Development Level

Tbio 176 | 11,651
Tdark 27 | 6,593
Tchem 7 | 1,388
Tclin 6 | 612

Collection

Kinase: IDG Consortium (Target... 3 | 125
RFA-RM-18-021 3 | 328

IMPC Phenotype

preweaning lethality, complete... 11 | 979
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 4 | 278
enlarged heart 2 | 210
increased startle reflex 2 | 112
prenatal lethality prior to he... 2 | 87
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal heart morphology 1 | 162
abnormal seminal vesicle morph... 1 | 114
decreased NK cell number 1 | 2
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased coping response 1 | 8
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
increased circulating chloride... 1 | 41
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
prolonged QT interval 1 | 38

Disease

ovarian cancer 95 | 8,520
Carcinoma 81 | 11,493
lung cancer 72 | 4,740
osteosarcoma 64 | 7,950
medulloblastoma, large-cell 50 | 6,241
diabetes mellitus 45 | 1,728
group 3 medulloblastoma 44 | 4,104
psoriasis 43 | 6,694
Multiple myeloma 36 | 1,332
colon cancer 30 | 1,478
glioblastoma 30 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,291
atypical teratoid / rhabdoid tumor 27 | 5,112
Diamond-Blackfan anemia 26 | 31
Waldenstrons macroglobulinemia 25 | 765
malignant mesothelioma 24 | 3,232
acute quadriplegic myopathy 23 | 1,158
Cardiac Arrhythmia 21 | 103
Cardiac conduction abnormalities 21 | 78
Conduction disorder of the heart 21 | 79
EKG abnormalities 21 | 78
Electrocardiogram abnormal 21 | 81
Electrocardiogram change 21 | 78
Intermittent migraine headaches 20 | 68
Migraine Disorders 20 | 76
Breast cancer 19 | 3,578
Fatigue 19 | 182
invasive ductal carcinoma 17 | 2,951
oligodendroglioma 17 | 2,850
Anemia 16 | 365
ependymoma 15 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
Cerebellar Ataxia 14 | 304
Delayed Puberty 14 | 97
Short stature 14 | 531
adult high grade glioma 14 | 3,801
non-small cell lung cancer 14 | 2,890
Abnormality of the urinary system 13 | 21
Anemia, Diamond-Blackfan 13 | 16
Anemia, Macrocytic 13 | 18
Cleft Palate 13 | 271
Disease Progression 13 | 136
Hand deformities 13 | 32
Pallor 13 | 40
Stomach Neoplasms 13 | 300
Uranostaphyloschisis 13 | 167
genital abnormal 13 | 17
reproductive system abnormality 13 | 17
sonic hedgehog group medulloblastoma 13 | 467
Adenocarcinoma of lung 12 | 142
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
primitive neuroectodermal tumor 12 | 3,035
Disease Models, Animal 11 | 155
Kidney cancer 11 | 2,613
Myopathy 11 | 185
Optic Atrophy 11 | 242
pediatric high grade glioma 11 | 1,064
Cancer 10 | 2,499
Mitochondrial myopathy 10 | 26
astrocytoma 10 | 1,146
non primary Sjogren syndrome sicca 10 | 891
subependymal giant cell astrocytoma 10 | 2,287
Blind spot located at fixation point 9 | 21
Blurred vision 9 | 19
Cerebral atrophy 9 | 178
Cognitive delay 9 | 608
Decreased visual acuity, slowly progressive 9 | 13
Dystonia 9 | 164
Global developmental delay 9 | 608
Leber hereditary optic neuropathy 9 | 14
Leber's optic atrophy 9 | 10
Mental and motor retardation 9 | 608
Mitochondrial respiratory chain defects 9 | 15
Optic Atrophy, Hereditary, Leber 9 | 14
Ragged-red fibers 9 | 21
Retinal telangiectasia 9 | 12
Scotoma, Central 9 | 21
Scotoma, Centrocecal 9 | 11
Sensorineural Hearing Loss (disorder) 9 | 284
Slow decrease in visual acuity 9 | 13
Tortuous retinal vessels 9 | 15
acute myeloid leukemia 9 | 783
astrocytic glioma 9 | 2,597
cystic fibrosis 9 | 1,696
Abnormal vision 8 | 52
Acidosis, Lactic 8 | 97
Bowen-Conradi syndrome 8 | 16
Central retinal vessel vascular tortuosity 8 | 9
Dystonic disease 8 | 106
Electromyogram abnormal 8 | 49
Highly variable severity 8 | 157
Lactic acidemia 8 | 95
Leigh disease 8 | 100
Mitochondrial Myopathies 8 | 21
Optic Neuropathy 8 | 12
Peripheral Neuropathy 8 | 134
Polyneuropathy 8 | 64
Static Tremor 8 | 21
Variable expressivity 8 | 157
dermatomyositis 8 | 966

Tissue

Endocrine System 213 | 18,159
Blood and immune system 212 | 16,909
Digestive Tract 212 | 17,369
Male tissues 212 | 17,142
Skin and soft tissues 212 | 17,230
Cardiovascular System 211 | 15,192
Female tissues 211 | 17,400
Liver and Pancreas 211 | 16,750
Nervous System 211 | 16,725
Respiratory system 211 | 16,393
Urinary Tract 211 | 16,678

Target Family

Non-IDG 159 | 12,091
Enzyme 52 | 4,145
Kinase 5 | 634

Reactome Pathway

rRNA processing 216 | 216
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
60S ribosomal protein L17 RPL17 Tbio Non-IDG -1.22337 16.5 217
THUMP domain-containing protein 1 THUMPD1 Tbio Non-IDG -2.79570 617.3 85
Ribonuclease P protein subunit p25 RPP25 Tbio Enzyme -1.05396 10.6 62
H/ACA ribonucleoprotein complex subunit 1 GAR1 Tbio Non-IDG -0.33131 2.70 86
WD repeat-containing protein 18 WDR18 Tbio Non-IDG -1.69131 43.0 108
Testis-expressed protein 10 TEX10 Tdark Non-IDG -0.59960 4.28 21
Probable rRNA-processing protein EBP2 EBNA1BP2 Tbio Non-IDG -1.54043 34.9 87
RNA-binding protein 28 RBM28 Tbio Non-IDG -1.90665 82.6 111
Dimethyladenosine transferase 1, mitochondrial TFB1M Tbio Enzyme -1.46427 30.6 104
U3 small nucleolar ribonucleoprotein protein IMP3 IMP3 Tbio Non-IDG -0.34242 1.83 146