Development Level

Tbio 10 | 10,625
Tclin 7 | 602
Tchem 2 | 1,890
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 1 | 633

Disease

Leber hereditary optic neuropathy 11 | 17
Mitochondrial myopathy 11 | 24
Leber's optic atrophy 10 | 10
Optic Atrophy, Hereditary, Leber 10 | 14
Leigh disease 9 | 81
Leigh syndrome 8 | 34
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes 8 | 9
Diabetes mellitus type 2 7 | 69
Lactic acidosis 7 | 43
Mitochondrial complex I deficiency 7 | 37
Treatment Refractory Type 2 Diabetes Mellitus 7 | 53
MELAS syndrome 5 | 17
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome 5 | 5
LEBER OPTIC ATROPHY AND DYSTONIA 4 | 4
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 4 | 14
Malaria 4 | 140
Mitochondrial Complex 1 Deficiency 4 | 28
Retinitis pigmentosa 4 | 156
ovarian cancer 4 | 8,492
Alzheimer's disease 3 | 644
Chagas disease 3 | 34
Cytochrome-c Oxidase Deficiency 3 | 15
Deafness, Aminoglycoside-Induced 3 | 4
Diphyllobothriasis 3 | 6
Dystonia 3 | 77
Echinococcosis 3 | 28
Mitochondrial complex IV deficiency 3 | 6
Neuropathy 3 | 210
Wolff-Parkinson-White syndrome 3 | 11
cytochrome-c oxidase deficiency disease 3 | 19
osteosarcoma 3 | 7,933
3-methylglutaconic aciduria 2 | 29
ALZHEIMER DISEASE, SUSCEPTIBILITY TO, MITOCHONDRIAL 2 | 2
Alzheimer disease mitochondrial 2 | 2
Amyloidosis 2 | 68
Coenurosis 2 | 4
Cysticercosis 2 | 12
DEAFNESS, NONSYNDROMIC SENSORINEURAL, MITOCHONDRIAL 2 | 2
Diabetes Mellitus, Experimental 2 | 106
Fascioliasis 2 | 18
Leber hereditary optic neuropathy with dystonia 2 | 2
Myiasis 2 | 8
Myopathy 2 | 128
Neurodegenerative disease 2 | 383
Nonsyndromic deafness 2 | 121
Optic Atrophies, Hereditary 2 | 2
Optic atrophy 2 | 43
Parkinson Disease 6, Autosomal Recessive Early-Onset 2 | 3
Recurrent myoglobinuria mitochondrial 2 | 2
diabetes mellitus 2 | 1,663
2-methyl-3-hydroxybutyric aciduria 1 | 1
2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency 1 | 1
Acatalasia 1 | 2
Adenocarcinoma of lung (disorder) 1 | 48
Adult-Onset Dystonias 1 | 1
Alzheimer Disease 1 | 10
Babesiosis 1 | 13
Breast Cancer, Familial 1 | 12
Cardiomyopathy, infantile histiocytoid 1 | 1
Chromosome 3q29 microduplication syndrome 1 | 6
Chronic granulomatous disease 1 | 13
Coccidiosis 1 | 4
Colon Carcinoma 1 | 25
Congenital ptosis 1 | 5
Congenital sideroblastic anemia-B-cell immunodeficiency-periodic fever-developmental delay syndrome 1 | 1
Cortical deafness 1 | 2
Eastern equine encephalitis 1 | 15
Endocardial fibroelastosis 1 | 6
Epilepsy, Temporal Lobe 1 | 23
Fatal infantile encephalocardiomyopathy 1 | 3
Histiocytoid Cardiomyopathy 1 | 1
Hydroxyacyl-CoA Dehydrogenase, Type 2, Deficiency 1 | 1
Impaired glucose tolerance 1 | 12
Kearns-Sayre syndrome 1 | 6
Lactocele 1 | 3
MENTAL RETARDATION, X-LINKED, SYNDROMIC 10 1 | 2
MERRF syndrome 1 | 5
Macrocephaly 1 | 5
Malignant tumor of prostate 1 | 26
Mental retardation, X-linked 17 1 | 2
Mental retardation, X-linked, syndromic, 10 1 | 1
Metabolic acidosis 1 | 49
Methemoglobinemia 1 | 17
Mitochondrial complex V deficiency, mitochondrial 2 1 | 1
Multisystem disorder 1 | 1
Opisthorchiasis 1 | 14
Oral candidiasis 1 | 9
PARKINSON DISEASE, LATE-ONSET 1 | 20
Paragonimiasis 1 | 9
Pneumocystosis 1 | 18
Prostate cancer, familial 1 | 13
Pyosalpinx 1 | 4
Scotoma 1 | 7
Sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay 1 | 1
Sparganosis 1 | 4
Striatonigral Degeneration, Infantile 1 | 4
Sudden infant death syndrome 1 | 34
Tinnitus 1 | 2
Wolfram syndrome 1 | 11
multidrug-resistant tuberculosis 1 | 7

Tissue

Blood and immune system 18 | 17,995
Cardiovascular System 18 | 17,958
Digestive Tract 18 | 18,473
Endocrine System 18 | 18,512
Female tissues 18 | 18,647
Liver and Pancreas 18 | 18,136
Male tissues 18 | 17,969
Nervous System 18 | 18,561
Respiratory system 18 | 17,484
Skin and soft tissues 18 | 18,115
Urinary Tract 18 | 18,444

Target Family

Enzyme 17 | 4,146
Non-IDG 3 | 11,969

Reactome Pathway

tRNA processing in the mitocho... 20 | 20
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 Tbio Enzyme -2.11508 131.7 319
CCA tRNA nucleotidyltransferase 1, mitochondrial TRNT1 Tbio Enzyme -1.33746 60.4 26
Cytochrome b MT-CYB Tbio Non-IDG -3.75654 5676.0 122
Mitochondrial ribonuclease P protein 3 KIAA0391 Tbio Enzyme -1.83696 66.3 56
Cytochrome c oxidase subunit 1 MT-CO1 Tchem Enzyme -3.64178 4179.7 118
Humanin MT-RNR2 Tdark Non-IDG 0.00000 0
NADH-ubiquinone oxidoreductase chain 2 MT-ND2 Tclin Enzyme -2.89583 759.5 31
NADH-ubiquinone oxidoreductase chain 1 MT-ND1 Tclin Enzyme -2.58934 376.4 123
NADH-ubiquinone oxidoreductase chain 3 MT-ND3 Tclin Enzyme -2.81425 629.0 80
NADH-ubiquinone oxidoreductase chain 4 MT-ND4 Tclin Enzyme -3.01595 1026.1 6