Development Level

Tdark 142 | 6,593
Tbio 103 | 11,651
Tchem 21 | 1,388
Tclin 14 | 612

Collection

GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 7 | 979
decreased lean body mass 4 | 135
abnormal seminal vesicle morph... 3 | 114
embryonic lethality prior to t... 3 | 278
increased total body fat amoun... 3 | 134
decreased body weight 2 | 161
decreased lymphocyte cell numb... 2 | 83
enlarged heart 2 | 210
increased erythrocyte cell num... 2 | 39
increased monocyte cell number 2 | 63
increased startle reflex 2 | 112
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal heart position or ori... 1 | 1
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal maxilla morphology 1 | 17
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating choleste... 1 | 93
decreased circulating phosphat... 1 | 27
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged seminal vesicle 1 | 10
female infertility 1 | 60
increased CD4-positive, alpha ... 1 | 4
increased blood urea nitrogen ... 1 | 48
increased circulating sodium l... 1 | 71
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
prolonged RR interval 1 | 8
thrombocytopenia 1 | 56

Disease

osteosarcoma 101 | 7,950
Carcinoma 84 | 11,493
interstitial cystitis 74 | 2,312
psoriasis 70 | 6,694
lung cancer 67 | 4,740
ovarian cancer 64 | 8,520
lung carcinoma 56 | 2,843
ulcerative colitis 53 | 1,819
cutaneous lupus erythematosus 50 | 1,057
tuberculosis 50 | 2,010
glioblastoma 46 | 5,792
primary Sjogren syndrome 44 | 735
Cancer 43 | 2,499
medulloblastoma, large-cell 37 | 6,241
invasive ductal carcinoma 33 | 2,951
lung adenocarcinoma 33 | 2,716
non-small cell lung cancer 32 | 2,890
Astrocytoma, Pilocytic 28 | 3,081
adult high grade glioma 28 | 3,801
periodontitis 25 | 293
subependymal giant cell astrocytoma 25 | 2,287
Breast cancer 24 | 3,578
Multiple myeloma 23 | 1,332
chronic lymphosyte leukemia 23 | 204
atypical teratoid / rhabdoid tumor 21 | 5,112
Rheumatoid arthritis 20 | 1,191
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
pancreatic cancer 19 | 2,398
Autosomal recessive predisposition 18 | 1,442
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
diabetes mellitus 17 | 1,728
ependymoma 17 | 4,679
mucosa-associated lymphoid tissue lymphoma 16 | 484
oligodendroglioma 16 | 2,850
Lymphoproliferative syndrome 14 | 58
active Crohn's disease 14 | 922
astrocytoma 14 | 1,146
colon cancer 14 | 1,478
cystic fibrosis 14 | 1,696
head and neck cancer and chronic obstructive pulmonary disease 14 | 239
juvenile dermatomyositis 14 | 1,187
malignant mesothelioma 14 | 3,232
Immunologic Deficiency Syndromes 13 | 113
acute myeloid leukemia 13 | 783
ductal carcinoma in situ 13 | 1,745
esophageal adenocarcinoma 13 | 737
group 3 medulloblastoma 13 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
Kidney cancer 12 | 2,613
Liver Cirrhosis, Experimental 12 | 769
Schizophrenia 12 | 1,160
nasopharyngeal carcinoma 12 | 1,058
primary pancreatic ductal adenocarcinoma 12 | 1,109
Crohn's disease 11 | 321
sarcoidosis 11 | 370
Asthma 10 | 385
Diarrhea 10 | 253
Multiple Sclerosis 10 | 540
Waldenstrons macroglobulinemia 10 | 765
astrocytic glioma 10 | 2,597
gastric cancer 10 | 459
group 4 medulloblastoma 10 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
primitive neuroectodermal tumor 10 | 3,035
Arthritis 9 | 290
Chronic Lymphocytic Leukemia 9 | 262
Fever 9 | 138
Melanoma 9 | 711
Severe combined immunodeficiency 9 | 51
active ulcerative colitis 9 | 764
cystic fibrosis and chronic rhinosinusitis 9 | 214
Agammaglobulinemia 8 | 34
Atopic dermatitis 8 | 952
Bipolar Disorder 8 | 666
Bronchiectasis 8 | 64
Celiac disease 8 | 116
Hepatomegaly 8 | 285
Hypersensitivity reaction type II disease 8 | 253
Recurrent respiratory infections 8 | 141
Splenomegaly 8 | 190
breast carcinoma 8 | 1,638
dermatomyositis 8 | 966
non-small cell lung carcinoma 8 | 317
Anemia 7 | 365
Chronic otitis media 7 | 52
Common variable immunodeficiency 7 | 101
Dysgammaglobulinemia 7 | 10
Failure to gain weight 7 | 365
Fatigue 7 | 182
Lupus erythematosus 7 | 57
Lymphoma 7 | 81
Pediatric failure to thrive 7 | 365
Systemic lupus erythematosus 7 | 194
ear infection chronic 7 | 52
pancreatic carcinoma 7 | 562
pituitary cancer 7 | 1,972
Pick disease 6 | 1,894
Prostatic Neoplasms 6 | 495
adrenocortical carcinoma 6 | 1,428
gastric carcinoma 6 | 807

Tissue

Blood and immune system 127 | 16,909
Female tissues 127 | 17,400
Liver and Pancreas 126 | 16,750
Skin and soft tissues 126 | 17,230
Digestive Tract 125 | 17,369
Endocrine System 125 | 18,159
Respiratory system 124 | 16,393
Urinary Tract 124 | 16,678
Male tissues 121 | 17,142
Cardiovascular System 115 | 15,192
Nervous System 110 | 16,725

Target Family

Non-IDG 241 | 12,091
Kinase 18 | 634
Enzyme 9 | 4,145
Transcription Factor 5 | 1,400
Ion Channel 4 | 344
GPCR 2 | 408
TF/Epigenetic 1 | 38

UniProt Keyword

Adaptive immunity 280 | 280
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
C-type lectin domain family 6 member A CLEC6A Tbio Non-IDG -1.54098 33.3 328
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
Drebrin-like protein DBNL Tbio Non-IDG -1.16567 21.1 172
CD166 antigen ALCAM Tbio Non-IDG -2.49297 326.4 492
EF-hand calcium-binding domain-containing protein 4B CRACR2A Tchem Non-IDG -0.52797 3.72 130
Src kinase-associated phosphoprotein 1 SKAP1 Tbio Enzyme -1.31527 25.2 175
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 PAG1 Tbio Non-IDG -1.69647 50.1 216