Development Level

Tbio 123 | 11,445
Tdark 105 | 6,588
Tchem 28 | 1,598
Tclin 2 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
decreased circulating insulin ... 6 | 76
increased lean body mass 6 | 172
preweaning lethality, incomple... 6 | 499
embryonic lethality prior to t... 5 | 278
increased neutrophil cell numb... 5 | 46
short tibia 5 | 97
abnormal bone structure 4 | 187
abnormal embryo size 4 | 220
decreased circulating amylase ... 4 | 28
decreased prepulse inhibition 4 | 82
hyperactivity 4 | 148
abnormal behavior 3 | 298
abnormal coat-hair pigmentatio... 3 | 64
abnormal gait 3 | 69
abnormal heart morphology 3 | 162
abnormal seminal vesicle morph... 3 | 114
decreased blood urea nitrogen ... 3 | 51
decreased body weight 3 | 161
decreased lean body mass 3 | 135
decreased startle reflex 3 | 75
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
enlarged heart 3 | 210
increased bone mineral content 3 | 108
increased total body fat amoun... 3 | 134
abnormal cornea morphology 2 | 31
abnormal iris morphology 2 | 13
abnormal lens morphology 2 | 81
abnormal pericardium morpholog... 2 | 26
abnormal response to new envir... 2 | 10
abnormal vertebrae morphology 2 | 18
abnormal vitelline vasculature... 2 | 6
absent pinna reflex 2 | 23
cataract 2 | 92
corneal opacity 2 | 32
decreased body length 2 | 101
decreased caudal vertebrae num... 2 | 53
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
improved glucose tolerance 2 | 79
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased erythrocyte cell num... 2 | 39
increased grip strength 2 | 41
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
increased or absent threshold ... 2 | 101
increased spleen weight 2 | 10
increased startle reflex 2 | 112
limb grasping 2 | 41
mammalian phenotype 2 | 17
pale yolk sac 2 | 25
persistence of hyaloid vascula... 2 | 33
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal heart looping 1 | 5
abnormal joint morphology 1 | 23
abnormal locomotor activation 1 | 16
abnormal motor capabilities-co... 1 | 5
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic disc morphology 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal snout morphology 1 | 23
abnormal tooth morphology 1 | 24
abnormal vitreous body morphol... 1 | 10
absent teeth 1 | 3
cystolithiasis 1 | 3
decreased circulating bilirubi... 1 | 19
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased food intake 1 | 13
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
decreased total retina thickne... 1 | 17
hemorrhage 1 | 23
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating aspartat... 1 | 15
increased circulating potassiu... 1 | 29
increased fasted circulating g... 1 | 76
increased leukocyte cell numbe... 1 | 47
increased red blood cell distr... 1 | 34
small superior vagus ganglion 1 | 74
small thymus 1 | 16
thrombocytosis 1 | 27

Disease

Carcinoma 181 | 11,493
osteosarcoma 105 | 7,950
ovarian cancer 105 | 8,520
atypical teratoid / rhabdoid tumor 83 | 5,112
glioblastoma 83 | 5,792
medulloblastoma, large-cell 82 | 6,241
psoriasis 67 | 6,694
adult high grade glioma 64 | 3,801
ependymoma 61 | 4,679
lung cancer 57 | 4,740
Kidney cancer 55 | 2,613
Astrocytoma, Pilocytic 48 | 3,081
primitive neuroectodermal tumor 47 | 3,035
oligodendroglioma 46 | 2,850
malignant mesothelioma 44 | 3,232
Breast cancer 43 | 3,578
group 3 medulloblastoma 41 | 4,104
astrocytic glioma 40 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,291
group 4 medulloblastoma 36 | 1,855
invasive ductal carcinoma 36 | 2,951
lung carcinoma 35 | 2,843
tuberculosis 33 | 2,010
non-small cell lung cancer 32 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,989
subependymal giant cell astrocytoma 31 | 2,287
Cancer 30 | 2,499
pancreatic cancer 29 | 2,398
Rheumatoid arthritis 26 | 1,191
interstitial cystitis 25 | 2,312
lung adenocarcinoma 25 | 2,716
Pick disease 24 | 1,894
cystic fibrosis 22 | 1,696
spina bifida 22 | 1,074
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
pituitary cancer 21 | 1,972
ductal carcinoma in situ 20 | 1,745
juvenile dermatomyositis 20 | 1,187
breast carcinoma 19 | 1,638
colon cancer 19 | 1,478
acute quadriplegic myopathy 17 | 1,158
Liver cancer 15 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 510
ulcerative colitis 15 | 1,819
Intellectual disability 14 | 1,016
adrenocortical carcinoma 14 | 1,428
Melanoma 13 | 711
Schizophrenia 13 | 1,160
astrocytoma 13 | 1,146
cutaneous lupus erythematosus 12 | 1,057
dermatomyositis 12 | 966
medulloblastoma 12 | 720
nasopharyngeal carcinoma 12 | 1,058
Duchenne muscular dystrophy 11 | 601
Hypertension 11 | 396
acute myeloid leukemia 11 | 783
pancreatic carcinoma 11 | 562
Atopic dermatitis 10 | 952
Liver Cirrhosis, Experimental 10 | 769
diabetes mellitus 10 | 1,728
Bipolar Disorder 9 | 666
Heart disease 9 | 306
Skin cancer 9 | 469
fibroadenoma 9 | 559
gastric carcinoma 9 | 807
pediatric high grade glioma 9 | 1,064
primary Sjogren syndrome 9 | 735
primary pancreatic ductal adenocarcinoma 9 | 1,109
progressive supranuclear palsy 9 | 676
Breast Neoplasms 8 | 445
Endometrial cancer 8 | 311
Epilepsy 8 | 792
gastric cancer 8 | 459
non primary Sjogren syndrome sicca 8 | 891
Alzheimer's disease 7 | 658
Amyotrophic lateral sclerosis 7 | 451
Asthma 7 | 385
Dull intelligence 7 | 645
Hypoplastic mandible condyle 7 | 275
Low intelligence 7 | 645
Mandibular hypoplasia 7 | 275
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Micrognathism 7 | 275
Neurodegenerative disease 7 | 414
Poor school performance 7 | 645
Seizures 7 | 596
Short stature 7 | 531
active Crohn's disease 7 | 922
active ulcerative colitis 7 | 764
aldosterone-producing adenoma 7 | 665
chronic rhinosinusitis 7 | 512
head and neck cancer 7 | 271
posterior fossa group A ependymoma 7 | 468
Autosomal recessive predisposition 6 | 1,442
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Multiple myeloma 6 | 1,332

Tissue

Endocrine System 243 | 18,159
Male tissues 229 | 17,142
Female tissues 227 | 17,400
Digestive Tract 225 | 17,369
Skin and soft tissues 224 | 17,230
Nervous System 219 | 16,725
Urinary Tract 218 | 16,678
Respiratory system 217 | 16,393
Liver and Pancreas 216 | 16,750
Blood and immune system 214 | 16,909
Cardiovascular System 203 | 15,192

Target Family

Non-IDG 185 | 12,091
Enzyme 45 | 4,145
Ion Channel 13 | 344
Kinase 8 | 634
Transcription Factor 4 | 1,400
Epigenetic 3 | 242

UniProt Keyword

ANK repeat 258 | 258
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260

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