Development Level

Tbio 12 | 11,445

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal heart morphology 2 | 162
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
hydrometra 2 | 53
small superior vagus ganglion 2 | 74
abnormal cecum morphology 1 | 7
abnormal heart shape 1 | 5
abnormal seminal vesicle morph... 1 | 114
absent pinna reflex 1 | 23
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased vertical activity 1 | 208
enlarged cecum 1 | 5
enlarged seminal vesicle 1 | 10
increased circulating free fat... 1 | 20
increased circulating insulin ... 1 | 3

Disease

ovarian cancer 12 | 8,520
Carcinoma 8 | 11,493
psoriasis 8 | 6,694
Breast cancer 6 | 3,578
atypical teratoid / rhabdoid tumor 5 | 5,112
ependymoma 5 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
medulloblastoma, large-cell 4 | 6,241
Cataract 8 multiple types 3 | 33
Congenital hypoplasia of penis 3 | 176
Cryptorchidism 3 | 296
Frontal bossing 3 | 157
Hypotrophic malar bone 3 | 129
Kidney cancer 3 | 2,613
Long philtrum 3 | 137
Malar flattening 3 | 129
Multiple myeloma 3 | 1,332
Orbital separation excessive 3 | 244
Robinow syndrome 3 | 11
cystic fibrosis 3 | 1,696
esophageal adenocarcinoma 3 | 737
glioblastoma 3 | 5,792
group 3 medulloblastoma 3 | 4,104
lung cancer 3 | 4,740
non-small cell lung cancer 3 | 2,890
osteosarcoma 3 | 7,950
Accessory kidney 2 | 5
Anteverted nostril 2 | 191
Big calvaria 2 | 147
Brachydactyly 2 | 156
Broad flat nasal bridge 2 | 236
Broad thumbs 2 | 28
Clitoral hypoplasia 2 | 11
Cognitive delay 2 | 608
Concave bridge of nose 2 | 195
Curvature of digit 2 | 57
Decreased projection of midface 2 | 105
Delayed bone age 2 | 136
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Downward slant of palpebral fissure 2 | 158
Dull intelligence 2 | 645
Exophthalmos 2 | 112
Flat face 2 | 52
Gingival Hyperplasia 2 | 34
Gingival Hypertrophy 2 | 34
Gingival Overgrowth 2 | 36
Hernia, Inguinal 2 | 89
Hydronephrosis 2 | 89
Hypoplastic mandible condyle 2 | 275
Hypotrophic midface 2 | 105
Inadequate arch length for tooth size 2 | 45
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Leber congenital amaurosis 2 | 69
Long palpebral fissure 2 | 17
Lung Neoplasms 2 | 232
Macroglossia 2 | 65
Mental and motor retardation 2 | 608
Midface retrusion 2 | 105
Nasal bridge wide 2 | 236
Pectus excavatum 2 | 100
Port-Wine Stain 2 | 8
Posteriorly rotated ear 2 | 61
Prominent eyes 2 | 96
Prominent globes 2 | 96
Protruding eyes 2 | 96
Short hands 2 | 50
Short nose 2 | 132
Small midface 2 | 105
Small nose 2 | 132
Thin upper lip vermilion 2 | 67
Tooth Crowding 2 | 45
Tooth mass arch size discrepancy 2 | 45
Tooth size discrepancy 2 | 45
Umbilical hernia 2 | 93
Ventricular Outflow Obstruction, Right 2 | 3
Wide anterior fontanel 2 | 44
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
cutaneous lupus erythematosus 2 | 1,057
ductal carcinoma in situ 2 | 1,745
fibroadenoma 2 | 559
glioblastoma multiforme 2 | 142
head and neck cancer and chronic obstructive pulmonary disease 2 | 239
interstitial cystitis 2 | 2,312
interstitial lung disease 2 | 298
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
sonic hedgehog group medulloblastoma 2 | 467
spina bifida 2 | 1,074
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Non-IDG 8 | 12,091
GPCR 2 | 408
Kinase 2 | 634

Reactome Pathway

WNT5A-dependent internalizatio... 12 | 12
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.66258 38.8 231
Inactive tyrosine-protein kinase transmembrane receptor ROR1 ROR1 Tbio Kinase -1.38904 30.7 332
Clathrin light chain A CLTA Tbio Non-IDG -1.32676 16.0 244
Clathrin light chain B CLTB Tbio Non-IDG -2.29105 193.6 153
Frizzled-5 FZD5 Tbio GPCR -1.54924 30.5 307
Protein Wnt-5a WNT5A Tbio Non-IDG -2.77525 650.2 321
AP-2 complex subunit beta AP2B1 Tbio Non-IDG -1.59767 34.8 212
AP-2 complex subunit alpha-2 AP2A2 Tbio Non-IDG -0.65996 4.74 124
Tyrosine-protein kinase transmembrane receptor ROR2 ROR2 Tbio Kinase -1.88065 80.4 419
AP-2 complex subunit sigma AP2S1 Tbio Non-IDG -1.42073 25.5 108