Development Level

Tbio 10 | 10,625
Tclin 7 | 602
Tchem 2 | 1,890
Tdark 1 | 7,003

IMPC Phenotype

preweaning lethality, complete... 1 | 633

Disease

Leber hereditary optic neuropathy 11 | 17
Mitochondrial myopathy 11 | 24
Leber's optic atrophy 10 | 10
Optic Atrophy, Hereditary, Leber 10 | 14
Leigh disease 9 | 81
Leigh syndrome 8 | 34
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes 8 | 9
Diabetes mellitus type 2 7 | 69
Lactic acidosis 7 | 43
Mitochondrial complex I deficiency 7 | 37
Treatment Refractory Type 2 Diabetes Mellitus 7 | 53
MELAS syndrome 5 | 17
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome 5 | 5
LEBER OPTIC ATROPHY AND DYSTONIA 4 | 4
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 4 | 14
Malaria 4 | 140
Mitochondrial Complex 1 Deficiency 4 | 28
Retinitis pigmentosa 4 | 156
ovarian cancer 4 | 8,491
Alzheimer's disease 3 | 644
Chagas disease 3 | 34
Cytochrome-c Oxidase Deficiency 3 | 15
Deafness, Aminoglycoside-Induced 3 | 4
Diphyllobothriasis 3 | 6
Dystonia 3 | 77
Echinococcosis 3 | 28
Mitochondrial complex IV deficiency 3 | 6
Neuropathy 3 | 210
Wolff-Parkinson-White syndrome 3 | 11
cytochrome-c oxidase deficiency disease 3 | 19
osteosarcoma 3 | 7,933
3-methylglutaconic aciduria 2 | 29
ALZHEIMER DISEASE, SUSCEPTIBILITY TO, MITOCHONDRIAL 2 | 2
Alzheimer disease mitochondrial 2 | 2
Amyloidosis 2 | 68
Coenurosis 2 | 4
Cysticercosis 2 | 12
DEAFNESS, NONSYNDROMIC SENSORINEURAL, MITOCHONDRIAL 2 | 2
Diabetes Mellitus, Experimental 2 | 106
Fascioliasis 2 | 18
Leber hereditary optic neuropathy with dystonia 2 | 2
Myiasis 2 | 8
Myopathy 2 | 128
Neurodegenerative disease 2 | 383
Nonsyndromic deafness 2 | 121
Optic Atrophies, Hereditary 2 | 2
Optic atrophy 2 | 43
Parkinson Disease 6, Autosomal Recessive Early-Onset 2 | 3
Recurrent myoglobinuria mitochondrial 2 | 2
diabetes mellitus 2 | 1,663
2-methyl-3-hydroxybutyric aciduria 1 | 1
2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency 1 | 1
Acatalasia 1 | 2
Adenocarcinoma of lung (disorder) 1 | 48
Adult-Onset Dystonias 1 | 1
Alzheimer Disease 1 | 10
Babesiosis 1 | 13
Breast Cancer, Familial 1 | 12
Cardiomyopathy, infantile histiocytoid 1 | 1
Chromosome 3q29 microduplication syndrome 1 | 6
Chronic granulomatous disease 1 | 13
Coccidiosis 1 | 4
Colon Carcinoma 1 | 25
Congenital ptosis 1 | 5
Congenital sideroblastic anemia-B-cell immunodeficiency-periodic fever-developmental delay syndrome 1 | 1
Cortical deafness 1 | 2
Eastern equine encephalitis 1 | 15
Endocardial fibroelastosis 1 | 6
Epilepsy, Temporal Lobe 1 | 23
Fatal infantile encephalocardiomyopathy 1 | 3
Histiocytoid Cardiomyopathy 1 | 1
Hydroxyacyl-CoA Dehydrogenase, Type 2, Deficiency 1 | 1
Impaired glucose tolerance 1 | 12
Kearns-Sayre syndrome 1 | 6
Lactocele 1 | 3
MENTAL RETARDATION, X-LINKED, SYNDROMIC 10 1 | 2
MERRF syndrome 1 | 5
Macrocephaly 1 | 5
Malignant tumor of prostate 1 | 26
Mental retardation, X-linked 17 1 | 2
Mental retardation, X-linked, syndromic, 10 1 | 1
Metabolic acidosis 1 | 49
Methemoglobinemia 1 | 17
Mitochondrial complex V deficiency, mitochondrial 2 1 | 1
Multisystem disorder 1 | 1
Opisthorchiasis 1 | 14
Oral candidiasis 1 | 9
PARKINSON DISEASE, LATE-ONSET 1 | 20
Paragonimiasis 1 | 9
Pneumocystosis 1 | 18
Prostate cancer, familial 1 | 13
Pyosalpinx 1 | 4
Scotoma 1 | 7
Sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay 1 | 1
Sparganosis 1 | 4
Striatonigral Degeneration, Infantile 1 | 4
Sudden infant death syndrome 1 | 34
Tinnitus 1 | 2
Wolfram syndrome 1 | 11
multidrug-resistant tuberculosis 1 | 7

Tissue

Blood and immune system 18 | 17,994
Cardiovascular System 18 | 17,957
Digestive Tract 18 | 18,472
Endocrine System 18 | 18,511
Female tissues 18 | 18,646
Liver and Pancreas 18 | 18,135
Male tissues 18 | 17,968
Nervous System 18 | 18,560
Respiratory system 18 | 17,483
Skin and soft tissues 18 | 18,114
Urinary Tract 18 | 18,443

Target Family

Enzyme 17 | 4,146
Non-IDG 3 | 11,969

Reactome Pathway

tRNA processing in the mitocho... 20 | 20
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CCA tRNA nucleotidyltransferase 1, mitochondrial TRNT1 Tbio Enzyme -1.33746 60.4 26
Mitochondrial-derived peptide MOTS-c MT-RNR1 Tbio Non-IDG 0.00000 0
Cytochrome c oxidase subunit 3 MT-CO3 Tbio Enzyme -3.40472 2347.9 83
ATP synthase subunit a MT-ATP6 Tbio Enzyme -2.72887 525.9 36
NADH-ubiquinone oxidoreductase chain 5 MT-ND5 Tclin Enzyme -2.72771 504.3 159
NADH-ubiquinone oxidoreductase chain 4L MT-ND4L Tclin Enzyme -1.92797 77.8 47
NADH-ubiquinone oxidoreductase chain 4 MT-ND4 Tclin Enzyme -3.01595 1026.1 6
Cytochrome c oxidase subunit 1 MT-CO1 Tchem Enzyme -3.64178 4179.7 118
Cytochrome c oxidase subunit 2 MT-CO2 Tchem Enzyme -2.94466 857.2 116
NADH-ubiquinone oxidoreductase chain 1 MT-ND1 Tclin Enzyme -2.58934 376.4 123