Development Level

Tbio 20 | 11,651

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal embryo size 4 | 220
embryonic lethality prior to o... 3 | 239
abnormal embryo turning 2 | 31
decreased caudal vertebrae num... 2 | 53
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
preweaning lethality, incomple... 2 | 499
abnormal skin appearance 1 | 3
absent startle reflex 1 | 24
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating insulin ... 1 | 76
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33

Disease

Carcinoma 18 | 11,493
ovarian cancer 12 | 8,520
medulloblastoma, large-cell 8 | 6,241
Kidney cancer 7 | 2,613
osteosarcoma 7 | 7,950
psoriasis 7 | 6,694
ependymoma 6 | 4,679
Breast cancer 5 | 3,578
Pick disease 5 | 1,894
acute quadriplegic myopathy 5 | 1,158
atypical teratoid / rhabdoid tumor 5 | 5,112
astrocytic glioma 4 | 2,597
diabetes mellitus 4 | 1,728
glioblastoma 4 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
juvenile dermatomyositis 4 | 1,187
oligodendroglioma 4 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Autosomal dominant polycystic kidney disease 3 | 31
Glaucoma 3 | 239
Obesity 3 | 678
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
group 4 medulloblastoma 3 | 1,855
pancreatic cancer 3 | 2,398
progressive supranuclear palsy 3 | 676
Abnormality of retinal pigmentation 2 | 111
Abnormality of the retinal vasculature 2 | 59
Anteverted nostril 2 | 191
Atypical scarring of skin 2 | 62
Autosomal recessive polycystic kidney disease 2 | 41
Autosomal recessive predisposition 2 | 1,442
Blind Vision 2 | 111
Blindness 2 | 88
Blindness, Legal 2 | 110
Broad flat nasal bridge 2 | 236
Cataract 2 | 297
Ciliopathy 2 | 71
Conductive hearing loss 2 | 123
Cone dystrophy 2 | 71
Congenital anomaly of testis 2 | 52
Congenital hypoplasia of penis 2 | 176
Difficulties with night vision 2 | 87
Dull intelligence 2 | 645
Electroretinogram abnormal 2 | 95
Fundus with peripheral 'bony spicules' 2 | 12
Hyperinsulinism 2 | 133
Hypogonadism 2 | 173
Intellectual disability 2 | 1,016
Keratoconus 2 | 113
Kidney Failure 2 | 111
Kidney disease 2 | 430
Lens Opacities 2 | 231
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Multiple myeloma 2 | 1,332
Nasal bridge wide 2 | 236
Night Blindness 2 | 101
Night blindness, progressive 2 | 51
Nystagmus 2 | 317
Ophthalmoplegia 2 | 106
Optic Atrophy 2 | 242
Photodysphoria 2 | 121
Photophobia 2 | 121
Polycystic Kidney - body part 2 | 18
Polycystic Kidney Diseases 2 | 20
Polycystic Kidney, Autosomal Dominant 2 | 7
Polycystic liver disease 2 | 16
Poor school performance 2 | 645
Renal Insufficiency 2 | 90
Renal failure in adulthood 2 | 76
Retinal Degeneration 2 | 106
Retinal pigment epithelial abnormality 2 | 111
Retinitis Pigmentosa 2 | 226
Rheumatoid arthritis 2 | 1,191
Sensorineural Hearing Loss (disorder) 2 | 284
adult high grade glioma 2 | 3,801
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
gastric carcinoma 2 | 807
invasive ductal carcinoma 2 | 2,951
non primary Sjogren syndrome sicca 2 | 891
pituitary cancer 2 | 1,972
sarcoidosis 2 | 370
sonic hedgehog group medulloblastoma 2 | 467
subependymal giant cell astrocytoma 2 | 2,287
substance-related disorder 2 | 162
tuberculosis 2 | 2,010
Disease Models, Animal 1 | 155
Leber congenital amaurosis 1 | 69
Neurodegenerative Disorders 1 | 79
Oculocerebrorenal syndrome 1 | 29
Polycystic kidney disease 1 1 | 21
Polycystic kidney disease 2 1 | 11
Retinal Detachment 1 | 51
Retinal Diseases 1 | 55
Situs Inversus 1 | 65
Vascular Diseases 1 | 16

Tissue

Endocrine System 19 | 18,159
Nervous System 19 | 16,725
Blood and immune system 18 | 16,909
Digestive Tract 18 | 17,369
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678
Cardiovascular System 16 | 15,192

Target Family

Non-IDG 13 | 12,091
Ion Channel 4 | 344
Enzyme 2 | 4,145
GPCR 1 | 408

Reactome Pathway

VxPx cargo-targeting to cilium 20 | 20
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Exocyst complex component 1 EXOC1 Tbio Non-IDG -1.85438 74.2 51
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.65458 432.1 352
Exocyst complex component 8 EXOC8 Tbio Non-IDG -1.20083 14.8 75
Cyclic nucleotide-gated olfactory channel CNGA2 Tbio Ion Channel -1.79780 61.2 204
Rhodopsin RHO Tbio GPCR -3.79531 6099.3 424
Exocyst complex component 6 EXOC6 Tbio Non-IDG -1.56101 35.8 46
Rab11 family-interacting protein 3 RAB11FIP3 Tbio Non-IDG -0.89095 6.62 68
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 GBF1 Tbio Non-IDG -0.60758 4.31 61
Exocyst complex component 5 EXOC5 Tbio Non-IDG -1.45220 28.7 83
Exocyst complex component 4 EXOC4 Tbio Non-IDG -1.61492 39.1 121