Development Level

Tbio 158 | 11,445
Tdark 16 | 6,588
Tchem 5 | 1,598

IMPC Phenotype

preweaning lethality, complete... 26 | 979
embryonic lethality prior to o... 8 | 239
abnormal behavior 4 | 298
embryonic lethality prior to t... 4 | 278
prenatal lethality prior to he... 4 | 87
preweaning lethality, incomple... 4 | 499
decreased leukocyte cell numbe... 3 | 73
decreased lymphocyte cell numb... 3 | 83
decreased neutrophil cell numb... 3 | 42
hypoactivity 3 | 132
increased fasted circulating g... 3 | 76
increased mean corpuscular vol... 3 | 92
abnormal coat-hair pigmentatio... 2 | 64
abnormal embryo size 2 | 220
decreased bone mineral density 2 | 126
decreased circulating triglyce... 2 | 79
decreased mean corpuscular hem... 2 | 31
decreased total body fat amoun... 2 | 207
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased circulating free fat... 2 | 20
increased lean body mass 2 | 172
increased lymphocyte cell numb... 2 | 32
increased mean platelet volume 2 | 45
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal esophagus morphology 1 | 5
abnormal pericardium morpholog... 1 | 26
absent pinna reflex 1 | 23
decreased circulating HDL chol... 1 | 68
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased startle reflex 1 | 75
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
hyperactivity 1 | 148
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
male infertility 1 | 123
thrombocytosis 1 | 27

Disease

ovarian cancer 129 | 8,520
Carcinoma 111 | 11,493
osteosarcoma 85 | 7,950
psoriasis 68 | 6,694
group 3 medulloblastoma 64 | 4,104
lung cancer 64 | 4,740
medulloblastoma, large-cell 60 | 6,241
Multiple myeloma 52 | 1,332
glioblastoma 52 | 5,792
ependymoma 46 | 4,679
oligodendroglioma 40 | 2,850
atypical teratoid / rhabdoid tumor 38 | 5,112
malignant mesothelioma 34 | 3,232
acute quadriplegic myopathy 31 | 1,158
Kidney cancer 29 | 2,613
primitive neuroectodermal tumor 29 | 3,035
Waldenstrons macroglobulinemia 28 | 765
astrocytic glioma 28 | 2,597
Breast cancer 27 | 3,578
diabetes mellitus 27 | 1,728
astrocytoma 25 | 1,146
dermatomyositis 25 | 966
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
lung adenocarcinoma 22 | 2,716
Pick disease 21 | 1,894
adult high grade glioma 19 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
Intellectual disability 18 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
subependymal giant cell astrocytoma 18 | 2,287
non-small cell lung cancer 17 | 2,890
progressive supranuclear palsy 17 | 676
Cancer 15 | 2,499
acute myeloid leukemia 14 | 783
breast carcinoma 13 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
Gaucher disease type 1 12 | 180
juvenile dermatomyositis 12 | 1,187
pancreatic cancer 12 | 2,398
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
non primary Sjogren syndrome sicca 11 | 891
Conductive hearing loss 10 | 123
group 4 medulloblastoma 10 | 1,855
hepatocellular carcinoma 10 | 547
invasive ductal carcinoma 10 | 2,951
tuberculosis and treatment for 6 months 10 | 409
Amyotrophic lateral sclerosis 9 | 451
Broad flat nasal bridge 9 | 236
Nasal bridge wide 9 | 236
Rheumatoid arthritis 9 | 1,191
aldosterone-producing adenoma 9 | 665
pediatric high grade glioma 9 | 1,064
Anteverted nostril 8 | 191
Retinitis Pigmentosa 8 | 226
atypical teratoid/rhabdoid tumor 8 | 357
nasopharyngeal carcinoma 8 | 1,058
relapsing-remitting multiple sclerosis 8 | 18
Blind Vision 7 | 111
Blindness, Legal 7 | 110
Cataract 7 | 297
Keratoconus 7 | 113
Lens Opacities 7 | 231
Nystagmus 7 | 317
Obesity 7 | 678
Ophthalmoplegia 7 | 106
pituitary cancer 7 | 1,972
Abnormality of retinal pigmentation 6 | 111
Autosomal recessive predisposition 6 | 1,442
Cleft Palate 6 | 271
Cognitive delay 6 | 608
Congenital anomaly of testis 6 | 52
Congenital hypoplasia of penis 6 | 176
Electroretinogram abnormal 6 | 95
Epilepsy 6 | 792
Frontotemporal dementia 6 | 51
Glaucoma 6 | 239
Global developmental delay 6 | 608
HIV Infections 6 | 102
Hyperinsulinism 6 | 133
Hypogonadism 6 | 173
Hypoplastic mandible condyle 6 | 275
Mandibular hypoplasia 6 | 275
Mental and motor retardation 6 | 608
Microcephaly 6 | 166
Micrognathism 6 | 275
Optic Atrophy 6 | 242
Photophobia 6 | 121
Polycystic ovary syndrome 6 | 360
Retinal pigment epithelial abnormality 6 | 111
Sensorineural Hearing Loss (disorder) 6 | 284
Short stature 6 | 531
Small head 6 | 374
Stomach Neoplasms 6 | 300
Uranostaphyloschisis 6 | 167
adrenocortical carcinoma 6 | 1,428
pancreatic carcinoma 6 | 562

Tissue

Blood and immune system 179 | 16,909
Cardiovascular System 179 | 15,192
Digestive Tract 179 | 17,369
Endocrine System 179 | 18,159
Female tissues 179 | 17,400
Liver and Pancreas 179 | 16,750
Male tissues 179 | 17,142
Nervous System 179 | 16,725
Respiratory system 179 | 16,393
Skin and soft tissues 179 | 17,230
Urinary Tract 179 | 16,678

Target Family

Non-IDG 144 | 12,091
Enzyme 31 | 4,145
Epigenetic 2 | 242
Transcription Factor 2 | 1,400

Reactome Pathway

mRNA Splicing - Major Pathway 179 | 179
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
RNA-binding protein 8A RBM8A Tbio Non-IDG -3.16448 1415.1 94
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Pre-mRNA-splicing factor CWC25 homolog CWC25 Tdark Non-IDG -0.71222 5.53 18
U6 snRNA-associated Sm-like protein LSm4 LSM4 Tbio Non-IDG -2.13782 132.0 149
Cleavage and polyadenylation specificity factor subunit 3 CPSF3 Tbio Non-IDG -1.47182 27.3 190
Pre-mRNA-splicing factor RBM22 RBM22 Tbio Non-IDG -0.84549 7.65 130
Heterogeneous nuclear ribonucleoprotein U-like protein 1 HNRNPUL1 Tbio Non-IDG -0.99811 11.3 132
ATP-dependent RNA helicase DDX42 DDX42 Tbio Enzyme -1.10894 13.3 60
Heterogeneous nuclear ribonucleoprotein M HNRNPM Tbio Non-IDG -1.64443 45.9 331