Development Level

Tbio 72 | 11,651
Tchem 18 | 1,388
Tclin 5 | 612
Tdark 3 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 3 | 298
abnormal heart morphology 3 | 162
decreased circulating serum al... 3 | 82
decreased exploration in new e... 3 | 11
enlarged heart 3 | 210
increased circulating alkaline... 3 | 122
increased circulating potassiu... 3 | 29
increased lean body mass 3 | 172
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal sleep behavior 2 | 70
decreased body weight 2 | 161
decreased circulating glucose ... 2 | 126
decreased lymphocyte cell numb... 2 | 83
decreased red blood cell distr... 2 | 41
embryonic lethality prior to t... 2 | 278
hyperactivity 2 | 148
hypoactivity 2 | 132
impaired righting response 2 | 26
increased blood urea nitrogen ... 2 | 48
increased circulating choleste... 2 | 66
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal pericardium morpholog... 1 | 26
abnormal pupil morphology 1 | 2
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased circulating unsatura... 1 | 2
decreased erythrocyte cell num... 1 | 62
decreased heart rate variabili... 1 | 13
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cellular hemoglobin ... 1 | 1
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 36
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
limb grasping 1 | 41
macrophthalmia 1 | 2
male infertility 1 | 123
mydriasis 1 | 6
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prolonged PR interval 1 | 15
small adrenal glands 1 | 16
small kidney 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
stereotypic behavior 1 | 3
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

Carcinoma 65 | 11,493
psoriasis 53 | 6,694
osteosarcoma 41 | 7,950
ovarian cancer 34 | 8,520
glioblastoma 30 | 5,792
medulloblastoma, large-cell 29 | 6,241
Autosomal recessive predisposition 26 | 1,442
ependymoma 26 | 4,679
lung cancer 25 | 4,740
atypical teratoid / rhabdoid tumor 24 | 5,112
Breast cancer 23 | 3,578
Obesity 23 | 678
group 3 medulloblastoma 22 | 4,104
lung carcinoma 22 | 2,843
Night Blindness 21 | 101
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
Difficulties with night vision 20 | 87
Retinitis Pigmentosa 20 | 226
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
invasive ductal carcinoma 20 | 2,951
non-small cell lung cancer 20 | 2,890
primitive neuroectodermal tumor 20 | 3,035
Intellectual disability 19 | 1,016
adult high grade glioma 19 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
lung adenocarcinoma 19 | 2,716
diabetes mellitus 18 | 1,728
ductal carcinoma in situ 18 | 1,745
malignant mesothelioma 18 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Cancer 17 | 2,499
Photodysphoria 17 | 121
Photophobia 17 | 121
astrocytic glioma 17 | 2,597
Abnormality of retinal pigmentation 16 | 111
Astrocytoma, Pilocytic 16 | 3,081
Broad flat nasal bridge 16 | 236
Cataract 16 | 297
Cone dystrophy 16 | 71
Dull intelligence 16 | 645
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Nasal bridge wide 16 | 236
Nystagmus 16 | 317
Poor school performance 16 | 645
Retinal pigment epithelial abnormality 16 | 111
pituitary cancer 16 | 1,972
Electroretinogram abnormal 15 | 95
Lens Opacities 15 | 231
Retinal Degeneration 15 | 106
Sensorineural Hearing Loss (disorder) 15 | 284
Anteverted nostril 14 | 191
Fundus dystrophy 14 | 83
Hyperinsulinism 14 | 133
oligodendroglioma 14 | 2,850
pancreatic cancer 14 | 2,398
subependymal giant cell astrocytoma 14 | 2,287
Blind Vision 13 | 111
Blindness, Legal 13 | 110
Keratoconus 13 | 113
Kidney cancer 13 | 2,613
Low Vision 13 | 174
Reduced visual acuity 13 | 63
Visual Impairment 13 | 174
group 4 medulloblastoma 13 | 1,855
Abnormality of the retinal vasculature 12 | 59
Atypical scarring of skin 12 | 62
Conductive hearing loss 12 | 123
Congenital anomaly of testis 12 | 52
Congenital hypoplasia of penis 12 | 176
Glaucoma 12 | 239
Hypogonadism 12 | 173
Night blindness, progressive 12 | 51
Ophthalmoplegia 12 | 106
Optic Atrophy 12 | 242
Schizophrenia 12 | 1,160
cystic fibrosis 12 | 1,696
interstitial cystitis 12 | 2,312
Atherosclerosis 11 | 291
Blindness 11 | 88
Lipid metabolism disorder 11 | 114
active ulcerative colitis 11 | 764
Coronary artery disease 10 | 268
Leber congenital amaurosis 10 | 69
fibroadenoma 10 | 559
Atopic dermatitis 9 | 952
Hypertension 9 | 396
adrenocortical carcinoma 9 | 1,428
astrocytoma 9 | 1,146
spina bifida 9 | 1,074
Kidney disease 8 | 430
Liver Cirrhosis, Experimental 8 | 769
Myopia 8 | 176
breast carcinoma 8 | 1,638
cutaneous lupus erythematosus 8 | 1,057
nasopharyngeal carcinoma 8 | 1,058
pediatric high grade glioma 8 | 1,064
tuberculosis 8 | 2,010
ulcerative colitis 8 | 1,819

Tissue

Endocrine System 94 | 18,159
Digestive Tract 92 | 17,369
Skin and soft tissues 90 | 17,230
Female tissues 85 | 17,400
Male tissues 85 | 17,142
Blood and immune system 83 | 16,909
Urinary Tract 83 | 16,678
Nervous System 82 | 16,725
Liver and Pancreas 80 | 16,750
Respiratory system 76 | 16,393
Cardiovascular System 69 | 15,192

Target Family

Enzyme 42 | 4,145
Non-IDG 42 | 12,091
Kinase 7 | 634
GPCR 4 | 408
Ion Channel 2 | 344
Transporter 1 | 473

Reactome Pathway

Visual phototransduction 98 | 98
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Long-wave-sensitive opsin 1 OPN1LW Tbio GPCR -2.37983 238.7 47
Medium-wave-sensitive opsin 1 OPN1MW Tbio GPCR -0.97721 8.41 18
Syndecan-4 SDC4 Tbio Non-IDG -2.39649 274.8 297
cGMP-gated cation channel alpha-1 CNGA1 Tchem Ion Channel -1.86143 69.8 62
Guanine nucleotide-binding protein G(T) subunit gamma-T1 GNGT1 Tbio Non-IDG -1.43842 22.5 61
Transthyretin TTR Tclin Non-IDG -3.79596 6198.3 750
Phospholipase B1, membrane-associated PLB1 Tdark Enzyme -1.65839 46.0 43
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.06808 938.9 585
Methionine aminopeptidase 2 METAP2 Tchem Enzyme -0.86233 8.18 191
Retinol-binding protein 4 RBP4 Tchem Non-IDG -2.69398 556.8 924