Development Level

Tbio 3,968 | 10,625
Tchem 1,162 | 1,890
Tdark 418 | 7,003
Tclin 339 | 602

Collection

Eligible Kinase Proteins 43 | 134
Eligible Ion Channel Proteins 14 | 117
Eligible non-olfactory GPCR Proteins 9 | 143

IMPC Term

preweaning lethality, complete... 288 | 633
preweaning lethality, incomple... 112 | 260
abnormal behavior 92 | 226
embryonic lethality prior to t... 82 | 187
decreased lean body mass 79 | 195
decreased total body fat amoun... 74 | 186
embryonic lethality prior to o... 74 | 148
decreased body weight 72 | 174
decreased bone mineral content 59 | 157
abnormal embryo size 57 | 112
increased circulating alkaline... 54 | 119
abnormal bone structure 50 | 131
decreased grip strength 49 | 123
enlarged heart 47 | 111
decreased circulating glucose ... 45 | 121
decreased body length 44 | 108
decreased circulating choleste... 44 | 85
decreased circulating HDL chol... 42 | 77
increased or absent threshold ... 42 | 128
abnormal retina morphology 41 | 100
decreased bone mineral density 41 | 126
increased mean corpuscular hem... 41 | 93
hypoactivity 39 | 89
increased lean body mass 38 | 107
hyperactivity 36 | 108
abnormal lens morphology 35 | 73
increased bone mineral content 35 | 92
increased grip strength 35 | 83
increased mean corpuscular vol... 35 | 91
decreased circulating serum al... 34 | 79
decreased circulating insulin ... 32 | 75
decreased circulating triglyce... 31 | 83
short tibia 28 | 82
increased circulating sodium l... 25 | 71
increased fasted circulating g... 25 | 68
decreased circulating alanine ... 24 | 53
increased total body fat amoun... 24 | 57
abnormal retinal pigmentation 23 | 61
decreased circulating LDL chol... 23 | 37
increased circulating chloride... 23 | 43
prenatal lethality prior to he... 23 | 64
decreased fasted circulating g... 22 | 49
increased circulating HDL chol... 22 | 63
decreased caudal vertebrae num... 21 | 49
decreased mean corpuscular vol... 21 | 50
improved glucose tolerance 21 | 56
increased hemoglobin content 21 | 45
increased sacral vertebrae num... 21 | 62
male infertility 21 | 62
decreased circulating alkaline... 20 | 41
decreased circulating total pr... 20 | 41
decreased hemoglobin content 20 | 53
abnormal bone mineralization 19 | 55
abnormal neural tube closure 19 | 37
abnormal sleep behavior 19 | 63
decreased leukocyte cell numbe... 19 | 54
impaired glucose tolerance 19 | 52
increased bone mineral density 19 | 52
thrombocytopenia 19 | 46
abnormal behavioral response t... 18 | 52
abnormal coat/hair pigmentatio... 18 | 54
decreased erythrocyte cell num... 18 | 43
increased blood urea nitrogen ... 18 | 44
increased body weight 18 | 42
increased circulating choleste... 18 | 53
abnormal gait 17 | 51
decreased circulating fructosa... 17 | 31
decreased lumbar vertebrae num... 17 | 62
decreased rib number 17 | 59
increased exploration in new e... 17 | 56
increased leukocyte cell numbe... 17 | 37
small testis 17 | 37
abnormal eye morphology 16 | 38
female infertility 16 | 34
increased hematocrit 16 | 36
increased startle reflex 16 | 38
abnormal seminal vesicle morph... 15 | 47
decreased CD4-positive, CD25-p... 15 | 24
decreased T cell number 15 | 31
decreased eosinophil cell numb... 15 | 41
decreased prepulse inhibition 15 | 52
decreased startle reflex 15 | 48
hydrops fetalis 15 | 22
tremors 15 | 34
abnormal heart morphology 14 | 51
abnormal hindbrain development 14 | 24
cardiovascular system phenotyp... 14 | 35
corneal opacity 14 | 25
decreased circulating aspartat... 14 | 27
decreased circulating chloride... 14 | 32
decreased circulating iron lev... 14 | 25
decreased heart weight 14 | 44
decreased mean corpuscular hem... 14 | 34
enlarged spleen 14 | 26
increased circulating creatini... 14 | 29
abnormal cornea morphology 13 | 24
decreased B cell number 13 | 30
decreased circulating creatini... 13 | 31
decreased hematocrit 13 | 25
increased circulating triglyce... 13 | 24

Disease

ovarian cancer 3,259 | 8,484
osteosarcoma 2,822 | 7,933
psoriasis 2,471 | 6,685
medulloblastoma, large-cell 2,211 | 6,234
glioblastoma 2,090 | 5,572
lung cancer 2,056 | 4,466
Cancer 1,548 | 2,346
atypical teratoid / rhabdoid tumor 1,517 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,320 | 3,289
malignant mesothelioma 1,315 | 3,162
Breast cancer 1,225 | 3,094
invasive ductal carcinoma 1,180 | 2,950
non-small cell lung cancer 1,177 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 1,165 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 1,123 | 2,956
lung carcinoma 1,101 | 2,844
primitive neuroectodermal tumor 1,101 | 3,031
lung adenocarcinoma 1,096 | 2,713
pilocytic astrocytoma 1,088 | 3,086
oligodendroglioma 1,069 | 2,849
pediatric high grade glioma 1,024 | 2,712
pancreatic cancer 1,016 | 2,300
ulcerative colitis 940 | 2,087
interstitial cystitis 936 | 2,299
subependymal giant cell astrocytoma 901 | 2,287
ependymoma 863 | 2,514
group 3 medulloblastoma 812 | 2,254
Carcinoma 789 | 2,147
astrocytic glioma 783 | 2,241
diabetes mellitus 765 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 761 | 1,795
adult high grade glioma 728 | 2,148
Pick disease 696 | 1,893
tuberculosis 693 | 1,557
astrocytoma 692 | 1,493
pituitary cancer 692 | 1,972
ductal carcinoma in situ 679 | 1,745
Multiple myeloma 666 | 1,327
group 4 medulloblastoma 659 | 1,875
breast carcinoma 642 | 1,614
cystic fibrosis 641 | 1,665
colon cancer 636 | 1,475
posterior fossa group A ependymoma 590 | 1,511
adrenocortical carcinoma 570 | 1,427
medulloblastoma 553 | 1,524
Rheumatoid Arthritis 547 | 1,160
primary pancreatic ductal adenocarcinoma 541 | 1,271
acute quadriplegic myopathy 535 | 1,157
juvenile dermatomyositis 520 | 1,189
sonic hedgehog group medulloblastoma 512 | 1,482
dermatomyositis 502 | 933
cutaneous lupus erythematosus 489 | 1,056
Waldenstrons macroglobulinemia 423 | 765
posterior fossa group B ependymoma 418 | 1,530
spina bifida 411 | 1,064
Atopic dermatitis 394 | 944
nasopharyngeal carcinoma 391 | 1,056
atypical teratoid/rhabdoid tumor 386 | 1,095
primary Sjogren syndrome 377 | 789
acute myeloid leukemia 363 | 780
gastric carcinoma 363 | 832
active Crohn's disease 357 | 918
esophageal adenocarcinoma 351 | 737
Alzheimer's disease 328 | 644
Prostatic Neoplasms 308 | 471
Obesity 307 | 616
non primary Sjogren syndrome sicca 290 | 840
Mammary Neoplasms 285 | 410
aldosterone-producing adenoma 273 | 664
Intellectual disability 269 | 573
Duchenne muscular dystrophy 267 | 602
Kidney disease 260 | 396
progressive supranuclear palsy 255 | 674
Multiple Sclerosis 249 | 498
Down syndrome 244 | 548
Endometriosis 244 | 535
IGA Glomerulonephritis 244 | 454
pancreatic carcinoma 244 | 567
tuberculosis and treatment for 6 months 243 | 686
mucosa-associated lymphoid tissue lymphoma 234 | 480
Asthma 230 | 349
Schizophrenia 215 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 213 | 499
hepatocellular carcinoma 213 | 532
Amyotrophic Lateral Sclerosis 208 | 431
Neurodegenerative disease 204 | 383
non-small cell lung carcinoma 196 | 413
fibroadenoma 194 | 557
Stomach Neoplasms 190 | 282
Vascular disease 188 | 281
Hypertension 186 | 287
Heart disease 185 | 279
Arthritis 179 | 248
Atherosclerosis 179 | 275
inflammatory breast cancer 176 | 404
gastric cancer 175 | 430
Polycystic Ovary Syndrome 173 | 332
Liver carcinoma 172 | 217
Parkinson's disease 171 | 364
Autistic Disorder 167 | 320

Tissue

Nervous System 5,807 | 18,561
Digestive Tract 5,803 | 18,473
Female tissues 5,802 | 18,647
Endocrine System 5,790 | 18,512
Blood and immune system 5,783 | 17,995
Urinary Tract 5,777 | 18,444
Liver and Pancreas 5,771 | 18,136
Cardiovascular System 5,752 | 17,958
Male tissues 5,747 | 17,969
Skin and soft tissues 5,728 | 18,115
Respiratory system 5,709 | 17,484

Target Family

Non-IDG 3,166 | 11,971
Enzyme 1,614 | 4,146
Kinase 380 | 634
Transcription Factor 282 | 1,400
Epigenetic 176 | 242
GPCR 100 | 406
Ion Channel 80 | 341
Nuclear Receptor 43 | 48
TF/Epigenetic 23 | 38
Transporter 23 | 473

UniProt Keyword

3D-structure 5,887 | 5,887
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95