Development Level

Tbio 538 | 11,445
Tdark 127 | 6,588
Tchem 44 | 1,598
Tclin 11 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 72 | 979
preweaning lethality, incomple... 24 | 499
embryonic lethality prior to t... 21 | 278
abnormal embryo size 19 | 220
embryonic lethality prior to o... 17 | 239
abnormal behavior 16 | 298
decreased total body fat amoun... 15 | 207
decreased circulating choleste... 12 | 93
decreased vertical activity 12 | 208
decreased body weight 10 | 161
enlarged heart 10 | 210
hyperactivity 10 | 148
decreased bone mineral content 9 | 151
cardiovascular system phenotyp... 8 | 36
decreased circulating HDL chol... 8 | 68
decreased circulating LDL chol... 8 | 38
embryonic growth retardation 8 | 106
increased circulating alkaline... 8 | 122
increased lean body mass 8 | 172
increased mean corpuscular vol... 8 | 92
abnormal heart morphology 7 | 162
abnormal lens morphology 7 | 81
cataract 7 | 92
decreased circulating alanine ... 7 | 47
decreased circulating serum al... 7 | 82
decreased mean corpuscular hem... 7 | 50
abnormal bone structure 6 | 187
abnormal seminal vesicle morph... 6 | 114
abnormal sleep behavior 6 | 70
decreased caudal vertebrae num... 6 | 53
decreased circulating glucose ... 6 | 126
decreased circulating triglyce... 6 | 79
decreased fasted circulating g... 6 | 65
decreased leukocyte cell numbe... 6 | 73
enlarged spleen 6 | 41
hydrometra 6 | 53
increased bone mineral content 6 | 108
increased fasted circulating g... 6 | 76
increased heart weight 6 | 62
increased hematocrit 6 | 46
increased or absent threshold ... 6 | 101
prenatal lethality prior to he... 6 | 87
abnormal retina morphology 5 | 71
decreased bone mineral density 5 | 126
decreased circulating insulin ... 5 | 76
decreased grip strength 5 | 116
enlarged lymph nodes 5 | 37
hypoactivity 5 | 132
impaired glucose tolerance 5 | 75
increased circulating choleste... 5 | 66
increased grip strength 5 | 41
increased mean corpuscular hem... 5 | 96
increased mean corpuscular hem... 5 | 36
increased startle reflex 5 | 112
abnormal coat-hair pigmentatio... 4 | 64
abnormal kidney morphology 4 | 65
abnormal pericardium morpholog... 4 | 26
abnormal spleen morphology 4 | 55
decreased circulating aspartat... 4 | 34
decreased circulating free fat... 4 | 31
decreased hemoglobin content 4 | 68
decreased lean body mass 4 | 135
decreased mean corpuscular vol... 4 | 79
decreased prepulse inhibition 4 | 82
edema 4 | 59
increased bone mineral density 4 | 72
increased total body fat amoun... 4 | 134
prolonged QT interval 4 | 38
abnormal behavioral response t... 3 | 66
abnormal embryo turning 3 | 31
abnormal eye morphology 3 | 68
abnormal femur morphology 3 | 14
abnormal testis morphology 3 | 43
abnormal tooth morphology 3 | 24
decreased blood urea nitrogen ... 3 | 51
decreased body length 3 | 101
decreased circulating amylase ... 3 | 28
decreased circulating total pr... 3 | 49
decreased erythrocyte cell num... 3 | 62
decreased heart rate 3 | 18
decreased heart rate variabili... 3 | 13
decreased hematocrit 3 | 46
decreased lactate dehydrogenas... 3 | 16
decreased mean corpuscular hem... 3 | 31
improved glucose tolerance 3 | 79
increased circulating HDL chol... 3 | 80
increased circulating LDL chol... 3 | 13
increased circulating free fat... 3 | 20
increased leukocyte cell numbe... 3 | 47
increased mean platelet volume 3 | 45
limb grasping 3 | 41
male infertility 3 | 123
pallor 3 | 34
persistence of hyaloid vascula... 3 | 33
short tibia 3 | 97
small superior vagus ganglion 3 | 74
small testis 3 | 58
thrombocytopenia 3 | 56
thrombocytosis 3 | 27
abnormal limb bud morphology 2 | 17

Disease

Carcinoma 421 | 11,493
ovarian cancer 412 | 8,520
osteosarcoma 353 | 7,950
medulloblastoma, large-cell 259 | 6,241
psoriasis 258 | 6,694
glioblastoma 244 | 5,792
atypical teratoid / rhabdoid tumor 217 | 5,112
lung cancer 194 | 4,740
ependymoma 189 | 4,679
Breast cancer 154 | 3,578
adult high grade glioma 153 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 139 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 137 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 134 | 2,989
malignant mesothelioma 134 | 3,232
Kidney cancer 130 | 2,613
group 3 medulloblastoma 130 | 4,104
invasive ductal carcinoma 130 | 2,951
non-small cell lung cancer 123 | 2,890
Astrocytoma, Pilocytic 120 | 3,081
lung adenocarcinoma 118 | 2,716
lung carcinoma 111 | 2,843
oligodendroglioma 108 | 2,850
pancreatic cancer 105 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 101 | 1,962
primitive neuroectodermal tumor 100 | 3,035
astrocytic glioma 99 | 2,597
subependymal giant cell astrocytoma 97 | 2,287
Pick disease 94 | 1,894
Multiple myeloma 93 | 1,332
Cancer 91 | 2,499
tuberculosis 91 | 2,010
diabetes mellitus 87 | 1,728
interstitial cystitis 87 | 2,312
group 4 medulloblastoma 82 | 1,855
Autosomal recessive predisposition 79 | 1,442
acute quadriplegic myopathy 75 | 1,158
breast carcinoma 73 | 1,638
ductal carcinoma in situ 72 | 1,745
juvenile dermatomyositis 70 | 1,187
astrocytoma 63 | 1,146
pituitary cancer 63 | 1,972
dermatomyositis 60 | 966
ulcerative colitis 60 | 1,819
adrenocortical carcinoma 59 | 1,428
primary pancreatic ductal adenocarcinoma 58 | 1,109
spina bifida 58 | 1,074
Schizophrenia 55 | 1,160
colon cancer 54 | 1,478
cystic fibrosis 54 | 1,696
Intellectual disability 51 | 1,016
Rheumatoid arthritis 51 | 1,191
Epilepsy 49 | 792
Waldenstrons macroglobulinemia 44 | 765
cutaneous lupus erythematosus 44 | 1,057
pediatric high grade glioma 43 | 1,064
Neurodegenerative disease 41 | 414
non primary Sjogren syndrome sicca 41 | 891
Atopic dermatitis 40 | 952
Alzheimer's disease 39 | 658
Cognitive delay 39 | 608
Global developmental delay 39 | 608
Mental and motor retardation 39 | 608
Liver Cirrhosis, Experimental 38 | 769
esophageal adenocarcinoma 38 | 737
gastric carcinoma 37 | 807
Dull intelligence 36 | 645
Low intelligence 36 | 645
Mental Retardation 36 | 645
Mental deficiency 36 | 645
Poor school performance 36 | 645
Seizures 36 | 596
Bipolar Disorder 35 | 666
Duchenne muscular dystrophy 33 | 601
acute myeloid leukemia 33 | 783
hereditary spastic paraplegia 32 | 318
active Crohn's disease 31 | 922
mucosa-associated lymphoid tissue lymphoma 31 | 484
Liver cancer 30 | 604
Muscle hypotonia 30 | 571
aldosterone-producing adenoma 30 | 665
primary Sjogren syndrome 29 | 735
progressive supranuclear palsy 29 | 676
Kidney disease 28 | 430
Melanoma 28 | 711
nasopharyngeal carcinoma 28 | 1,058
Down syndrome 27 | 499
autosomal dominant Emery-Dreifuss muscular dystrophy 27 | 510
pancreatic carcinoma 27 | 562
hepatocellular carcinoma 26 | 547
Neuropathy 25 | 261
Parkinson's disease 25 | 392
Small head 25 | 374
Acquired scoliosis 24 | 281
Amyotrophic lateral sclerosis 24 | 451
Curvature of spine 24 | 282
Obesity 24 | 678
Short stature 24 | 531
Depressive disorder 23 | 409
sonic hedgehog group medulloblastoma 23 | 467

Tissue

Endocrine System 640 | 18,159
Female tissues 636 | 17,400
Skin and soft tissues 636 | 17,230
Digestive Tract 634 | 17,369
Urinary Tract 632 | 16,678
Male tissues 630 | 17,142
Blood and immune system 628 | 16,909
Liver and Pancreas 628 | 16,750
Nervous System 626 | 16,725
Respiratory system 625 | 16,393
Cardiovascular System 616 | 15,192

Target Family

Non-IDG 589 | 12,091
Enzyme 103 | 4,145
Kinase 15 | 634
GPCR 6 | 408
Transporter 3 | 473
Ion Channel 2 | 344
Transcription Factor 2 | 1,400

Reactome Pathway

Vesicle-mediated transport 720 | 720
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kinesin-like protein KIF25 KIF25 Tbio Non-IDG -0.75019 5.59 191
Rab-3A-interacting protein RAB3IP Tbio Non-IDG -1.03500 11.6 89
Ras-related protein Rab-39A RAB39A Tdark Enzyme -0.57787 3.49 68
Scavenger receptor cysteine-rich type 1 protein M130 CD163 Tbio Non-IDG -2.93036 825.2 985
Endophilin-A2 SH3GL1 Tbio Non-IDG -2.15479 134.2 257
Gap junction delta-2 protein GJD2 Tbio Non-IDG -2.48933 326.9 192
Sorting nexin-5 SNX5 Tbio Non-IDG -1.23706 20.8 141
Kinesin-like protein KIF18B KIF18B Tbio Non-IDG -0.83463 5.23 17
Stabilin-1 STAB1 Tbio Non-IDG -1.61013 45.4 107
ADP-ribosylation factor-related protein 1 ARFRP1 Tbio Enzyme -1.22088 20.8 63