73943 58.4 161