Development Level

Tbio 43 | 10,625
Tdark 14 | 7,003
Tchem 1 | 1,890

IMPC Term

preweaning lethality, complete... 7 | 633
abnormal blood vessel morpholo... 1 | 2
abnormal embryo size 1 | 112
abnormal facial morphology 1 | 9
decreased circulating insulin ... 1 | 75
embryonic growth retardation 1 | 28
preweaning lethality, incomple... 1 | 260

Disease

lung cancer 35 | 4,466
ovarian cancer 32 | 8,484
osteosarcoma 29 | 7,933
medulloblastoma, large-cell 20 | 6,234
group 3 medulloblastoma 17 | 2,254
glioblastoma 16 | 5,572
atypical teratoid / rhabdoid tumor 14 | 4,369
Breast cancer 11 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
oligodendroglioma 11 | 2,849
primitive neuroectodermal tumor 11 | 3,031
Carcinoma 10 | 2,147
non-small cell lung cancer 10 | 2,798
pediatric high grade glioma 10 | 2,712
psoriasis 10 | 6,685
Multiple myeloma 9 | 1,327
dermatomyositis 9 | 933
acute quadriplegic myopathy 8 | 1,157
malignant mesothelioma 8 | 3,162
Pick disease 7 | 1,893
Waldenstrons macroglobulinemia 7 | 765
astrocytic glioma 7 | 2,241
colon cancer 7 | 1,475
astrocytoma 6 | 1,493
ependymoma 6 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,988
invasive ductal carcinoma 6 | 2,950
sonic hedgehog group medulloblastoma 6 | 1,482
Pontocerebellar hypoplasia 5 | 29
Rheumatoid Arthritis 5 | 1,160
acute myeloid leukemia 5 | 780
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
pilocytic astrocytoma 5 | 3,086
posterior fossa group B ependymoma 5 | 1,530
Microcephaly 4 | 149
Neurodegenerative disease 4 | 383
atypical teratoid/rhabdoid tumor 4 | 1,095
nasopharyngeal carcinoma 4 | 1,056
Atopic dermatitis 3 | 944
Cancer 3 | 2,346
Deglutition Disorders 3 | 4
Intellectual disability 3 | 573
Movement Disorders 3 | 21
Pontocerebellar Hypoplasia Type 2 3 | 4
Vision Disorders 3 | 5
adult high grade glioma 3 | 2,148
breast carcinoma 3 | 1,614
diabetes mellitus 3 | 1,663
group 4 medulloblastoma 3 | 1,875
hepatocellular carcinoma 3 | 532
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
tuberculosis and treatment for 6 months 3 | 686
Amyotrophic Lateral Sclerosis 2 | 431
HIV Infections 2 | 100
Influenza 2 | 142
Leukemia 2 | 88
Leukemia, Myelocytic, Acute 2 | 113
Peripheral vascular disease 2 | 90
Prostate cancer 2 | 172
Prostatic Neoplasms 2 | 471
Systemic scleroderma 2 | 66
Weight Gain 2 | 87
adrenocortical carcinoma 2 | 1,427
cutaneous lupus erythematosus 2 | 1,056
ductal carcinoma in situ 2 | 1,745
gastric cancer 2 | 430
interstitial lung disease 2 | 291
juvenile dermatomyositis 2 | 1,189
lung adenocarcinoma 2 | 2,713
medulloblastoma 2 | 1,524
non primary Sjogren syndrome sicca 2 | 840
pancreatic cancer 2 | 2,300
pancreatic carcinoma 2 | 567
progressive supranuclear palsy 2 | 674
spina bifida 2 | 1,064
subependymal giant cell astrocytoma 2 | 2,287
triple-A syndrome 2 | 18
tuberculosis 2 | 1,557
ulcerative colitis 2 | 2,087
Animal Mammary Neoplasms 1 | 136
Anorexia nervosa 1 | 59
Bejel 1 | 5
Brain disease 1 | 83
COPD 1 | 113
Degenerative polyarthritis 1 | 93
Familial atrial fibrillation 1 | 16
Gaucher disease type 1 1 | 171
Hemolytic anemia 1 | 66
Infectious mononucleosis 1 | 15
Mammary Neoplasms, Experimental 1 | 150
Melanoma 1 | 261
Pontocerebellar Hypoplasia Type 1 1 | 5
Retinitis pigmentosa 1 | 153
Sideroblastic anemia 1 | 18
Syringomyelia 1 | 9
X-linked cerebral adrenoleukodystrophy 1 | 115
Yaws 1 | 8
cystic fibrosis and chronic rhinosinusitis 1 | 213
ovarian neoplasm 1 | 97
permanent atrial fibrillation 1 | 44

Tissue

Blood and immune system 58 | 17,995
Cardiovascular System 58 | 17,958
Female tissues 58 | 18,647
Liver and Pancreas 58 | 18,136
Male tissues 58 | 17,969
Nervous System 58 | 18,561
Digestive Tract 57 | 18,473
Endocrine System 57 | 18,512
Respiratory system 56 | 17,484
Skin and soft tissues 56 | 18,115
Urinary Tract 56 | 18,444

Target Family

Non-IDG 34 | 11,971
Enzyme 24 | 4,146

Reactome Pathway

tRNA processing in the nucleus 58 | 58
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172
Nucleoporin p58/p45 NUP58 Tdark Non-IDG -0.70757 5.23 31
Nucleoporin-like protein 2 NUPL2 Tbio Non-IDG -0.99049 10.1 66
GTP-binding nuclear protein Ran RAN Tbio Enzyme -2.52041 303.8 437
Protein archease ZBTB8OS Tbio Enzyme -2.32213 214.4 22
Hydroxyacyl-thioester dehydratase type 2, mitochondrial RPP14 Tdark Enzyme 0.00000 15
Cleavage and polyadenylation specificity factor subunit 1 CPSF1 Tbio Non-IDG -0.93972 7.17 45
Nuclear pore complex protein Nup85 NUP85 Tbio Non-IDG -1.18116 15.9 128
Ribonuclease P protein subunit p25 RPP25 Tbio Enzyme -0.99834 10.4 51