Development Level

Tbio 162 | 11,445
Tdark 25 | 6,588
Tchem 5 | 1,598

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 3 | 278
enlarged heart 2 | 210
increased startle reflex 2 | 112
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal heart morphology 1 | 162
abnormal seminal vesicle morph... 1 | 114
decreased NK cell number 1 | 2
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased coping response 1 | 8
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
increased circulating chloride... 1 | 41
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38

Disease

ovarian cancer 89 | 8,520
Carcinoma 72 | 11,493
lung cancer 71 | 4,740
osteosarcoma 59 | 7,950
medulloblastoma, large-cell 50 | 6,241
group 3 medulloblastoma 42 | 4,104
psoriasis 42 | 6,694
diabetes mellitus 38 | 1,728
Multiple myeloma 35 | 1,332
colon cancer 30 | 1,478
glioblastoma 30 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,291
atypical teratoid / rhabdoid tumor 27 | 5,112
Diamond-Blackfan anemia 26 | 31
Waldenstrons macroglobulinemia 25 | 765
acute quadriplegic myopathy 23 | 1,158
malignant mesothelioma 23 | 3,232
Breast cancer 18 | 3,578
invasive ductal carcinoma 17 | 2,951
oligodendroglioma 17 | 2,850
Anemia 16 | 365
ependymoma 15 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
Delayed Puberty 14 | 97
adult high grade glioma 14 | 3,801
non-small cell lung cancer 14 | 2,890
Abnormality of the urinary system 13 | 21
Anemia, Diamond-Blackfan 13 | 16
Anemia, Macrocytic 13 | 18
Cardiac Arrhythmia 13 | 103
Cardiac conduction abnormalities 13 | 78
Cleft Palate 13 | 271
Conduction disorder of the heart 13 | 79
Disease Progression 13 | 136
EKG abnormalities 13 | 78
Electrocardiogram abnormal 13 | 81
Electrocardiogram change 13 | 78
Fatigue 13 | 182
Hand deformities 13 | 32
Intermittent migraine headaches 13 | 68
Migraine Disorders 13 | 76
Pallor 13 | 40
Stomach Neoplasms 13 | 300
Uranostaphyloschisis 13 | 167
genital abnormal 13 | 17
reproductive system abnormality 13 | 17
sonic hedgehog group medulloblastoma 13 | 467
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
primitive neuroectodermal tumor 12 | 3,035
Adenocarcinoma of lung 11 | 142
Disease Models, Animal 11 | 155
Kidney cancer 11 | 2,613
pediatric high grade glioma 11 | 1,064
non primary Sjogren syndrome sicca 10 | 891
Cancer 9 | 2,499
acute myeloid leukemia 9 | 783
astrocytic glioma 9 | 2,597
astrocytoma 9 | 1,146
cystic fibrosis 9 | 1,696
subependymal giant cell astrocytoma 9 | 2,287
Bowen-Conradi syndrome 8 | 16
dermatomyositis 8 | 966
Astrocytoma, Pilocytic 7 | 3,081
Autosomal recessive predisposition 7 | 1,442
Breast Neoplasms 7 | 445
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Mammary Neoplasms 7 | 425
Mental and motor retardation 7 | 608
Short stature 7 | 531
Small head 7 | 374
group 4 medulloblastoma 7 | 1,855
juvenile dermatomyositis 7 | 1,187
lung adenocarcinoma 7 | 2,716
mucosa-associated lymphoid tissue lymphoma 7 | 484
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Intellectual disability 6 | 1,016
cutaneous lupus erythematosus 6 | 1,057
pancreatic cancer 6 | 2,398
Hemoglobin low 5 | 124
Hyperpigmentation 5 | 37
Osteoporosis 5 | 363
Reticulocytopenia 5 | 10
Rheumatoid arthritis 5 | 1,191
Shwachman-Diamond syndrome 5 | 17
Systemic scleroderma 5 | 60
hepatocellular carcinoma 5 | 547
spina bifida 5 | 1,074
Dull intelligence 4 | 645
Hypoplastic mandible condyle 4 | 275
Infantile onset 4 | 238
Liver Cirrhosis 4 | 181
Pancytopenia 4 | 45
Pick disease 4 | 1,894
Polycystic ovary syndrome 4 | 360
Poor school performance 4 | 645
breast carcinoma 4 | 1,638
medulloblastoma 4 | 720
non diabetic and post-ischemic heart failure 4 | 200
ulcerative colitis 4 | 1,819

Tissue

Endocrine System 191 | 18,159
Blood and immune system 190 | 16,909
Digestive Tract 190 | 17,369
Male tissues 190 | 17,142
Skin and soft tissues 190 | 17,230
Cardiovascular System 189 | 15,192
Female tissues 189 | 17,400
Liver and Pancreas 189 | 16,750
Nervous System 189 | 16,725
Respiratory system 189 | 16,393
Urinary Tract 189 | 16,678

Target Family

Non-IDG 155 | 12,091
Enzyme 32 | 4,145
Kinase 5 | 634

Reactome Pathway

rRNA processing in the nucleus... 192 | 192
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
60S ribosomal protein L36 RPL36 Tbio Non-IDG -1.62928 39.9 123
U3 small nucleolar RNA-associated protein 18 homolog UTP18 Tdark Non-IDG -0.50488 2.92 52
H/ACA ribonucleoprotein complex subunit 2 NHP2 Tbio Non-IDG -1.51951 28.7 54
Exosome component 10 EXOSC10 Tbio Non-IDG -2.45249 279.1 123
Ribosome biogenesis protein TSR3 homolog TSR3 Tdark Non-IDG -0.42233 2.29 16
KRR1 small subunit processome component homolog KRR1 Tbio Non-IDG -0.93152 9.98 134
Ribosomal biogenesis protein LAS1L LAS1L Tdark Non-IDG -0.48801 2.91 109
60S ribosomal protein L35 RPL35 Tbio Non-IDG -1.30696 19.1 124