Development Level

Tbio 729 | 11,445
Tchem 448 | 1,598
Tdark 134 | 6,588
Tclin 69 | 613

Collection

Kinase: IDG Consortium (Target... 114 | 125
Kinase: IDG Consortium (Comple... 37 | 37
Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

preweaning lethality, complete... 140 | 979
embryonic lethality prior to o... 45 | 239
preweaning lethality, incomple... 45 | 499
embryonic lethality prior to t... 42 | 278
abnormal embryo size 36 | 220
abnormal behavior 32 | 298
decreased body weight 23 | 161
abnormal bone structure 20 | 187
decreased bone mineral content 19 | 151
decreased lean body mass 18 | 135
embryonic growth retardation 18 | 106
increased total body fat amoun... 16 | 134
abnormal behavioral response t... 14 | 66
hyperactivity 14 | 148
decreased bone mineral density 13 | 126
decreased total body fat amoun... 13 | 207
decreased circulating glucose ... 12 | 126
enlarged heart 12 | 210
increased or absent threshold ... 12 | 101
decreased body length 11 | 101
decreased vertical activity 11 | 208
increased bone mineral content 11 | 108
male infertility 11 | 123
abnormal seminal vesicle morph... 10 | 114
decreased circulating choleste... 10 | 93
decreased grip strength 10 | 116
decreased prepulse inhibition 10 | 82
increased lean body mass 10 | 172
increased startle reflex 10 | 112
abnormal lens morphology 9 | 81
increased bone mineral density 9 | 72
increased circulating HDL chol... 9 | 80
increased circulating alkaline... 9 | 122
increased mean corpuscular hem... 9 | 96
increased mean corpuscular vol... 9 | 92
prenatal lethality prior to he... 9 | 87
decreased fasted circulating g... 8 | 65
decreased leukocyte cell numbe... 8 | 73
decreased lymphocyte cell numb... 8 | 83
impaired glucose tolerance 8 | 75
increased circulating choleste... 8 | 66
increased circulating sodium l... 8 | 71
increased fasted circulating g... 8 | 76
increased heart weight 8 | 62
abnormal coat-hair pigmentatio... 7 | 64
abnormal heart morphology 7 | 162
cataract 7 | 92
decreased circulating serum al... 7 | 82
decreased circulating total pr... 7 | 49
decreased circulating triglyce... 7 | 79
decreased mean corpuscular vol... 7 | 79
decreased neutrophil cell numb... 7 | 42
decreased startle reflex 7 | 75
increased hematocrit 7 | 46
small testis 7 | 58
abnormal bone mineralization 6 | 38
abnormal epididymis morphology 6 | 42
abnormal gait 6 | 69
abnormal neural tube closure 6 | 46
abnormal retina morphology 6 | 71
decreased circulating HDL chol... 6 | 68
decreased hemoglobin content 6 | 68
edema 6 | 59
hypoactivity 6 | 132
increased blood urea nitrogen ... 6 | 48
increased body length 6 | 32
increased erythrocyte cell num... 6 | 39
increased grip strength 6 | 41
short tibia 6 | 97
abnormal cranium morphology 5 | 36
abnormal embryo turning 5 | 31
abnormal kidney morphology 5 | 65
abnormal skin morphology 5 | 50
abnormal sleep behavior 5 | 70
abnormal spleen morphology 5 | 55
cardiovascular system phenotyp... 5 | 36
decreased blood urea nitrogen ... 5 | 51
decreased circulating alanine ... 5 | 47
decreased circulating alkaline... 5 | 46
decreased heart left ventricle... 5 | 28
decreased mean corpuscular hem... 5 | 50
decreased mean platelet volume 5 | 25
decreased red blood cell distr... 5 | 41
enlarged epididymis 5 | 31
enlarged lymph nodes 5 | 37
improved glucose tolerance 5 | 79
increased circulating chloride... 5 | 41
increased leukocyte cell numbe... 5 | 47
increased mean platelet volume 5 | 45
increased monocyte cell number 5 | 63
prenatal lethality 5 | 28
thin ventricular wall 5 | 24
abnormal eye morphology 4 | 68
decreased circulating aspartat... 4 | 34
decreased circulating calcium ... 4 | 36
decreased circulating creatini... 4 | 39
decreased hematocrit 4 | 46
increased hemoglobin content 4 | 45
microphthalmia 4 | 26
pallor 4 | 34

Disease

Carcinoma 1,135 | 11,493
ovarian cancer 754 | 8,520
osteosarcoma 699 | 7,950
medulloblastoma, large-cell 582 | 6,241
psoriasis 561 | 6,694
glioblastoma 508 | 5,792
lung cancer 479 | 4,740
atypical teratoid / rhabdoid tumor 461 | 5,112
Kidney cancer 396 | 2,613
ependymoma 396 | 4,679
group 3 medulloblastoma 377 | 4,104
Breast cancer 346 | 3,578
malignant mesothelioma 325 | 3,232
adult high grade glioma 319 | 3,801
Cancer 297 | 2,499
primitive neuroectodermal tumor 295 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 283 | 3,291
non-small cell lung cancer 282 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 264 | 2,989
Astrocytoma, Pilocytic 245 | 3,081
invasive ductal carcinoma 245 | 2,951
oligodendroglioma 240 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 232 | 2,955
lung adenocarcinoma 229 | 2,716
astrocytic glioma 220 | 2,597
lung carcinoma 220 | 2,843
pancreatic cancer 198 | 2,398
Autosomal recessive predisposition 189 | 1,442
Pick disease 184 | 1,894
subependymal giant cell astrocytoma 170 | 2,287
interstitial cystitis 159 | 2,312
ulcerative colitis 153 | 1,819
adrenocortical carcinoma 151 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 149 | 1,962
tuberculosis 148 | 2,010
group 4 medulloblastoma 144 | 1,855
pituitary cancer 144 | 1,972
colon cancer 140 | 1,478
ductal carcinoma in situ 140 | 1,745
Multiple myeloma 136 | 1,332
diabetes mellitus 133 | 1,728
cystic fibrosis 132 | 1,696
breast carcinoma 129 | 1,638
Intellectual disability 127 | 1,016
juvenile dermatomyositis 120 | 1,187
Rheumatoid arthritis 114 | 1,191
Schizophrenia 113 | 1,160
acute quadriplegic myopathy 112 | 1,158
astrocytoma 112 | 1,146
Liver cancer 107 | 604
nasopharyngeal carcinoma 107 | 1,058
Epilepsy 104 | 792
dermatomyositis 104 | 966
pediatric high grade glioma 100 | 1,064
Dull intelligence 97 | 645
Low intelligence 97 | 645
Mental Retardation 97 | 645
Mental deficiency 97 | 645
Poor school performance 97 | 645
Melanoma 91 | 711
Waldenstrons macroglobulinemia 90 | 765
Cognitive delay 86 | 608
Global developmental delay 86 | 608
Mental and motor retardation 86 | 608
Seizures 81 | 596
primary pancreatic ductal adenocarcinoma 81 | 1,109
spina bifida 80 | 1,074
Renal Cell Carcinoma 78 | 214
primary Sjogren syndrome 77 | 735
Muscle hypotonia 75 | 571
Atopic dermatitis 74 | 952
Skin cancer 74 | 469
Small head 74 | 374
progressive supranuclear palsy 74 | 676
Bipolar Disorder 73 | 666
Short stature 73 | 531
cutaneous lupus erythematosus 73 | 1,057
medulloblastoma 73 | 720
active Crohn's disease 64 | 922
Endometriosis 63 | 540
Failure to gain weight 63 | 365
Pediatric failure to thrive 63 | 365
Neurodegenerative disease 62 | 414
Endometrial cancer 59 | 311
acute myeloid leukemia 59 | 783
esophageal adenocarcinoma 59 | 737
Alzheimer's disease 58 | 658
Colorectal Neoplasms 57 | 243
Chronic Myelocytic Leukemia Accelerated Phase 55 | 59
aldosterone-producing adenoma 55 | 665
non primary Sjogren syndrome sicca 55 | 891
Blastic phase chronic myeloid leukemia 54 | 58
Liver Cirrhosis, Experimental 53 | 769
Down syndrome 52 | 499
Breast Neoplasms 51 | 445
Hypoplastic mandible condyle 51 | 275
Mandibular hypoplasia 51 | 275
Micrognathism 51 | 275
Obesity 51 | 678
gastric carcinoma 50 | 807

Tissue

Endocrine System 1,358 | 18,159
Digestive Tract 1,328 | 17,369
Female tissues 1,326 | 17,400
Skin and soft tissues 1,326 | 17,230
Male tissues 1,324 | 17,142
Blood and immune system 1,306 | 16,909
Liver and Pancreas 1,306 | 16,750
Urinary Tract 1,304 | 16,678
Nervous System 1,299 | 16,725
Respiratory system 1,292 | 16,393
Cardiovascular System 1,241 | 15,192

Target Family

Kinase 593 | 634
Enzyme 337 | 4,145
Non-IDG 334 | 12,091
Transporter 82 | 473
Epigenetic 18 | 242
Ion Channel 16 | 344

UniProt Keyword

ATP-binding 1,380 | 1,380
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Adenylate kinase 2, mitochondrial AK2 Tbio Kinase -2.00007 98.7 330
IQ and AAA domain-containing protein 1 IQCA1 Tbio Non-IDG -0.80618 5.26 77
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
NACHT domain- and WD repeat-containing protein 1 NWD1 Tdark Non-IDG 0.08 1.22 3
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
E3 ubiquitin-protein ligase SHPRH SHPRH Tbio Epigenetic -0.99196 10.7 137
Serine/threonine-protein kinase tousled-like 1 TLK1 Tchem Kinase -1.25235 19.2 305
Serine/threonine-protein kinase MRCK beta CDC42BPB Tbio Kinase -0.59618 3.72 111
Nicotinamide riboside kinase 1 NMRK1 Tbio Kinase -0.84939 6.66 143