Development Level

Tbio 4,541 | 11,651
Tchem 922 | 1,388
Tclin 394 | 612
Tdark 369 | 6,593

Collection

RFA-RM-18-021 57 | 328
Kinase: IDG Consortium (Target... 40 | 125
Kinase: IDG Consortium (Comple... 16 | 37
Ion Channel: IDG Consortium (T... 13 | 99
GPCR: IDG Consortium (Targets) 6 | 126
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 487 | 979
preweaning lethality, incomple... 197 | 499
embryonic lethality prior to t... 133 | 278
embryonic lethality prior to o... 130 | 239
abnormal behavior 125 | 298
abnormal embryo size 110 | 220
decreased total body fat amoun... 88 | 207
enlarged heart 86 | 210
abnormal bone structure 80 | 187
decreased body weight 74 | 161
decreased vertical activity 70 | 208
increased lean body mass 64 | 172
abnormal heart morphology 62 | 162
hypoactivity 60 | 132
decreased bone mineral content 59 | 151
increased circulating alkaline... 57 | 122
increased total body fat amoun... 56 | 134
decreased bone mineral density 54 | 126
decreased lean body mass 54 | 135
decreased circulating glucose ... 51 | 126
embryonic growth retardation 51 | 106
hyperactivity 51 | 148
increased bone mineral content 50 | 108
increased startle reflex 50 | 112
cataract 45 | 92
decreased circulating choleste... 45 | 93
abnormal lens morphology 42 | 81
abnormal seminal vesicle morph... 42 | 114
decreased grip strength 42 | 116
decreased mean corpuscular vol... 42 | 79
increased mean corpuscular hem... 42 | 96
increased mean corpuscular vol... 42 | 92
prenatal lethality prior to he... 42 | 87
male infertility 40 | 123
abnormal retina morphology 38 | 71
decreased circulating serum al... 37 | 82
edema 37 | 59
improved glucose tolerance 37 | 79
increased bone mineral density 37 | 72
short tibia 36 | 97
decreased body length 35 | 101
decreased circulating HDL chol... 34 | 68
decreased lymphocyte cell numb... 34 | 83
increased fasted circulating g... 34 | 76
increased or absent threshold ... 34 | 101
impaired glucose tolerance 32 | 75
increased circulating HDL chol... 32 | 80
decreased circulating insulin ... 30 | 76
decreased fasted circulating g... 30 | 65
small superior vagus ganglion 30 | 74
decreased prepulse inhibition 29 | 82
increased circulating sodium l... 29 | 71
increased monocyte cell number 29 | 63
abnormal eye morphology 28 | 68
decreased circulating alanine ... 28 | 47
decreased leukocyte cell numbe... 28 | 73
decreased circulating triglyce... 27 | 79
decreased startle reflex 27 | 75
increased circulating choleste... 27 | 66
decreased erythrocyte cell num... 26 | 62
decreased hemoglobin content 26 | 68
small testis 26 | 58
thrombocytopenia 26 | 56
abnormal sleep behavior 25 | 70
decreased circulating total pr... 25 | 49
hydrometra 25 | 53
abnormal neural tube closure 24 | 46
increased hemoglobin content 24 | 45
abnormal coat-hair pigmentatio... 23 | 64
abnormal gait 23 | 69
decreased circulating LDL chol... 23 | 38
increased blood urea nitrogen ... 23 | 48
increased leukocyte cell numbe... 23 | 47
abnormal behavioral response t... 22 | 66
decreased caudal vertebrae num... 22 | 53
female infertility 22 | 60
increased circulating chloride... 22 | 41
increased mean platelet volume 22 | 45
abnormal kidney morphology 21 | 65
abnormal skin morphology 21 | 50
increased heart weight 21 | 62
pallor 21 | 34
abnormal craniofacial morpholo... 20 | 33
decreased blood urea nitrogen ... 20 | 51
decreased circulating alkaline... 20 | 46
decreased hematocrit 20 | 46
decreased neutrophil cell numb... 20 | 42
increased hematocrit 20 | 46
increased neutrophil cell numb... 20 | 46
corneal opacity 19 | 32
decreased circulating iron lev... 19 | 32
enlarged spleen 19 | 41
increased circulating triglyce... 19 | 42
tremors 19 | 39
abnormal embryo turning 18 | 31
decreased circulating aspartat... 18 | 34
decreased circulating chloride... 18 | 30
decreased mean corpuscular hem... 18 | 50
decreased red blood cell distr... 18 | 41
increased lymphocyte cell numb... 18 | 32

Disease

Carcinoma 3,836 | 11,493
ovarian cancer 3,462 | 8,520
osteosarcoma 2,977 | 7,950
psoriasis 2,591 | 6,694
medulloblastoma, large-cell 2,336 | 6,241
glioblastoma 2,286 | 5,792
lung cancer 2,236 | 4,740
atypical teratoid / rhabdoid tumor 1,868 | 5,112
Cancer 1,695 | 2,499
ependymoma 1,655 | 4,679
group 3 medulloblastoma 1,542 | 4,104
Breast cancer 1,485 | 3,578
malignant mesothelioma 1,429 | 3,232
adult high grade glioma 1,401 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,376 | 3,291
non-small cell lung cancer 1,259 | 2,890
invasive ductal carcinoma 1,228 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 1,224 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,173 | 2,955
primitive neuroectodermal tumor 1,155 | 3,035
lung adenocarcinoma 1,147 | 2,716
lung carcinoma 1,139 | 2,843
Astrocytoma, Pilocytic 1,134 | 3,081
oligodendroglioma 1,113 | 2,850
pancreatic cancer 1,093 | 2,398
astrocytic glioma 992 | 2,597
interstitial cystitis 973 | 2,312
Kidney cancer 969 | 2,613
subependymal giant cell astrocytoma 943 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 897 | 1,962
tuberculosis 895 | 2,010
ulcerative colitis 858 | 1,819
diabetes mellitus 823 | 1,728
Autosomal recessive predisposition 784 | 1,442
Pick disease 737 | 1,894
pituitary cancer 727 | 1,972
Multiple myeloma 725 | 1,332
ductal carcinoma in situ 709 | 1,745
group 4 medulloblastoma 690 | 1,855
cystic fibrosis 684 | 1,696
breast carcinoma 678 | 1,638
colon cancer 673 | 1,478
Schizophrenia 617 | 1,160
adrenocortical carcinoma 592 | 1,428
Rheumatoid arthritis 588 | 1,191
astrocytoma 566 | 1,146
acute quadriplegic myopathy 561 | 1,158
juvenile dermatomyositis 545 | 1,187
dermatomyositis 532 | 966
Intellectual disability 510 | 1,016
cutaneous lupus erythematosus 508 | 1,057
primary pancreatic ductal adenocarcinoma 470 | 1,109
Waldenstrons macroglobulinemia 448 | 765
spina bifida 431 | 1,074
pediatric high grade glioma 430 | 1,064
Atopic dermatitis 415 | 952
Epilepsy 415 | 792
nasopharyngeal carcinoma 411 | 1,058
Liver Cirrhosis, Experimental 395 | 769
acute myeloid leukemia 390 | 783
active Crohn's disease 374 | 922
gastric carcinoma 367 | 807
esophageal adenocarcinoma 365 | 737
primary Sjogren syndrome 360 | 735
Obesity 358 | 678
Seizures 353 | 596
Dull intelligence 345 | 645
Low intelligence 345 | 645
Mental Retardation 345 | 645
Mental deficiency 345 | 645
Poor school performance 345 | 645
Alzheimer's disease 340 | 658
Bipolar Disorder 340 | 666
non primary Sjogren syndrome sicca 338 | 891
Cognitive delay 332 | 608
Global developmental delay 332 | 608
Mental and motor retardation 332 | 608
Prostatic Neoplasms 329 | 495
Breast Neoplasms 315 | 445
Muscle hypotonia 305 | 571
Mammary Neoplasms 303 | 425
active ulcerative colitis 299 | 764
Melanoma 298 | 711
aldosterone-producing adenoma 288 | 665
Short stature 287 | 531
Duchenne muscular dystrophy 280 | 601
Kidney disease 280 | 430
Multiple Sclerosis 276 | 540
Hypertension 275 | 396
Depressive disorder 270 | 409
progressive supranuclear palsy 269 | 676
medulloblastoma 260 | 720
Endometriosis 257 | 540
pancreatic carcinoma 256 | 562
Asthma 253 | 385
mucosa-associated lymphoid tissue lymphoma 240 | 484
Down syndrome 239 | 499
Anemia 238 | 365
hepatocellular carcinoma 237 | 547
Liver cancer 236 | 604

Tissue

Endocrine System 6,055 | 18,159
Digestive Tract 6,005 | 17,369
Female tissues 5,986 | 17,400
Skin and soft tissues 5,978 | 17,230
Male tissues 5,925 | 17,142
Blood and immune system 5,917 | 16,909
Liver and Pancreas 5,912 | 16,750
Urinary Tract 5,894 | 16,678
Nervous System 5,852 | 16,725
Respiratory system 5,823 | 16,393
Cardiovascular System 5,572 | 15,192

Target Family

Non-IDG 3,354 | 12,091
Enzyme 1,710 | 4,145
Kinase 391 | 634
Transcription Factor 296 | 1,400
Epigenetic 182 | 242
GPCR 110 | 408
Ion Channel 85 | 344
Nuclear Receptor 43 | 48
Transporter 29 | 473
TF/Epigenetic 26 | 38

UniProt Keyword

3D-structure 6,226 | 6,226
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Relaxin-3 RLN3 Tbio Non-IDG -1.88808 92.6 93
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Eukaryotic translation initiation factor 1 EIF1 Tbio Non-IDG -2.06392 118.5 92