Development Level

Tclin 8 | 602
Tchem 6 | 1,890
Tbio 4 | 10,625

Collection

Eligible Ion Channel Proteins 2 | 117

IMPC Term

abnormal behavior 1 | 226
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
decreased circulating bilirubi... 1 | 14
decreased eosinophil cell numb... 1 | 41
embryonic lethality prior to t... 1 | 187
preweaning lethality, incomple... 1 | 260
small epididymis 1 | 3

Disease

medulloblastoma, large-cell 13 | 6,234
atypical teratoid / rhabdoid tumor 9 | 4,369
oligodendroglioma 9 | 2,849
ovarian cancer 9 | 8,484
Atrial Fibrillation 8 | 110
Chronic heart failure 8 | 46
Myocardial Perfusion Imaging Adjunct 8 | 25
Platelet Aggregation Inhibition 8 | 22
Prevention of Cerebral Thrombosis 8 | 29
colon cancer 8 | 1,475
glioblastoma 8 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
invasive ductal carcinoma 8 | 2,950
lung cancer 8 | 4,466
malignant mesothelioma 8 | 3,162
Breast cancer 7 | 3,094
astrocytic glioma 7 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
lung carcinoma 7 | 2,844
pediatric high grade glioma 7 | 2,712
pilocytic astrocytoma 7 | 3,086
Impotence 6 | 45
breast carcinoma 6 | 1,614
lung adenocarcinoma 6 | 2,713
osteosarcoma 6 | 7,933
primitive neuroectodermal tumor 6 | 3,031
Carcinoma 5 | 2,147
Pick disease 5 | 1,893
ependymoma 5 | 2,514
group 4 medulloblastoma 5 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
pituitary cancer 5 | 1,972
psoriasis 5 | 6,685
ulcerative colitis 5 | 2,087
cystic fibrosis 4 | 1,665
interstitial cystitis 4 | 2,299
posterior fossa group A ependymoma 4 | 1,511
subependymal giant cell astrocytoma 4 | 2,287
Obesity 3 | 616
Pulmonary hypertension 3 | 52
Rheumatoid Arthritis 3 | 1,160
ductal carcinoma in situ 3 | 1,745
medulloblastoma 3 | 1,524
non-small cell lung cancer 3 | 2,798
non-small cell lung carcinoma 3 | 413
posterior fossa group B ependymoma 3 | 1,530
sonic hedgehog group medulloblastoma 3 | 1,482
Acquired metabolic disease 2 | 267
Acute heart failure 2 | 2
Asthma 2 | 349
Benign prostatic hyperplasia 2 | 7
Bipolar Disorder 2 | 266
Blood pressure finding 2 | 56
Gout 2 | 93
Hypertension 2 | 287
Migraine Disorders 2 | 26
Multiple Sclerosis 2 | 498
Systemic arterial pressure 2 | 56
adult high grade glioma 2 | 2,148
cutaneous lupus erythematosus 2 | 1,056
diabetes mellitus 2 | 1,663
fibroadenoma 2 | 557
group 3 medulloblastoma 2 | 2,254
interstitial lung disease 2 | 291
non-inflammatory breast cancer 2 | 208
pancreatic cancer 2 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
Age related macular degeneration 1 | 84
Anterior ischemic optic neuropathy 1 | 7
Aortic aneurysm 1 | 34
Asthma management 1 | 20
Autosomal dominant cerebellar ataxia 1 | 34
Brachydactyly 1 | 52
Bronchitis 1 | 44
Celiac disease 1 | 112
Cerebellar Ataxia 1 | 72
Cerebral amyloid angiopathy 1 | 9
Corneal disease 1 | 32
Dyspepsia 1 | 34
Globe disease 1 | 57
Heart conduction disease 1 | 65
Hippocampal sclerosis 1 | 2
Hypogonadism 1 | 70
Hypospadias 1 | 65
Major Depressive Disorder 1 | 106
Malignant neoplasm of breast 1 | 63
Mammary Neoplasms 1 | 410
Neoplasm Metastasis 1 | 138
Osteoporosis 1 | 257
Precancerous Conditions 1 | 69
Premature ejaculation 1 | 16
Pulmonary emphysema 1 | 34
Renal Cell Carcinoma 1 | 199
Sezary Syndrome 1 | 26
Spasticity 1 | 26
Vitreous detachment 1 | 9
X-linked cerebral adrenoleukodystrophy 1 | 115
axial spondyloarthropathy 1 | 28
cystic fibrosis and chronic rhinosinusitis 1 | 213
sarcoidosis 1 | 358

Tissue

Blood and immune system 18 | 17,995
Cardiovascular System 18 | 17,958
Digestive Tract 18 | 18,473
Endocrine System 18 | 18,512
Female tissues 18 | 18,647
Liver and Pancreas 18 | 18,136
Male tissues 18 | 17,969
Nervous System 18 | 18,561
Respiratory system 18 | 17,484
Skin and soft tissues 18 | 18,115
Urinary Tract 18 | 18,444

Target Family

Enzyme 9 | 4,146
Ion Channel 6 | 341
Kinase 2 | 634
Non-IDG 1 | 11,971

Reactome Pathway

cGMP effects 18 | 18
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A Tchem Enzyme -1.87754 73.1 142
Protein MRVI1 MRVI1 Tbio Non-IDG -1.38594 25.6 21
Calcium-activated potassium channel subunit beta-4 KCNMB4 Tbio Ion Channel -0.82723 6.57 115
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A Tchem Enzyme -1.51667 37.2 195
Calcium-activated potassium channel subunit alpha-1 KCNMA1 Tclin Ion Channel -3.06072 1170.6 213
cGMP-dependent protein kinase 1 PRKG1 Tchem Kinase -2.64884 418.8 220
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A Tclin Enzyme -1.24811 18.1 146
Calcium-activated potassium channel subunit beta-2 KCNMB2 Tbio Ion Channel 1.28 0.09 174
cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A Tclin Enzyme -1.75798 58.1 158