Development Level

Tbio 94 | 11,178
Tchem 41 | 1,885
Tdark 29 | 6,569
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
preweaning lethality, complete... 5 | 979
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
abnormal embryo size 2 | 220
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
hyperactivity 2 | 148
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased circulating phosphat... 2 | 26
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal bone structure 1 | 187
abnormal brain morphology 1 | 13
abnormal eye morphology 1 | 68
abnormal kidney morphology 1 | 65
abnormal lip morphology 1 | 2
abnormal lung morphology 1 | 26
abnormal maxilla morphology 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased circulating LDL chol... 1 | 38
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating creatine... 1 | 4
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
hydroencephaly 1 | 14
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating creatine... 1 | 5
increased circulating potassiu... 1 | 29
increased heart rate variabili... 1 | 7
increased or absent threshold ... 1 | 101
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74

Disease

Carcinoma 109 | 11,192
ovarian cancer 85 | 8,297
psoriasis 69 | 6,514
osteosarcoma 68 | 7,766
medulloblastoma, large-cell 53 | 6,086
glioblastoma 41 | 5,635
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,204
lung cancer 33 | 4,607
group 3 medulloblastoma 31 | 4,002
Breast cancer 29 | 3,469
adult high grade glioma 29 | 3,701
atypical teratoid / rhabdoid tumor 29 | 4,971
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,872
pancreatic ductal adenocarcinoma liver metastasis 29 | 1,911
ependymoma 26 | 4,559
invasive ductal carcinoma 26 | 2,867
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,902
malignant mesothelioma 24 | 3,135
primitive neuroectodermal tumor 24 | 2,957
group 4 medulloblastoma 21 | 1,806
Astrocytoma, Pilocytic 20 | 3,006
Autosomal recessive predisposition 20 | 1,407
tuberculosis 20 | 1,963
astrocytic glioma 19 | 2,530
Cancer 18 | 2,388
Kidney cancer 18 | 2,548
Intellectual disability 17 | 998
diabetes mellitus 17 | 1,683
oligodendroglioma 17 | 2,768
Obesity 16 | 655
Pick disease 16 | 1,856
astrocytoma 16 | 1,113
ductal carcinoma in situ 16 | 1,686
lung adenocarcinoma 16 | 2,627
pancreatic cancer 16 | 2,322
subependymal giant cell astrocytoma 16 | 2,230
interstitial cystitis 14 | 2,237
lung carcinoma 14 | 2,755
ulcerative colitis 14 | 1,765
Muscle hypotonia 13 | 562
Dull intelligence 12 | 634
Low intelligence 12 | 634
Mental Retardation 12 | 634
Mental deficiency 12 | 634
Multiple myeloma 12 | 1,296
Poor school performance 12 | 634
acute quadriplegic myopathy 12 | 1,133
Rheumatoid arthritis 11 | 1,156
non-small cell lung cancer 11 | 2,799
spina bifida 11 | 1,053
Schizophrenia 10 | 1,136
Seizures 10 | 584
adrenocortical carcinoma 10 | 1,385
breast carcinoma 10 | 1,589
colon cancer 10 | 1,428
pituitary cancer 10 | 1,915
primary pancreatic ductal adenocarcinoma 10 | 1,071
Atopic dermatitis 9 | 915
Fatty liver disease 9 | 102
Liver Cirrhosis, Experimental 9 | 733
active Crohn's disease 9 | 882
Alzheimer's disease 8 | 640
Bipolar Disorder 8 | 646
Breast Neoplasms 8 | 423
Cognitive delay 8 | 596
Epilepsy 8 | 775
Global developmental delay 8 | 596
Mental and motor retardation 8 | 596
Small head 8 | 366
fibroadenoma 8 | 538
pediatric high grade glioma 8 | 1,035
Blepharoptosis 7 | 229
Byzanthine arch palate 7 | 194
Cataract 7 | 290
Failure to gain weight 7 | 359
Mammary Neoplasms 7 | 403
Pediatric failure to thrive 7 | 359
Strabismus 7 | 265
Waldenstrons macroglobulinemia 7 | 742
active ulcerative colitis 7 | 736
cystic fibrosis 7 | 1,629
Atrial Septal Defects 6 | 81
Carnitine palmitoyltransferase II deficiency 6 | 14
Feeding difficulties in infancy 6 | 174
Hepatomegaly 6 | 280
Low set ears 6 | 178
Melanoma 6 | 689
Neurodegenerative disease 6 | 402
Neuropathy 6 | 254
Prostatic Neoplasms 6 | 472
acute myeloid leukemia 6 | 760
aldosterone-producing adenoma 6 | 646
dermatomyositis 6 | 941
esophageal adenocarcinoma 6 | 696
mucosa-associated lymphoid tissue lymphoma 6 | 473
non primary Sjogren syndrome sicca 6 | 861
Ventricular Septal Defects 5 | 113
hepatocellular carcinoma 5 | 536
juvenile dermatomyositis 5 | 1,147
primary Sjogren syndrome 5 | 710

Tissue

Endocrine System 157 | 18,159
Digestive Tract 155 | 17,369
Female tissues 155 | 17,400
Skin and soft tissues 155 | 17,230
Male tissues 153 | 17,142
Blood and immune system 151 | 16,909
Liver and Pancreas 150 | 16,750
Nervous System 150 | 16,725
Urinary Tract 147 | 16,678
Respiratory system 145 | 16,393
Cardiovascular System 139 | 15,192

Target Family

Enzyme 138 | 4,145
Epigenetic 17 | 242
Non-IDG 7 | 12,091
TF/Epigenetic 2 | 38
Kinase 1 | 634

UniProt Keyword

Acyltransferase 165 | 165
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable palmitoyltransferase ZDHHC12 ZDHHC12 Tdark Enzyme -0.20713 1.21 38
Probable palmitoyltransferase ZDHHC11B ZDHHC11B Tdark Enzyme 0.08 0.58 9
Serotonin N-acetyltransferase AANAT Tbio Enzyme -2.28389 189.1 196
Transcription initiation factor TFIID subunit 1 TAF1 Tbio Kinase -2.64215 426.1 228
Diamine acetyltransferase 1 SAT1 Tbio Enzyme -2.60045 409.5 159
Germinal-center associated nuclear protein MCM3AP Tbio Non-IDG -1.74285 63.4 158
Arginyl-tRNA--protein transferase 1 ATE1 Tbio Enzyme -1.88963 77.4 132
Glycine N-acyltransferase-like protein 2 GLYATL2 Tbio Enzyme -0.33244 2.11 52
Glycylpeptide N-tetradecanoyltransferase 1 NMT1 Tchem Enzyme -2.33602 222.5 129
Phosphatidylcholine-sterol acyltransferase LCAT Tchem Enzyme -2.52851 336.6 270