Development Level

Tbio 2,516 | 11,651
Tdark 421 | 6,593
Tchem 380 | 1,388
Tclin 92 | 612

Collection

RFA-RM-18-021 14 | 328
Kinase: IDG Consortium (Target... 13 | 125
Kinase: IDG Consortium (Comple... 9 | 37
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 374 | 979
preweaning lethality, incomple... 108 | 499
embryonic lethality prior to t... 94 | 278
embryonic lethality prior to o... 93 | 239
abnormal embryo size 70 | 220
abnormal behavior 65 | 298
decreased total body fat amoun... 57 | 207
decreased body weight 48 | 161
enlarged heart 43 | 210
abnormal bone structure 42 | 187
increased lean body mass 36 | 172
embryonic growth retardation 34 | 106
abnormal heart morphology 33 | 162
decreased circulating glucose ... 33 | 126
prenatal lethality prior to he... 32 | 87
hypoactivity 31 | 132
decreased bone mineral density 30 | 126
increased circulating alkaline... 30 | 122
decreased bone mineral content 29 | 151
increased startle reflex 28 | 112
male infertility 26 | 123
hyperactivity 25 | 148
abnormal lens morphology 24 | 81
decreased lean body mass 24 | 135
increased total body fat amoun... 24 | 134
decreased grip strength 23 | 116
increased mean corpuscular vol... 22 | 92
cataract 21 | 92
decreased circulating choleste... 21 | 93
decreased lymphocyte cell numb... 21 | 83
edema 21 | 59
increased bone mineral content 21 | 108
abnormal seminal vesicle morph... 20 | 114
decreased vertical activity 20 | 208
increased fasted circulating g... 20 | 76
short tibia 20 | 97
decreased circulating triglyce... 19 | 79
increased mean corpuscular hem... 19 | 96
decreased leukocyte cell numbe... 18 | 73
impaired glucose tolerance 18 | 75
increased circulating choleste... 18 | 66
abnormal coat-hair pigmentatio... 17 | 64
abnormal eye morphology 17 | 68
abnormal retina morphology 17 | 71
decreased circulating HDL chol... 17 | 68
decreased prepulse inhibition 17 | 82
increased or absent threshold ... 17 | 101
decreased circulating serum al... 16 | 82
decreased mean corpuscular vol... 16 | 79
pallor 16 | 34
decreased fasted circulating g... 15 | 65
improved glucose tolerance 15 | 79
increased circulating HDL chol... 15 | 80
increased grip strength 14 | 41
small superior vagus ganglion 14 | 74
abnormal craniofacial morpholo... 13 | 33
abnormal gait 13 | 69
decreased circulating total pr... 13 | 49
hemorrhage 13 | 23
increased heart weight 13 | 62
increased hematocrit 13 | 46
increased leukocyte cell numbe... 13 | 47
persistence of hyaloid vascula... 13 | 33
abnormal sleep behavior 12 | 70
anophthalmia 12 | 33
corneal opacity 12 | 32
decreased body length 12 | 101
decreased caudal vertebrae num... 12 | 53
decreased circulating LDL chol... 12 | 38
decreased circulating alkaline... 12 | 46
decreased neutrophil cell numb... 12 | 42
decreased red blood cell distr... 12 | 41
hydrometra 12 | 53
increased neutrophil cell numb... 12 | 46
small testis 12 | 58
thrombocytopenia 12 | 56
tremors 12 | 39
abnormal behavioral response t... 11 | 66
abnormal cranium morphology 11 | 36
abnormal kidney morphology 11 | 65
abnormal neural tube closure 11 | 46
abnormal skin morphology 11 | 50
decreased startle reflex 11 | 75
female infertility 11 | 60
increased bone mineral density 11 | 72
increased monocyte cell number 11 | 63
abnormal bone mineralization 10 | 38
abnormal cornea morphology 10 | 31
decreased blood urea nitrogen ... 10 | 51
decreased circulating insulin ... 10 | 76
decreased erythrocyte cell num... 10 | 62
decreased hematocrit 10 | 46
decreased hemoglobin content 10 | 68
increased blood urea nitrogen ... 10 | 48
increased body length 10 | 32
increased circulating sodium l... 10 | 71
increased erythrocyte cell num... 10 | 39
increased mean corpuscular hem... 10 | 36
increased mean platelet volume 10 | 45
prolonged QT interval 10 | 38

Disease

ovarian cancer 2,173 | 8,520
Carcinoma 2,051 | 11,493
osteosarcoma 1,724 | 7,950
psoriasis 1,361 | 6,694
medulloblastoma, large-cell 1,312 | 6,241
glioblastoma 1,251 | 5,792
lung cancer 1,227 | 4,740
atypical teratoid / rhabdoid tumor 1,070 | 5,112
group 3 medulloblastoma 881 | 4,104
ependymoma 867 | 4,679
Breast cancer 803 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 743 | 3,291
malignant mesothelioma 692 | 3,232
adult high grade glioma 682 | 3,801
Cancer 671 | 2,499
primitive neuroectodermal tumor 632 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 623 | 2,989
Multiple myeloma 604 | 1,332
non-small cell lung cancer 592 | 2,890
oligodendroglioma 583 | 2,850
invasive ductal carcinoma 581 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 565 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 560 | 1,962
astrocytic glioma 543 | 2,597
lung adenocarcinoma 540 | 2,716
pancreatic cancer 537 | 2,398
Kidney cancer 496 | 2,613
Astrocytoma, Pilocytic 475 | 3,081
subependymal giant cell astrocytoma 467 | 2,287
diabetes mellitus 433 | 1,728
Pick disease 427 | 1,894
acute quadriplegic myopathy 411 | 1,158
lung carcinoma 398 | 2,843
tuberculosis 385 | 2,010
Autosomal recessive predisposition 370 | 1,442
Waldenstrons macroglobulinemia 363 | 765
breast carcinoma 355 | 1,638
group 4 medulloblastoma 351 | 1,855
astrocytoma 350 | 1,146
dermatomyositis 341 | 966
colon cancer 340 | 1,478
ductal carcinoma in situ 320 | 1,745
ulcerative colitis 320 | 1,819
juvenile dermatomyositis 318 | 1,187
Intellectual disability 300 | 1,016
adrenocortical carcinoma 300 | 1,428
pituitary cancer 298 | 1,972
interstitial cystitis 289 | 2,312
primary pancreatic ductal adenocarcinoma 273 | 1,109
Rheumatoid arthritis 271 | 1,191
cystic fibrosis 253 | 1,696
acute myeloid leukemia 237 | 783
pediatric high grade glioma 235 | 1,064
Schizophrenia 222 | 1,160
Epilepsy 218 | 792
spina bifida 204 | 1,074
Cognitive delay 203 | 608
Global developmental delay 203 | 608
Mental and motor retardation 203 | 608
Dull intelligence 202 | 645
Low intelligence 202 | 645
Mental Retardation 202 | 645
Mental deficiency 202 | 645
Poor school performance 202 | 645
nasopharyngeal carcinoma 200 | 1,058
Muscle hypotonia 199 | 571
non primary Sjogren syndrome sicca 186 | 891
Liver Cirrhosis, Experimental 184 | 769
Seizures 176 | 596
progressive supranuclear palsy 174 | 676
aldosterone-producing adenoma 160 | 665
medulloblastoma 160 | 720
active Crohn's disease 158 | 922
cutaneous lupus erythematosus 156 | 1,057
Atopic dermatitis 154 | 952
Short stature 153 | 531
Amyotrophic lateral sclerosis 148 | 451
Alzheimer's disease 147 | 658
Duchenne muscular dystrophy 146 | 601
pancreatic carcinoma 143 | 562
esophageal adenocarcinoma 142 | 737
primary Sjogren syndrome 139 | 735
Obesity 138 | 678
Breast Neoplasms 135 | 445
Small head 131 | 374
Mammary Neoplasms 130 | 425
Failure to gain weight 128 | 365
Pediatric failure to thrive 128 | 365
hepatocellular carcinoma 128 | 547
Bipolar Disorder 126 | 666
gastric carcinoma 126 | 807
Down syndrome 122 | 499
gastric cancer 122 | 459
Neurodegenerative disease 121 | 414
autosomal dominant Emery-Dreifuss muscular dystrophy 121 | 510
tuberculosis and treatment for 6 months 121 | 409
Prostatic Neoplasms 119 | 495
active ulcerative colitis 115 | 764
Endometriosis 114 | 540
Stomach Neoplasms 110 | 300

Tissue

Endocrine System 3,377 | 18,159
Digestive Tract 3,372 | 17,369
Skin and soft tissues 3,371 | 17,230
Female tissues 3,365 | 17,400
Blood and immune system 3,363 | 16,909
Male tissues 3,361 | 17,142
Liver and Pancreas 3,359 | 16,750
Urinary Tract 3,354 | 16,678
Nervous System 3,344 | 16,725
Respiratory system 3,338 | 16,393
Cardiovascular System 3,292 | 15,192

Target Family

Non-IDG 1,961 | 12,091
Enzyme 989 | 4,145
Transcription Factor 149 | 1,400
Kinase 145 | 634
Epigenetic 93 | 242
Transporter 42 | 473
Nuclear Receptor 11 | 48
TF/Epigenetic 10 | 38
Ion Channel 6 | 344
GPCR 3 | 408

UniProt Keyword

Acetylation 3,409 | 3,409
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
Eukaryotic translation initiation factor 1 EIF1 Tbio Non-IDG -2.06392 118.5 92
Zinc finger protein 346 ZNF346 Tbio Non-IDG -2.28393 188.7 213
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90