Development Level

Tbio 150 | 10,625
Tdark 44 | 7,003
Tchem 9 | 1,890
Tclin 6 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 8 | 633
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 3 | 187
preweaning lethality, incomple... 3 | 260
enlarged heart 2 | 111
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal coat/hair pigmentatio... 1 | 54
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal rib morphology 1 | 28
abnormal seminal vesicle morph... 1 | 47
decreased NK cell number 1 | 16
decreased body weight 1 | 174
decreased circulating chloride... 1 | 32
decreased circulating sodium l... 1 | 18
increased KLRG1-positive CD4-p... 1 | 2
increased KLRG1-positive NK ce... 1 | 9
increased NK cell number 1 | 19
increased circulating chloride... 1 | 43
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 68
increased granulocyte number 1 | 8
increased mean platelet volume 1 | 19
prenatal lethality prior to he... 1 | 64

Disease

ovarian cancer 89 | 8,484
lung cancer 66 | 4,466
osteosarcoma 60 | 7,933
medulloblastoma, large-cell 46 | 6,234
psoriasis 41 | 6,685
diabetes mellitus 38 | 1,663
Multiple myeloma 35 | 1,327
group 3 medulloblastoma 33 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,289
colon cancer 27 | 1,475
glioblastoma 27 | 5,572
Waldenstrons macroglobulinemia 25 | 765
Diamond-Blackfan anemia 24 | 28
malignant mesothelioma 24 | 3,162
sonic hedgehog group medulloblastoma 21 | 1,482
acute quadriplegic myopathy 20 | 1,157
atypical teratoid / rhabdoid tumor 20 | 4,369
invasive ductal carcinoma 16 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
pediatric high grade glioma 15 | 2,712
non-small cell lung cancer 14 | 2,798
oligodendroglioma 14 | 2,849
Anemia, Diamond-Blackfan 13 | 15
Disease Progression 13 | 125
Stomach Neoplasms 13 | 282
Breast cancer 12 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,988
primitive neuroectodermal tumor 12 | 3,031
ependymoma 11 | 2,514
Leber hereditary optic neuropathy 10 | 17
Mitochondrial myopathy 10 | 23
astrocytoma 10 | 1,493
non primary Sjogren syndrome sicca 10 | 840
subependymal giant cell astrocytoma 10 | 2,287
Anemia 9 | 252
Optic Atrophy, Hereditary, Leber 9 | 14
acute myeloid leukemia 9 | 780
cystic fibrosis 9 | 1,665
Bowen-Conradi syndrome 8 | 16
Leigh disease 8 | 81
adult high grade glioma 8 | 2,148
atypical teratoid/rhabdoid tumor 8 | 1,095
lung adenocarcinoma 8 | 2,713
pilocytic astrocytoma 8 | 3,086
Cancer 7 | 2,346
Carcinoma 7 | 2,147
Mammary Neoplasms 7 | 410
astrocytic glioma 7 | 2,241
mucosa-associated lymphoid tissue lymphoma 7 | 480
pancreatic cancer 7 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
Diabetes mellitus type 2 6 | 69
Lactic acidosis 6 | 42
MITOCHONDRIAL COMPLEX I DEFICIENCY 6 | 37
Rheumatoid Arthritis 6 | 1,160
Treatment Refractory Type 2 Diabetes Mellitus 6 | 53
cutaneous lupus erythematosus 6 | 1,056
group 4 medulloblastoma 6 | 1,875
inflammatory breast cancer 6 | 404
juvenile dermatomyositis 6 | 1,189
Malaria 5 | 140
Neurodegenerative disease 5 | 383
Systemic scleroderma 5 | 66
dermatomyositis 5 | 933
glioblastoma multiforme 5 | 347
hepatocellular carcinoma 5 | 532
medulloblastoma 5 | 1,524
posterior fossa group B ependymoma 5 | 1,530
tuberculosis and treatment for 6 months 5 | 686
Alzheimer's disease 4 | 644
Animal Mammary Neoplasms 4 | 136
Dyskeratosis congenita 4 | 24
MELAS syndrome 4 | 17
Mammary Neoplasms, Experimental 4 | 150
Parkinson Disease 4 | 102
Polycystic Ovary Syndrome 4 | 332
Prostatic Neoplasms 4 | 471
Treacher Collins syndrome 4 | 29
X-linked cerebral adrenoleukodystrophy 4 | 115
breast carcinoma 4 | 1,614
spina bifida 4 | 1,064
Chagas disease 3 | 34
Duchenne muscular dystrophy 3 | 602
Nonsyndromic deafness 3 | 121
Obesity 3 | 616
Osteoporosis 3 | 257
Pick disease 3 | 1,893
Renal Cell Carcinoma 3 | 199
Sensorineural hearing loss 3 | 107
Shwachman-Diamond syndrome 3 | 16
Weight Gain 3 | 87
Wolff-Parkinson-White syndrome 3 | 11
active Crohn's disease 3 | 918
adrenocortical carcinoma 3 | 1,427
ductal carcinoma in situ 3 | 1,745
gastric carcinoma 3 | 832
pancreatic carcinoma 3 | 567
pituitary cancer 3 | 1,972
posterior fossa group A ependymoma 3 | 1,511
ulcerative colitis 3 | 2,087

Tissue

Blood and immune system 207 | 17,995
Cardiovascular System 206 | 17,958
Digestive Tract 206 | 18,473
Female tissues 206 | 18,647
Liver and Pancreas 206 | 18,136
Male tissues 206 | 17,969
Nervous System 206 | 18,561
Endocrine System 204 | 18,512
Urinary Tract 204 | 18,444
Respiratory system 203 | 17,484
Skin and soft tissues 201 | 18,115

Target Family

Non-IDG 153 | 11,971
Enzyme 51 | 4,146
Kinase 5 | 634

Reactome Pathway

rRNA processing 209 | 209
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP synthase protein 8 MT-ATP8 Tbio Enzyme -2.30895 191.4 20
U3 small nucleolar RNA-interacting protein 2 RRP9 Tbio Non-IDG -0.95790 8.59 56
Mitochondrial ribonuclease P protein 3 KIAA0391 Tbio Enzyme 66.3 56
Cytochrome b MT-CYB Tbio Non-IDG -3.74473 5676.0 122
60S ribosomal protein L7a RPL7A Tbio Non-IDG -1.66015 45.9 60
60S ribosomal protein L18 RPL18 Tbio Non-IDG -1.73537 50.7 134
Bystin BYSL Tbio Non-IDG -1.20821 15.6 54
60S ribosomal protein L38 RPL38 Tdark Non-IDG -1.39563 24.2 45
Nucleolar complex protein 4 homolog NOC4L Tdark Non-IDG 0.08 2.08 40
U3 small nucleolar RNA-associated protein 6 homolog UTP6 Tbio Non-IDG -1.00948 10.4 87