Development Level

Tbio 66 | 10,625
Tchem 21 | 1,890
Tclin 5 | 602
Tdark 4 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

abnormal behavior 3 | 226
decreased circulating serum al... 3 | 79
increased circulating alkaline... 3 | 119
increased circulating potassiu... 3 | 31
preweaning lethality, complete... 3 | 633
preweaning lethality, incomple... 3 | 260
abnormal lens morphology 2 | 73
abnormal retina morphology 2 | 100
abnormal sleep behavior 2 | 63
decreased body weight 2 | 174
decreased circulating amylase ... 2 | 24
decreased circulating glucose ... 2 | 121
decreased circulating triglyce... 2 | 83
embryonic lethality prior to t... 2 | 187
hyperactivity 2 | 108
hypoactivity 2 | 89
impaired righting response 2 | 19
increased circulating sodium l... 2 | 71
increased mean corpuscular vol... 2 | 91
mydriasis 2 | 9
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal coat/hair pigmentatio... 1 | 54
abnormal embryo size 1 | 112
abnormal glucose homeostasis 1 | 5
abnormal limb bud morphology 1 | 15
abnormal locomotor activation 1 | 26
abnormal motor coordination/ b... 1 | 4
abnormal pericardium morpholog... 1 | 11
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 21
cardiovascular system phenotyp... 1 | 35
decreased B cell number 1 | 30
decreased CD4-positive, alpha ... 1 | 19
decreased body length 1 | 108
decreased body temperature 1 | 2
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased circulating phosphat... 1 | 15
decreased circulating sodium l... 1 | 18
decreased exploration in new e... 1 | 9
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased neutrophil cell numb... 1 | 37
decreased red blood cell distr... 1 | 11
decreased rib number 1 | 59
embryonic lethality prior to o... 1 | 148
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged uterus 1 | 3
impaired pupillary reflex 1 | 14
increased NK T cell number 1 | 11
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 92
increased cellular hemoglobin ... 1 | 2
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating serum al... 1 | 25
increased circulating triglyce... 1 | 24
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased lymphocyte cell numb... 1 | 9
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean platelet volume 1 | 19
increased or absent threshold ... 1 | 128
increased red blood cell distr... 1 | 21
limb grasping 1 | 35
macrophthalmia 1 | 2
male infertility 1 | 62
pallor 1 | 13
persistence of hyaloid vascula... 1 | 22
small adrenal glands 1 | 15
small kidney 1 | 10
small testis 1 | 37
stereotypic behavior 1 | 3
trunk curl 1 | 15
vertebral fusion 1 | 23

Disease

psoriasis 53 | 6,685
osteosarcoma 42 | 7,933
ovarian cancer 32 | 8,484
medulloblastoma, large-cell 29 | 6,234
glioblastoma 27 | 5,572
atypical teratoid / rhabdoid tumor 23 | 4,369
lung cancer 22 | 4,466
lung carcinoma 22 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
Retinitis pigmentosa 20 | 153
lung adenocarcinoma 20 | 2,713
primitive neuroectodermal tumor 20 | 3,031
Breast cancer 19 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,956
invasive ductal carcinoma 19 | 2,950
non-small cell lung cancer 19 | 2,798
diabetes mellitus 18 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
Cancer 17 | 2,346
astrocytic glioma 17 | 2,241
ductal carcinoma in situ 17 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,795
Cone dystrophy 16 | 57
malignant mesothelioma 16 | 3,162
pediatric high grade glioma 16 | 2,712
pituitary cancer 16 | 1,972
pilocytic astrocytoma 15 | 3,086
posterior fossa group B ependymoma 15 | 1,530
Fundus dystrophy 14 | 77
oligodendroglioma 14 | 2,849
subependymal giant cell astrocytoma 14 | 2,287
Obesity 13 | 616
group 4 medulloblastoma 13 | 1,875
Carcinoma 12 | 2,147
cystic fibrosis 12 | 1,665
interstitial cystitis 12 | 2,299
pancreatic cancer 12 | 2,300
Blindness 11 | 84
Leber congenital amaurosis 11 | 72
Night Blindness 11 | 39
adult high grade glioma 11 | 2,148
ependymoma 11 | 2,514
group 3 medulloblastoma 11 | 2,254
Atherosclerosis 10 | 275
Coronary artery disease 10 | 240
Lipid metabolism disorder 10 | 102
fibroadenoma 10 | 557
medulloblastoma 10 | 1,524
Atopic dermatitis 9 | 944
astrocytoma 9 | 1,493
spina bifida 9 | 1,064
ulcerative colitis 9 | 2,087
Retinal Degeneration 8 | 49
active ulcerative colitis 8 | 477
adrenocortical carcinoma 8 | 1,427
breast carcinoma 8 | 1,614
cutaneous lupus erythematosus 8 | 1,056
nasopharyngeal carcinoma 8 | 1,056
sonic hedgehog group medulloblastoma 8 | 1,482
Alzheimer's disease 7 | 644
Hypercholesterolemia, Familial 7 | 16
Kidney disease 7 | 396
Metabolic syndrome X 7 | 155
active Crohn's disease 7 | 918
primary pancreatic ductal adenocarcinoma 7 | 1,271
Age related macular degeneration 6 | 84
Amyloidosis 6 | 68
Congenital stationary night blindness 6 | 27
Hypertension 6 | 287
Night blindness, congenital stationary 6 | 14
Polycystic Ovary Syndrome 6 | 332
Rheumatoid Arthritis 6 | 1,160
aldosterone-producing adenoma 6 | 664
non primary Sjogren syndrome sicca 6 | 840
posterior fossa group A ependymoma 6 | 1,511
tuberculosis 6 | 1,557
Bradyopsia 5 | 10
Cardiovascular Diseases 5 | 50
Cardiovascular system disease 5 | 194
Cerebrovascular disease 5 | 231
Coronary heart disease 5 | 59
Craniofacial Abnormalities 5 | 147
Duchenne muscular dystrophy 5 | 602
Fundus Albipunctatus 5 | 8
Heart disease 5 | 279
Multiple myeloma 5 | 1,327
Pancreatitis 5 | 97
Pick disease 5 | 1,893
Simpson-Golabi-Behmel syndrome 5 | 17
Uveitis 5 | 103
Vascular disease 5 | 281
acute quadriplegic myopathy 5 | 1,157
colon cancer 5 | 1,475
cone-rod dystrophy 5 | 56
facioscapulohumeral dystrophy 5 | 286
mucosa-associated lymphoid tissue lymphoma 5 | 480
nephrosclerosis 5 | 329
tuberculosis and treatment for 6 months 5 | 686
Schizophrenia 4 | 501
gastric carcinoma 4 | 832

Tissue

Nervous System 95 | 18,561
Cardiovascular System 94 | 17,958
Digestive Tract 94 | 18,473
Endocrine System 93 | 18,512
Female tissues 93 | 18,647
Liver and Pancreas 93 | 18,136
Skin and soft tissues 93 | 18,115
Urinary Tract 93 | 18,444
Blood and immune system 92 | 17,995
Male tissues 92 | 17,969
Respiratory system 89 | 17,484

Target Family

Non-IDG 42 | 11,971
Enzyme 40 | 4,146
Kinase 7 | 634
GPCR 3 | 406
Ion Channel 2 | 341
Transporter 2 | 473

Reactome Pathway

Visual phototransduction 96 | 96
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Glypican-3 GPC3 Tbio Non-IDG -2.85848 794.8 523
Short-wave-sensitive opsin 1 OPN1SW Tbio GPCR -1.90084 81.3 15
Apolipoprotein A-I APOA1 Tchem Non-IDG -3.60439 3516.7 901
Apolipoprotein C-II APOC2 Tbio Non-IDG -2.49982 337.4 18
Apolipoprotein A-II APOA2 Tbio Non-IDG -2.80284 593.9 352
Apolipoprotein C-III APOC3 Tbio Non-IDG -2.90374 836.7 239
Transthyretin TTR Tclin Non-IDG -3.74965 5822.8 617
Recoverin RCVRN Tbio Non-IDG -2.41555 275.7 360