Development Level

Tbio 54 | 11,445
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal lens morphology 1 | 81
abnormal pericardium morpholog... 1 | 26
cataract 1 | 92
decreased bone mineral density 1 | 126
decreased circulating aspartat... 1 | 34
decreased fasted circulating g... 1 | 65
decreased leukocyte cell numbe... 1 | 73
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased circulating creatini... 1 | 38
increased fasted circulating g... 1 | 76
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 40 | 11,493
ovarian cancer 37 | 8,520
osteosarcoma 25 | 7,950
lung cancer 23 | 4,740
group 3 medulloblastoma 20 | 4,104
medulloblastoma, large-cell 20 | 6,241
psoriasis 17 | 6,694
glioblastoma 14 | 5,792
Breast cancer 13 | 3,578
ependymoma 13 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
Multiple myeloma 12 | 1,332
malignant mesothelioma 12 | 3,232
acute quadriplegic myopathy 11 | 1,158
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
non-small cell lung cancer 10 | 2,890
Kidney cancer 9 | 2,613
atypical teratoid / rhabdoid tumor 9 | 5,112
primitive neuroectodermal tumor 9 | 3,035
Waldenstrons macroglobulinemia 8 | 765
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
oligodendroglioma 8 | 2,850
astrocytic glioma 7 | 2,597
astrocytoma 7 | 1,146
lung adenocarcinoma 7 | 2,716
tuberculosis and treatment for 6 months 7 | 409
Gaucher disease type 1 6 | 180
Pick disease 6 | 1,894
group 4 medulloblastoma 6 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
subependymal giant cell astrocytoma 6 | 2,287
dermatomyositis 5 | 966
invasive ductal carcinoma 5 | 2,951
progressive supranuclear palsy 5 | 676
Cancer 4 | 2,499
Intellectual disability 4 | 1,016
adult high grade glioma 4 | 3,801
aldosterone-producing adenoma 4 | 665
diabetes mellitus 4 | 1,728
juvenile dermatomyositis 4 | 1,187
Autosomal recessive predisposition 3 | 1,442
HIV Infections 3 | 102
Hematologic cancer 3 | 12
Immune system cancer 3 | 140
Microcephaly 3 | 166
acute myeloid leukemia 3 | 783
adrenocortical carcinoma 3 | 1,428
atypical teratoid/rhabdoid tumor 3 | 357
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
hepatocellular carcinoma 3 | 547
nasopharyngeal carcinoma 3 | 1,058
pancreatic cancer 3 | 2,398
pancreatic carcinoma 3 | 562
pediatric high grade glioma 3 | 1,064
pituitary cancer 3 | 1,972
spina bifida 3 | 1,074
Acquired immunodeficiency syndrome 2 | 197
Acrofacial dysostosis 2 | 8
Alzheimer's disease 2 | 658
Amyotrophic lateral sclerosis 2 | 451
Bilateral fifth finger clinodactyly 2 | 110
Bipolar Disorder 2 | 666
Byzanthine arch palate 2 | 194
Cognitive delay 2 | 608
Cryptorchidism 2 | 296
Curvature of little finger 2 | 110
Disease Progression 2 | 136
Global developmental delay 2 | 608
Infertility 2 | 188
Male infertility 2 | 206
Mastocytosis 2 | 27
Mental and motor retardation 2 | 608
Neuronal ceroid lipofuscinosis 1 2 | 15
Polycystic ovary syndrome 2 | 360
Polycythemia vera 2 | 27
Rheumatoid arthritis 2 | 1,191
Schizophrenia 2 | 1,160
Spinocerebellar ataxia type 31 2 | 8
Stomach Neoplasms 2 | 300
interstitial cystitis 2 | 2,312
non primary Sjogren syndrome sicca 2 | 891
posterior fossa group B ependymoma 2 | 416
relapsing-remitting multiple sclerosis 2 | 18
tuberculosis and treatment for 3 months 2 | 179
Abnormality of the pharynx 1 | 19
Absent radii and thrombocytopenia 1 | 1
Acute Promyelocytic Leukemia 1 | 40
Amebiasis 1 | 21
Aortic Valve Insufficiency 1 | 40
Deglutition Disorders 1 | 132
Dyspepsia 1 | 33
Esotropia 1 | 31
Hypobetalipoproteinemia 1 | 3
Kaposi's sarcoma 1 | 22
Muscle weakness of limb 1 | 21
Myelodysplastic Syndromes 1 | 26
Rectal prolapse 1 | 19
Rift Valley fever 1 | 14
Spinocerebellar ataxia type 1 1 | 16

Tissue

Endocrine System 57 | 18,159
Blood and immune system 56 | 16,909
Cardiovascular System 56 | 15,192
Digestive Tract 56 | 17,369
Female tissues 56 | 17,400
Liver and Pancreas 56 | 16,750
Male tissues 56 | 17,142
Nervous System 56 | 16,725
Respiratory system 56 | 16,393
Skin and soft tissues 56 | 17,230
Urinary Tract 56 | 16,678

Target Family

Non-IDG 51 | 12,091
Enzyme 6 | 4,145

Reactome Pathway

mRNA 3'-end processing 57 | 57
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RNA-binding protein 8A RBM8A Tbio Non-IDG -3.16448 1415.1 94
THO complex subunit 7 homolog THOC7 Tbio Non-IDG -0.34772 2.04 61
THO complex subunit 5 homolog THOC5 Tbio Non-IDG -1.14189 16.8 116
Cleavage and polyadenylation specificity factor subunit 3 CPSF3 Tbio Non-IDG -1.47182 27.3 190
THO complex subunit 6 homolog THOC6 Tbio Non-IDG -1.77416 57.9 131
Splicing factor U2AF 26 kDa subunit U2AF1L4 Tbio Non-IDG -0.17609 1.86 61
Polyadenylate-binding protein 2 PABPN1 Tbio Non-IDG -2.48757 316.4 120
Splicing factor U2AF 35 kDa subunit-like protein U2AF1 Tbio Non-IDG -1.71712 73.6 0
Cleavage and polyadenylation specificity factor subunit 1 CPSF1 Tbio Non-IDG -1.00806 8.79 51
Pre-mRNA cleavage complex 2 protein Pcf11 PCF11 Tbio Non-IDG -1.38684 23.0 33