Development Level

Tbio 14 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

embryonic lethality prior to o... 4 | 239
preweaning lethality, complete... 4 | 979
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal heart morphology 1 | 162
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating insulin ... 1 | 76
enlarged heart 1 | 210
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating total pr... 1 | 28
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
vertebral transformation 1 | 12

Disease

osteosarcoma 12 | 7,950
ovarian cancer 9 | 8,520
Carcinoma 6 | 11,493
group 3 medulloblastoma 5 | 4,104
psoriasis 5 | 6,694
Autosomal recessive predisposition 4 | 1,442
astrocytic glioma 4 | 2,597
medulloblastoma, large-cell 4 | 6,241
Failure to gain weight 3 | 365
Multiple myeloma 3 | 1,332
Pediatric failure to thrive 3 | 365
acute myeloid leukemia 3 | 783
ependymoma 3 | 4,679
glioblastoma 3 | 5,792
group 4 medulloblastoma 3 | 1,855
lung cancer 3 | 4,740
malignant mesothelioma 3 | 3,232
oligodendroglioma 3 | 2,850
Afro-textured hair 2 | 13
Biopsy shows villous atrophy 2 | 16
Brittle hair 2 | 25
Bulging forehead 2 | 66
Cerebral atrophy 2 | 178
Clastothrix 2 | 4
Cognitive delay 2 | 608
Diarrhea 2 | 253
Duodenal villous atrophy 2 | 16
Feeding difficulties 2 | 127
Fetal Growth Retardation 2 | 189
Fractured hair 2 | 25
Fragile hair 2 | 25
Global developmental delay 2 | 608
Hepatomegaly 2 | 285
Infant, Small for Gestational Age 2 | 176
Intrauterine retardation 2 | 176
Kidney cancer 2 | 2,613
Kinky hair texture 2 | 13
Liver Cirrhosis 2 | 181
Low Birth Weights 2 | 69
Mental and motor retardation 2 | 608
Nappy hair texture 2 | 13
Neurodegenerative disease 2 | 414
Orbital separation excessive 2 | 244
Polyhydramnios 2 | 108
Pontocerebellar Hypoplasia Type 1 2 | 5
Pontocerebellar hypoplasia 2 | 36
Prominent forehead 2 | 66
Reduced tensile strength of hair 2 | 25
Small for gestational age (disorder) 2 | 69
Small intestine biopsy shows villous atrophy 2 | 16
Sparse hair 2 | 59
Thin, sparse hair 2 | 59
Trichohepatoenteric Syndrome 2 | 2
Trichohepatoenteric syndrome 1 2 | 2
Variable degree of villous atrophy 2 | 16
Villous atrophy 2 | 16
Villous atrophy of intestine 2 | 16
Waldenstrons macroglobulinemia 2 | 765
Wide nose 2 | 35
Wooly hair 2 | 17
X-linked cerebral adrenoleukodystrophy 2 | 116
colon cancer 2 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
non-small cell lung cancer 2 | 2,890
Axial hypotonia 1 | 46
Brachydactyly 1 | 156
Colitis 1 | 54
Congenital deafness 1 | 185
Deafness 1 | 198
Degenerative brain disorder 1 | 100
Downward slant of palpebral fissure 1 | 158
Fibrosis, Liver 1 | 32
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Hearing Loss, Partial 1 | 185
Hemolytic anemia 1 | 77
Hypoalbuminemia 1 | 24
Icterus 1 | 82
Immunologic Deficiency Syndromes 1 | 113
Liver Failure 1 | 73
Muscle Weakness 1 | 170
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Poor growth 1 | 114
Prenatal onset 1 | 139
Prominent eyes 1 | 96
Prominent globes 1 | 96
Protruding eyes 1 | 96
Respiratory Failure 1 | 104
Respiratory Insufficiency 1 | 132
Respiratory function loss 1 | 121
Retinitis pigmentosa 49 1 | 14
Spinal muscular atrophy 1 | 34
Supratentorial atrophy 1 | 94
Thalassemia 1 | 53
Underdeveloped brows 1 | 38
Underdeveloped supraorbital ridges 1 | 38
Very poor growth 1 | 114
hearing impairment 1 | 199
interstitial lung disease 1 | 298

Tissue

Blood and immune system 15 | 16,909
Cardiovascular System 15 | 15,192
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678

Target Family

Enzyme 9 | 4,145
Non-IDG 6 | 12,091

Reactome Pathway

mRNA decay by 3' to 5' exoribo... 15 | 15
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Exosome complex exonuclease RRP44 DIS3 Tbio Enzyme -1.80730 64.2 141
Exosome complex component RRP4 EXOSC2 Tbio Non-IDG -0.28065 2.13 121
Exosome complex component MTR3 EXOSC6 Tbio Enzyme -0.78888 5.11 84
Exosome complex component RRP41 EXOSC4 Tbio Enzyme -1.96200 85.3 113
WD repeat-containing protein 61 WDR61 Tbio Non-IDG -1.27258 18.3 189
Exosome complex component RRP45 EXOSC9 Tbio Enzyme -1.17714 13.5 92
7-methylguanosine phosphate-specific 5'-nucleotidase NT5C3B Tdark Enzyme -0.47850 3.49 63
Exosome complex component RRP46 EXOSC5 Tbio Enzyme -1.31759 21.1 114
Exosome complex component CSL4 EXOSC1 Tbio Non-IDG -2.07438 110.2 129
HBS1-like protein HBS1L Tbio Non-IDG -2.55785 357.2 263