Development Level

Tchem 8 | 1,598
Tbio 3 | 11,445
Tclin 1 | 613

IMPC Phenotype

increased circulating glucose ... 2 | 24
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal femur morphology 1 | 14
abnormal joint morphology 1 | 23
abnormal optic disc morphology 1 | 10
decreased circulating iron lev... 1 | 32
increased circulating iron lev... 1 | 30
increased leukocyte cell numbe... 1 | 47
prenatal lethality 1 | 28
preweaning lethality, complete... 1 | 979
short tibia 1 | 97

Disease

Carcinoma 10 | 11,493
osteosarcoma 9 | 7,950
psoriasis 9 | 6,694
Cancer 8 | 2,499
glioblastoma 7 | 5,792
atypical teratoid / rhabdoid tumor 6 | 5,112
ependymoma 6 | 4,679
medulloblastoma, large-cell 6 | 6,241
lung cancer 5 | 4,740
ovarian cancer 5 | 8,520
group 3 medulloblastoma 4 | 4,104
Colorectal Neoplasms 3 | 243
Intellectual disability 3 | 1,016
Kidney cancer 3 | 2,613
Noonan syndrome 3 | 34
Stomach Neoplasms 3 | 300
Transitional cell carcinoma of bladder 3 | 17
adult high grade glioma 3 | 3,801
breast carcinoma 3 | 1,638
group 4 medulloblastoma 3 | 1,855
juvenile dermatomyositis 3 | 1,187
malignant mesothelioma 3 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010
Abnormal dermatoglyphic pattern 2 | 24
Abnormal hair quantity 2 | 16
Abnormal platelet function 2 | 12
Abnormality of the spleen 2 | 13
Abnormality of vision 2 | 40
Aplasia/Hypoplasia of the abdominal wall musculature 2 | 17
Asymmetric growth 2 | 5
Asymmetry of the posterior cranium 2 | 20
Basal cell carcinoma 2 | 54
Basal cell nevi 2 | 23
Blastic phase chronic myeloid leukemia 2 | 58
Bleeding tendency 2 | 37
COPD 2 | 118
Carcinoma of colon 2 | 32
Chronic Myelocytic Leukemia Accelerated Phase 2 | 59
Chronic phase chronic myeloid leukemia 2 | 45
Coarse hair 2 | 31
Congenital pectus carinatum 2 | 52
Connective tissue cancer 2 | 10
Curly hair (finding) 2 | 14
Decreased projection of midface 2 | 105
Defect of vertebral segmentation 2 | 17
Dental abnormalities 2 | 60
Enlarged thorax 2 | 18
Excess nuchal skin 2 | 30
Facial asymmetry 2 | 32
Fetal overgrowth 2 | 16
Flattening of head 2 | 20
Follicular thyroid carcinoma 2 | 14
Full lower lip 2 | 64
Generalized osteopenia 2 | 99
Generalized overgrowth 2 | 16
Genu recurvatum 2 | 12
Hemangioma 2 | 69
Hemangioma, Cavernous 2 | 20
Hereditary nonpolyposis colorectal carcinoma 2 | 18
Horseshoe Kidney 2 | 16
Hypogonadism, Isolated Hypogonadotropic 2 | 71
Hypogonadotropic hypogonadism 2 | 89
Hypopigmentation disorder 2 | 25
Hypotrophic midface 2 | 105
Increased gastric cancer 2 | 21
Irregular hyperpigmentation 2 | 33
Juvenile Myelomonocytic Leukemia 2 | 21
Kyphoscoliosis deformity of spine 2 | 60
Leiomyosarcoma of uterus 2 | 13
Leukemia, Myeloid, Acute 2 | 105
Leukemia, Myelomonocytic, Juvenile 2 | 20
Low posterior hairline 2 | 52
Lymphoid leukemia 2 | 160
Midface retrusion 2 | 105
Neoplasms, Experimental 2 | 40
Noncancerous mole 2 | 28
Osteopenia 2 | 99
Overgrowth 2 | 16
Papillary thyroid carcinoma 2 | 43
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 2 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 2 | 47
Plagiocephaly 2 | 20
Plagiocephaly, Nonsynostotic 2 | 20
Porencephaly 2 | 20
Prominent lower lip 2 | 64
Pulmonary artery stenosis 2 | 22
Rectal Neoplasms 2 | 18
Renal Cell Carcinoma 2 | 214
Rhabdomyosarcoma 2 | 39
Rhomboid shaped head 2 | 20
Rough hair texture 2 | 31
Sebaceous adenoma 2 | 26
Small midface 2 | 105
Thickened helices 2 | 15
Thyroid cancer 2 | 36
Tooth Abnormalities 2 | 69
Upper respiratory tract disease 2 | 15
Wide spaced nipples 2 | 46

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Kinase 7 | 634
Enzyme 4 | 4,145
Non-IDG 1 | 12,091

Reactome Pathway

p38MAPK events 12 | 12
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase 14 MAPK14 Tchem Kinase -3.36007 2240.8 1574
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -4.00292 9201.7 1455
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
MAP kinase-activated protein kinase 2 MAPKAPK2 Tchem Kinase -2.16502 140.7 702
Ras-related protein Ral-A RALA Tbio Enzyme -2.22188 169.9 225
Ras-related protein Ral-B RALB Tbio Enzyme -1.71078 50.9 228
MAP kinase-activated protein kinase 3 MAPKAPK3 Tchem Kinase -1.71703 51.6 242
Mitogen-activated protein kinase 11 MAPK11 Tchem Kinase -2.06160 98.6 336
Mitogen-activated protein kinase 12 MAPK12 Tchem Kinase -1.95173 88.4 378