Development Level

Tbio 143 | 10,625
Tdark 25 | 7,003
Tchem 9 | 1,890

IMPC Phenotype

preweaning lethality, complete... 12 | 633
embryonic lethality prior to o... 4 | 148
abnormal behavior 3 | 226
decreased leukocyte cell numbe... 3 | 54
decreased neutrophil cell numb... 3 | 37
embryonic lethality prior to t... 3 | 187
preweaning lethality, incomple... 3 | 260
abnormal coat-hair pigmentatio... 2 | 54
decreased circulating glucose ... 2 | 121
decreased lymphocyte cell numb... 2 | 9
increased fasted circulating g... 2 | 68
prenatal lethality prior to he... 2 | 64
thrombocytosis 2 | 23
abnormal embryo size 1 | 112
abnormal esophagus morphology 1 | 4
abnormal retinal pigmentation 1 | 61
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased body length 1 | 108
decreased circulating calcium ... 1 | 33
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased gamma-delta T cell n... 1 | 18
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased lean body mass 1 | 195
decreased monocyte cell number 1 | 28
enlarged heart 1 | 111
female infertility 1 | 34
hyperactivity 1 | 108
impaired righting response 1 | 19
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating glucose ... 1 | 16
increased circulating serum al... 1 | 25
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased or absent threshold ... 1 | 128
increased prepulse inhibition 1 | 21
increased total body fat amoun... 1 | 57
male infertility 1 | 62
oligodactyly 1 | 14
sparse hair 1 | 6

Disease

ovarian cancer 128 | 8,491
osteosarcoma 86 | 7,933
psoriasis 68 | 6,685
lung cancer 61 | 4,473
medulloblastoma, large-cell 61 | 6,234
Multiple myeloma 52 | 1,327
group 3 medulloblastoma 52 | 2,254
glioblastoma 51 | 5,572
oligodendroglioma 40 | 2,849
ependymoma 39 | 2,514
atypical teratoid / rhabdoid tumor 33 | 4,369
malignant mesothelioma 33 | 3,163
astrocytoma 32 | 1,493
acute quadriplegic myopathy 31 | 1,157
Waldenstrons macroglobulinemia 28 | 764
primitive neuroectodermal tumor 28 | 3,031
diabetes mellitus 26 | 1,663
dermatomyositis 25 | 966
Breast cancer 24 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,988
Pick disease 21 | 1,893
astrocytic glioma 21 | 2,241
lung adenocarcinoma 21 | 2,714
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,956
pediatric high grade glioma 19 | 2,712
non-small cell lung cancer 18 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,795
subependymal giant cell astrocytoma 18 | 2,287
Carcinoma 17 | 2,147
progressive supranuclear palsy 17 | 674
Cancer 15 | 2,346
acute myeloid leukemia 14 | 785
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
sonic hedgehog group medulloblastoma 14 | 1,482
atypical teratoid/rhabdoid tumor 13 | 1,095
breast carcinoma 13 | 1,614
Gaucher disease type 1 12 | 171
juvenile dermatomyositis 12 | 1,189
pancreatic cancer 12 | 2,300
Intellectual disability 11 | 573
invasive ductal carcinoma 11 | 2,950
tuberculosis and treatment for 6 months 11 | 686
adult high grade glioma 10 | 2,148
group 4 medulloblastoma 10 | 1,875
hepatocellular carcinoma 10 | 550
non primary Sjogren syndrome sicca 10 | 840
nasopharyngeal carcinoma 9 | 1,056
Amyotrophic Lateral Sclerosis 8 | 432
Rheumatoid Arthritis 8 | 1,170
aldosterone-producing adenoma 8 | 664
HIV Infections 7 | 99
Retinitis pigmentosa 7 | 156
medulloblastoma 7 | 1,524
pituitary cancer 7 | 1,972
Mixed connective tissue disease 6 | 16
Polycystic Ovary Syndrome 6 | 334
Stomach Neoplasms 6 | 282
adrenocortical carcinoma 6 | 1,427
pancreatic carcinoma 6 | 567
posterior fossa group B ependymoma 6 | 1,530
relapsing-remitting multiple sclerosis 6 | 18
Disease Progression 5 | 125
Frontotemporal dementia 5 | 47
Lupus erythematosus 5 | 80
Microcephaly 5 | 149
Subcutaneous panniculitis-like T-cell lymphoma 5 | 16
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
gastric cancer 5 | 436
pilocytic astrocytoma 5 | 3,086
primary pancreatic ductal adenocarcinoma 5 | 1,271
Alzheimer's disease 4 | 644
Animal Mammary Neoplasms 4 | 135
Cockayne syndrome 4 | 54
Immune system cancer 4 | 38
Mammary Neoplasms 4 | 410
Mammary Neoplasms, Experimental 4 | 149
Nager acrofacial dysostosis 4 | 21
colon cancer 4 | 1,475
cystic fibrosis 4 | 1,670
glioblastoma multiforme 4 | 347
inflammatory breast cancer 4 | 404
interstitial lung disease 4 | 292
posterior fossa group A ependymoma 4 | 1,511
primary Sjogren syndrome 4 | 788
spina bifida 4 | 1,064
tuberculosis and treatment for 3 months 4 | 327
Atopic dermatitis 3 | 944
Epilepsy 3 | 346
Hematologic cancer 3 | 9
Melanoma 3 | 261
Neurodegenerative disease 3 | 383
Pneumonia 3 | 133
Spinal muscular atrophy 3 | 24
Spinocerebellar ataxia type 1 3 | 16
Treacher Collins syndrome 3 | 29
active Crohn's disease 3 | 918
ductal carcinoma in situ 3 | 1,745
gastric carcinoma 3 | 832
tuberculosis 3 | 1,563
non diabetic and post-ischemic heart failure 2 | 200

Tissue

Blood and immune system 176 | 17,994
Digestive Tract 176 | 18,472
Endocrine System 176 | 18,511
Female tissues 176 | 18,646
Liver and Pancreas 176 | 18,135
Male tissues 176 | 17,968
Nervous System 176 | 18,560
Respiratory system 176 | 17,483
Cardiovascular System 175 | 17,957
Urinary Tract 175 | 18,443
Skin and soft tissues 174 | 18,114

Target Family

Non-IDG 145 | 11,969
Enzyme 28 | 4,146
Epigenetic 2 | 242
Transcription Factor 2 | 1,400

Reactome Pathway

mRNA Splicing - Major Pathway 177 | 177
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 DHX15 Tbio Enzyme -1.70052 49.6 108
U4/U6 small nuclear ribonucleoprotein Prp4 PRPF4 Tchem Non-IDG -0.55879 7.56 79
Nuclear cap-binding protein subunit 1 NCBP1 Tbio Non-IDG -2.31776 194.4 161
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.14104 13.5 159
DNA-directed RNA polymerase II subunit RPB11-a POLR2J Tbio Enzyme -1.42612 28.8 182
RNA-binding motif protein, X chromosome RBMX Tbio Non-IDG -1.49173 32.8 82
Peptidyl-prolyl cis-trans isomerase E PPIE Tbio Enzyme -1.30532 19.4 143
Pleiotropic regulator 1 PLRG1 Tbio Non-IDG -0.93540 8.69 172
Pre-mRNA-processing factor 6 PRPF6 Tbio Non-IDG -1.35844 27.6 163