Development Level

Tbio 8 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
decreased bone mineral content 1 | 151
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased hematocrit 1 | 46
pale yolk sac 1 | 25
pallor 1 | 34

Disease

Carcinoma 4 | 11,493
lung carcinoma 4 | 2,843
Breast Neoplasms 3 | 445
Cancer 3 | 2,499
Psychotic Disorders 3 | 151
dermatomyositis 3 | 966
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
medulloblastoma, large-cell 3 | 6,241
ovarian cancer 3 | 8,520
psoriasis 3 | 6,694
Mammary Neoplasms 2 | 425
Neoplasms 2 | 63
Neoplastic Processes 2 | 10
Nonorganic psychosis 2 | 84
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
cutaneous lupus erythematosus 2 | 1,057
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung cancer 2 | 4,740
osteosarcoma 2 | 7,950
tuberculosis 2 | 2,010
AICARDI-GOUTIERES SYNDROME 1 1 | 5
AICARDI-GOUTIERES SYNDROME 6 1 | 1
Acquired immunodeficiency syndrome 1 | 197
Adenocarcinoma of lung 1 | 142
Adenocarcinoma of lung (disorder) 1 | 60
Aicardi-Goutieres syndrome 1 | 19
Amyotrophic lateral sclerosis 1 | 451
Anogenital venereal wart 1 | 14
Arhinencephaly 1 | 5
Arthritis, Juvenile 1 | 126
Astrocytoma, Pilocytic 1 | 3,081
Atherosclerosis 1 | 291
Atopic dermatitis 1 | 952
Bipolar Disorder 1 | 666
Bladder Neoplasm 1 | 112
Carcinoma, Squamous Cell 1 | 110
Chronic obstructive pulmonary disease 1 | 184
Coloboma of eyelid 1 | 15
Contact Dermatitis 1 | 81
Dowling-Degos disease 1 | 7
Duchenne muscular dystrophy 1 | 601
Dyschromatosis symmetrica hereditaria 1 | 4
Dyschromatosis universalis hereditaria 1 | 6
Dystonia Musculorum Deformans 1 | 5
Head and Neck Neoplasms 1 | 26
Hemiplegia and hemiparesis 1 | 38
Immunodeficiency with hyper-IgM type 2 1 | 3
Infantile onset 1 | 238
Juvenile arthritis 1 | 126
Kidney cancer 1 | 2,613
Liver Cirrhosis, Experimental 1 | 769
Loss of ability to walk 1 | 3
Loss of speech 1 | 16
Macular hyperpigmentation 1 | 1
Macule 1 | 19
Multiple myeloma 1 | 1,332
Muscle Rigidity 1 | 49
Muscle Spasticity 1 | 195
Polycystic ovary syndrome 1 | 360
Porencephaly 1 | 20
Profound Mental Retardation 1 | 31
Profound intellectual disabilities 1 | 31
Reticulate acropigmentation of Kitamura 1 | 9
STRIATONIGRAL DEGENERATION, INFANTILE (disorder) 1 | 3
Schizophrenia 1 | 1,160
Spindle cell hemangioma 1 | 16
Squamous cell carcinoma 1 | 129
Steatitis 1 | 2
Striatonigral Degeneration, Infantile 1 | 4
Symmetrical dyschromatosis of extremities 1 | 1
Systemic lupus erythematosus 1 | 194
Tremor 1 | 113
Urinary Bladder Neoplasms 1 | 114
Urinary bladder cancer 1 | 36
Uterine Cervical Neoplasm 1 | 25
Uterine Cervical Neoplasms 1 | 26
Waldenstrons macroglobulinemia 1 | 765
active Crohn's disease 1 | 922
active ulcerative colitis 1 | 764
acute myeloid leukemia 1 | 783
acute quadriplegic myopathy 1 | 1,158
astrocytic glioma 1 | 2,597
astrocytoma 1 | 1,146
breast carcinoma 1 | 1,638
chronic lymphosyte leukemia 1 | 204
cystic fibrosis 1 | 1,696
gastric carcinoma 1 | 807
glioblastoma 1 | 5,792
interstitial cystitis 1 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
mucosa-associated lymphoid tissue lymphoma 1 | 484
non-small cell lung cancer 1 | 2,890
non-small cell lung carcinoma 1 | 317
oligodendroglioma 1 | 2,850
posterior fossa group B ependymoma 1 | 416
primitive neuroectodermal tumor 1 | 3,035
subependymal giant cell astrocytoma 1 | 2,287

Tissue

Digestive Tract 9 | 17,369
Blood and immune system 8 | 16,909
Cardiovascular System 8 | 15,192
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 7 | 16,678

Target Family

Non-IDG 7 | 12,091
Enzyme 2 | 4,145

Reactome Pathway

mRNA Editing 9 | 9
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative C->U-editing enzyme APOBEC-4 APOBEC4 Tdark Non-IDG -0.53411 2.24 183
Double-stranded RNA-specific editase 1 ADARB1 Tbio Enzyme -2.08959 118.0 103
DNA dC->dU-editing enzyme APOBEC-3A APOBEC3A Tbio Non-IDG -1.79111 52.4 187
DNA dC->dU-editing enzyme APOBEC-3H APOBEC3H Tbio Non-IDG -1.57989 44.4 28
Double-stranded RNA-specific adenosine deaminase ADAR Tbio Enzyme -2.87338 784.2 197
C->U-editing enzyme APOBEC-2 APOBEC2 Tbio Non-IDG -1.26963 19.0 223
DNA dC->dU-editing enzyme APOBEC-3B APOBEC3B Tbio Non-IDG -1.93458 95.6 134
DNA dC->dU-editing enzyme APOBEC-3C APOBEC3C Tbio Non-IDG -1.74299 47.3 173
C->U-editing enzyme APOBEC-1 APOBEC1 Tbio Non-IDG -2.02305 96.3 122