Development Level

Tbio 8 | 11,445
Tchem 2 | 1,598
Tclin 1 | 613

IMPC Phenotype

abnormal seminal vesicle morph... 2 | 114
abnormal behavior 1 | 298
abnormal cecum morphology 1 | 7
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal kidney morphology 1 | 65
abnormal sleep behavior 1 | 70
absent pinna reflex 1 | 23
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased heart weight 1 | 27
decreased vertical activity 1 | 208
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
hydrometra 1 | 53
hyperactivity 1 | 148
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased exploration in new e... 1 | 8
increased mean corpuscular hem... 1 | 96
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

Carcinoma 8 | 11,493
ovarian cancer 8 | 8,520
psoriasis 7 | 6,694
Breast cancer 3 | 3,578
Cataract 8 multiple types 3 | 33
Kidney cancer 3 | 2,613
active Crohn's disease 3 | 922
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
malignant mesothelioma 3 | 3,232
medulloblastoma, large-cell 3 | 6,241
osteosarcoma 3 | 7,950
Atherosclerosis 2 | 291
Cholestasis 2 | 155
Lipid metabolism disorder 2 | 114
Multiple myeloma 2 | 1,332
active ulcerative colitis 2 | 764
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
esophageal adenocarcinoma 2 | 737
head and neck cancer and chronic obstructive pulmonary disease 2 | 239
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
pancreatic cancer 2 | 2,398
posterior fossa group B ependymoma 2 | 416
spina bifida 2 | 1,074
ulcerative colitis 2 | 1,819
Abetalipoproteinemia 1 | 7
Abnormality of metabolism/homeostasis 1 | 134
Acquired flat foot 1 | 72
Action Tremor 1 | 22
Adenocarcinoma 1 | 122
Arcus Senilis 1 | 11
Ataxia telangiectasia 1 | 34
Ataxia, Truncal 1 | 21
Atrophy of cerebellum 1 | 103
Autistic Disorder 1 | 364
Autosomal dominant nonsyndromic deafness 13 1 | 2
Autosomal dominant nonsyndromic deafness 21 1 | 3
Autosomal dominant nonsyndromic deafness 31 1 | 3
Brain disease 1 | 96
Broad-based gait 1 | 19
Calcium pyrophosphate deposition disease 1 | 13
Carcinoma, Hepatocellular 1 | 228
Cardiovascular system disease 1 | 246
Cerebellar Dysmetria 1 | 56
Cerebellar degeneration 1 | 103
Cerebral palsy 1 | 40
Cerebrovascular disease 1 | 238
Charcot-Marie-Tooth disease type 4D 1 | 1
Chemical and Drug Induced Liver Injury 1 | 195
Coronary artery disease 1 | 268
Cortical gyral simplification 1 | 19
Delayed speech and language development 1 | 112
Diffuse large B-cell lymphoma 1 | 39
Dysarthria 1 | 192
Dysdiadochokinesis 1 | 25
Fatty Liver 1 | 70
Flatfoot 1 | 73
Gait Ataxia 1 | 51
Heart disease 1 | 306
Hypercalcemia 1 | 59
Hypercholesterolemia 1 | 44
Hyperreflexia 1 | 209
Hypoparathyroidism 1 | 41
Hypoplasia of the brainstem 1 | 22
Inflammatory myofibroblastic tumor 1 | 8
Infratentorial atrophy 1 | 103
Language Delay 1 | 112
Leber congenital amaurosis 1 | 69
Lipoma 1 | 32
Lissencephaly 1 | 69
Liver cancer 1 | 604
Liver carcinoma 1 | 240
Lymphoma, Large B-Cell, Diffuse 1 | 34
Metabolic syndrome X 1 | 52
Nasopharyngitis 1 | 11
Nephroblastoma 1 | 51
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Nystagmus, End-Position 1 | 12
Pachygyria 1 | 41
Pain agnosia 1 | 104
Pancreatitis 1 | 123
Poor speech 1 | 37
Prenatal onset 1 | 139
Problems speaking 1 | 37
Seizures 1 | 596
Skeletal muscle atrophy 1 | 139
Speech Delay 1 | 112
Speech impairment 1 | 112
Strabismus 1 | 270
Telangiectasis 1 | 36
Terminal tremor 1 | 20
Wolff-Parkinson-White syndrome 1 | 19
interstitial lung disease 1 | 298
muscle degeneration 1 | 139
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 11 | 16,909
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678
Cardiovascular System 10 | 15,192

Target Family

Non-IDG 7 | 12,091
Enzyme 2 | 4,145
Nuclear Receptor 2 | 48

Reactome Pathway

VLDLR internalisation and degr... 11 | 11
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.66258 38.8 231
Clathrin light chain A CLTA Tbio Non-IDG -1.32676 16.0 244
E3 ubiquitin-protein ligase MYLIP MYLIP Tbio Enzyme -2.05580 115.6 135
AP-2 complex subunit beta AP2B1 Tbio Non-IDG -1.59767 34.8 212
AP-2 complex subunit alpha-2 AP2A2 Tbio Non-IDG -0.65996 4.74 124
AP-2 complex subunit sigma AP2S1 Tbio Non-IDG -1.42073 25.5 108
Proprotein convertase subtilisin/kexin type 9 PCSK9 Tclin Enzyme -3.23656 1735.1 468
Very low-density lipoprotein receptor VLDLR Tbio Non-IDG -2.41777 260.3 283
AP-2 complex subunit mu AP2M1 Tbio Non-IDG -2.61068 397.1 345
Oxysterols receptor LXR-beta NR1H2 Tchem Nuclear Receptor -1.76175 49.8 287