Development Level

Tbio 709 | 10,625
Tchem 455 | 1,890
Tdark 148 | 7,003
Tclin 65 | 602

Collection

Eligible Kinase Proteins 120 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 96 | 633
embryonic lethality prior to o... 31 | 148
embryonic lethality prior to t... 29 | 187
abnormal behavior 26 | 226
decreased lean body mass 24 | 195
decreased body weight 23 | 174
preweaning lethality, incomple... 22 | 260
abnormal embryo size 19 | 112
decreased bone mineral content 15 | 157
decreased total body fat amoun... 15 | 186
decreased body length 14 | 108
increased circulating alkaline... 13 | 119
increased or absent threshold ... 13 | 128
decreased grip strength 12 | 123
abnormal behavioral response t... 11 | 52
abnormal bone structure 11 | 131
increased grip strength 11 | 83
abnormal retina morphology 10 | 100
decreased circulating glucose ... 10 | 121
abnormal lens morphology 9 | 73
decreased circulating choleste... 9 | 85
decreased circulating serum al... 9 | 79
hyperactivity 9 | 108
increased bone mineral content 9 | 92
increased circulating HDL chol... 9 | 63
increased mean corpuscular hem... 9 | 93
abnormal bone mineralization 8 | 55
decreased bone mineral density 8 | 126
decreased circulating triglyce... 8 | 83
increased blood urea nitrogen ... 8 | 44
increased circulating choleste... 8 | 53
abnormal retinal pigmentation 7 | 61
abnormal seminal vesicle morph... 7 | 47
enlarged heart 7 | 111
increased circulating chloride... 7 | 43
increased circulating sodium l... 7 | 71
increased lean body mass 7 | 107
male infertility 7 | 62
abnormal gait 6 | 51
decreased blood urea nitrogen ... 6 | 31
decreased circulating HDL chol... 6 | 77
increased fasted circulating g... 6 | 68
increased mean corpuscular vol... 6 | 91
increased total body fat amoun... 6 | 57
prenatal lethality prior to he... 6 | 64
short tibia 6 | 82
small testis 6 | 37
abnormal coat/hair pigmentatio... 5 | 54
abnormal hindbrain development 5 | 24
abnormal kidney morphology 5 | 30
abnormal neural tube closure 5 | 37
abnormal sleep behavior 5 | 63
cardiovascular system phenotyp... 5 | 35
decreased leukocyte cell numbe... 5 | 54
decreased prepulse inhibition 5 | 52
hypoactivity 5 | 89
increased circulating potassiu... 5 | 31
increased erythrocyte cell num... 5 | 26
increased exploration in new e... 5 | 56
increased heart weight 5 | 37
increased hemoglobin content 5 | 45
abnormal cranium morphology 4 | 32
abnormal forebrain development 4 | 18
abnormal maxilla morphology 4 | 16
abnormal midbrain development 4 | 22
abnormal response to tactile s... 4 | 16
abnormal snout morphology 4 | 18
abnormal tooth morphology 4 | 24
anophthalmia 4 | 20
decreased circulating alanine ... 4 | 53
decreased circulating aspartat... 4 | 27
decreased circulating creatini... 4 | 31
decreased circulating total pr... 4 | 41
decreased fasted circulating g... 4 | 49
decreased heart weight 4 | 44
decreased hemoglobin content 4 | 53
decreased lumbar vertebrae num... 4 | 62
decreased neutrophil cell numb... 4 | 37
decreased startle reflex 4 | 48
female infertility 4 | 34
impaired glucose tolerance 4 | 52
improved glucose tolerance 4 | 56
increased NK cell number 4 | 19
increased bone mineral density 4 | 52
increased hematocrit 4 | 36
increased leukocyte cell numbe... 4 | 37
microphthalmia 4 | 15
abnormal epididymis morphology 3 | 31
abnormal spleen morphology 3 | 36
abnormal vocalization 3 | 21
decreased caudal vertebrae num... 3 | 49
decreased circulating glycerol... 3 | 19
decreased red blood cell distr... 3 | 11
increased NK T cell number 3 | 11
increased body weight 3 | 42
increased circulating aspartat... 3 | 17
increased circulating bilirubi... 3 | 16
increased circulating iron lev... 3 | 25
thrombocytopenia 3 | 46
tremors 3 | 34

Disease

ovarian cancer 741 | 8,484
osteosarcoma 698 | 7,933
medulloblastoma, large-cell 578 | 6,234
psoriasis 559 | 6,685
glioblastoma 489 | 5,572
lung cancer 450 | 4,466
atypical teratoid / rhabdoid tumor 386 | 4,369
Carcinoma 354 | 2,147
malignant mesothelioma 315 | 3,162
primitive neuroectodermal tumor 293 | 3,031
Cancer 283 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 282 | 3,289
Breast cancer 281 | 3,094
non-small cell lung cancer 278 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 264 | 2,988
pediatric high grade glioma 260 | 2,712
invasive ductal carcinoma 243 | 2,950
pilocytic astrocytoma 243 | 3,086
oligodendroglioma 239 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 232 | 2,956
lung adenocarcinoma 229 | 2,713
ependymoma 225 | 2,514
lung carcinoma 219 | 2,844
group 3 medulloblastoma 211 | 2,254
astrocytic glioma 186 | 2,241
Pick disease 183 | 1,893
pancreatic cancer 177 | 2,300
ulcerative colitis 173 | 2,087
subependymal giant cell astrocytoma 166 | 2,287
interstitial cystitis 158 | 2,299
adult high grade glioma 155 | 2,148
adrenocortical carcinoma 150 | 1,427
astrocytoma 143 | 1,493
pituitary cancer 143 | 1,972
medulloblastoma 140 | 1,524
colon cancer 139 | 1,475
group 4 medulloblastoma 139 | 1,875
ductal carcinoma in situ 138 | 1,745
Multiple myeloma 134 | 1,327
posterior fossa group B ependymoma 134 | 1,530
pancreatic ductal adenocarcinoma liver metastasis 131 | 1,795
cystic fibrosis 128 | 1,665
diabetes mellitus 127 | 1,663
sonic hedgehog group medulloblastoma 127 | 1,482
breast carcinoma 121 | 1,614
juvenile dermatomyositis 120 | 1,189
posterior fossa group A ependymoma 114 | 1,511
tuberculosis 114 | 1,557
Rheumatoid Arthritis 112 | 1,160
acute quadriplegic myopathy 112 | 1,157
nasopharyngeal carcinoma 104 | 1,056
dermatomyositis 103 | 933
atypical teratoid/rhabdoid tumor 102 | 1,095
primary pancreatic ductal adenocarcinoma 97 | 1,271
Waldenstrons macroglobulinemia 90 | 765
spina bifida 80 | 1,064
primary Sjogren syndrome 77 | 789
progressive supranuclear palsy 74 | 674
Atopic dermatitis 73 | 944
cutaneous lupus erythematosus 73 | 1,056
Renal Cell Carcinoma 72 | 199
Intellectual disability 66 | 573
tuberculosis and treatment for 6 months 65 | 686
IGA Glomerulonephritis 64 | 454
active Crohn's disease 62 | 918
Endometriosis 61 | 535
Neurodegenerative disease 58 | 383
acute myeloid leukemia 58 | 780
esophageal adenocarcinoma 58 | 737
Alzheimer's disease 56 | 644
Down syndrome 56 | 548
Chronic Myelocytic Leukemia Accelerated Phase 55 | 59
Colorectal Neoplasms 55 | 217
Peripheral Neuropathy 55 | 303
aldosterone-producing adenoma 55 | 664
non primary Sjogren syndrome sicca 55 | 840
Blastic phase chronic myeloid leukemia 54 | 58
Obesity 49 | 616
chronic rhinosinusitis 49 | 512
gastric carcinoma 49 | 832
Gastrointestinal stromal tumor 47 | 61
Amyotrophic Lateral Sclerosis 46 | 431
Mammary Neoplasms 46 | 410
Parkinson's disease 43 | 364
Philadelphia chromosome-positive acute lymphoblastic leukemia 43 | 47
Schizophrenia 43 | 501
Pancreatic Neuroendocrine Tumor 42 | 45
Prostatic Neoplasms 42 | 471
non-small cell lung carcinoma 42 | 413
Chronic phase chronic myeloid leukemia 41 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 41 | 45
Vascular disease 39 | 281
fibroadenoma 39 | 557
pancreatic carcinoma 39 | 567
Hamman-Rich syndrome 35 | 35
hepatocellular carcinoma 35 | 532
Epilepsy 34 | 346
Kidney disease 33 | 396
Neuropathy 32 | 210
gastric cancer 30 | 430

Tissue

Nervous System 1,354 | 18,561
Blood and immune system 1,353 | 17,995
Digestive Tract 1,352 | 18,473
Endocrine System 1,352 | 18,512
Female tissues 1,352 | 18,647
Liver and Pancreas 1,351 | 18,136
Male tissues 1,351 | 17,969
Urinary Tract 1,351 | 18,444
Cardiovascular System 1,349 | 17,958
Skin and soft tissues 1,339 | 18,115
Respiratory system 1,337 | 17,484

Target Family

Kinase 593 | 634
Enzyme 336 | 4,146
Non-IDG 333 | 11,971
Transporter 82 | 473
Epigenetic 18 | 242
Ion Channel 15 | 341

UniProt Keyword

ATP-binding 1,377 | 1,377
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Insulin receptor-related protein INSRR Tchem Kinase -1.96888 93.2 241
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Uridine-cytidine kinase 2 UCK2 Tbio Kinase -1.39159 27.7 106
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
ATP-binding cassette sub-family A member 2 ABCA2 Tbio Transporter -1.41708 32.2 125
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.80191 64.7 120