Development Level

Tbio 725 | 11,178
Tchem 453 | 1,885
Tdark 134 | 6,569
Tclin 68 | 612

Collection

Kinase: IDG Consortium (Target... 114 | 125
Kinase: IDG Consortium (Comple... 37 | 37
Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

preweaning lethality, complete... 140 | 979
embryonic lethality prior to o... 45 | 239
preweaning lethality, incomple... 45 | 499
embryonic lethality prior to t... 42 | 278
abnormal embryo size 36 | 220
abnormal behavior 32 | 298
decreased body weight 23 | 161
abnormal bone structure 20 | 187
decreased bone mineral content 19 | 151
decreased lean body mass 18 | 135
embryonic growth retardation 18 | 106
increased total body fat amoun... 16 | 134
abnormal behavioral response t... 14 | 66
hyperactivity 14 | 148
decreased bone mineral density 13 | 126
decreased total body fat amoun... 13 | 207
decreased circulating glucose ... 12 | 126
enlarged heart 12 | 210
increased or absent threshold ... 12 | 101
decreased body length 11 | 101
decreased vertical activity 11 | 208
increased bone mineral content 11 | 108
male infertility 11 | 123
abnormal seminal vesicle morph... 10 | 114
decreased circulating choleste... 10 | 93
decreased grip strength 10 | 116
decreased prepulse inhibition 10 | 82
increased lean body mass 10 | 172
increased startle reflex 10 | 112
abnormal lens morphology 9 | 81
increased bone mineral density 9 | 72
increased circulating HDL chol... 9 | 80
increased circulating alkaline... 9 | 122
increased mean corpuscular hem... 9 | 96
increased mean corpuscular vol... 9 | 92
prenatal lethality prior to he... 9 | 87
decreased fasted circulating g... 8 | 65
decreased leukocyte cell numbe... 8 | 73
decreased lymphocyte cell numb... 8 | 83
impaired glucose tolerance 8 | 75
increased circulating choleste... 8 | 66
increased circulating sodium l... 8 | 71
increased fasted circulating g... 8 | 76
increased heart weight 8 | 62
abnormal coat-hair pigmentatio... 7 | 64
abnormal heart morphology 7 | 162
cataract 7 | 92
decreased circulating serum al... 7 | 82
decreased circulating total pr... 7 | 49
decreased circulating triglyce... 7 | 79
decreased mean corpuscular vol... 7 | 79
decreased neutrophil cell numb... 7 | 42
decreased startle reflex 7 | 75
increased hematocrit 7 | 46
small testis 7 | 58
abnormal bone mineralization 6 | 38
abnormal epididymis morphology 6 | 42
abnormal gait 6 | 69
abnormal neural tube closure 6 | 46
abnormal retina morphology 6 | 71
decreased circulating HDL chol... 6 | 68
decreased hemoglobin content 6 | 68
edema 6 | 59
hypoactivity 6 | 132
increased blood urea nitrogen ... 6 | 48
increased body length 6 | 32
increased erythrocyte cell num... 6 | 39
increased grip strength 6 | 41
short tibia 6 | 97
abnormal cranium morphology 5 | 36
abnormal embryo turning 5 | 31
abnormal kidney morphology 5 | 65
abnormal skin morphology 5 | 50
abnormal sleep behavior 5 | 70
abnormal spleen morphology 5 | 55
cardiovascular system phenotyp... 5 | 36
decreased blood urea nitrogen ... 5 | 51
decreased circulating alanine ... 5 | 47
decreased circulating alkaline... 5 | 46
decreased heart left ventricle... 5 | 28
decreased mean corpuscular hem... 5 | 50
decreased mean platelet volume 5 | 25
decreased red blood cell distr... 5 | 41
enlarged epididymis 5 | 31
enlarged lymph nodes 5 | 37
improved glucose tolerance 5 | 79
increased circulating chloride... 5 | 41
increased leukocyte cell numbe... 5 | 47
increased mean platelet volume 5 | 45
increased monocyte cell number 5 | 63
prenatal lethality 5 | 28
thin ventricular wall 5 | 24
abnormal eye morphology 4 | 68
decreased circulating aspartat... 4 | 34
decreased circulating calcium ... 4 | 36
decreased circulating creatini... 4 | 39
decreased hematocrit 4 | 46
increased hemoglobin content 4 | 45
microphthalmia 4 | 26
pallor 4 | 34

Disease

Carcinoma 1,127 | 11,192
ovarian cancer 746 | 8,297
osteosarcoma 695 | 7,766
medulloblastoma, large-cell 578 | 6,086
psoriasis 557 | 6,514
glioblastoma 504 | 5,635
lung cancer 476 | 4,607
atypical teratoid / rhabdoid tumor 456 | 4,971
Kidney cancer 396 | 2,548
ependymoma 390 | 4,559
group 3 medulloblastoma 373 | 4,002
Breast cancer 346 | 3,469
malignant mesothelioma 321 | 3,135
adult high grade glioma 316 | 3,701
Cancer 294 | 2,388
primitive neuroectodermal tumor 291 | 2,957
intraductal papillary-mucinous neoplasm (IPMN) 281 | 3,204
non-small cell lung cancer 281 | 2,799
intraductal papillary-mucinous carcinoma (IPMC) 261 | 2,902
invasive ductal carcinoma 243 | 2,867
Astrocytoma, Pilocytic 242 | 3,006
oligodendroglioma 235 | 2,768
intraductal papillary-mucinous adenoma (IPMA) 229 | 2,872
lung adenocarcinoma 229 | 2,627
lung carcinoma 218 | 2,755
astrocytic glioma 212 | 2,530
pancreatic cancer 197 | 2,322
Autosomal recessive predisposition 186 | 1,407
Pick disease 181 | 1,856
subependymal giant cell astrocytoma 169 | 2,230
interstitial cystitis 157 | 2,237
adrenocortical carcinoma 150 | 1,385
ulcerative colitis 150 | 1,765
tuberculosis 147 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 146 | 1,911
pituitary cancer 144 | 1,915
group 4 medulloblastoma 143 | 1,806
ductal carcinoma in situ 139 | 1,686
colon cancer 138 | 1,428
Multiple myeloma 135 | 1,296
cystic fibrosis 131 | 1,629
diabetes mellitus 130 | 1,683
breast carcinoma 129 | 1,589
Intellectual disability 127 | 998
juvenile dermatomyositis 120 | 1,147
Rheumatoid arthritis 113 | 1,156
Schizophrenia 113 | 1,136
acute quadriplegic myopathy 112 | 1,133
astrocytoma 112 | 1,113
Liver cancer 107 | 589
nasopharyngeal carcinoma 107 | 1,024
Epilepsy 104 | 775
dermatomyositis 103 | 941
pediatric high grade glioma 99 | 1,035
Dull intelligence 97 | 634
Low intelligence 97 | 634
Mental Retardation 97 | 634
Mental deficiency 97 | 634
Poor school performance 97 | 634
Melanoma 91 | 689
Waldenstrons macroglobulinemia 90 | 742
Cognitive delay 85 | 596
Global developmental delay 85 | 596
Mental and motor retardation 85 | 596
Seizures 81 | 584
primary pancreatic ductal adenocarcinoma 80 | 1,071
spina bifida 80 | 1,053
Renal Cell Carcinoma 77 | 211
primary Sjogren syndrome 77 | 710
Atopic dermatitis 74 | 915
Muscle hypotonia 74 | 562
Skin cancer 74 | 451
Small head 74 | 366
Bipolar Disorder 73 | 646
medulloblastoma 73 | 702
progressive supranuclear palsy 73 | 656
Short stature 72 | 514
cutaneous lupus erythematosus 72 | 1,016
active Crohn's disease 64 | 882
Endometriosis 63 | 521
Failure to gain weight 63 | 359
Pediatric failure to thrive 63 | 359
Endometrial cancer 59 | 301
Neurodegenerative disease 59 | 402
acute myeloid leukemia 59 | 760
esophageal adenocarcinoma 59 | 696
Alzheimer's disease 58 | 640
Colorectal Neoplasms 57 | 235
Chronic Myelocytic Leukemia Accelerated Phase 55 | 59
aldosterone-producing adenoma 55 | 646
non primary Sjogren syndrome sicca 55 | 861
Blastic phase chronic myeloid leukemia 54 | 58
Liver Cirrhosis, Experimental 53 | 733
Down syndrome 52 | 480
Breast Neoplasms 51 | 423
Hypoplastic mandible condyle 51 | 273
Mandibular hypoplasia 51 | 273
Micrognathism 51 | 273
Obesity 50 | 655
gastric carcinoma 50 | 781

Tissue

Endocrine System 1,358 | 18,159
Digestive Tract 1,328 | 17,369
Female tissues 1,326 | 17,400
Skin and soft tissues 1,326 | 17,230
Male tissues 1,324 | 17,142
Blood and immune system 1,306 | 16,909
Liver and Pancreas 1,306 | 16,750
Urinary Tract 1,304 | 16,678
Nervous System 1,299 | 16,725
Respiratory system 1,292 | 16,393
Cardiovascular System 1,241 | 15,192

Target Family

Kinase 593 | 634
Enzyme 337 | 4,145
Non-IDG 334 | 12,091
Transporter 82 | 473
Epigenetic 18 | 242
Ion Channel 16 | 344

UniProt Keyword

ATP-binding 1,380 | 1,380
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable gluconokinase IDNK Tbio Kinase -1.00330 9.91 94
Ryanodine receptor 1 RYR1 Tclin Ion Channel -3.00978 1018.9 103
ATP-dependent DNA helicase DDX11 DDX11 Tbio Enzyme -1.05592 30.0 163
Protein monoglycylase TTLL8 TTLL8 Tdark Enzyme -0.12494 0.88 19
Chromodomain-helicase-DNA-binding protein 6 CHD6 Tbio Epigenetic -1.01113 11.4 31
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Serine/threonine-protein kinase D1 PRKD1 Tchem Kinase -2.88440 775.2 667
Serine/threonine-protein kinase N1 PKN1 Tchem Kinase -2.03368 117.6 153
2-5A-dependent ribonuclease RNASEL Tchem Kinase -2.71673 525.8 127
Serine/threonine-protein kinase N2 PKN2 Tchem Kinase -2.01264 103.6 159