Development Level

Tbio 92 | 11,651
Tdark 18 | 6,593
Tclin 7 | 612
Tchem 3 | 1,388

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 14 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
cataract 2 | 92
decreased grip strength 2 | 116
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
increased mean corpuscular vol... 2 | 92
abnormal behavior 1 | 298
abnormal blood vessel morpholo... 1 | 5
abnormal facial morphology 1 | 17
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal snout morphology 1 | 23
abnormal vibrissa morphology 1 | 25
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased mean corpuscular vol... 1 | 79
decreased total retina thickne... 1 | 17
enlarged heart 1 | 210
excessive tearing 1 | 2
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased grip strength 1 | 41
increased mean platelet volume 1 | 45
male infertility 1 | 123
premature death 1 | 5
tremors 1 | 39

Disease

Carcinoma 71 | 11,493
ovarian cancer 60 | 8,520
osteosarcoma 50 | 7,950
lung cancer 48 | 4,740
group 3 medulloblastoma 37 | 4,104
medulloblastoma, large-cell 37 | 6,241
atypical teratoid / rhabdoid tumor 27 | 5,112
glioblastoma 26 | 5,792
psoriasis 24 | 6,694
diabetes mellitus 17 | 1,728
primitive neuroectodermal tumor 16 | 3,035
ependymoma 15 | 4,679
Breast cancer 14 | 3,578
Cerebellar Ataxia 14 | 304
Multiple myeloma 14 | 1,332
Pick disease 14 | 1,894
oligodendroglioma 14 | 2,850
Kidney cancer 13 | 2,613
Myopathy 13 | 185
non-small cell lung cancer 13 | 2,890
Mitochondrial myopathy 12 | 26
Optic Atrophy 12 | 242
acute quadriplegic myopathy 12 | 1,158
adult high grade glioma 12 | 3,801
astrocytic glioma 12 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
invasive ductal carcinoma 12 | 2,951
malignant mesothelioma 12 | 3,232
Acidosis, Lactic 11 | 97
Dystonia 11 | 164
Intellectual disability 11 | 1,016
Lactic acidemia 11 | 95
Leigh disease 11 | 100
Mitochondrial respiratory chain defects 11 | 15
Blind spot located at fixation point 10 | 21
Blurred vision 10 | 19
Cardiac Arrhythmia 10 | 103
Cardiac conduction abnormalities 10 | 78
Conduction disorder of the heart 10 | 79
Decreased visual acuity, slowly progressive 10 | 13
Dystonic disease 10 | 106
EKG abnormalities 10 | 78
Electrocardiogram abnormal 10 | 81
Electrocardiogram change 10 | 78
Lactic acidosis 10 | 51
Leber hereditary optic neuropathy 10 | 14
Leber's optic atrophy 10 | 10
Optic Atrophy, Hereditary, Leber 10 | 14
Ragged-red fibers 10 | 21
Retinal telangiectasia 10 | 12
Scotoma, Central 10 | 21
Scotoma, Centrocecal 10 | 11
Slow decrease in visual acuity 10 | 13
Tortuous retinal vessels 10 | 15
colon cancer 10 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
pediatric high grade glioma 10 | 1,064
Abnormal vision 9 | 52
Central retinal vessel vascular tortuosity 9 | 9
Developmental regression 9 | 95
Diabetes Mellitus, Non-Insulin-Dependent 9 | 145
Electromyogram abnormal 9 | 49
Increased serum lactate 9 | 60
Loss of developmental milestones 9 | 95
MELAS syndrome 9 | 18
Mental deterioration in childhood 9 | 95
Mitochondrial Myopathies 9 | 21
Neurodevelopmental regression 9 | 95
Optic Neuropathy 9 | 12
Peripheral Neuropathy 9 | 134
Polyneuropathy 9 | 64
Psychomotor regression 9 | 95
Psychomotor regression beginning in infancy 9 | 95
Psychomotor regression in infants 9 | 95
Psychomotor regression, progressive 9 | 95
Sensorineural Hearing Loss (disorder) 9 | 284
Short stature 9 | 531
Static Tremor 9 | 21
Waldenstrons macroglobulinemia 9 | 765
dermatomyositis 9 | 966
Attention deficit hyperactivity disorder 8 | 278
Blepharoptosis 8 | 231
Cerebral atrophy 8 | 178
Dementia 8 | 175
Encephalopathies 8 | 43
Hallucinations 8 | 34
Hallucinations, Sensory 8 | 33
Hemianopsia 8 | 15
Highly variable severity 8 | 157
Intermittent migraine headaches 8 | 68
Microcephaly 8 | 166
Migraine Disorders 8 | 76
Mitochondrial complex I deficiency 8 | 46
Respiratory Insufficiency 8 | 132
Respiratory function loss 8 | 121
Variable expressivity 8 | 157
Wolff-Parkinson-White syndrome 8 | 19
acute myeloid leukemia 8 | 783
breast carcinoma 8 | 1,638
progressive supranuclear palsy 8 | 676

Tissue

Blood and immune system 117 | 16,909
Digestive Tract 117 | 17,369
Endocrine System 117 | 18,159
Female tissues 117 | 17,400
Liver and Pancreas 117 | 16,750
Male tissues 117 | 17,142
Nervous System 117 | 16,725
Respiratory system 117 | 16,393
Skin and soft tissues 117 | 17,230
Urinary Tract 117 | 16,678
Cardiovascular System 116 | 15,192

Target Family

Enzyme 72 | 4,145
Non-IDG 47 | 12,091
Kinase 1 | 634

Reactome Pathway

tRNA processing 120 | 120
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
tRNA-specific adenosine deaminase 1 ADAT1 Tbio Enzyme -1.08814 11.8 136
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase FTSJ1 Tbio Enzyme -1.64419 45.9 108
tRNA (guanine(26)-N(2))-dimethyltransferase TRMT1 Tbio Enzyme -1.61554 40.5 122
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like DUS2 Tbio Enzyme -0.88176 8.73 109
Ribonuclease P protein subunit p25 RPP25 Tbio Enzyme -1.05396 10.6 62
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.52487 33.2 60
Nuclear pore complex protein Nup50 NUP50 Tbio Non-IDG -1.18445 15.9 270
Ubiquitin-related modifier 1 URM1 Tbio Non-IDG -1.43070 29.6 95
Ribonuclease P protein subunit p29 POP4 Tbio Enzyme -1.56086 36.1 72
tRNA-splicing endonuclease subunit Sen15 TSEN15 Tdark Enzyme -0.37883 2.48 71