Development Level

Tbio 116 | 10,625
Tdark 112 | 7,003
Tchem 28 | 1,890
Tclin 2 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 8 | 633
abnormal behavior 5 | 226
decreased body weight 4 | 174
decreased circulating amylase ... 4 | 24
decreased circulating insulin ... 4 | 75
decreased lean body mass 4 | 195
hyperactivity 4 | 108
increased grip strength 4 | 83
preweaning lethality, incomple... 4 | 260
abnormal gait 3 | 51
decreased blood urea nitrogen ... 3 | 31
decreased bone mineral density 3 | 126
decreased circulating glucose ... 3 | 121
decreased circulating triglyce... 3 | 83
decreased grip strength 3 | 123
decreased total body fat amoun... 3 | 186
increased bone mineral content 3 | 92
increased or absent threshold ... 3 | 128
short tibia 3 | 82
abnormal cornea morphology 2 | 24
abnormal embryo size 2 | 112
abnormal lens morphology 2 | 73
abnormal response to new envir... 2 | 8
abnormal seminal vesicle morph... 2 | 47
absent pinna reflex 2 | 21
cataract 2 | 26
corneal opacity 2 | 25
decreased body length 2 | 108
decreased circulating alanine ... 2 | 53
decreased circulating serum al... 2 | 79
decreased leukocyte cell numbe... 2 | 54
decreased prepulse inhibition 2 | 52
decreased startle reflex 2 | 48
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
enlarged heart 2 | 111
increased hemoglobin content 2 | 45
increased lean body mass 2 | 107
increased neutrophil cell numb... 2 | 15
limb grasping 2 | 35
abnormal QRS complex 1 | 25
abnormal allantois morphology 1 | 3
abnormal behavioral response t... 1 | 52
abnormal cranium morphology 1 | 32
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal eyelid morphology 1 | 6
abnormal femur morphology 1 | 14
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 20
abnormal heart morphology 1 | 51
abnormal iris morphology 1 | 12
abnormal limb bud morphology 1 | 15
abnormal locomotor activation 1 | 26
abnormal motor capabilities/co... 1 | 4
abnormal neural tube closure 1 | 37
abnormal neural tube morpholog... 1 | 8
abnormal pelvic girdle bone mo... 1 | 11
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal snout morphology 1 | 18
abnormal tail bud morphology 1 | 6
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 17
absent teeth 1 | 4
corneal vascularization 1 | 5
cystolithiasis 1 | 1
decreased Ly6C low monocyte nu... 1 | 23
decreased circulating bilirubi... 1 | 14
decreased circulating glycerol... 1 | 19
decreased circulating sodium l... 1 | 18
decreased mean corpuscular hem... 1 | 19
decreased rib number 1 | 59
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
hypoactivity 1 | 89
increased CD4-positive, CD25-p... 1 | 18
increased Ly6C high monocyte n... 1 | 12
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased leukocyte cell numbe... 1 | 37
increased mean platelet volume 1 | 19
increased respiratory quotient 1 | 12
increased rib number 1 | 41
increased vertical activity 1 | 18
lethargy 1 | 5
pallor 1 | 13
persistence of hyaloid vascula... 1 | 22
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
small thymus 1 | 11
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

osteosarcoma 105 | 7,933
ovarian cancer 104 | 8,484
medulloblastoma, large-cell 82 | 6,234
glioblastoma 80 | 5,572
atypical teratoid / rhabdoid tumor 72 | 4,369
psoriasis 67 | 6,685
Carcinoma 57 | 2,147
pilocytic astrocytoma 48 | 3,086
primitive neuroectodermal tumor 47 | 3,031
lung cancer 46 | 4,466
oligodendroglioma 46 | 2,849
malignant mesothelioma 43 | 3,162
adult high grade glioma 41 | 2,148
ependymoma 38 | 2,514
group 4 medulloblastoma 37 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,289
invasive ductal carcinoma 36 | 2,950
lung carcinoma 35 | 2,844
astrocytic glioma 33 | 2,241
pediatric high grade glioma 32 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,988
non-small cell lung cancer 31 | 2,798
subependymal giant cell astrocytoma 31 | 2,287
Breast cancer 30 | 3,094
Cancer 30 | 2,346
pancreatic cancer 28 | 2,300
Rheumatoid Arthritis 26 | 1,160
lung adenocarcinoma 26 | 2,713
tuberculosis 26 | 1,557
Pick disease 24 | 1,893
interstitial cystitis 24 | 2,299
cystic fibrosis 22 | 1,665
medulloblastoma 22 | 1,524
spina bifida 22 | 1,064
pituitary cancer 21 | 1,972
sonic hedgehog group medulloblastoma 21 | 1,482
ductal carcinoma in situ 20 | 1,745
juvenile dermatomyositis 20 | 1,189
astrocytoma 19 | 1,493
breast carcinoma 19 | 1,614
colon cancer 19 | 1,475
ulcerative colitis 19 | 2,087
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,795
posterior fossa group B ependymoma 18 | 1,530
acute quadriplegic myopathy 17 | 1,157
posterior fossa group A ependymoma 16 | 1,511
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 499
adrenocortical carcinoma 14 | 1,427
atypical teratoid/rhabdoid tumor 14 | 1,095
cutaneous lupus erythematosus 12 | 1,056
dermatomyositis 12 | 933
nasopharyngeal carcinoma 12 | 1,056
primary pancreatic ductal adenocarcinoma 12 | 1,271
Duchenne muscular dystrophy 11 | 602
acute myeloid leukemia 11 | 780
group 3 medulloblastoma 11 | 2,254
pancreatic carcinoma 11 | 567
Alzheimer's disease 10 | 644
Atopic dermatitis 10 | 944
Schizophrenia 10 | 501
diabetes mellitus 10 | 1,663
Heart disease 9 | 279
fibroadenoma 9 | 557
gastric carcinoma 9 | 832
primary Sjogren syndrome 9 | 789
progressive supranuclear palsy 9 | 674
Hypertension 8 | 287
Intellectual disability 8 | 573
gastric cancer 8 | 430
non primary Sjogren syndrome sicca 8 | 840
Amyotrophic Lateral Sclerosis 7 | 431
Down syndrome 7 | 548
active Crohn's disease 7 | 918
aldosterone-producing adenoma 7 | 664
chronic rhinosinusitis 7 | 512
head and neck cancer 7 | 270
tuberculosis and treatment for 6 months 7 | 686
Mammary Neoplasms 6 | 410
Multiple Sclerosis 6 | 498
Multiple myeloma 6 | 1,327
Neurodegenerative disease 6 | 383
esophageal adenocarcinoma 6 | 737
hepatocellular carcinoma 6 | 532
nephrosclerosis 6 | 329
Autistic Disorder 5 | 320
Cerebrovascular disease 5 | 231
Crohn's disease 5 | 304
Dentin sensitivity 5 | 14
Kidney disease 5 | 396
Lung Neoplasms 5 | 171
Melanoma 5 | 261
Obesity 5 | 616
Polycystic kidney disease 5 | 54
glioblastoma multiforme 5 | 347
non-small cell lung carcinoma 5 | 413
tuberculosis and treatment for 3 months 5 | 327
urothelial carcinoma 5 | 318
Migraine 4 | 79
non diabetic and post-ischemic heart failure 4 | 200

Tissue

Nervous System 248 | 18,561
Blood and immune system 247 | 17,995
Endocrine System 247 | 18,512
Female tissues 247 | 18,647
Digestive Tract 246 | 18,473
Urinary Tract 246 | 18,444
Cardiovascular System 244 | 17,958
Liver and Pancreas 244 | 18,136
Male tissues 244 | 17,969
Skin and soft tissues 239 | 18,115
Respiratory system 238 | 17,484

Target Family

Non-IDG 185 | 11,971
Enzyme 45 | 4,146
Ion Channel 13 | 341
Kinase 8 | 634
Transcription Factor 4 | 1,400
Epigenetic 3 | 242

UniProt Keyword

ANK repeat 258 | 258
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

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