Development Level

Tbio 22 | 11,651
Tchem 20 | 1,388
Tclin 6 | 612

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328

IMPC Phenotype

decreased body weight 2 | 161
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal duodenum morphology 1 | 4
abnormal hair texture 1 | 4
abnormal incisor morphology 1 | 4
abnormal maxilla morphology 1 | 17
abnormal retinal vasculature m... 1 | 27
abnormal vibrissa morphology 1 | 25
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased fasted circulating g... 1 | 65
decreased lactate dehydrogenas... 1 | 16
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
enlarged spleen 1 | 41
female infertility 1 | 60
increased blood urea nitrogen ... 1 | 48
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
long tibia 1 | 25
male infertility 1 | 123
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 39 | 11,493
ovarian cancer 31 | 8,520
psoriasis 27 | 6,694
medulloblastoma, large-cell 26 | 6,241
osteosarcoma 26 | 7,950
glioblastoma 23 | 5,792
lung cancer 23 | 4,740
Autosomal recessive predisposition 20 | 1,442
group 3 medulloblastoma 20 | 4,104
atypical teratoid / rhabdoid tumor 19 | 5,112
malignant mesothelioma 18 | 3,232
non-small cell lung cancer 18 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
ependymoma 17 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
invasive ductal carcinoma 15 | 2,951
primitive neuroectodermal tumor 14 | 3,035
Astrocytoma, Pilocytic 13 | 3,081
Breast cancer 13 | 3,578
Kidney cancer 13 | 2,613
adult high grade glioma 13 | 3,801
lung carcinoma 13 | 2,843
Schizophrenia 12 | 1,160
Seizures 12 | 596
Epilepsy 11 | 792
diabetes mellitus 10 | 1,728
oligodendroglioma 10 | 2,850
adrenocortical carcinoma 9 | 1,428
pancreatic cancer 9 | 2,398
subependymal giant cell astrocytoma 9 | 2,287
tuberculosis 9 | 2,010
Bipolar Disorder 8 | 666
Cancer 8 | 2,499
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Hypertension 8 | 396
Mental and motor retardation 8 | 608
astrocytic glioma 8 | 2,597
breast carcinoma 8 | 1,638
ductal carcinoma in situ 8 | 1,745
group 4 medulloblastoma 8 | 1,855
lung adenocarcinoma 8 | 2,716
pituitary cancer 8 | 1,972
Dull intelligence 7 | 645
Intellectual disability 7 | 1,016
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Obesity 7 | 678
Poor school performance 7 | 645
Psychotic Disorders 7 | 151
aldosterone-producing adenoma 7 | 665
colon cancer 7 | 1,478
dermatomyositis 7 | 966
interstitial cystitis 7 | 2,312
ulcerative colitis 7 | 1,819
Glycogen storage disease 6 | 39
Liver Cirrhosis, Experimental 6 | 769
Myocardial Ischemia 6 | 169
primary Sjogren syndrome 6 | 735
Anemia 5 | 365
Carcinoma, Hepatocellular 5 | 228
Coronary artery disease 5 | 268
Depressive disorder 5 | 409
Hypertensive disease 5 | 292
Liver carcinoma 5 | 240
Muscle Weakness 5 | 170
Muscle hypotonia 5 | 571
Myopathy 5 | 185
Osteoporosis 5 | 363
Pick disease 5 | 1,894
Waldenstrons macroglobulinemia 5 | 765
astrocytoma 5 | 1,146
cystic fibrosis 5 | 1,696
esophageal adenocarcinoma 5 | 737
pediatric high grade glioma 5 | 1,064
Adenocarcinoma of lung 4 | 142
Alzheimer's disease 4 | 658
Atrial Fibrillation 4 | 124
Dementia 4 | 175
Diabetes Mellitus, Experimental 4 | 108
Disease Models, Animal 4 | 155
Highly variable severity 4 | 157
Hyperreflexia 4 | 209
Hypoglycemia 4 | 152
Irritation - emotion 4 | 68
Neurodegenerative disease 4 | 414
Rheumatoid arthritis 4 | 1,191
Type 2 diabetes mellitus 4 | 272
Variable expressivity 4 | 157
acute quadriplegic myopathy 4 | 1,158
cutaneous lupus erythematosus 4 | 1,057
juvenile dermatomyositis 4 | 1,187
medulloblastoma 4 | 720
spina bifida 4 | 1,074
Attention deficit hyperactivity disorder 3 | 278
Down syndrome 3 | 499
nephrosclerosis 3 | 333

Tissue

Blood and immune system 48 | 16,909
Digestive Tract 48 | 17,369
Endocrine System 48 | 18,159
Liver and Pancreas 48 | 16,750
Skin and soft tissues 48 | 17,230
Urinary Tract 48 | 16,678
Female tissues 47 | 17,400
Male tissues 47 | 17,142
Nervous System 47 | 16,725
Respiratory system 45 | 16,393
Cardiovascular System 43 | 15,192

Target Family

Enzyme 29 | 4,145
Kinase 16 | 634
Non-IDG 3 | 12,091

UniProt Keyword

Allosteric enzyme 48 | 48
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
ATP-dependent 6-phosphofructokinase, liver type PFKL Tbio Kinase -2.07015 107.6 240
Glycogen [starch] synthase, liver GYS2 Tbio Enzyme -1.61077 38.6 69
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 SAMHD1 Tbio Enzyme -3.96722 8709.0 274
cGMP-dependent protein kinase 1 PRKG1 Tchem Kinase -2.70325 459.4 238
ATP-dependent 6-phosphofructokinase, platelet type PFKP Tbio Kinase -1.93210 79.7 302
Hexokinase-3 HK3 Tbio Kinase -1.72467 51.4 355
Glycogen [starch] synthase, muscle GYS1 Tchem Enzyme -2.18151 151.1 227
Glucokinase GCK Tchem Kinase -2.90428 758.6 336