Development Level

Tbio 41 | 11,445
Tdark 9 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased grip strength 1 | 116
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
enlarged heart 1 | 210
hypoactivity 1 | 132
impaired righting response 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
thrombocytosis 1 | 27

Disease

ovarian cancer 35 | 8,520
Carcinoma 23 | 11,493
lung cancer 19 | 4,740
osteosarcoma 19 | 7,950
medulloblastoma, large-cell 16 | 6,241
group 3 medulloblastoma 15 | 4,104
glioblastoma 13 | 5,792
Multiple myeloma 11 | 1,332
diabetes mellitus 11 | 1,728
psoriasis 11 | 6,694
atypical teratoid / rhabdoid tumor 10 | 5,112
ependymoma 10 | 4,679
Kidney cancer 9 | 2,613
astrocytoma 9 | 1,146
Breast cancer 7 | 3,578
Conductive hearing loss 7 | 123
dermatomyositis 7 | 966
oligodendroglioma 7 | 2,850
Intellectual disability 6 | 1,016
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
malignant mesothelioma 6 | 3,232
non-small cell lung cancer 6 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
primitive neuroectodermal tumor 6 | 3,035
Dull intelligence 5 | 645
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Poor school performance 5 | 645
Waldenstrons macroglobulinemia 5 | 765
acute myeloid leukemia 5 | 783
astrocytic glioma 5 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
Anteverted nostril 4 | 191
Cleft Palate 4 | 271
Hereditary spherocytosis type 5 4 | 12
Hypoplastic mandible condyle 4 | 275
Mandibular hypoplasia 4 | 275
Micrognathism 4 | 275
Pick disease 4 | 1,894
Uranostaphyloschisis 4 | 167
acute quadriplegic myopathy 4 | 1,158
adult high grade glioma 4 | 3,801
breast carcinoma 4 | 1,638
group 4 medulloblastoma 4 | 1,855
invasive ductal carcinoma 4 | 2,951
lung adenocarcinoma 4 | 2,716
subependymal giant cell astrocytoma 4 | 2,287
Abnormality of retinal pigmentation 3 | 111
Abnormality of the retinal vasculature 3 | 59
Absent auditory canals 3 | 23
Absent external auditory canals 3 | 23
Atresia of the external auditory canal 3 | 23
Atretic auditory canal 3 | 23
Atypical scarring of skin 3 | 62
Autosomal recessive predisposition 3 | 1,442
Blind Vision 3 | 111
Blindness, Legal 3 | 110
Broad flat nasal bridge 3 | 236
Cancer 3 | 2,499
Cataract 3 | 297
Congenital anomaly of testis 3 | 52
Congenital hypoplasia of penis 3 | 176
Electroretinogram abnormal 3 | 95
Gaucher disease type 1 3 | 180
Glaucoma 3 | 239
HIV Infections 3 | 102
Hyperinsulinism 3 | 133
Hypogonadism 3 | 173
Hypotrophic malar bone 3 | 129
Keratoconus 3 | 113
Lens Opacities 3 | 231
Low set ears 3 | 181
Malar flattening 3 | 129
Mixed connective tissue disease 3 | 16
Nager acrofacial dysostosis 3 | 21
Nasal bridge wide 3 | 236
Night blindness, progressive 3 | 51
Nystagmus 3 | 317
Obesity 3 | 678
Ophthalmoplegia 3 | 106
Optic Atrophy 3 | 242
Photodysphoria 3 | 121
Photophobia 3 | 121
Preauricular skin tag 3 | 19
Retinal pigment epithelial abnormality 3 | 111
Retinitis Pigmentosa 3 | 226
Sensorineural Hearing Loss (disorder) 3 | 284
Short stature 3 | 531
Skin tag on the posterior cheek 3 | 19
Small head 3 | 374
Treacher Collins syndrome 3 | 27
non primary Sjogren syndrome sicca 3 | 891
pancreatic cancer 3 | 2,398
pediatric high grade glioma 3 | 1,064
progressive supranuclear palsy 3 | 676
relapsing-remitting multiple sclerosis 3 | 18
hepatocellular carcinoma 2 | 547
pituitary cancer 2 | 1,972
sonic hedgehog group medulloblastoma 2 | 467

Tissue

Blood and immune system 51 | 16,909
Cardiovascular System 51 | 15,192
Digestive Tract 51 | 17,369
Endocrine System 51 | 18,159
Female tissues 51 | 17,400
Liver and Pancreas 51 | 16,750
Male tissues 51 | 17,142
Nervous System 51 | 16,725
Respiratory system 51 | 16,393
Skin and soft tissues 51 | 17,230
Urinary Tract 51 | 16,678

Target Family

Non-IDG 36 | 12,091
Enzyme 14 | 4,145
Transcription Factor 1 | 1,400

Reactome Pathway

mRNA Splicing - Minor Pathway 51 | 51
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
ATP-dependent RNA helicase DDX42 DDX42 Tbio Enzyme -1.10894 13.3 60
Splicing factor 3B subunit 2 SF3B2 Tbio Non-IDG -1.32229 20.7 163
Splicing factor 3B subunit 6 SF3B6 Tbio Non-IDG -0.65964 4.59 100
U6 snRNA-associated Sm-like protein LSm2 LSM2 Tbio Non-IDG -1.40226 23.0 121
DNA-directed RNA polymerases I, II, and III subunit RPABC2 POLR2F Tbio Enzyme -1.13403 13.9 68
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.90716 7.36 65
U11/U12 small nuclear ribonucleoprotein 25 kDa protein SNRNP25 Tdark Non-IDG 0.08 0.74 24
Splicing factor 3B subunit 5 SF3B5 Tdark Non-IDG -0.22812 1.30 24
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.13403 13.5 180