Development Level

Tbio 2,299 | 10,625
Tdark 499 | 7,003
Tchem 486 | 1,890
Tclin 88 | 602

Collection

Eligible Kinase Proteins 15 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 228 | 633
embryonic lethality prior to t... 60 | 187
preweaning lethality, incomple... 60 | 260
embryonic lethality prior to o... 59 | 148
decreased body weight 51 | 174
decreased total body fat amoun... 50 | 186
decreased lean body mass 47 | 195
abnormal behavior 40 | 226
abnormal embryo size 38 | 112
decreased circulating glucose ... 31 | 121
increased circulating alkaline... 31 | 119
abnormal retina morphology 29 | 100
decreased bone mineral content 26 | 157
increased or absent threshold ... 26 | 128
abnormal bone structure 25 | 131
decreased bone mineral density 24 | 126
decreased grip strength 24 | 123
abnormal lens morphology 23 | 73
prenatal lethality prior to he... 23 | 64
increased grip strength 22 | 83
increased lean body mass 22 | 107
decreased circulating HDL chol... 21 | 77
increased mean corpuscular hem... 21 | 93
decreased circulating choleste... 20 | 85
decreased circulating triglyce... 20 | 83
decreased body length 18 | 108
hyperactivity 18 | 108
hypoactivity 18 | 89
enlarged heart 17 | 111
increased fasted circulating g... 17 | 68
increased mean corpuscular vol... 17 | 91
decreased circulating serum al... 16 | 79
short tibia 16 | 82
decreased fasted circulating g... 15 | 49
male infertility 15 | 62
abnormal coat/hair pigmentatio... 14 | 54
abnormal retinal pigmentation 14 | 61
decreased leukocyte cell numbe... 14 | 54
abnormal bone mineralization 13 | 55
decreased circulating LDL chol... 13 | 37
decreased circulating total pr... 13 | 41
decreased lumbar vertebrae num... 13 | 62
improved glucose tolerance 13 | 56
increased bone mineral content 13 | 92
decreased rib number 12 | 59
increased circulating choleste... 12 | 53
abnormal cranium morphology 11 | 32
abnormal sleep behavior 11 | 63
decreased circulating alkaline... 11 | 41
decreased circulating fructosa... 11 | 31
decreased mean corpuscular vol... 11 | 50
increased blood urea nitrogen ... 11 | 44
increased leukocyte cell numbe... 11 | 37
abnormal behavioral response t... 10 | 52
decreased Ly6C low monocyte nu... 10 | 23
decreased T cell number 10 | 31
decreased hemoglobin content 10 | 53
decreased neutrophil cell numb... 10 | 37
increased circulating chloride... 10 | 43
increased circulating phosphat... 10 | 24
increased hematocrit 10 | 36
abnormal eye morphology 9 | 38
abnormal gait 9 | 51
cataract 9 | 26
decreased CD4-positive, CD25-p... 9 | 24
decreased caudal vertebrae num... 9 | 49
decreased eosinophil cell numb... 9 | 41
decreased prepulse inhibition 9 | 52
impaired glucose tolerance 9 | 52
increased heart weight 9 | 37
increased rib number 9 | 41
increased sacral vertebrae num... 9 | 62
abnormal locomotor activation 8 | 26
abnormal neural tube closure 8 | 37
abnormal skin morphology 8 | 23
cardiovascular system phenotyp... 8 | 35
decreased NK T cell number 8 | 28
decreased circulating calcium ... 8 | 33
decreased circulating insulin ... 8 | 75
decreased erythrocyte cell num... 8 | 43
decreased mean corpuscular hem... 8 | 34
decreased threshold for audito... 8 | 32
increased CD4-positive, alpha ... 8 | 15
increased body length 8 | 20
increased bone mineral density 8 | 52
increased circulating HDL chol... 8 | 63
increased hemoglobin content 8 | 45
increased red blood cell distr... 8 | 21
increased startle reflex 8 | 38
increased total body fat amoun... 8 | 57
abnormal cornea morphology 7 | 24
abnormal epididymis morphology 7 | 31
anophthalmia 7 | 20
decreased circulating iron lev... 7 | 25
increased body weight 7 | 42
increased circulating sodium l... 7 | 71
increased exploration in new e... 7 | 56
small testis 7 | 37
thrombocytopenia 7 | 46
tremors 7 | 34

Disease

ovarian cancer 2,147 | 8,484
osteosarcoma 1,696 | 7,933
psoriasis 1,344 | 6,685
medulloblastoma, large-cell 1,298 | 6,234
glioblastoma 1,200 | 5,572
lung cancer 1,180 | 4,466
atypical teratoid / rhabdoid tumor 895 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 736 | 3,289
Breast cancer 709 | 3,094
malignant mesothelioma 669 | 3,162
Cancer 623 | 2,346
primitive neuroectodermal tumor 622 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 618 | 2,988
Multiple myeloma 596 | 1,327
oligodendroglioma 579 | 2,849
invasive ductal carcinoma 576 | 2,950
non-small cell lung cancer 573 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 559 | 2,956
pediatric high grade glioma 551 | 2,712
ependymoma 548 | 2,514
lung adenocarcinoma 532 | 2,713
pancreatic ductal adenocarcinoma liver metastasis 512 | 1,795
pancreatic cancer 508 | 2,300
group 3 medulloblastoma 507 | 2,254
pilocytic astrocytoma 470 | 3,086
astrocytic glioma 463 | 2,241
subependymal giant cell astrocytoma 462 | 2,287
astrocytoma 418 | 1,493
Pick disease 413 | 1,893
diabetes mellitus 412 | 1,663
acute quadriplegic myopathy 406 | 1,157
lung carcinoma 393 | 2,844
Carcinoma 368 | 2,147
group 4 medulloblastoma 365 | 1,875
ulcerative colitis 365 | 2,087
Waldenstrons macroglobulinemia 363 | 765
adult high grade glioma 356 | 2,148
dermatomyositis 339 | 933
breast carcinoma 335 | 1,614
colon cancer 335 | 1,475
juvenile dermatomyositis 316 | 1,189
ductal carcinoma in situ 314 | 1,745
medulloblastoma 308 | 1,524
primary pancreatic ductal adenocarcinoma 305 | 1,271
tuberculosis 300 | 1,557
adrenocortical carcinoma 297 | 1,427
sonic hedgehog group medulloblastoma 289 | 1,482
interstitial cystitis 287 | 2,299
pituitary cancer 287 | 1,972
Rheumatoid Arthritis 270 | 1,160
posterior fossa group A ependymoma 247 | 1,511
cystic fibrosis 242 | 1,665
atypical teratoid/rhabdoid tumor 232 | 1,095
acute myeloid leukemia 231 | 780
posterior fossa group B ependymoma 203 | 1,530
nasopharyngeal carcinoma 198 | 1,056
spina bifida 197 | 1,064
tuberculosis and treatment for 6 months 187 | 686
non primary Sjogren syndrome sicca 177 | 840
progressive supranuclear palsy 169 | 674
aldosterone-producing adenoma 159 | 664
Intellectual disability 156 | 573
cutaneous lupus erythematosus 156 | 1,056
Atopic dermatitis 153 | 944
active Crohn's disease 148 | 918
pancreatic carcinoma 146 | 567
primary Sjogren syndrome 146 | 789
Duchenne muscular dystrophy 145 | 602
Amyotrophic Lateral Sclerosis 144 | 431
esophageal adenocarcinoma 140 | 737
Alzheimer's disease 139 | 644
IGA Glomerulonephritis 135 | 454
gastric carcinoma 130 | 832
Mammary Neoplasms 127 | 410
Down syndrome 124 | 548
hepatocellular carcinoma 121 | 532
autosomal dominant Emery-Dreifuss muscular dystrophy 117 | 499
Obesity 115 | 616
gastric cancer 114 | 430
Endometriosis 112 | 535
Neurodegenerative disease 110 | 383
Prostatic Neoplasms 109 | 471
hereditary spastic paraplegia 102 | 313
Stomach Neoplasms 98 | 282
Liver carcinoma 90 | 217
Polycystic Ovary Syndrome 90 | 332
Parkinson's disease 89 | 364
Schizophrenia 84 | 501
non-small cell lung carcinoma 83 | 413
inflammatory breast cancer 80 | 404
chronic rhinosinusitis 77 | 512
fibroadenoma 76 | 557
Gaucher disease type 1 71 | 171
Vascular disease 71 | 281
mucosa-associated lymphoid tissue lymphoma 70 | 480
Multiple Sclerosis 67 | 498
tuberculosis and treatment for 3 months 66 | 327
Osteoporosis 64 | 257
Peripheral Neuropathy 63 | 303
Melanoma 62 | 261

Tissue

Nervous System 3,354 | 18,561
Digestive Tract 3,353 | 18,473
Female tissues 3,353 | 18,647
Blood and immune system 3,352 | 17,995
Endocrine System 3,350 | 18,512
Liver and Pancreas 3,350 | 18,136
Cardiovascular System 3,349 | 17,958
Male tissues 3,348 | 17,969
Urinary Tract 3,346 | 18,444
Respiratory system 3,333 | 17,484
Skin and soft tissues 3,320 | 18,115

Target Family

Non-IDG 1,946 | 11,971
Enzyme 971 | 4,146
Transcription Factor 148 | 1,400
Kinase 146 | 634
Epigenetic 91 | 242
Transporter 40 | 473
Nuclear Receptor 11 | 48
TF/Epigenetic 10 | 38
Ion Channel 6 | 341
GPCR 3 | 406

UniProt Keyword

Acetylation 3,372 | 3,372
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166