Development Level

Tchem 3 | 1,598
Tbio 2 | 11,445

IMPC Phenotype

abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal rib morphology 1 | 10
abnormal scapula morphology 1 | 3
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
absent mammary gland 1 | 1
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating phosphat... 1 | 27
decreased grip strength 1 | 116
decreased skeletal muscle mass 1 | 1
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
hypoactivity 1 | 132
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
short tibia 1 | 97
small heart 1 | 10
small kidney 1 | 16
small ovary 1 | 1
small spleen 1 | 19
small uterus 1 | 3
thin skin 1 | 2

Disease

Carcinoma 4 | 11,493
glioblastoma 3 | 5,792
psoriasis 3 | 6,694
Cancer 2 | 2,499
Hypocalcemic vitamin D-dependent rickets 2 | 2
Pick disease 2 | 1,894
Rickets 2 | 49
Schizophrenia 2 | 1,160
Vitamin D-dependent rickets, type 1 2 | 2
adult high grade glioma 2 | 3,801
fibroadenoma 2 | 559
invasive ductal carcinoma 2 | 2,951
medulloblastoma, large-cell 2 | 6,241
non-small cell lung cancer 2 | 2,890
osteosarcoma 2 | 7,950
ovarian cancer 2 | 8,520
'Bulging' epiphyses 1 | 3
Ablepharon macrostomia syndrome 1 | 6
Addison's disease 1 | 31
Adenocarcinoma 1 | 122
Adenomatous Polyposis Coli 1 | 16
Alkaline phosphatase serum increased 1 | 29
Alopecia 1 | 115
Barber-Say syndrome 1 | 3
Barrett Esophagus 1 | 16
Bone Diseases, Metabolic 1 | 14
Bone pain 1 | 42
Colonic Neoplasms 1 | 142
Craniosynostosis 1 | 74
Defective enamel matrix 1 | 35
Delayed epiphyseal ossification 1 | 10
Delayed maturation of end part of long bone 1 | 10
Dental Enamel Hypoplasia 1 | 43
DiGeorge syndrome 1 | 47
Difficulty walking 1 | 28
Diffuse idiopathic skeletal hyperostosis 1 | 6
Dysplasia of tooth enamel 1 | 35
Enlargement of the ankles 1 | 3
Enlargement of the costochondral junction 1 | 4
Enlargement of the wrists 1 | 5
Esophageal Neoplasms 1 | 69
Failure to gain weight 1 | 365
Femoral bowing 1 | 20
Fibular bowing 1 | 5
Flat back of the head 1 | 26
Flat occiput 1 | 26
Frequent fractures 1 | 53
Frontal bossing 1 | 157
Generalized aminoaciduria 1 | 9
Genu varum 1 | 29
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Hypercalcemia 1 | 59
Hyperparathyroidism 1 | 48
Hyperparathyroidism, Secondary 1 | 7
Hyperphosphatemia 1 | 32
Hypervitaminosis A 1 | 13
Hypophosphatemia 1 | 40
Imperforate anus 1 | 25
Increased fracture rate 1 | 53
Increased serum parathyroid hormone 1 | 14
Irritation - emotion 1 | 68
Late tooth eruption 1 | 61
Liver Cirrhosis 1 | 181
Liver Cirrhosis, Experimental 1 | 769
Lyme disease 1 | 26
Metabolic Bone Disorder 1 | 11
Metaphyseal irregularity 1 | 23
Motor delay 1 | 147
Mouth Diseases 1 | 12
Multiple Sclerosis 1 | 540
No development of motor milestones 1 | 147
Nonorganic psychosis 1 | 84
Osteomalacia 1 | 35
Pediatric failure to thrive 1 | 365
Poor growth 1 | 114
Protuberant abdomen 1 | 16
Psychotic Disorders 1 | 151
Refractive error 1 | 50
Renal agenesis 1 | 29
Sick sinus syndrome 1 | 15
Sparse bone trabeculae 1 | 3
Thin bony cortex 1 | 9
Thin dental enamel 1 | 35
Tibial bowing 1 | 19
Varying degree of multiple fractures 1 | 53
Velocardiofacial syndrome 1 | 46
Very poor growth 1 | 114
Widely patent fontanels and sutures 1 | 12
active Crohn's disease 1 | 922
axial spondyloarthropathy 1 | 28
breast carcinoma 1 | 1,638
cystic fibrosis 1 | 1,696
cystic fibrosis and chronic rhinosinusitis 1 | 214
head and neck cancer 1 | 271
head and neck cancer and chronic obstructive pulmonary disease 1 | 239
medulloblastoma 1 | 720
nutritional deficiency disease 1 | 9
severe Alzheimer's disease 1 | 47

Tissue

Blood and immune system 5 | 16,909
Endocrine System 5 | 18,159
Nervous System 5 | 16,725
Digestive Tract 4 | 17,369
Female tissues 4 | 17,400
Liver and Pancreas 4 | 16,750
Male tissues 4 | 17,142
Respiratory system 3 | 16,393
Skin and soft tissues 3 | 17,230
Urinary Tract 3 | 16,678
Cardiovascular System 2 | 15,192

Target Family

Enzyme 3 | 4,145
Non-IDG 2 | 12,091

Reactome Pathway

Vitamins 5 | 5
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 Tchem Enzyme -2.70628 492.9 68
Cytochrome P450 26B1 CYP26B1 Tchem Non-IDG -1.89806 73.0 179
Vitamin D 25-hydroxylase CYP2R1 Tbio Enzyme -1.96830 95.4 152
Cytochrome P450 26A1 CYP26A1 Tchem Enzyme -2.44772 290.1 197
Cytochrome P450 26C1 CYP26C1 Tbio Non-IDG -1.00437 8.71 78