Development Level

Tbio 64 | 11,445
Tchem 20 | 1,598
Tdark 8 | 6,588
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 7 | 499
decreased total body fat amoun... 3 | 207
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal cornea morphology 2 | 31
abnormal gait 2 | 69
abnormal vibrissa morphology 2 | 25
decreased circulating glucose ... 2 | 126
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
increased circulating alkaline... 2 | 122
increased circulating free fat... 2 | 20
increased lean body mass 2 | 172
tremors 2 | 39
abnormal brain morphology 1 | 13
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal sensory capabilities-... 1 | 8
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal tail morphology 1 | 25
absent spleen 1 | 3
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
convulsive seizures 1 | 13
cyanosis 1 | 7
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased coping response 1 | 8
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged urinary bladder 1 | 8
hemorrhage 1 | 23
hydroencephaly 1 | 14
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mature B cell number 1 | 1
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
respiratory system phenotype 1 | 2
thin ventricular wall 1 | 24
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 74 | 11,493
ovarian cancer 56 | 8,520
osteosarcoma 52 | 7,950
glioblastoma 50 | 5,792
medulloblastoma, large-cell 47 | 6,241
atypical teratoid / rhabdoid tumor 38 | 5,112
Cancer 36 | 2,499
ependymoma 36 | 4,679
psoriasis 35 | 6,694
adult high grade glioma 32 | 3,801
lung cancer 32 | 4,740
Kidney cancer 31 | 2,613
primitive neuroectodermal tumor 28 | 3,035
group 3 medulloblastoma 27 | 4,104
Astrocytoma, Pilocytic 25 | 3,081
subependymal giant cell astrocytoma 23 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
oligodendroglioma 22 | 2,850
group 4 medulloblastoma 21 | 1,855
malignant mesothelioma 21 | 3,232
astrocytic glioma 20 | 2,597
non-small cell lung cancer 20 | 2,890
Breast cancer 19 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
invasive ductal carcinoma 18 | 2,951
lung adenocarcinoma 18 | 2,716
lung carcinoma 18 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
Pick disease 16 | 1,894
pancreatic cancer 16 | 2,398
ulcerative colitis 16 | 1,819
Schizophrenia 15 | 1,160
astrocytoma 15 | 1,146
tuberculosis 15 | 2,010
Alzheimer's disease 14 | 658
pituitary cancer 14 | 1,972
Multiple myeloma 12 | 1,332
breast carcinoma 12 | 1,638
diabetes mellitus 12 | 1,728
Intellectual disability 11 | 1,016
ductal carcinoma in situ 11 | 1,745
cystic fibrosis 10 | 1,696
pediatric high grade glioma 10 | 1,064
Neurodegenerative disease 9 | 414
Rheumatoid arthritis 9 | 1,191
colon cancer 9 | 1,478
primary pancreatic ductal adenocarcinoma 9 | 1,109
Depressive disorder 8 | 409
Melanoma 8 | 711
Mental Depression 8 | 333
Multiple Sclerosis 8 | 540
Waldenstrons macroglobulinemia 8 | 765
acute quadriplegic myopathy 8 | 1,158
aldosterone-producing adenoma 8 | 665
spina bifida 8 | 1,074
Amyotrophic lateral sclerosis 7 | 451
Asthma 7 | 385
Endometriosis 7 | 540
Hypertension 7 | 396
Liver cancer 7 | 604
Neuropathy 7 | 261
acute myeloid leukemia 7 | 783
cutaneous lupus erythematosus 7 | 1,057
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
progressive supranuclear palsy 7 | 676
Arthritis 6 | 290
Bipolar Disorder 6 | 666
Down syndrome 6 | 499
Inflammatory bowel disease 6 | 151
Liver Cirrhosis, Experimental 6 | 769
Prostatic Neoplasms 6 | 495
Seizures 6 | 596
adrenocortical carcinoma 6 | 1,428
interstitial cystitis 6 | 2,312
mucosa-associated lymphoid tissue lymphoma 6 | 484
Cell Transformation, Neoplastic 5 | 97
Cerebrovascular disease 5 | 238
Neoplastic Cell Transformation 5 | 89
Nerve Degeneration 5 | 121
Skin cancer 5 | 469
Toxic encephalopathy 5 | 141
dermatomyositis 5 | 966
gastric cancer 5 | 459
hepatocellular carcinoma 5 | 547
medulloblastoma 5 | 720
Atopic dermatitis 4 | 952
Brain Ischemia 4 | 110
Crohn's disease 4 | 321
Dementia 4 | 175
Diabetes Mellitus, Type 2 4 | 142
Endometrial cancer 4 | 311
Epilepsy 4 | 792
Huntington's disease 4 | 76
Lung disease 4 | 142
Parkinson's disease 4 | 392
Reperfusion Injury 4 | 86
Vascular disease 4 | 319
juvenile dermatomyositis 4 | 1,187
nasopharyngeal carcinoma 4 | 1,058
pancreatic carcinoma 4 | 562

Tissue

Digestive Tract 96 | 17,369
Endocrine System 96 | 18,159
Blood and immune system 95 | 16,909
Female tissues 95 | 17,400
Liver and Pancreas 95 | 16,750
Male tissues 95 | 17,142
Nervous System 95 | 16,725
Urinary Tract 95 | 16,678
Respiratory system 94 | 16,393
Skin and soft tissues 94 | 17,230
Cardiovascular System 92 | 15,192

Target Family

Non-IDG 70 | 12,091
Enzyme 12 | 4,145
Kinase 8 | 634
Epigenetic 3 | 242
Transcription Factor 2 | 1,400
TF/Epigenetic 1 | 38

Reactome Pathway

p75 NTR receptor-mediated sign... 96 | 96
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rho guanine nucleotide exchange factor 33 ARHGEF33 Tdark Non-IDG 1.00 0.05 51
PR domain zinc finger protein 4 PRDM4 Tbio TF/Epigenetic -0.87918 7.84 221
Melanoma-associated antigen D1 MAGED1 Tbio Non-IDG -1.55131 46.3 245
Rho guanine nucleotide exchange factor 17 ARHGEF17 Tbio Non-IDG -1.38408 25.0 61
Rho guanine nucleotide exchange factor 10-like protein ARHGEF10L Tdark Non-IDG 0.19 0.86 25
Caspase-2 CASP2 Tchem Enzyme -2.62373 431.8 571
Beta-nerve growth factor NGF Tchem Non-IDG -4.01592 10936.7 735
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Rho guanine nucleotide exchange factor 5 ARHGEF5 Tbio Non-IDG -0.48804 5.75 249
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143