Development Level

Tclin 39 | 613
Tbio 3 | 11,445

Collection

Ion Channel: IDG Consortium (T... 16 | 99
RFA-RM-18-021 16 | 328

IMPC Phenotype

abnormal behavior 5 | 298
hyperactivity 4 | 148
abnormal behavioral response t... 2 | 66
increased bone mineral content 2 | 108
increased mean corpuscular vol... 2 | 92
abnormal brain morphology 1 | 13
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal locomotor behavior 1 | 24
abnormal seminal vesicle morph... 1 | 114
cardiovascular system phenotyp... 1 | 36
decreased cardiac stroke volum... 1 | 6
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
hydroencephaly 1 | 14
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased circulating serum al... 1 | 22
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
increased vertical activity 1 | 24
kyphosis 1 | 5
preweaning lethality, complete... 1 | 979
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
shortened QT interval 1 | 4
shortened ST segment 1 | 10

Disease

Carcinoma 39 | 11,493
Eaton-Lambert syndrome 39 | 40
Multiple Sclerosis 39 | 540
ependymoma 23 | 4,679
medulloblastoma, large-cell 21 | 6,241
glioblastoma 20 | 5,792
adult high grade glioma 19 | 3,801
atypical teratoid / rhabdoid tumor 19 | 5,112
Kidney cancer 18 | 2,613
group 3 medulloblastoma 18 | 4,104
primitive neuroectodermal tumor 17 | 3,035
Astrocytoma, Pilocytic 15 | 3,081
osteosarcoma 14 | 7,950
astrocytic glioma 13 | 2,597
lung cancer 13 | 4,740
oligodendroglioma 13 | 2,850
Epilepsy 12 | 792
malignant mesothelioma 11 | 3,232
ovarian cancer 11 | 8,520
psoriasis 11 | 6,694
Long QT syndrome 9 | 39
lung carcinoma 9 | 2,843
pituitary cancer 8 | 1,972
Intellectual disability 7 | 1,016
Episodic ataxia 6 | 22
Melanoma 6 | 711
Muscle hypotonia 6 | 571
Pick disease 6 | 1,894
Schizophrenia 6 | 1,160
Seizures 6 | 596
Skin cancer 6 | 469
subependymal giant cell astrocytoma 6 | 2,287
Breast cancer 5 | 3,578
Heart disease 5 | 306
Liver cancer 5 | 604
Myoclonus 5 | 74
Acquired metabolic disease 4 | 336
Atrial Fibrillation 4 | 124
Bipolar Disorder 4 | 666
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Infantile onset 4 | 238
Mental and motor retardation 4 | 608
Partial Epilepsy Treatment Adjunct 4 | 16
colon cancer 4 | 1,478
cystic fibrosis 4 | 1,696
progressive supranuclear palsy 4 | 676
Amyotrophic lateral sclerosis 3 | 451
Benign neonatal seizures 3 | 4
Brugada syndrome 3 | 29
Cerebellar Ataxia 3 | 304
Dull intelligence 3 | 645
Enophthalmos 3 | 75
Epileptic encephalopathy 3 | 26
Familial atrial fibrillation 3 | 23
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Palpitations 3 | 18
Poor school performance 3 | 645
Spinocerebellar ataxia type 13 3 | 5
Sunken eyes 3 | 63
Type 2 diabetes mellitus 3 | 272
adrenocortical carcinoma 3 | 1,428
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
invasive ductal carcinoma 3 | 2,951
non-small cell lung cancer 3 | 2,890
Atrophy of cerebellum 2 | 103
Broad flat nasal bridge 2 | 236
Cerebellar degeneration 2 | 103
Chronic obstructive pulmonary disease 2 | 184
Coarse facial features 2 | 108
Concave bridge of nose 2 | 195
Congenital Epicanthus 2 | 177
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Dysarthria 2 | 192
Fragile X syndrome 2 | 34
Gait Ataxia 2 | 51
Heart conduction disease 2 | 83
Hepatomegaly 2 | 285
Infratentorial atrophy 2 | 103
Long philtrum 2 | 137
Muscle Hypertonia 2 | 88
Myopia 2 | 176
Nasal bridge wide 2 | 236
Neurodegenerative disease 2 | 414
Osteoporosis 2 | 363
Progressive disorder 2 | 142
Psychotic Disorders 2 | 151
Slow progression 2 | 89
Thickened facial skin with coarse facial features 2 | 108
Ventricular Fibrillation 2 | 17
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
fibroadenoma 2 | 559
medulloblastoma 2 | 720
pediatric high grade glioma 2 | 1,064
tuberculosis 2 | 2,010

Tissue

Endocrine System 41 | 18,159
Female tissues 39 | 17,400
Nervous System 39 | 16,725
Digestive Tract 38 | 17,369
Male tissues 38 | 17,142
Liver and Pancreas 35 | 16,750
Skin and soft tissues 35 | 17,230
Urinary Tract 34 | 16,678
Blood and immune system 32 | 16,909
Respiratory system 31 | 16,393
Cardiovascular System 25 | 15,192

Target Family

Ion Channel 42 | 344

Reactome Pathway

Voltage gated Potassium channe... 42 | 42
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
Potassium voltage-gated channel subfamily C member 2 KCNC2 Tclin Ion Channel -1.45272 28.7 178
Potassium voltage-gated channel subfamily H member 3 KCNH3 Tclin Ion Channel -1.07866 11.8 67
Potassium voltage-gated channel subfamily D member 3 KCND3 Tclin Ion Channel -2.34610 217.9 162
Potassium voltage-gated channel subfamily G member 1 KCNG1 Tclin Ion Channel -1.83662 59.3 87
Potassium voltage-gated channel subfamily B member 1 KCNB1 Tclin Ion Channel -2.57484 386.0 303
Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 Tclin Ion Channel -2.08808 103.9 111
Potassium voltage-gated channel subfamily H member 2 KCNH2 Tclin Ion Channel -3.22575 1653.9 243
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.90675 800.2 365
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150