Development Level

Tbio 16 | 11,445

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal embryo size 2 | 220
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal hindbrain morphology 1 | 10
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
increased circulating aspartat... 1 | 15
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 13 | 11,493
ovarian cancer 12 | 8,520
glioblastoma 9 | 5,792
Acrodermatitis enteropathica 8 | 18
medulloblastoma, large-cell 8 | 6,241
pancreatic cancer 8 | 2,398
atypical teratoid / rhabdoid tumor 7 | 5,112
osteosarcoma 7 | 7,950
Breast cancer 5 | 3,578
active Crohn's disease 5 | 922
ependymoma 5 | 4,679
lung adenocarcinoma 5 | 2,716
lung cancer 5 | 4,740
psoriasis 5 | 6,694
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
non-small cell lung cancer 4 | 2,890
primary pancreatic ductal adenocarcinoma 4 | 1,109
ulcerative colitis 4 | 1,819
Alzheimer's disease 3 | 658
Astrocytoma, Pilocytic 3 | 3,081
Multiple myeloma 3 | 1,332
Respiratory Hypersensitivity 3 | 19
Schizophrenia 3 | 1,160
Waldenstrons macroglobulinemia 3 | 765
adult high grade glioma 3 | 3,801
diabetes mellitus 3 | 1,728
esophageal adenocarcinoma 3 | 737
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung carcinoma 3 | 2,843
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
tuberculosis 3 | 2,010
Acquired metabolic disease 2 | 336
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Endometriosis 2 | 540
Liver Cirrhosis, Experimental 2 | 769
Neoplasm Metastasis 2 | 168
Type 2 diabetes mellitus 2 | 272
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
astrocytic glioma 2 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
breast carcinoma 2 | 1,638
cystic fibrosis 2 | 1,696
head and neck cancer 2 | 271
invasive ductal carcinoma 2 | 2,951
juvenile dermatomyositis 2 | 1,187
nasopharyngeal carcinoma 2 | 1,058
pediatric high grade glioma 2 | 1,064
primary Sjogren syndrome 2 | 735
primitive neuroectodermal tumor 2 | 3,035
subependymal giant cell astrocytoma 2 | 2,287
Abnormal blistering of the skin 1 | 54
Alopecia 1 | 115
Alzheimer Disease 1 | 83
Barrett's esophagus 1 | 182
Blister of skin 1 | 54
Borna disease 1 | 6
Breast Neoplasms 1 | 445
Cerebral atrophy 1 | 178
Congenital disorder of glycosylation 1 | 54
Dermatitis 1 | 157
Diabetes Mellitus, Type 2 1 | 142
Diarrhea 1 | 253
Disease of mental health 1 | 36
Dry skin 1 | 75
Dystonia 1 | 164
Epilepsy 1 | 792
Esophageal Neoplasms 1 | 69
Esophageal Squamous Cell Carcinoma 1 | 77
Essential Hypertension 1 | 94
Failure to gain weight 1 | 365
Flushing 1 | 60
Hepatomegaly 1 | 285
Infantile onset 1 | 238
Lethargy 1 | 77
Liver cancer 1 | 604
Malabsorption 1 | 82
Mammary Neoplasms 1 | 425
Mood swings 1 | 77
Multiple Sclerosis 1 | 540
Myopia 1 | 176
Neoplasm Invasiveness 1 | 161
Neurodegenerative disease 1 | 414
Osteoarthritis 1 | 184
Parkinson's disease 1 | 392
Pediatric failure to thrive 1 | 365
Photodysphoria 1 | 121
Photophobia 1 | 121
Psychotic Disorders 1 | 151
Skin Ulcer 1 | 48
Skin bulla 1 | 54
Small testicle 1 | 75
Squamous cell carcinoma of esophagus 1 | 77
Tremor 1 | 113
Xerosis 1 | 75

Tissue

Blood and immune system 16 | 16,909
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Liver and Pancreas 15 | 16,750
Urinary Tract 15 | 16,678
Cardiovascular System 13 | 15,192

Target Family

Transporter 16 | 473

Reactome Pathway

Zinc transporters 16 | 16
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc transporter ZIP10 SLC39A10 Tbio Transporter -1.20558 16.3 102
Zinc transporter ZIP6 SLC39A6 Tbio Transporter -1.66663 50.0 172
Zinc transporter 3 SLC30A3 Tbio Transporter -2.01559 111.7 67
Zinc transporter 2 SLC30A2 Tbio Transporter -1.59498 39.4 26
Zinc transporter 8 SLC30A8 Tbio Transporter -2.20313 168.0 122
Zinc transporter ZIP3 SLC39A3 Tbio Transporter -0.52290 3.15 87
Zinc transporter SLC39A7 SLC39A7 Tbio Transporter -1.48099 31.2 181
Zinc transporter ZIP2 SLC39A2 Tbio Transporter -1.63982 41.5 59
Zinc transporter 7 SLC30A7 Tbio Transporter -1.38652 25.4 42
Zinc transporter 5 SLC30A5 Tbio Transporter -1.39046 25.7 29