Development Level

Tbio 5 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal sensory capabilities-... 1 | 8
abnormal vibrissa morphology 1 | 25
absent vibrissae 1 | 12
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
increased or absent threshold ... 1 | 101
long tibia 1 | 25
small adrenal glands 1 | 16

Disease

Carcinoma 5 | 11,493
Brown-Vialetto-Van Laere syndrome 4 | 5
Multiple acyl-CoA dehydrogenase deficiency 4 | 25
lung cancer 4 | 4,740
Breast cancer 3 | 3,578
Sensorineural hearing loss 3 | 106
ovarian cancer 3 | 8,520
psoriasis 3 | 6,694
Chronic apical periodontitis 2 | 2
Multiple myeloma 2 | 1,332
Progressive bulbar palsy 2 | 4
adult high grade glioma 2 | 3,801
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
diabetes mellitus 2 | 1,728
glioblastoma 2 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
lung carcinoma 2 | 2,843
medulloblastoma, large-cell 2 | 6,241
non-small cell lung cancer 2 | 2,890
osteosarcoma 2 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
Abnormal skeletal development 1 | 60
Abnormal trabecular bone morphology 1 | 6
Abnormality of the cerebral vasculature 1 | 6
Angioid streaks 1 | 11
Ankylosis 1 | 28
Arterial calcification of infancy 1 | 6
Asperger syndrome 1 | 37
Bone pain 1 | 42
Calcification of coronary artery 1 | 3
Calcinosis 1 | 70
Chondrocalcinosis 1 | 9
Congestive heart failure 1 | 113
Contractures of the large joints 1 | 5
Craniosynostosis 1 | 74
Dental abscess 1 | 4
Diabetes Mellitus, Non-Insulin-Dependent 1 | 145
Diabetes Mellitus, Noninsulin-Dependent 1 | 31
Diabetes Mellitus, Type 2 1 | 142
Dicarboxylic aciduria 1 | 4
Ecchymosis 1 | 66
Elevated plasma acylcarnitine levels 1 | 1
Endometriosis 1 | 540
Enlargement of the wrists 1 | 5
Enthesitis 1 | 3
Esophageal Squamous Cell Carcinoma 1 | 77
Exanthema 1 | 43
Excess nuchal skin 1 | 30
Excessive wrinkled skin 1 | 16
Genu varum 1 | 29
Heart failure 1 | 162
Hip joint varus deformity - observation 1 | 24
Hypercementosis 1 | 5
Hyperkeratosis 1 | 50
Hyperphosphaturia 1 | 21
Hypoglycemia 1 | 152
Hypophosphatasia 1 | 10
Hypophosphatemia 1 | 40
Hypophosphatemic Rickets 1 | 11
Increased serum bone-specific alkaline phosphatase 1 | 4
Increased tendency to bruise 1 | 66
Late tooth eruption 1 | 61
Leg Length Inequality 1 | 6
Linear atrophy 1 | 15
Lipid Storage Myopathy Due to Flavin Adenine Dinucleotide Synthetase Deficiency 1 | 1
Malabsorption 1 | 82
Metabolic acidosis 1 | 90
Myocardial Infarction 1 | 151
Myopathy with Abnormal Lipid Metabolism 1 | 1
Myopia 1 | 176
Ossification of the posterior longitudinal ligament of spine 1 | 9
Osteoarthritis 1 | 184
Osteochondrodysplasias 1 | 72
Osteomalacia 1 | 35
Osteosclerosis 1 | 31
Polyarthritis 1 | 11
Poor suck 1 | 17
Pseudoxanthoma elasticum 1 | 18
Renal phosphate wasting 1 | 7
Retinal Diseases 1 | 55
Retinal Hemorrhage 1 | 6
Riboflavin Deficiency 1 | 1
Rickets 1 | 49
Sensorineural Hearing Loss (disorder) 1 | 284
Skull malformation 1 | 38
Spinal canal stenosis 1 | 12
Squamous cell carcinoma of esophagus 1 | 77
Tibial bowing 1 | 19
Urine phosphorous concentration above normal 1 | 21
ariboflavinosis 1 | 5
chronic rhinosinusitis 1 | 512
cystic fibrosis 1 | 1,696
lung adenocarcinoma 1 | 2,716
medulloblastoma 1 | 720
pituitary cancer 1 | 1,972
severe Alzheimer's disease 1 | 47

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678

Target Family

Enzyme 3 | 4,145
Transporter 3 | 473

Reactome Pathway

Vitamin B2 (riboflavin) metabo... 6 | 6
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Solute carrier family 52, riboflavin transporter, member 1 SLC52A1 Tbio Transporter -0.89390 8.86 127
FAD synthase FLAD1 Tbio Enzyme -1.57330 36.9 112
Riboflavin kinase RFK Tbio Enzyme -1.71840 55.6 104
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1 Tchem Enzyme -2.74480 552.8 275
Solute carrier family 52, riboflavin transporter, member 2 SLC52A2 Tbio Transporter -1.42102 23.2 37
Solute carrier family 52, riboflavin transporter, member 3 SLC52A3 Tbio Transporter -1.82473 71.3 31