Development Level

Tbio 9 | 11,445
Tclin 7 | 613
Tchem 2 | 1,598
Tdark 1 | 6,588

Disease

Cerebellar Ataxia 13 | 304
Myopathy 12 | 185
Mitochondrial myopathy 11 | 26
Optic Atrophy 11 | 242
Blind spot located at fixation point 10 | 21
Blurred vision 10 | 19
Decreased visual acuity, slowly progressive 10 | 13
Dystonia 10 | 164
Leber hereditary optic neuropathy 10 | 14
Leber's optic atrophy 10 | 10
Mitochondrial respiratory chain defects 10 | 15
Optic Atrophy, Hereditary, Leber 10 | 14
Ragged-red fibers 10 | 21
Retinal telangiectasia 10 | 12
Scotoma, Central 10 | 21
Scotoma, Centrocecal 10 | 11
Slow decrease in visual acuity 10 | 13
Tortuous retinal vessels 10 | 15
Abnormal vision 9 | 52
Acidosis, Lactic 9 | 97
Carcinoma 9 | 11,493
Cardiac Arrhythmia 9 | 103
Cardiac conduction abnormalities 9 | 78
Central retinal vessel vascular tortuosity 9 | 9
Conduction disorder of the heart 9 | 79
Dystonic disease 9 | 106
EKG abnormalities 9 | 78
Electrocardiogram abnormal 9 | 81
Electrocardiogram change 9 | 78
Electromyogram abnormal 9 | 49
Lactic acidemia 9 | 95
Leigh disease 9 | 100
Mitochondrial Myopathies 9 | 21
Optic Neuropathy 9 | 12
Peripheral Neuropathy 9 | 134
Polyneuropathy 9 | 64
Sensorineural Hearing Loss (disorder) 9 | 284
Static Tremor 9 | 21
Dementia 8 | 175
Developmental regression 8 | 95
Hallucinations 8 | 34
Hallucinations, Sensory 8 | 33
Hemianopsia 8 | 15
Highly variable severity 8 | 157
Intermittent migraine headaches 8 | 68
Leigh syndrome 8 | 28
Loss of developmental milestones 8 | 95
MELAS syndrome 8 | 18
Mental deterioration in childhood 8 | 95
Migraine Disorders 8 | 76
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes 8 | 9
Neurodevelopmental regression 8 | 95
Psychomotor regression 8 | 95
Psychomotor regression beginning in infancy 8 | 95
Psychomotor regression in infants 8 | 95
Psychomotor regression, progressive 8 | 95
Short stature 8 | 531
Tonic - clonic seizures 8 | 44
Variable expressivity 8 | 157
Wolff-Parkinson-White syndrome 8 | 19
diabetes mellitus 8 | 1,728
Abdominal Pain 7 | 98
Abnormality of mitochondrial metabolism 7 | 9
Anorexia 7 | 43
Anxiety 7 | 136
Anxiety disease 7 | 113
Blepharoptosis 7 | 231
Blindness, Cortical 7 | 24
Cachexia 7 | 50
Cerebellar hypoplasia and atrophy 7 | 41
Cerebral Ischemia 7 | 37
Cerebral atrophy 7 | 178
Cerebral calcification 7 | 43
Clonus 7 | 18
Congenital Bilateral Cataracts 7 | 50
Congenital cataract 7 | 50
Congestive heart failure 7 | 113
Death in early adulthood 7 | 24
Decreased nerve conduction velocity 7 | 35
Diabetes mellitus type 2 7 | 69
Encephalopathies 7 | 43
Episodic vomiting 7 | 10
Fatigue 7 | 182
Forgetful 7 | 40
Frequent vomiting 7 | 10
Heart failure 7 | 162
Hemiparesis 7 | 34
Increased serum lactate 7 | 60
Lactic acidosis 7 | 51
Left Ventricular Hypertrophy 7 | 47
Memory Loss 7 | 40
Memory impairment 7 | 40
Mitochondrial complex I deficiency 7 | 46
Muscle Weakness 7 | 170
Nausea and vomiting 7 | 97
Ophthalmoplegia 7 | 106
Pancreatitis 7 | 123
Respiratory Insufficiency 7 | 132
Respiratory function loss 7 | 121
Treatment Refractory Type 2 Diabetes Mellitus 7 | 53

Tissue

Blood and immune system 17 | 16,909
Cardiovascular System 17 | 15,192
Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Female tissues 17 | 17,400
Liver and Pancreas 17 | 16,750
Male tissues 17 | 17,142
Nervous System 17 | 16,725
Respiratory system 17 | 16,393
Skin and soft tissues 17 | 17,230
Urinary Tract 17 | 16,678

Target Family

Enzyme 16 | 4,145
Non-IDG 3 | 12,091

Reactome Pathway

tRNA processing in the mitocho... 19 | 19
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP synthase protein 8 MT-ATP8 Tbio Enzyme -2.35771 201.5 23
Cytochrome b MT-CYB Tbio Non-IDG -3.77047 5856.5 134
NADH-ubiquinone oxidoreductase chain 3 MT-ND3 Tclin Enzyme -2.82915 655.6 93
Cytochrome c oxidase subunit 1 MT-CO1 Tchem Enzyme -3.69205 4610.4 141
Cytochrome c oxidase subunit 3 MT-CO3 Tbio Enzyme -3.41708 2551.3 96
Cytochrome c oxidase subunit 2 MT-CO2 Tchem Enzyme -2.96018 880.4 127
NADH-ubiquinone oxidoreductase chain 4L MT-ND4L Tclin Enzyme -1.94310 80.5 57
NADH-ubiquinone oxidoreductase chain 4 MT-ND4 Tclin Enzyme -3.03991 1074.3 9
ATP synthase subunit a MT-ATP6 Tbio Enzyme -2.74832 542.1 40
Mitochondrial-derived peptide MOTS-c MT-RNR1 Tbio Non-IDG 0.00000 0