Development Level

Tbio 524 | 10,625
Tchem 83 | 1,890
Tdark 41 | 7,003
Tclin 9 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 42 | 633
preweaning lethality, incomple... 14 | 260
embryonic lethality prior to t... 13 | 187
decreased lean body mass 12 | 195
abnormal bone structure 11 | 131
decreased total body fat amoun... 10 | 186
abnormal behavior 9 | 226
abnormal embryo size 8 | 112
decreased body length 8 | 108
decreased body weight 8 | 174
decreased bone mineral content 8 | 157
decreased circulating choleste... 8 | 85
increased circulating alkaline... 8 | 119
abnormal retina morphology 7 | 100
decreased circulating triglyce... 7 | 83
embryonic lethality prior to o... 7 | 148
increased mean corpuscular vol... 7 | 91
abnormal bone mineralization 6 | 55
decreased bone mineral density 6 | 126
decreased circulating glucose ... 6 | 121
increased or absent threshold ... 6 | 128
short tibia 6 | 82
abnormal retinal pigmentation 5 | 61
decreased T cell number 5 | 31
decreased caudal vertebrae num... 5 | 49
decreased circulating HDL chol... 5 | 77
decreased circulating insulin ... 5 | 75
decreased circulating serum al... 5 | 79
decreased leukocyte cell numbe... 5 | 54
decreased lumbar vertebrae num... 5 | 62
increased bone mineral content 5 | 92
increased lean body mass 5 | 107
increased sacral vertebrae num... 5 | 62
thrombocytopenia 5 | 46
abnormal cornea morphology 4 | 24
abnormal eye morphology 4 | 38
decreased circulating alkaline... 4 | 41
decreased circulating creatini... 4 | 31
decreased circulating fructosa... 4 | 31
decreased erythrocyte cell num... 4 | 43
decreased prepulse inhibition 4 | 52
enlarged heart 4 | 111
increased circulating choleste... 4 | 53
increased grip strength 4 | 83
prenatal lethality prior to he... 4 | 64
abnormal behavioral response t... 3 | 52
abnormal coping response 3 | 12
abnormal sleep behavior 3 | 63
decreased CD4-positive, alpha ... 3 | 19
decreased Ly6C low monocyte nu... 3 | 23
decreased blood urea nitrogen ... 3 | 31
decreased circulating LDL chol... 3 | 37
decreased circulating alanine ... 3 | 53
decreased circulating total pr... 3 | 41
decreased eosinophil cell numb... 3 | 41
decreased grip strength 3 | 123
decreased hemoglobin content 3 | 53
hypoactivity 3 | 89
improved glucose tolerance 3 | 56
increased B cell number 3 | 23
increased bone mineral density 3 | 52
increased circulating HDL chol... 3 | 63
increased circulating sodium l... 3 | 71
increased circulating triglyce... 3 | 24
increased fasted circulating g... 3 | 68
increased lactate dehydrogenas... 3 | 3
increased mean corpuscular hem... 3 | 93
increased total body fat amoun... 3 | 57
abnormal coat/hair pigmentatio... 2 | 54
abnormal cranium morphology 2 | 32
abnormal embryo turning 2 | 15
abnormal gait 2 | 51
abnormal head morphology 2 | 10
abnormal heart morphology 2 | 51
abnormal lens morphology 2 | 73
abnormal neural tube closure 2 | 37
abnormal startle reflex 2 | 14
abnormal tooth morphology 2 | 24
anophthalmia 2 | 20
corneal opacity 2 | 25
decreased IgG1 level 2 | 4
decreased circulating calcium ... 2 | 33
decreased circulating chloride... 2 | 32
decreased circulating sodium l... 2 | 18
decreased gamma-delta T cell n... 2 | 18
decreased hematocrit 2 | 25
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
decreased vertical activity 2 | 22
embryonic growth retardation 2 | 28
impaired glucose tolerance 2 | 52
increased circulating amylase ... 2 | 13
increased circulating chloride... 2 | 43
increased circulating serum al... 2 | 25
increased effector memory CD4-... 2 | 15
increased exploration in new e... 2 | 56
increased hemoglobin content 2 | 45
thin ventricular wall 2 | 5
vertebral fusion 2 | 23

Disease

ovarian cancer 367 | 8,484
osteosarcoma 340 | 7,933
psoriasis 271 | 6,685
medulloblastoma, large-cell 263 | 6,234
glioblastoma 212 | 5,572
lung cancer 207 | 4,466
Cancer 202 | 2,346
atypical teratoid / rhabdoid tumor 181 | 4,369
malignant mesothelioma 160 | 3,162
Breast cancer 145 | 3,094
primitive neuroectodermal tumor 132 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 130 | 3,289
invasive ductal carcinoma 127 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 120 | 2,988
oligodendroglioma 114 | 2,849
pediatric high grade glioma 110 | 2,712
Carcinoma 109 | 2,147
intraductal papillary-mucinous adenoma (IPMA) 109 | 2,956
group 4 medulloblastoma 101 | 1,875
lung carcinoma 101 | 2,844
ependymoma 99 | 2,514
group 3 medulloblastoma 99 | 2,254
astrocytoma 98 | 1,493
ulcerative colitis 98 | 2,087
non-small cell lung cancer 97 | 2,798
pancreatic cancer 96 | 2,300
pituitary cancer 93 | 1,972
subependymal giant cell astrocytoma 93 | 2,287
lung adenocarcinoma 91 | 2,713
pilocytic astrocytoma 86 | 3,086
ductal carcinoma in situ 85 | 1,745
Pick disease 84 | 1,893
breast carcinoma 81 | 1,614
interstitial cystitis 79 | 2,299
astrocytic glioma 78 | 2,241
juvenile dermatomyositis 78 | 1,189
Rheumatoid Arthritis 77 | 1,160
acute quadriplegic myopathy 71 | 1,157
diabetes mellitus 70 | 1,663
sonic hedgehog group medulloblastoma 70 | 1,482
Multiple myeloma 66 | 1,327
dermatomyositis 65 | 933
primary pancreatic ductal adenocarcinoma 61 | 1,271
adult high grade glioma 59 | 2,148
colon cancer 59 | 1,475
medulloblastoma 59 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 58 | 1,795
cystic fibrosis 57 | 1,665
adrenocortical carcinoma 55 | 1,427
spina bifida 55 | 1,064
posterior fossa group A ependymoma 54 | 1,511
tuberculosis 52 | 1,557
acute myeloid leukemia 51 | 780
posterior fossa group B ependymoma 44 | 1,530
Intellectual disability 43 | 573
primary Sjogren syndrome 43 | 789
Mammary Neoplasms 42 | 410
Obesity 41 | 616
aldosterone-producing adenoma 41 | 664
atypical teratoid/rhabdoid tumor 41 | 1,095
cutaneous lupus erythematosus 41 | 1,056
tuberculosis and treatment for 6 months 40 | 686
autosomal dominant Emery-Dreifuss muscular dystrophy 39 | 499
gastric carcinoma 38 | 832
Atopic dermatitis 37 | 944
Prostatic Neoplasms 37 | 471
Waldenstrons macroglobulinemia 37 | 765
nasopharyngeal carcinoma 36 | 1,056
Alzheimer's disease 33 | 644
Endometriosis 32 | 535
fibroadenoma 31 | 557
Amyotrophic Lateral Sclerosis 30 | 431
active Crohn's disease 28 | 918
non primary Sjogren syndrome sicca 28 | 840
progressive supranuclear palsy 28 | 674
Acquired metabolic disease 26 | 267
esophageal adenocarcinoma 25 | 737
hepatocellular carcinoma 25 | 532
Liver carcinoma 24 | 217
Multiple Sclerosis 24 | 498
Crohn's disease 23 | 304
Stomach Neoplasms 23 | 282
Duchenne muscular dystrophy 21 | 602
Down syndrome 20 | 548
Parkinson's disease 20 | 364
glioblastoma multiforme 20 | 347
pancreatic carcinoma 20 | 567
Bipolar Disorder 19 | 266
Craniofacial Abnormalities 19 | 147
Heart disease 19 | 279
Kidney disease 19 | 396
Peripheral Neuropathy 19 | 303
Polycystic Ovary Syndrome 19 | 332
Vascular disease 19 | 281
inflammatory breast cancer 19 | 404
Adenoid Cystic Carcinoma 18 | 99
Prostate cancer 18 | 172
active ulcerative colitis 18 | 477
chronic lymphosyte leukemia 18 | 232
gastric cancer 18 | 430

Tissue

Digestive Tract 651 | 18,473
Female tissues 651 | 18,647
Endocrine System 649 | 18,512
Nervous System 647 | 18,561
Urinary Tract 646 | 18,444
Liver and Pancreas 645 | 18,136
Skin and soft tissues 642 | 18,115
Cardiovascular System 641 | 17,958
Male tissues 641 | 17,969
Blood and immune system 638 | 17,995
Respiratory system 627 | 17,484

Target Family

Transcription Factor 350 | 1,400
Non-IDG 180 | 11,971
Enzyme 51 | 4,146
Epigenetic 37 | 242
Nuclear Receptor 23 | 48
Kinase 8 | 634
TF/Epigenetic 7 | 38
Transporter 1 | 473

UniProt Keyword

Activator 657 | 657
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Basic helix-loop-helix transcription factor scleraxis SCX Tbio Transcription Factor -2.80657 344.1 42
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Histone-lysine N-methyltransferase SETD1B SETD1B Tbio Epigenetic -1.20916 14.6 78
Interferon regulatory factor 9 IRF9 Tbio Transcription Factor -1.79340 61.7 168
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
CUGBP Elav-like family member 4 CELF4 Tbio Non-IDG -1.46075 29.8 40
Multicilin MCIDAS Tbio Non-IDG -2.00076 101.0 59
Zinc finger protein GLIS1 GLIS1 Tbio Transcription Factor -0.87828 10.0 91